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Blood, ISSN 0006-4971, 2009, Volume 114, Issue 13, pp. 2667 - 2677
Journal Article
Journal of Psychopharmacology, ISSN 0269-8811, 01/2009, Volume 23, Issue 1, pp. 65 - 73
Asenapine is a novel psychopharmacologic agent under development for the treatment of schizophrenia and bipolar disorder. We determined and compared the human... 
Schizophrenia | Affinity | Bipolar disorder | Asenapine | Human receptor | NEGATIVE SYMPTOMS | PSYCHIATRY | FOCUS | SEROTONIN RECEPTORS | DISORDERS | RISPERIDONE | schizophrenia | COGNITION | NEUROSCIENCES | CLINICAL NEUROLOGY | bipolar disorder | DOPAMINE D-3 RECEPTOR | PSYCHOSIS | ATYPICAL ANTIPSYCHOTIC-DRUG | PHARMACOLOGY & PHARMACY | asenapine | human receptor | affinity | Humans | Receptors, Serotonin - drug effects | Substrate Specificity | Receptors, Serotonin - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Psychotropic Drugs - therapeutic use | Receptors, Dopamine - drug effects | Clozapine - pharmacology | Histamine Release - genetics | Receptors, Muscarinic - drug effects | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Receptors, Adrenergic - drug effects | Psychotropic Drugs - pharmacology | Cloning, Molecular | Receptors, Adrenergic - genetics | Receptors, Dopamine D2 - drug effects | Inhibitory Concentration 50 | Molecular Structure | Radioligand Assay | Histamine Release - drug effects | Receptors, Muscarinic - genetics | Benzodiazepines - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Clinical Trials as Topic | Psychotropic Drugs - chemistry | Bipolar Disorder - drug therapy | Receptors, Dopamine D2 - physiology | Schizophrenia - drug therapy | Receptors, Dopamine - genetics | Histamine receptors | Drugs | Neuroleptics | Olanzapine | Acetylcholine receptors (muscarinic) | Mental disorders | Dopamine D4 receptors | Serotonin S1 receptors | Serotonin S7 receptors | Psychotropic drugs | Receptors | Histamine H2 receptors | Risperidone | Dopamine D2 receptors | Dopamine receptors | Binding | Dopamine | Serotonin | Dopamine D3 receptors | Serotonin S6 receptors | Serotonin S2 receptors | Histamine | Dopamine D1 receptors | Serotonin receptors | Receptors (physiology) | Index Medicus
Journal Article
1999, Lung biology in health and disease, ISBN 0824701909, Volume 125., xviii, 381
Book
Journal of Clinical Investigation, ISSN 0021-9738, 05/2015, Volume 125, Issue 5, pp. 2046 - 2058
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells, Tregs, and NI( cells. Here, we determined that TIGIT is upregulated... 
MEDICINE, RESEARCH & EXPERIMENTAL | ADHESION MOLECULE | LIGANDS | DNAM-1 | INHIBITORY RECEPTORS | CHRONIC VIRAL-INFECTION | NECTIN-2 CD112 | UP-REGULATION | PVR CD155 | EXPRESSION | POLIOVIRUS RECEPTOR CD155 | Up-Regulation | Receptors, Immunologic - physiology | Receptors, Virus - biosynthesis | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Neoplasm Proteins - antagonists & inhibitors | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Programmed Cell Death 1 Receptor - physiology | Receptors, Virus - genetics | Receptors, Immunologic - antagonists & inhibitors | Receptors, Immunologic - biosynthesis | Programmed Cell Death 1 Receptor - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Interleukin-2 Receptor beta Subunit - genetics | Neoplasm Proteins - genetics | Antibodies, Monoclonal - immunology | Antigen-Presenting Cells - metabolism | Antigens, Neoplasm - immunology | Lymphocyte Activation | Neoplasm Proteins - biosynthesis | Antibodies, Monoclonal - pharmacology | Immunophenotyping | Interleukin-2 Receptor beta Subunit - biosynthesis | Melanoma - pathology | Antigen-Presenting Cells - immunology | Melanoma - immunology | Antigens, Differentiation, T-Lymphocyte - genetics | Cell Line, Tumor | T-Cell Antigen Receptor Specificity | Immunologic Memory | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD8-Positive T-Lymphocytes - immunology | Receptors, Immunologic - genetics | Programmed Cell Death 1 Receptor - genetics | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Oncology | Immunology | Dermatology | Therapeutics
Journal Article
Journal Article
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 11/2014, Volume 10, Issue 11, pp. 3270 - 3285
Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs... 
IFI16, interferon, gamma-inducible protein 16 | IRF, interferon regulatory factor | CDNs, cyclic dinucleotides | AIM2, absent in melanoma 2 | LT, lethal toxin | MIB, mind bomb | ALRs, AIM2-like receptors | MDP, muramyl dipeptide | LUBAC, linear ubiquitin assembly complex | innate immunity | TRIF, TIR domain-containing adaptor inducing IFN-b | DDX41, DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | IKK, IkB kinase | MyD88, myeloid differentiation factor 88 | TRAILR, tumor-necrosis factor-related apoptosis-inducing ligand receptor | AMPK, AMP activated protein kinase | LBP, LPS-binding protein | NEMO, NF-kB essential modulator | TRIMs, tripartite motif containing proteins | IKKi, inducible IkB kinase | PKC-d, protein kinase C delta | LRR, leucine-rich repeat | TAK1, TGF-b-activating kinase 1 | RIP, receptor-interacting protein | TBK1, TANK binding kinase 1 | TRIP, TRAF-interacting protein | TLRs, Toll-like receptors | LGP 2, laboratory of genetics and physiology 2 | PKR, dsRNA-dependent protein kinase | PRRs, pathogen recognition receptors | STING, stimulator of interferon gene | GBP5, guanylate-binding protein 5 | RLRs, RIG-I-like receptors | ULK1, autophagy related serine threonine UNC-51- like kinase | TIR, Toll IL-1 receptor | LPS, lipopolysaccharide | TRAF, TNFR-associated factor | Atg16L, autophagy related 16-like | cDC, conventional dendritic cell | MDA5, melanoma differentiation-associated protein 5 | DCs, dendritic cells | CARD, caspase recruitment domain | PRRs | KSHV, Kaposi's sarcoma-associated herpesvirus | RAUL, RTA-associated E3 ligase | CLRs, C-type lectin receptors | pDC, plasmacytoid dendritic cell | MAVS, mitochondrial antiviral signaling protein | inflammation | NAIPs, neuronal apoptosis inhibitory proteins | CYLD, the familial cylindromatosis tumor suppressor gene | SIGIRR, single Ig IL-1-related receptor | ROS, reactive oxygen species | RIG-I, retinoic acid-inducible gene 1 | TANK, TRAF family-member-associated NF-kB activator | ASC, apoptosis-associated speck-like protein containing a CARD | DAMPs, danger-associated molecular patterns | IFN, interferon | TRAM, TRIF-related adaptor molecule | TIRAP, TIR domain-containing adapter protein | iE-DAP, g-D-glutamyl-meso-diaminopimelic acid | PAMPs, pathogen-associated molecular patterns | cGAS, cyclic GMP-AMP synthase | cIAP, cellular inhibitor of apoptosis protein | GSK3β, Glycogen synthase kinase 3β | NOD, nucleotide-binding oligomerization domain | IRAK, interleukin-1 receptor-associated kinase | BMM, bone marrow-derived macrophage | type I interferon | RACK1, receptor for activated C kinase 1 | SARM, sterile a- and armadillo motif-containing protein | SOCS, suppressor of cytokine signaling | CMV, cytomegalovirus | cancer | NLRs, Nod- like receptors | Nrdp1, neuregulin receptor degradation protein 1 | HCC, hepatocellular carcinoma | ER, endoplasmic reticulum | Innate immunity | Inflammation | Type I interferon | Cancer | linear ubiquitin assembly complex | C-type lectin receptors | IKKi | TRIP | TRAF | apoptosis-associated speck-like protein containing a CARD | I INTERFERON INDUCTION | neuregulin receptor degradation protein 1 | RIG-I | TRAM | CARD | TRIF-related adaptor molecule | dendritic cells | TBK1 | cytomegalovirus | cyclic dinucleotides | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | cellular inhibitor of apoptosis protein | GSK3 | PAMPs | retinoic acid-inducible gene 1 | CDNs | hepatocellular carcinoma | TANK binding kinase 1 | RAUL | GBP5 | Toll IL-1 receptor | cDC | MIB | protein kinase C delta | iE-DAP | CMV | SARM | SIGIRR | IRAK | sterile a- and armadillo motif-containing protein | cyclic GMP-AMP synthase | TNFR-associated factor | autophagy related serine threonine UNC-51-like kinase | AMPK | ULK1 | lipopolysaccharide | TRIF | IRF | RLRs | Nrdp1 | receptor-interacting protein | LPS-binding protein | plasmacytoid dendritic cell | tripartite motif containing proteins | LPS | ANTIVIRAL SIGNAL-TRANSDUCTION | DAMPs | melanoma differentiation-associated protein 5 | ASC | TAK1 | KSHV | LGP 2 | neuronal apoptosis inhibitory proteins | TRIMs | danger-associated molecular patterns | cGAS | RIG-I-like receptors | lethal toxin | OXYGEN SPECIES PRODUCTION | BMM | muramyl dipeptide | interleukin-1 receptor-associated kinase | IKK | AMP activated protein kinase | absent in melanoma 2 | IkB kinase | CYLD | dsRNA-dependent protein kinase | MAVS | Kaposi's sarcoma-associated herpesvirus | TIR domain-containing adaptor inducing IFN-b | STING | TIR | TOLL-LIKE-RECEPTORS | AIM2-like receptors | laboratory of genetics and physiology 2 | DDX41 | IMMUNOLOGY | LRR | MyD88 | nucleotide-binding oligomerization domain | CLRs | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | myeloid differentiation factor 88 | MDP | RACK1 | LBP | TRAF-interacting protein | bone marrow-derived macrophage | NF-KAPPA-B | NOD-LIKE RECEPTOR | NOD | conventional dendritic cell | NLRP3 INFLAMMASOME ACTIVATION | HCC | TGF-b-activating kinase 1 | inducible IkB kinase | TIRAP | Atg16L | mind bomb | pathogen-associated molecular patterns | AIM2 | PKR | TRAF family-member-associated NF-kB activator | ROS | interferon regulatory factor | g-D-glutamyl-meso-diaminopimelic acid | pathogen recognition receptors | NLRs | UBIQUITIN-DEPENDENT KINASE | DEUBIQUITINATING ENZYME CYLD | NEMO | stimulator of interferon gene | RTA-associated E3 ligase | Nod- like receptors | the familial cylindromatosis tumor suppressor gene | tumor-necrosis factor-related apoptosis-inducing ligand receptor | TANK | MDA5 | IFN | mitochondrial antiviral signaling protein | ALRs | IFI16 | DCs | TRAILR | reactive oxygen species | Toll-like receptors | cIAP | TIR domain-containing adapter protein | PATTERN-RECOGNITION RECEPTORS | single Ig IL-1-related receptor | guanylate-binding protein 5 | suppressor of cytokine signaling | autophagy related 16-like | leucine-rich repeat | NF-kB essential modulator | Glycogen synthase kinase 3 | SOCS | interferon | LUBAC | caspase recruitment domain | pDC | NAIPs | receptor for activated C kinase 1 | PKC-d | RIP | gamma-inducible protein 16 | TLRs | endoplasmic reticulum | Immunity, Innate - immunology | Signal Transduction - immunology | Neoplasms - immunology | Humans | Inflammasomes - immunology | RNA Viruses - immunology | Toll-Like Receptors - immunology | Interferon Type I - immunology | DNA Viruses - immunology
Journal Article
Cell Reports, ISSN 2211-1247, 08/2016, Volume 16, Issue 7, pp. 1962 - 1973
Here, we uncover a mechanism for regulating the number of active presynaptic GABA receptors (GABA Rs) at nerve terminals, an important determinant of... 
Ca2+ signaling | GABAB receptors | hippocampus | single-particle tracking | lateral diffusion | NMDA receptors | bungarotoxin binding site | quantum dots | GABA receptors | AMPK | homeostatic signaling | presynaptic terminal | excitotoxicity | phosphorylation | receptor mobility | sushi domains | glutamate receptors | signaling | receptors | GABA | Ca | INHIBITORY NEUROTRANSMISSION | SUSHI DOMAINS | PROTEIN-KINASE | GLUTAMATE | HETEROSYNAPTIC DEPRESSION | LATERAL MOBILITY | CENTRAL-NERVOUS-SYSTEM | SURFACE TRAFFICKING | SYNAPTIC PLASTICITY | GABA(B) RECEPTOR INTERNALIZATION | CELL BIOLOGY | Phosphorylation | Calcium - metabolism | Embryo, Mammalian | gamma-Aminobutyric Acid - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Neurons - cytology | Protein Subunits - metabolism | Synaptic Transmission | Receptors, N-Methyl-D-Aspartate - genetics | Cell Membrane - metabolism | Neurons - metabolism | Diffusion | Neurons - drug effects | Cell Membrane - drug effects | Protein Subunits - genetics | Receptors, GABA-B - genetics | Gene Expression | Receptor Cross-Talk | Glutamic Acid - pharmacology | Presynaptic Terminals - drug effects | Signal Transduction | Tissue Culture Techniques | gamma-Aminobutyric Acid - pharmacology | Rats, Sprague-Dawley | Feedback, Physiological | Animals | Presynaptic Terminals - metabolism | Glutamic Acid - metabolism | Hippocampus - anatomy & histology | Hippocampus - physiology | Receptors, GABA-B - metabolism
Journal Article
Frontiers in Neuroendocrinology, ISSN 0091-3022, 2008, Volume 29, Issue 2, pp. 292 - 312
Abstract Rapid, progestin actions initiated at the cell surface that are often nongenomic have been described in a variety of reproductive tissues, but until... 
Endocrinology & Metabolism | mPRα | Progesterone membrane receptor component 1 | Progesterone withdrawal | Rapid progesterone actions | Novel membrane progesterone receptors | Membrane progestin receptor alpha | PGMRC1 | Sperm motility | Antiapoptotic actions in granulosa cells | Oocyte maturation | novel membrane progesterone receptors | sperm motility | progesterone withdrawal | MATURATION-INDUCING HORMONE | SPERM HYPERACTIVATED MOTILITY | mPR alpha | INNER ZONE ANTIGEN | RAT CORPUS-LUTEUM | PROTEIN-COUPLED RECEPTORS | rapid progesterone actions | NEUROSCIENCES | antiapoptotic actions in granulosa cells | BREAST-CANCER CELLS | PORCINE LIVER-MICROSOMES | SPOTTED SEA-TROUT | membrane progestin receptor alpha | ENDOCRINOLOGY & METABOLISM | progesterone membrane receptor component 1 | oocyte maturation | INHIBITORY G-PROTEIN | SIGNAL-TRANSDUCTION PATHWAY | T-Lymphocytes - physiology | Jurkat Cells | Humans | Male | Recombinant Proteins - biosynthesis | Immunity - drug effects | Tissue Distribution | Sperm Motility - drug effects | Animals | Oocytes - physiology | Transfection | Progestins - physiology | Receptors, Progesterone - physiology | Membrane Proteins - physiology | Acrosome Reaction - drug effects | Female | Signal Transduction - physiology | Receptors, G-Protein-Coupled - chemistry | Receptors, G-Protein-Coupled - physiology | Receptors, Progesterone - chemistry
Journal Article
Biochimie, ISSN 0300-9084, 12/2015, Volume 119, pp. 175 - 182
Interleukin (IL)-6 and IL-11 are the only canonical members of the IL-6 family of cytokines that induce signaling through a homodimer of the common β-receptor... 
Signal transduction | Proliferation | Interleukin-11 | Proteolysis | Plasticity | Interleukin-6 | ACTIVATION | HUMAN IL-6 RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GP130 | LEUKEMIA INHIBITORY FACTOR | CYTOKINE | SIGNAL-TRANSDUCTION | ONCOSTATIN-M | GLYCOPROTEIN 130 | CILIARY NEUROTROPHIC FACTOR | BINDING | Protein Subunits | Receptors, Interleukin-6 - chemistry | Cell Proliferation | Cytokine Receptor gp130 - genetics | Humans | Interleukin-11 Receptor alpha Subunit - agonists | Cytokine Receptor gp130 - agonists | Interleukin-6 Receptor alpha Subunit - metabolism | Interleukin-6 Receptor alpha Subunit - agonists | Protein Interaction Domains and Motifs | Interleukin-11 Receptor alpha Subunit - genetics | Binding Sites | Interleukin-6 - metabolism | Peptide Fragments - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Cell Line | Peptide Fragments - metabolism | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Signal Transduction | Receptors, Interleukin-6 - genetics | Cytokine Receptor gp130 - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Interleukin-11 - genetics | Interleukin-11 - metabolism | Interleukin-11 Receptor alpha Subunit - metabolism | Interleukin-6 Receptor alpha Subunit - chemistry | Interleukin-6 Receptor alpha Subunit - genetics | Peptide Fragments - chemistry | Animals | Interleukin-11 Receptor alpha Subunit - chemistry | Peptide Fragments - agonists | Ligands | Mice | Receptors, Interleukin-6 - agonists | Receptors, Interleukin-6 - metabolism
Journal Article