X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1414463) 1414463
Newsletter (21456) 21456
Newspaper Article (11489) 11489
Book Chapter (5899) 5899
Magazine Article (4215) 4215
Web Resource (3080) 3080
Dissertation (2869) 2869
Conference Proceeding (2645) 2645
Publication (1066) 1066
Book / eBook (944) 944
Government Document (890) 890
Transcript (527) 527
Trade Publication Article (441) 441
Book Review (278) 278
Reference (189) 189
Streaming Video (77) 77
Journal / eJournal (39) 39
Paper (39) 39
Report (18) 18
Data Set (4) 4
Library Holding (1) 1
Video Recording (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (711740) 711740
animals (556317) 556317
male (367712) 367712
female (284987) 284987
rats (199589) 199589
mice (187488) 187488
biochemistry & molecular biology (172858) 172858
pharmacology & pharmacy (157092) 157092
middle aged (136287) 136287
adult (120986) 120986
inhibitors (114534) 114534
oncology (110980) 110980
expression (105883) 105883
aged (103803) 103803
enzyme inhibitors - pharmacology (100007) 100007
cancer (90663) 90663
cell biology (86880) 86880
dose-response relationship, drug (86785) 86785
research (86084) 86084
apoptosis (82752) 82752
analysis (80397) 80397
cells, cultured (78857) 78857
cell line, tumor (72852) 72852
neurosciences (69256) 69256
proteins (68984) 68984
chemistry, medicinal (68459) 68459
activation (67541) 67541
kinetics (66238) 66238
time factors (65129) 65129
treatment outcome (64728) 64728
inhibitor (63857) 63857
phosphorylation (58370) 58370
cell line (58315) 58315
rats, sprague-dawley (56085) 56085
inhibition (54362) 54362
cells (54334) 54334
in vitro techniques (52076) 52076
signal transduction (51959) 51959
structure-activity relationship (51794) 51794
immunology (49318) 49318
care and treatment (49211) 49211
chemistry, organic (47031) 47031
risk factors (45203) 45203
health aspects (44951) 44951
molecular sequence data (43988) 43988
physiological aspects (43672) 43672
in-vitro (43253) 43253
gene expression (43049) 43049
hematology (42685) 42685
apoptosis - drug effects (42574) 42574
therapy (42190) 42190
enzymes (41437) 41437
mutation (41287) 41287
amino acid sequence (40411) 40411
research article (40390) 40390
rats, wistar (39562) 39562
inflammation (39533) 39533
disease models, animal (39517) 39517
cardiac & cardiovascular systems (39264) 39264
antineoplastic agents - pharmacology (39125) 39125
drug therapy (38059) 38059
signal transduction - drug effects (37726) 37726
binding sites (37423) 37423
protein binding (37085) 37085
mice, inbred c57bl (35612) 35612
physiology (35388) 35388
protein (34972) 34972
molecular structure (34505) 34505
models, molecular (34418) 34418
chemistry, multidisciplinary (34387) 34387
medicine, research & experimental (34293) 34293
peripheral vascular disease (34218) 34218
endocrinology & metabolism (33930) 33930
aged, 80 and over (33700) 33700
binding (33396) 33396
multidisciplinary sciences (33183) 33183
cell proliferation - drug effects (31918) 31918
growth (31796) 31796
identification (31008) 31008
medicine, general & internal (30896) 30896
biophysics (30732) 30732
drug therapy, combination (30499) 30499
tumor cells, cultured (30460) 30460
gene-expression (30137) 30137
protease inhibitors (30070) 30070
oxidative stress (29495) 29495
blotting, western (29474) 29474
in-vivo (29130) 29130
medicine & public health (29109) 29109
enzyme inhibitors (28756) 28756
adolescent (28578) 28578
kinases (28372) 28372
abridged index medicus (28243) 28243
medicine (27728) 27728
disease (27573) 27573
derivatives (27405) 27405
tumors (27385) 27385
chemotherapy (27272) 27272
immunohistochemistry (26989) 26989
genetic aspects (26920) 26920
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (476) 476
Online Resources - Online (390) 390
Collection Dvlpm't (Acquisitions) - Vendor file (88) 88
Collection Dvlpm't (Acquisitions) - Closed Orders (46) 46
UofT at Mississauga - Stacks (37) 37
Engineering & Comp. Sci. - Stacks (32) 32
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (14) 14
Chemistry (A D Allen) - Stacks (13) 13
UTL at Downsview - May be requested (13) 13
Gerstein Science - Periodical Stacks (8) 8
UofT at Scarborough - Stacks (8) 8
Gerstein Science - Theses (7) 7
Earth Sciences (Noranda) - Stacks (4) 4
Robarts - Stacks (4) 4
Gerstein Science - Bindery (3) 3
Gerstein Science - Missing (3) 3
Scarborough Hospital - General (3) 3
Collection Dvlpm't (Acquisitions) - Cancelled Order (2) 2
Gerstein Science - Circulation Desk (2) 2
Scarborough Hospital - Online (2) 2
University Archives - Archives (2) 2
University College (Laidlaw) - Stacks (2) 2
Baycrest Hospital - Stacks (1) 1
Chemistry (A D Allen) - May be requested in 6-10 wks (1) 1
Humber River Regional Hospital - Church Stacks (1) 1
Humber River Regional Hospital - Online (1) 1
Knox College (Caven) - Stacks (1) 1
Lakeridge Health Sciences - Online (1) 1
Markham Stouffville Hospital - Stacks (1) 1
Media Commons - Audio Visual (1) 1
Patient Education (1) 1
Pharmacy (1) 1
Providence Healthcare - Stacks (1) 1
Scarborough Hospital - Birchmount (1) 1
Scarborough Hospital - Hospital Department (1) 1
St. Michael's College (John M. Kelly) - 2nd Floor (1) 1
St. Michael's Hospital - Stacks (1) 1
UofT Schools - Stacks (1) 1
UofT at Scarborough - May be requested in 6-10 wks (1) 1
UofT at Scarborough - Withdrawn (1) 1
Victoria University E.J. Pratt - Stacks (1) 1
Women's College Hospital - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1401797) 1401797
Japanese (21251) 21251
German (14055) 14055
Russian (13011) 13011
French (12153) 12153
Chinese (9860) 9860
Spanish (5691) 5691
Italian (2965) 2965
Polish (2492) 2492
Portuguese (1794) 1794
Korean (1436) 1436
Czech (1053) 1053
Dutch (811) 811
Hungarian (780) 780
Danish (574) 574
Swedish (536) 536
Ukrainian (495) 495
Norwegian (409) 409
Turkish (365) 365
Romanian (233) 233
Finnish (231) 231
Slovak (217) 217
Hebrew (183) 183
Bulgarian (165) 165
Croatian (162) 162
Serbian (120) 120
Slovenian (60) 60
Lithuanian (55) 55
Persian (51) 51
Indonesian (27) 27
Icelandic (23) 23
Arabic (20) 20
Bosnian (18) 18
Greek (11) 11
Afrikaans (8) 8
Latvian (5) 5
Catalan (4) 4
Malay (3) 3
Welsh (3) 3
Breton (2) 2
Amharic (1) 1
Azerbaijani (1) 1
Belarusian (1) 1
Latin (1) 1
Pushto (1) 1
Vietnamese (1) 1
Zhuang (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 2002
Journal
Nature reviews. Cancer, ISSN 1474-1768, 2017, Volume 17, Issue 2, pp. 93 - 115
Journal Article
Journal of enzyme inhibition, ISSN 8755-5093, 1985
Journal
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 06/2015, Volume 15, Issue 9, pp. 762 - 775
The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method of the synthesis of different 2,5-disubstituted 1,3,4-thiadiazoles... 
1,3,4-thiadiazoles | Cyclooxygenase inhibitors | Leishmanicidal agents | Metalloproteinases inhibitors | Anticonvulsant activity | Diuretics | Carbonic anhydrase inhibitors | Anticancer agents | VITRO ANTITUBERCULOSIS ACTIVITY | CHEMISTRY, MEDICINAL | leishmanicidal agents | GYNECOLOGIC-ONCOLOGY-GROUP | SELECTIVE PDE7 INHIBITORS | HELICOBACTER-PYLORI ACTIVITY | HUMAN ISOFORM-II | IN-VITRO | metalloproteinases inhibitors | anticonvulsant activity | carbonic anhydrase inhibitors | diuretics | AMINOPEPTIDASE-N INHIBITORS | cyclooxygenase inhibitors | SUBSTITUTED 1,3,4-THIADIAZOLES | CARBONIC-ANHYDRASE INHIBITORS | Phosphodiesterase Inhibitors - therapeutic use | Carbonic Anhydrase Inhibitors - chemistry | Humans | Matrix Metalloproteinase Inhibitors - chemistry | Antineoplastic Agents - therapeutic use | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Matrix Metalloproteinase Inhibitors - metabolism | Matrix Metalloproteinase Inhibitors - therapeutic use | Neoplasms - drug therapy | Antineoplastic Agents - metabolism | Animals | Phosphodiesterase Inhibitors - metabolism | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Protein Binding | Phosphodiesterase Inhibitors - chemistry | Thiadiazoles - metabolism | Carbonic Anhydrase Inhibitors - metabolism | Cyclooxygenase Inhibitors - therapeutic use | Quantitative Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - therapeutic use
Journal Article
CA: a cancer journal for clinicians, ISSN 0007-9235, 2010, Volume 60, Issue 4, pp. 222 - 243
Angiogenesis has become an attractive target for drug therapy because of its key role in tumor growth. An extensive array of compounds is currently in... 
TYROSINE KINASE INHIBITORS | CELL LUNG-CANCER | PHASE-III TRIAL | FARNESYL-PROTEIN TRANSFERASE | FACTOR 1-ALPHA | ONCOLOGY | ENDOTHELIAL-GROWTH-FACTOR | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | FACTOR EXPRESSION | VASCULAR-PERMEABILITY FACTOR | TUMOR-GROWTH | Neoplasms - metabolism | Nucleic Acid Synthesis Inhibitors - pharmacology | Humans | Receptor Protein-Tyrosine Kinases - physiology | Antibodies, Monoclonal - therapeutic use | Receptors, Notch - antagonists & inhibitors | Protein Binding - drug effects | Angiogenesis Inhibitors - therapeutic use | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Neovascularization, Pathologic - prevention & control | Farnesyltranstransferase - antagonists & inhibitors | Thioredoxins - antagonists & inhibitors | Nucleic Acid Synthesis Inhibitors - therapeutic use | Basic Helix-Loop-Helix Transcription Factors - physiology | Antibodies, Monoclonal - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Angiogenesis Inhibitors - pharmacology | Receptors, Notch - physiology | Neoplasms - blood supply | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Neoplasms - drug therapy | Signal Transduction - drug effects | Cell Transformation, Neoplastic | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - physiology | Complications and side effects | Care and treatment | Ligands (Biochemistry) | Physiological aspects | Development and progression | Dosage and administration | Angiogenesis inhibitors | Neovascularization | Identification and classification | Growth factors | Cancer | Angiogenesis | Pharmacology | FDA approval | Drug therapy | Kinases | Tumors | hypoxia inducible factor (HIF) | kinase inhibitors | growth factors | angiogenesis inhibitors | VEGF | anti-angiogenesis
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2004, Volume 172, Issue 1, pp. 567 - 576
The signaling mechanism by which the anti-inflammatory cytokine IL-10 mediates suppression of proinflammatory cytokine synthesis remains largely unknown.... 
RHEUMATOID-ARTHRITIS | TUMOR-NECROSIS-FACTOR | DNA-BINDING | HUMAN NEUTROPHILS | TYROSINE PHOSPHORYLATION | INTERLEUKIN-10 RECEPTOR | GENE-EXPRESSION | KAPPA-B-ALPHA | IMMUNOLOGY | HUMAN MONOCYTES | MONONUCLEAR PHAGOCYTES | Protein Binding - genetics | Protein Biosynthesis | Interleukin-6 - antagonists & inhibitors | Humans | Tumor Necrosis Factor-alpha - genetics | Immunoglobulins - genetics | Lipopolysaccharides - antagonists & inhibitors | RNA, Messenger - metabolism | Suppressor of Cytokine Signaling Proteins | Repressor Proteins - antagonists & inhibitors | Antigens, CD - metabolism | Trans-Activators - physiology | Protein Tyrosine Phosphatases - antagonists & inhibitors | RNA, Messenger - biosynthesis | Protein Tyrosine Phosphatases - genetics | Inflammation Mediators - physiology | Glycoproteins - genetics | DNA-Binding Proteins - physiology | Protein Tyrosine Phosphatases - biosynthesis | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction - genetics | DNA - metabolism | Down-Regulation - genetics | Macrophages - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 2 | Repressor Proteins - biosynthesis | Up-Regulation - immunology | Interleukin-10 - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Adenoviruses, Human - genetics | Interleukin-10 - immunology | Tumor Necrosis Factor-alpha - biosynthesis | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Antigens, CD - biosynthesis | Receptors, Cell Surface | Receptors, IgG - biosynthesis | Receptors, IgG - antagonists & inhibitors | Interleukin-10 - physiology | Signal Transduction - immunology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Receptors, Tumor Necrosis Factor - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Receptors, Tumor Necrosis Factor, Type II | Trans-Activators - genetics | Inflammation Mediators - antagonists & inhibitors | Trans-Activators - biosynthesis | Immunoglobulins - biosynthesis | Macrophages - immunology | Inflammation Mediators - immunology | Receptors, Tumor Necrosis Factor - metabolism | Immune Sera - pharmacology | Proteins - physiology | Cells, Cultured | Glycoproteins - antagonists & inhibitors | Histocompatibility Antigens Class II - biosynthesis | Tissue Inhibitor of Metalloproteinase-1 - antagonists & inhibitors | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Up-Regulation - genetics | DNA-Binding Proteins - genetics | DNA - antagonists & inhibitors | Glycoproteins - biosynthesis | Suppressor of Cytokine Signaling 3 Protein | Down-Regulation - immunology | Interleukin-6 - biosynthesis | Receptors, Tumor Necrosis Factor - biosynthesis | STAT3 Transcription Factor | Trans-Activators - antagonists & inhibitors | Genetic Vectors | DNA-Binding Proteins - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Cancer discovery, ISSN 2159-8290, 2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
REARRANGEMENT | ONCOGENE | ONCOLOGY | ANALOG SECRETORY CARCINOMA | LANDSCAPE | KINASE FUSIONS | SARCOMAS | ETV6-NTRK3 GENE FUSION | CRIZOTINIB | GENOMIC ALTERATIONS | CLINICAL-RESPONSE | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2011, Volume 378, Issue 9798, pp. 1231 - 1243
Summary Background Although most cardiovascular disease occurs in low-income and middle-income countries, little is known about the use of effective secondary... 
Internal Medicine | STROKE | MEDICINE, GENERAL & INTERNAL | RISK-FACTORS | THERAPY | MYOCARDIAL-INFARCTION | AVAILABILITY | HEART-FAILURE | SELF-REPORT | ACUTE CORONARY SYNDROMES | MEDICINES | VALIDITY | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Data Collection | Secondary Prevention | Stroke - drug therapy | Urban Population | Antihypertensive Agents - therapeutic use | Drug Utilization | Cardiovascular Agents - therapeutic use | Developed Countries | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Rural Population | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Coronary Disease - drug therapy | Adult | Female | Aged | Developing Countries | Platelet Aggregation Inhibitors - therapeutic use | Adrenergic beta-Antagonists - therapeutic use | Care and treatment | Research | Cardiovascular diseases | Health aspects | Cardiovascular agents | Studies | Low income groups | Stroke | Households | Socioeconomic factors | Data collection | Cardiovascular disease | Epidemiology | Economic development | Community | Drug use | Antihypertensive Agents/therapeutic use | Angiotensin-Converting Enzyme Inhibitors/therapeutic use | Cardiovascular Agents/therapeutic use | Coronary Disease/drug therapy | Cardiovascular Diseases/prevention & control | Platelet Aggregation Inhibitors/therapeutic use | Stroke/drug therapy | MEDICIN OCH HÄLSOVETENSKAP | Adrenergic beta-Antagonists/therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use | MEDICAL AND HEALTH SCIENCES
Journal Article
Journal Article