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Biochemical Society Transactions, ISSN 0300-5127, 08/2015, Volume 43, Issue 4, pp. 621 - 626
Journal Article
Molecular Genetics and Metabolism Reports, ISSN 2214-4269, 2014, Volume 1, Issue 1, pp. 324 - 333
In Manitoba, Canada, the overall incidence of Severe Combined Immunodeficiency (SCID) is three-fold higher than the national average, with SCID overrepresented... 
Archived Guthrie cards | Newborn screening | Severe Combined Immunodeficiency | T-cell receptor excision circle | Dried blood spots | T-cell positive primary immunodeficiency
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 09/2011, Volume 6, Issue 9, pp. 1521 - 1529
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB) (IKK-β/IKK-2), which activates NF-κB, is a substrate of the KEAP1-CUL3-RBX1... 
IKBKB | NF-κB signaling | KEAP1 | CUL3 | RBX1 | Genetic disruption | OXIDATIVE STRESS | PROTEIN | CELL-LINES | HUMAN GENOME | CATALOG | NRF2 | ONCOLOGY | RESPIRATORY SYSTEM | ADAPTER | TARGETS | MUTATIONS | NF-kappa B signaling | REQUIREMENT | RNA, Small Interfering - genetics | Adenocarcinoma - pathology | Prognosis | Oligonucleotide Array Sequence Analysis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | NF-kappa B - metabolism | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Adenocarcinoma - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Cullin Proteins - metabolism | Adenocarcinoma - genetics | Tumor Cells, Cultured | Intracellular Signaling Peptides and Proteins - genetics | Kelch-Like ECH-Associated Protein 1 | Lung Neoplasms - genetics | NF-kappa B - antagonists & inhibitors | Cullin Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | Survival Rate | Gene Dosage | I-kappa B Kinase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cullin Proteins - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | NF-kappa B - genetics | Biomarkers, Tumor - genetics | Neoplasm Staging | genetic disruption
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 02/2018, Volume 95, pp. 108 - 112
Constitutive NF-κB signalling has been implicated in the pathogenesis of most human malignancies and virtually all non-malignant pathologies. Accordingly, the... 
NF-κB | DTP3 | IKKβ | GADD45β | Cancer | GADD45 beta | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | CELL BIOLOGY | UBIQUITINATION | BCL-2 | IKK beta | NF-kappa B | INHIBITION | PATHWAY | GADD45-BETA | Neoplasms - metabolism | Cell Survival - drug effects | Molecular Targeted Therapy - adverse effects | NF-kappa B - antagonists & inhibitors | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Apoptosis - drug effects | Humans | Drugs, Investigational - therapeutic use | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - chemistry | Neoplasm Proteins - metabolism | Neoplasms - drug therapy | Drugs, Investigational - chemistry | Animals | Molecular Targeted Therapy - trends | Signal Transduction - drug effects | Antineoplastic Agents - adverse effects | Models, Biological | Drug Design | Antineoplastic Agents - pharmacology | Neoplasms - pathology | GBM, glioblastoma multiforme | SCF, SKP1-Cullin 1-F-box protein | MCL1, myeloid cell leukaemia sequence 1 | JNK, c-Jun N-terminal kinase | IL-1β, interleukin-1β | IκBα, nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor α | GADD45β, growth arrest and DNA damage inducible β | cFLIP, cellular FLICE-inhibitory protein | DIABLO, direct inhibitor of apoptosis protein (IAP)-binding protein with low pI | NF-κB, nuclear factor κ B (nuclear factor binding to the κ-light-chain-enhancer B site) | BCL-XL, B-cell lymphoma-extra large | DLBCL, diffuse large B-cell lymphoma | RAS, rat sarcoma virus oncogene | MALT, mucosa-associated lymphoid tissue | FLICE, FADD-like IL-1β-converting enzyme | FDA, US Food and Drug Administration | βTrCPP, β-transducin repeat-containing proteint | IKK, IκBα kinase | XIAP, X chromosome-linked inhibitor of apoptosis protein | BCL-2, B-cell lymphoma 2 | MAP, mitogen activated protein | TME, tumour microenvironment | cIAP, cellular inhibitor of apoptosis | CLL, chronic lymphocytic leukaemia | SMAC, second mitochondria-derived activator of caspases | BFL-1, Bcl-2-related gene expressed in foetal liver | PTEN, phosphatase and tensin homolog
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2018, Volume 144, Issue 6, pp. 761 - 779
Journal Article
Journal Article