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Higher Cord Blood Levels of Fatty Acids in Pregnant Women With Type 1 Diabetes Mellitus
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2018, Volume 103, Issue 7, pp. 2620 - 2629
Context: Type 1 diabetes mellitus (T1DM) is associated with a disturbance of carbohydrate and lipid metabolism. Objective: To determine whether T1DM alters...
MOTHERS | METABOLISM | DOCOSAHEXAENOIC ACID | PLASMA LEPTIN LEVELS | GROWTH | INFANTS | ENDOCRINOLOGY & METABOLISM | HUMAN-PLACENTA | BINDING PROTEIN | NEWBORNS | CORRELATE | C-Peptide - blood | Humans | Insulin Resistance | Umbilical Arteries - chemistry | Umbilical Veins - chemistry | Pregnancy | Young Adult | Fatty Acids, Unsaturated - blood | Leptin - blood | Diabetes Mellitus, Type 1 - blood | Fetal Blood - chemistry | Adult | Fatty Acids, Monounsaturated - blood | Female | Fatty Acids - blood | Pregnancy in Diabetics - blood | Infant, Newborn | Infants (Newborn) | Women | Pregnant women | Type 1 diabetes | Leptin | Physiological aspects | Carbohydrate metabolism | Insulin resistance | Fatty acids | Health aspects | Diabetes therapy
MOTHERS | METABOLISM | DOCOSAHEXAENOIC ACID | PLASMA LEPTIN LEVELS | GROWTH | INFANTS | ENDOCRINOLOGY & METABOLISM | HUMAN-PLACENTA | BINDING PROTEIN | NEWBORNS | CORRELATE | C-Peptide - blood | Humans | Insulin Resistance | Umbilical Arteries - chemistry | Umbilical Veins - chemistry | Pregnancy | Young Adult | Fatty Acids, Unsaturated - blood | Leptin - blood | Diabetes Mellitus, Type 1 - blood | Fetal Blood - chemistry | Adult | Fatty Acids, Monounsaturated - blood | Female | Fatty Acids - blood | Pregnancy in Diabetics - blood | Infant, Newborn | Infants (Newborn) | Women | Pregnant women | Type 1 diabetes | Leptin | Physiological aspects | Carbohydrate metabolism | Insulin resistance | Fatty acids | Health aspects | Diabetes therapy
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 03/2001, Volume 86, Issue 3, pp. 1154 - 1159
There is increasing evidence that systemic inflammation and insulin resistance constitute interrelated events that contribute to atherosclerosis. We studied...
C-REACTIVE PROTEIN | DIABETES-MELLITUS | DAYTIME SLEEPINESS | OBESITY | INFLAMMATION | DISEASE | ENDOCRINOLOGY & METABOLISM | RESISTANCE | INNATE IMMUNE-SYSTEM | CYTOKINE | EXPRESSION | Blood Pressure | Body Constitution | Body Mass Index | Insulin - pharmacology | Fasting | Diastole | Humans | Middle Aged | Insulin Resistance | Linear Models | Male | Sex Characteristics | Systole | Insulin - blood | Interleukin-6 - blood | Adult | Female | C-Reactive Protein - analysis | Smoking
C-REACTIVE PROTEIN | DIABETES-MELLITUS | DAYTIME SLEEPINESS | OBESITY | INFLAMMATION | DISEASE | ENDOCRINOLOGY & METABOLISM | RESISTANCE | INNATE IMMUNE-SYSTEM | CYTOKINE | EXPRESSION | Blood Pressure | Body Constitution | Body Mass Index | Insulin - pharmacology | Fasting | Diastole | Humans | Middle Aged | Insulin Resistance | Linear Models | Male | Sex Characteristics | Systole | Insulin - blood | Interleukin-6 - blood | Adult | Female | C-Reactive Protein - analysis | Smoking
Journal Article
Clinical Biochemistry, ISSN 0009-9120, 02/2018, Volume 52, pp. 67 - 72
Familial dysbetalipoproteinemia (FD) or Type III hyperlipoproteinemia is a mixed hyperlipidemia closely associated with the ε2ε2 genotype of the common...
Type III hyperlipidemia | High-density lipoprotein | Apolipoprotein E | Familial dysbetalipoproteinemia | Apolipoprotein A-I | Apolipoprotein A-II | Apolipoprotein E2 - analysis | Lipoproteins, HDL - genetics | Lipoproteins, HDL - blood | Humans | Middle Aged | Male | Apolipoproteins E - analysis | Netherlands | Hyperlipoproteinemia Type III - etiology | Adult | Female | Lipoproteins, HDL - analysis | Apolipoprotein E2 - blood | Hyperlipoproteinemia Type III - physiopathology | Insulin Resistance | Genotype | Apolipoprotein E2 - metabolism | Apolipoprotein A-II - blood | Apolipoproteins E - blood | Lipoproteins, VLDL - blood | Apolipoproteins E - genetics | Triglycerides - blood | Cholesterol, HDL - blood | Aged | Apolipoprotein A-I - blood | Hyperlipoproteinemia Type III - metabolism
Type III hyperlipidemia | High-density lipoprotein | Apolipoprotein E | Familial dysbetalipoproteinemia | Apolipoprotein A-I | Apolipoprotein A-II | Apolipoprotein E2 - analysis | Lipoproteins, HDL - genetics | Lipoproteins, HDL - blood | Humans | Middle Aged | Male | Apolipoproteins E - analysis | Netherlands | Hyperlipoproteinemia Type III - etiology | Adult | Female | Lipoproteins, HDL - analysis | Apolipoprotein E2 - blood | Hyperlipoproteinemia Type III - physiopathology | Insulin Resistance | Genotype | Apolipoprotein E2 - metabolism | Apolipoprotein A-II - blood | Apolipoproteins E - blood | Lipoproteins, VLDL - blood | Apolipoproteins E - genetics | Triglycerides - blood | Cholesterol, HDL - blood | Aged | Apolipoprotein A-I - blood | Hyperlipoproteinemia Type III - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e107174
Objective: Klotho is an aging-modulating protein expressed mainly in the kidneys and choroid plexus, which can also be shed, released into the circulation and...
COMMUNITY-DWELLING ADULTS | GH DEFICIENCY | IGF-I | PLASMA KLOTHO | THERAPY | SOLUBLE ALPHA-KLOTHO | MULTIDISCIPLINARY SCIENCES | SERUM-LEVELS | TUMOR-SUPPRESSOR | PUBERTAL CHANGES | CHRONIC KIDNEY-DISEASE | Body Weight | Humans | Adolescent | Child, Preschool | Female | Human Growth Hormone - deficiency | Male | Glucuronidase - blood | Growth and Development | Child | Choroid plexus | Adolescence | Pediatrics | Insulin-like growth factor I | Anthropometry | Impairment | Acromegaly | Oncology | Insulin-like growth factors | Atrophy | Secretory vesicles | Fibroblasts | Aging | Children | Adolescents | Growth factors | Enzyme-linked immunosorbent assay | Kidneys | Metabolism | Insulin | Blood levels | Medicine | Serum levels | Hospitals | Klotho protein | Biomarkers | Growth hormones | Diabetes | Kidney diseases | Growth hormone | Endocrinology
COMMUNITY-DWELLING ADULTS | GH DEFICIENCY | IGF-I | PLASMA KLOTHO | THERAPY | SOLUBLE ALPHA-KLOTHO | MULTIDISCIPLINARY SCIENCES | SERUM-LEVELS | TUMOR-SUPPRESSOR | PUBERTAL CHANGES | CHRONIC KIDNEY-DISEASE | Body Weight | Humans | Adolescent | Child, Preschool | Female | Human Growth Hormone - deficiency | Male | Glucuronidase - blood | Growth and Development | Child | Choroid plexus | Adolescence | Pediatrics | Insulin-like growth factor I | Anthropometry | Impairment | Acromegaly | Oncology | Insulin-like growth factors | Atrophy | Secretory vesicles | Fibroblasts | Aging | Children | Adolescents | Growth factors | Enzyme-linked immunosorbent assay | Kidneys | Metabolism | Insulin | Blood levels | Medicine | Serum levels | Hospitals | Klotho protein | Biomarkers | Growth hormones | Diabetes | Kidney diseases | Growth hormone | Endocrinology
Journal Article
Journal of Human Hypertension, ISSN 0950-9240, 07/2016, Volume 30, Issue 7, pp. 414 - 417
Associations between high serum uric acid (SUA) levels and high blood pressure (BP), as well as between SUA levels and metabolic syndrome (MetS) have already...
APOB/APOA1 RATIO | I RATIO | INSULIN | MORTALITY | STROKE | PREDICTOR | HYPERURICEMIA | DISEASE | RISK | PERIPHERAL VASCULAR DISEASE | Blood Pressure | Up-Regulation | Humans | Middle Aged | Apolipoprotein B-100 - blood | Male | Metabolic Syndrome - blood | Lipids - blood | Metabolic Syndrome - physiopathology | Adult | Female | Uric Acid - blood | Hypertension - diagnosis | Hyperuricemia - complications | Hyperuricemia - diagnosis | Risk Factors | Biomarkers - blood | Hypertension - physiopathology | Metabolic Syndrome - complications | Hyperuricemia - blood | Waist Circumference | Metabolic Syndrome - diagnosis | Triglycerides - blood | Cholesterol, HDL - blood | Hypertension - complications | Aged | Blood Glucose - metabolism | Apolipoprotein A-I - blood | Analysis | Physiological aspects | Uric acid | Metabolic syndrome X | Diagnosis | Research | Risk factors
APOB/APOA1 RATIO | I RATIO | INSULIN | MORTALITY | STROKE | PREDICTOR | HYPERURICEMIA | DISEASE | RISK | PERIPHERAL VASCULAR DISEASE | Blood Pressure | Up-Regulation | Humans | Middle Aged | Apolipoprotein B-100 - blood | Male | Metabolic Syndrome - blood | Lipids - blood | Metabolic Syndrome - physiopathology | Adult | Female | Uric Acid - blood | Hypertension - diagnosis | Hyperuricemia - complications | Hyperuricemia - diagnosis | Risk Factors | Biomarkers - blood | Hypertension - physiopathology | Metabolic Syndrome - complications | Hyperuricemia - blood | Waist Circumference | Metabolic Syndrome - diagnosis | Triglycerides - blood | Cholesterol, HDL - blood | Hypertension - complications | Aged | Blood Glucose - metabolism | Apolipoprotein A-I - blood | Analysis | Physiological aspects | Uric acid | Metabolic syndrome X | Diagnosis | Research | Risk factors
Journal Article
PLoS Genetics, ISSN 1553-7390, 09/2010, Volume 6, Issue 9, p. e1001113
While recent scans for genetic variation associated with human disease have been immensely successful in uncovering large numbers of loci, far fewer studies...
HEART-DISEASE | QUANTITATIVE TRAITS | MYOCARDIAL-INFARCTION | INSULIN-RESISTANCE | DENSITY-LIPOPROTEIN | GENETICS & HEREDITY | ACTIVATED MAST-CELLS | GENE-EXPRESSION | ATHEROSCLEROSIS | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Lipoproteins, HDL - blood | Humans | Middle Aged | Hypersensitivity - immunology | Apolipoproteins B - blood | Obesity - blood | Obesity - genetics | Genetic Variation | Metabolic Syndrome - blood | Lipids - blood | Adult | Hypersensitivity - genetics | Gene Regulatory Networks - genetics | Gene Expression Regulation | Inflammation Mediators - blood | Regression Analysis | Metabolic Syndrome - genetics | Triglycerides - blood | Aged | Models, Genetic | Immunity - genetics | Leukocytes - metabolism | Cohort Studies | Hypersensitivity - blood | Quantitative Trait Loci - genetics | Measurement | Immunogenetics | High density lipoproteins | Physiological aspects | Blood lipids | Research | Gene expression | Lipids | Cardiovascular disease | Apolipoproteins | Genomics | Cholesterol
HEART-DISEASE | QUANTITATIVE TRAITS | MYOCARDIAL-INFARCTION | INSULIN-RESISTANCE | DENSITY-LIPOPROTEIN | GENETICS & HEREDITY | ACTIVATED MAST-CELLS | GENE-EXPRESSION | ATHEROSCLEROSIS | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Lipoproteins, HDL - blood | Humans | Middle Aged | Hypersensitivity - immunology | Apolipoproteins B - blood | Obesity - blood | Obesity - genetics | Genetic Variation | Metabolic Syndrome - blood | Lipids - blood | Adult | Hypersensitivity - genetics | Gene Regulatory Networks - genetics | Gene Expression Regulation | Inflammation Mediators - blood | Regression Analysis | Metabolic Syndrome - genetics | Triglycerides - blood | Aged | Models, Genetic | Immunity - genetics | Leukocytes - metabolism | Cohort Studies | Hypersensitivity - blood | Quantitative Trait Loci - genetics | Measurement | Immunogenetics | High density lipoproteins | Physiological aspects | Blood lipids | Research | Gene expression | Lipids | Cardiovascular disease | Apolipoproteins | Genomics | Cholesterol
Journal Article
Diabetologia, ISSN 0012-186X, 8/2015, Volume 58, Issue 8, pp. 1759 - 1768
Obesity is associated with elevated monocyte chemoattractant protein-1 (MCP-1), a proinflammatory chemokine related to diabetes and cardiovascular disease....
MCP-1 | Adipose tissue | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Inflammation | GIP | ADIPOCYTES | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | NECROSIS-FACTOR-ALPHA | DIABETES-MELLITUS | OBESITY | GLUCOSE | ENDOCRINOLOGY & METABOLISM | RESISTANCE | FAT | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | Single-Blind Method | Gene Expression - drug effects | Humans | Middle Aged | Male | Adipocytes - drug effects | Insulin - blood | Inflammation - blood | Young Adult | Adipose Tissue - metabolism | Inflammation - metabolism | Adult | Chemokine CCL2 - metabolism | Gastric Inhibitory Polypeptide - pharmacology | Cells, Cultured | Gastric Inhibitory Polypeptide - blood | Chemokine CCL2 - genetics | Chemokine CCL2 - blood | Obesity - metabolism | Cross-Over Studies | Diet | Signal Transduction - drug effects | Adipocytes - metabolism | Adolescent | Aged | Adipose Tissue - drug effects | Adipose tissues | DNA microarrays | Analysis | Genetic research | Glucose | Gene expression | Dextrose
MCP-1 | Adipose tissue | Medicine & Public Health | Human Physiology | Metabolic Diseases | Internal Medicine | Inflammation | GIP | ADIPOCYTES | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | NECROSIS-FACTOR-ALPHA | DIABETES-MELLITUS | OBESITY | GLUCOSE | ENDOCRINOLOGY & METABOLISM | RESISTANCE | FAT | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | Single-Blind Method | Gene Expression - drug effects | Humans | Middle Aged | Male | Adipocytes - drug effects | Insulin - blood | Inflammation - blood | Young Adult | Adipose Tissue - metabolism | Inflammation - metabolism | Adult | Chemokine CCL2 - metabolism | Gastric Inhibitory Polypeptide - pharmacology | Cells, Cultured | Gastric Inhibitory Polypeptide - blood | Chemokine CCL2 - genetics | Chemokine CCL2 - blood | Obesity - metabolism | Cross-Over Studies | Diet | Signal Transduction - drug effects | Adipocytes - metabolism | Adolescent | Aged | Adipose Tissue - drug effects | Adipose tissues | DNA microarrays | Analysis | Genetic research | Glucose | Gene expression | Dextrose
Journal Article
Metabolism, ISSN 0026-0495, 12/2018, Volume 89, pp. 27 - 38
We investigated whether PPARγ modulates adipose tissue BCAA metabolism, and whether this mediates the attenuation of obesity-associated insulin resistance...
MAMMALIAN TARGET | SKELETAL-MUSCLE | ACTIVATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | AGONIST ROSIGLITAZONE | DIET-INDUCED OBESITY | RAPAMYCIN PATHWAY | LEUCINE | INSULIN-RECEPTOR SUBSTRATE-1 | METABOLITE PROFILES
MAMMALIAN TARGET | SKELETAL-MUSCLE | ACTIVATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | AGONIST ROSIGLITAZONE | DIET-INDUCED OBESITY | RAPAMYCIN PATHWAY | LEUCINE | INSULIN-RECEPTOR SUBSTRATE-1 | METABOLITE PROFILES
Journal Article
Diabetologia, ISSN 0012-186X, 12/2014, Volume 57, Issue 12, pp. 2492 - 2500
To determine the extent to which gestational fasting and postload levels of glucose explain differences in infant fat mass between UK-born Pakistani and white...
Cord-blood insulin | Ethnicity | Medicine & Public Health | Human Physiology | Cord-blood leptin | Metabolic Diseases | Birthweight | Internal Medicine | Gestational diabetes | Glucose | Epidemiology | ETHNIC-DIFFERENCES | RISK-FACTORS | BIRTH-WEIGHT | GESTATIONAL DIABETES-MELLITUS | BODY-COMPOSITION | CHILDREN | ORIGIN | HYPERGLYCEMIA | ENDOCRINOLOGY & METABOLISM | ADIPOSITY | SOUTH ASIANS | Body Mass Index | Diabetes, Gestational - blood | Glucose Tolerance Test | Pakistan - ethnology | Prospective Studies | Diabetes, Gestational - ethnology | Humans | Infant | Insulin - blood | Incidence | Pregnancy | Ethnic Groups | Leptin - blood | Fasting - blood | Female | Blood Glucose - metabolism | Fetal Blood | United Kingdom - epidemiology | Glucose metabolism | Pregnant women | Leptin | Analysis | Insulin | Dextrose
Cord-blood insulin | Ethnicity | Medicine & Public Health | Human Physiology | Cord-blood leptin | Metabolic Diseases | Birthweight | Internal Medicine | Gestational diabetes | Glucose | Epidemiology | ETHNIC-DIFFERENCES | RISK-FACTORS | BIRTH-WEIGHT | GESTATIONAL DIABETES-MELLITUS | BODY-COMPOSITION | CHILDREN | ORIGIN | HYPERGLYCEMIA | ENDOCRINOLOGY & METABOLISM | ADIPOSITY | SOUTH ASIANS | Body Mass Index | Diabetes, Gestational - blood | Glucose Tolerance Test | Pakistan - ethnology | Prospective Studies | Diabetes, Gestational - ethnology | Humans | Infant | Insulin - blood | Incidence | Pregnancy | Ethnic Groups | Leptin - blood | Fasting - blood | Female | Blood Glucose - metabolism | Fetal Blood | United Kingdom - epidemiology | Glucose metabolism | Pregnant women | Leptin | Analysis | Insulin | Dextrose
Journal Article
Obesity Surgery, ISSN 0960-8923, 6/2011, Volume 21, Issue 6, pp. 738 - 743
Gastric bypass (GBP) has proved its efficacy 30 years ago in the management of diabetes mellitus (T2DM) for severe obese patients. More recently, interesting...
Medicine & Public Health | Surgery | SURGERY | WEIGHT-LOSS | THERAPY | OPERATION | GHRELIN | Body Mass Index | Glycated Hemoglobin A - analysis | Obesity - surgery | Prospective Studies | Obesity - complications | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Insulin - administration & dosage | Male | Treatment Outcome | Laparoscopy | Diabetes Mellitus, Type 2 - blood | Gastrectomy - methods | Hypoglycemic Agents - administration & dosage | Weight Loss | Adult | Female | Aged | Gastric Bypass - methods | Diabetes Mellitus, Type 2 - drug therapy | Diabetes Mellitus, Type 2 - complications | Care and treatment | Analysis | Gastric bypass | Glycosylated hemoglobin | Laparoscopic surgery | Diabetes | Universities and colleges | France | Surgical outcomes | Obesity | Surgical techniques | Gastrointestinal surgery | Life Sciences | Human health and pathology | Endocrinology and metabolism
Medicine & Public Health | Surgery | SURGERY | WEIGHT-LOSS | THERAPY | OPERATION | GHRELIN | Body Mass Index | Glycated Hemoglobin A - analysis | Obesity - surgery | Prospective Studies | Obesity - complications | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Insulin - administration & dosage | Male | Treatment Outcome | Laparoscopy | Diabetes Mellitus, Type 2 - blood | Gastrectomy - methods | Hypoglycemic Agents - administration & dosage | Weight Loss | Adult | Female | Aged | Gastric Bypass - methods | Diabetes Mellitus, Type 2 - drug therapy | Diabetes Mellitus, Type 2 - complications | Care and treatment | Analysis | Gastric bypass | Glycosylated hemoglobin | Laparoscopic surgery | Diabetes | Universities and colleges | France | Surgical outcomes | Obesity | Surgical techniques | Gastrointestinal surgery | Life Sciences | Human health and pathology | Endocrinology and metabolism
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2018, Volume 501, Issue 4, pp. 1041 - 1047
Probiotics such as and improve the balance of intestinal microflora and have various physiological functions beneficial to human health. It is not always known...
Blood glucose | Probiotics | Serum cholesterol | Sterilized bifidobacteria | Fat accumulation | ANIMALS | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXEMIA | GUT MICROBIOTA | DIET-INDUCED OBESITY | BIOPHYSICS | GLUCAGON-LIKE PEPTIDE-1 | INFLAMMATION | MICE | Glucose metabolism | Obesity | Microbiota (Symbiotic organisms) | Blood sugar | Physiological aspects | Insulin resistance | Triglycerides | Insulin
Blood glucose | Probiotics | Serum cholesterol | Sterilized bifidobacteria | Fat accumulation | ANIMALS | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXEMIA | GUT MICROBIOTA | DIET-INDUCED OBESITY | BIOPHYSICS | GLUCAGON-LIKE PEPTIDE-1 | INFLAMMATION | MICE | Glucose metabolism | Obesity | Microbiota (Symbiotic organisms) | Blood sugar | Physiological aspects | Insulin resistance | Triglycerides | Insulin
Journal Article
Environmental Pollution, ISSN 0269-7491, 05/2019, Volume 248, pp. 66 - 73
Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the...
Trace element | Cross-sectional study | Mediation model | Metabolic syndrome | MiRNA | Heavy metal | POPULATION | DIFFERENTIAL EXPRESSION | RISK-FACTORS | CORONARY COLLATERAL GROWTH | COPPER | PREVALENCE | SELENIUM | ZINC | BIOMARKERS | ENVIRONMENTAL SCIENCES | INSULIN-RESISTANCE | Hypertension | MicroRNA | Mediation | Analysis | Heavy metals
Trace element | Cross-sectional study | Mediation model | Metabolic syndrome | MiRNA | Heavy metal | POPULATION | DIFFERENTIAL EXPRESSION | RISK-FACTORS | CORONARY COLLATERAL GROWTH | COPPER | PREVALENCE | SELENIUM | ZINC | BIOMARKERS | ENVIRONMENTAL SCIENCES | INSULIN-RESISTANCE | Hypertension | MicroRNA | Mediation | Analysis | Heavy metals
Journal Article