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Journal of Computational Chemistry, ISSN 0192-8651, 06/2017, Volume 38, Issue 15, pp. 1158 - 1166
Insulin plays a crucial physiological role in glucose control by initiating a number of signaling events on binding and activating its cell surface receptor.... 
metadynamics | insulin receptor | insulin | molecular dynamics | insulin mimetic peptides | enhanced sampling | RECEPTOR-ALPHA-SUBUNIT | LIGAND-BINDING | BETA-HAIRPIN | FREE-ENERGY LANDSCAPE | MEMBRANE-SPANNING DOMAIN | HIV-1 GP41 | 1ST 3 DOMAINS | CHEMISTRY, MULTIDISCIPLINARY | HORMONE-BINDING ELEMENT | MOLECULAR-DYNAMICS SIMULATIONS | ALANINE-SCANNING MUTAGENESIS
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 10/2016, Volume 99, pp. 557 - 571
Impaired insulin signaling and the associated insulin-resistance in liver, adipose tissue, and skeletal muscle, represents a hallmark of the pathogenesis of... 
Oxidative stress | ERK1/2 | Insulin receptors | Akt/PKB | Diabetes | Insulin receptor | Thioredoxin mimetics | ACTIVATED PROTEIN-KINASE | DB/DB MICE | ELEVATED GLUCOSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | P38 MAPK | TYROSINE PHOSPHATASES | S-NITROSYLATION | OBESITY | TYPE-2 DIABETIC-PATIENTS | SKELETAL-MUSCLE CELLS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | Liver - pathology | Diabetes Mellitus, Type 2 - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Diabetes Mellitus, Type 2 - metabolism | Proto-Oncogene Proteins c-akt - genetics | Molecular Mimicry | Peptides - chemical synthesis | Liver - drug effects | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Thioredoxins - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Thiazolidinediones - pharmacology | Disease Models, Animal | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Liver - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Mice | Diabetes Mellitus, Type 2 - pathology | Oxidative Stress - drug effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Oligopeptides - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Type 2 diabetes | Peptides | Blood sugar | Liver | Muscles | Thioredoxin | Insulin | Cell death | Analysis | Insulin resistance | Mitogens | Protein kinases
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 30, pp. 15473 - 15481
Journal Article
DIABETES, ISSN 0012-1797, 12/2010, Volume 59, Issue 12, pp. 3223 - 3228
OBJECTIVE-To determine the effect of the apolipoprotein A-I (ApoA-I) mimetic peptide, D-4F, on atherosclerosis development in a pre-existing diabetic... 
SCAVENGER RECEPTOR BI | LIPID-PEROXIDATION | INSULIN-RESISTANCE | SELECTIVE UPTAKE | ENDOCRINOLOGY & METABOLISM | KUPFFER CELLS | E-DEFICIENT MICE | OXIDIZED LIPIDS | INHIBITS 3 | HIGH-DENSITY-LIPOPROTEIN | TRANSGENIC MICE
Journal Article
Diabetologia, ISSN 0012-186X, 9/2015, Volume 58, Issue 9, pp. 2144 - 2153
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 04/2013, Volume 85, Issue 7, pp. 977 - 990
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 07/2009, Volume 50, Issue 7, pp. 1293 - 1304
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 517 - 527
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 08/2012, Volume 342, Issue 2, pp. 255 - 262
Journal Article
by Qin, XH and You, H and Cao, F and Wu, Y and Peng, JH and Pang, JW and Xu, H and Chen, Y and Chen, LG and Vitek, MP and Li, FQ and Sun, XC and Jiang, Y
JOURNAL OF NEUROTRAUMA, ISSN 0897-7151, 02/2017, Volume 34, Issue 4, pp. 943 - 951
Traumatic brain injury (TBI) disrupts the blood-brain barrier (BBB) and reduces cerebral glucose uptake. Vascular endothelial growth factor (VEGF) is believed... 
brain edema | MICROGLIAL ACTIVATION | ANGIOGENESIS | VEGF | INJURY | NEUROSCIENCES | RAT MODEL | CLINICAL NEUROLOGY | INSULIN | COG1410 | CORTEX | INFLAMMATION | metabolism | TBI | ENDOTHELIAL GROWTH-FACTOR | CRITICAL CARE MEDICINE
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2018, Volume 26, Issue 10, pp. 2827 - 2841
Peptidomimetics are designed to overcome the poor pharmacokinetics and pharmacodynamics associated with the native peptide or protein on which they are based.... 
Peptides | Insulin-like peptides | Insulin | Relaxin | INSL5 | B-CHAIN | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | H2 RELAXIN | CHIMERIC PEPTIDE | PRIMARY BINDING-SITE | RELAXIN FAMILY PEPTIDES | TERMINAL REGION | ALANINE-SCANNING MUTAGENESIS | CLASS-A MODULE | PROTEIN-COUPLED-RECEPTOR | Neurosciences
Journal Article