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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 32, pp. E4671 - E4680
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 20, pp. 17921 - 17933
Innate cellular immunity is the immediate host response against pathogens, and activation of innate immunity also modulates the induction of adaptive immunity.... 
AIM2 INFLAMMASOME | GLOMERULAR MESANGIAL CELLS | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MURINE MACROPHAGES | INNATE IMMUNE-RESPONSE | MONONUCLEAR-CELLS | NLRP3 INFLAMMASOME | CASPASE-1 ACTIVATION | VIRAL REPLICATION | NALP3 INFLAMMASOME | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Herpesvirus 3, Human - immunology | Transplantation, Heterologous | Caspase 1 - immunology | Interleukin-1beta - genetics | Chickenpox - immunology | Enzyme Activation - immunology | Herpesvirus 3, Human - metabolism | Interleukin-1beta - metabolism | Skin Transplantation | Nuclear Proteins - genetics | Carrier Proteins - immunology | DNA-Binding Proteins | Herpes Zoster - immunology | Interleukin-1beta - immunology | Nuclear Proteins - metabolism | Chickenpox - metabolism | Herpes Zoster - metabolism | Immunity, Innate | Mice, SCID | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Chickenpox - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Inflammasomes - immunology | Herpes Zoster - genetics | Cell Line, Tumor | Mice | Enzyme Activation - genetics | Index Medicus | ASC | Immunology | Reactive Oxygen Species (ROS) | Varicella-Zoster Virus | Pathogen-associated Molecular Pattern (PAMP) | NLRP3 | Inflammation | Interferon | Inflammasome | Lipopolysaccharide (LPS) | Caspase-1
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2013, Volume 32, Issue 1, pp. 86 - 99
Infection of macrophages by bacterial pathogens can trigger Toll‐like receptor (TLR) activation as well as Nod‐like receptors (NLRs) leading to inflammasome... 
pyroptosis | Toll‐like receptor | HMGB1 | inflammasome | Nod‐like receptor C4 | Nod-like receptor C4 | Toll-like receptor | APOPTOSIS | CASPASE-1 | INFLAMMASOME ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NLRC4 INFLAMMASOME | NLRP3 INFLAMMASOME | CELL-DEATH | CELL BIOLOGY | III SECRETION APPARATUS | INFECTION | CYTOKINE RELEASE | Inflammasomes - metabolism | Calcium-Binding Proteins - agonists | Molecular Sequence Data | Caspase 1 - metabolism | Neuronal Apoptosis-Inhibitory Protein - immunology | Protein Isoforms - metabolism | Calcium-Binding Proteins - immunology | HMGB1 Protein - metabolism | Cell Death | Acetylation | Toll-Like Receptors - metabolism | Macrophages - immunology | Macrophages - microbiology | Neuronal Apoptosis-Inhibitory Protein - agonists | Calcium-Binding Proteins - metabolism | Macrophage Activation - physiology | Macrophages - physiology | Amino Acid Sequence | Cell Line | Apoptosis Regulatory Proteins - immunology | Gene Expression | HMGB1 Protein - analysis | Signal Transduction | Toll-Like Receptors - immunology | Neuronal Apoptosis-Inhibitory Protein - metabolism | Apoptosis Regulatory Proteins - metabolism | Host-Pathogen Interactions | Animals | Inflammasomes - immunology | Apoptosis Regulatory Proteins - agonists | Bacterial Proteins - metabolism | Mice | Apoptosis | Molecular biology | Immunology | Index Medicus | Klinisk medicin | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Infektionsmedicin | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Kidney International, ISSN 0085-2538, 09/2016, Volume 90, Issue 3, pp. 525 - 539
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 3, pp. 1123 - 1136
Many immunostimulants act as vaccine adjuvants via activation of the innate immune system, although in many cases it is unclear which specific molecules... 
ADAPTIVE IMMUNITY | MONOPHOSPHORYL-LIPID-A | HEALTHY ADULT VOLUNTEERS | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NLRP3 INFLAMMASOME | T-CELL | ISCOMATRIX ADJUVANT | PARTICULATE VACCINE ADJUVANTS | QUILLAJA-SAPONARIA MOLINA | NALP3 INFLAMMASOME | HIV Envelope Protein gp120 - agonists | Lipid A - agonists | Adjuvants, Immunologic - analysis | Adjuvants, Immunologic - pharmacology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Lipid A - analogs & derivatives | AIDS Vaccines - immunology | AIDS Vaccines - agonists | Th2 Cells - immunology | Th1 Cells - immunology | GTP-Binding Proteins - genetics | Th2 Cells - drug effects | Saponins - chemistry | HIV Envelope Protein gp120 - immunology | Th1 Cells - metabolism | Immunoglobulin G - biosynthesis | Inflammasomes - drug effects | Adjuvants, Immunologic - chemistry | Bone Marrow Cells - immunology | Bone Marrow Cells - drug effects | Dendritic Cells - drug effects | Immunoglobulin G - analysis | Macrophages - immunology | Cell Survival - drug effects | Th1 Cells - drug effects | Immunity, Innate - drug effects | Bone Marrow Cells - cytology | Mice, Inbred C57BL | Cells, Cultured | Solubility | Saponins - analysis | Macrophages - cytology | Th2 Cells - metabolism | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | Lipid A - pharmacology | Macrophages - drug effects | Dendritic Cells - cytology | GTP-Binding Proteins - metabolism | Saponins - pharmacology | Index Medicus | vaccine | Immunology | human immunodeficiency virus (HIV) | caspase 1 (CASP1) | inflammasome | saponin | NLRP3 | Toll-like receptor 4 (TLR4) | monophosphoryl lipid A | adjuvants
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article