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PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, p. e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2012, Volume 188, Issue 7, pp. 2967 - 2971
The host response to Chikungunya virus is dependent on the direct action of type I IFN on infected nonhematopoietic cells. Prior studies have demonstrated that... 
PATHOGENESIS | VIRUS | PROTEIN | MODEL | IMMUNOLOGY | DISTINCT | Age Factors | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Interferon Regulatory Factor-7 - physiology | Interferon-alpha - genetics | Bone Marrow Transplantation | Hematopoietic Stem Cells - virology | Fibroblasts - metabolism | Animals, Newborn | Chikungunya Fever | Fibroblasts - virology | Toll-Like Receptor 7 - genetics | Interferon-alpha - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 7 - deficiency | Hematopoietic Stem Cells - metabolism | Radiation Chimera | Alphavirus Infections - immunology | Chikungunya virus - growth & development | Chikungunya virus - immunology | Interferon Regulatory Factor-3 - physiology | Membrane Glycoproteins - genetics | Mice, Knockout | Host-Pathogen Interactions | Adaptor Proteins, Signal Transducing - physiology | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Interferon Regulatory Factor-7 - deficiency | Mice | Membrane Glycoproteins - deficiency | Interferon Regulatory Factor-7/deficiency | Toll-Like Receptor 7/genetics | Membrane Glycoproteins/genetics | Hematopoietic Stem Cells/metabolism | Myeloid Differentiation Factor 88/genetics | Life Sciences | Alphavirus Infections/immunology | Immunology | Fibroblasts/metabolism | Chikungunya virus/growth & development | Myeloid Differentiation Factor 88/deficiency | Toll-Like Receptor 7/deficiency | Interferon Regulatory Factor-3/physiology | Interferon Regulatory Factor-3/genetics | Interferon-alpha/biosynthesis | Adaptor Proteins, Signal Transducing/physiology | Hematopoietic Stem Cells/virology | Membrane Glycoproteins/deficiency | Interferon Regulatory Factor-3/deficiency | Chikungunya virus/immunology
Journal Article
Current topics in microbiology and immunology, ISBN 9783540713289, Volume 316., vi, 391
Book
Journal of Virology, ISSN 0022-538X, 2017, Volume 91, Issue 1
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection in >95% of adults worldwide and are associated with a variety of malignancies.... 
Acute infection | Interferon | IRF-1 | Viral replication | Gammaherpesvirus | CELLS | GENE INDUCTION | IFN-GAMMA | PERIPHERAL-BLOOD | interferon | ALPHA-INTERFERON | viral replication | ANTIVIRAL RESPONSE | gammaherpesvirus | REPLICATION | VIROLOGY | acute infection | LYMPHOPROLIFERATIVE DISEASE | REACTIVATION | TRANSCRIPTION FACTOR | Spleen - virology | Interferon-Induced Helicase, IFIH1 - genetics | Interferon-beta - immunology | Spleen - immunology | Herpesviridae Infections - mortality | Humans | Gammaherpesvirinae - pathogenicity | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Lung - virology | Macrophages - virology | Interferon-alpha - genetics | Interferon-beta - genetics | Receptor, Interferon alpha-beta - genetics | Herpesviridae Infections - genetics | Interferon-gamma - genetics | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Interferon Regulatory Factor-3 - immunology | Gammaherpesvirinae - growth & development | Signal Transduction | Interferon Regulatory Factor-1 - immunology | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Regulatory Factor-7 - immunology | Herpesviridae Infections - virology | Interferon-Induced Helicase, IFIH1 - immunology | Antigens, Differentiation, Myelomonocytic - genetics | Proteins - immunology | Interferon Regulatory Factor-1 - genetics | Interferon-alpha - immunology | Mice, Knockout | Host-Pathogen Interactions | Proteins - genetics | Animals | Antigens, Nuclear - genetics | Receptor, Interferon alpha-beta - immunology | Interferon-gamma - immunology | Survival Analysis | Mice | Primary Cell Culture | Antigens, Nuclear - immunology | Lung - immunology | Herpesviridae Infections - immunology
Journal Article
1966, xviii, 340
Book
Immunity, ISSN 1074-7613, 09/2019, Volume 51, Issue 3, p. 415
Type I and type III interferons (IFNs) activate similar antiviral transcriptional programs, but the type I IFN response is more inflammatory. In this issue of... 
Interferon
Journal Article
Circulation Research, ISSN 0009-7330, 02/2014, Volume 114, Issue 4, pp. 677 - 688
RATIONALE:Evidence is increasing of a link between interferon (IFN) and pulmonary arterial hypertension (PAH). Conditions with chronically elevated endogenous... 
SURVIVAL | systemic | LUNG | CARDIAC & CARDIOVASCULAR SYSTEMS | chemokine CXCL10 | VIRUS | scleroderma | CHRONIC HEPATITIS-C | ALPHA | RECEPTOR | IFNAR1 subunit | SYSTEMIC-SCLEROSIS | interferon alpha-beta receptor | inflammation | interferon type I | ENDOTHELIAL-CELLS | DISEASE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | endothelin-1 | HEMATOLOGY | pulmonary arterial hypertension | Interferon-alpha - pharmacology | Interferon-beta - immunology | Humans | Male | Lung - cytology | Signal Transduction - immunology | Chemokine CXCL10 - immunology | Receptor, Interferon alpha-beta - genetics | Organ Culture Techniques | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Interferon-alpha - metabolism | Endothelin-1 - metabolism | Mice, Inbred C57BL | Scleroderma, Systemic - metabolism | Cells, Cultured | Familial Primary Pulmonary Hypertension | Hypertension, Pulmonary - immunology | Hypertension, Pulmonary - metabolism | Scleroderma, Systemic - immunology | Interferon-alpha - immunology | Mice, Knockout | Endothelial Cells - immunology | Endothelin-1 - immunology | Animals | Interferon-beta - metabolism | Interferon-beta - pharmacology | Receptor, Interferon alpha-beta - immunology | Endothelial Cells - cytology | Interferon-gamma - immunology | Mice | Chemokine CXCL10 - metabolism | Interferon-gamma - pharmacology | scleroderma, systemic | IFNAR1 subunit, interferon alpha-beta receptor
Journal Article
by M Chen and C Quan and L Diao and F Xue and K Xue and B Wang and X Li and X Zhu and J Zheng and H Cao
British Journal of Dermatology, ISSN 0007-0963, 12/2018, Volume 179, Issue 6, pp. e251 - e251
皮肌炎 (DM) 是一种慢性免疫疾病,主要影响肌肉、皮肤,甚至肺部和心脏。目前正在研究 DM 的确切病因和运作方式,以及用于监测患者疾病活动和预测其对治疗的反应的方法。细胞因子和趋化因子的异常在炎症性疾病中很常见,它们可能在 DM 中起作用。本研究旨在发现患有 DM 或一种被称为临床淀粉样肌炎 (CADM)... 
Interferon
Journal Article
Journal of Neurology, Neurosurgery & Psychiatry, ISSN 0022-3050, 06/2018, Volume 89, Issue 6, pp. A29 - A29
IntroductionThe 5 year, observational, phase 4 POP study explores the long-term safety and effectiveness of peginterferon beta-1a 125 mcg every 2 weeks in RRMS... 
Interferon
Journal Article
The American journal of gastroenterology, ISSN 0002-9270, 03/2018, Volume 113, Issue 3, p. 447
This corrects the article DOI: 10.1038/ajg.2017.494. 
Interferon
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 05/2019, Volume 97, Issue 5, pp. 442 - 444
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2015, Volume 466, Issue 3, pp. 511 - 524
Evidence is accumulating for the existence of a signal transducer and activator of transcription 2 (STAT2)/interferon regulatory factor 9 (IRF9)-dependent,... 
Signal transduction | STAT transcription factor | Alternative interferon response pathway | Microarray | Cytokines/interferon | Host-pathogen interactions | cytokines/interferon | IMMUNE-RESPONSE | CELLS | ACTIVATION | CYTOKINES | signal transduction | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | alternative interferon response pathway | GAMMA-INTERFERON | ALPHA | host-pathogen interactions | microarray | DNA | GENE-EXPRESSION | INFECTION | Cell Line | STAT1 Transcription Factor - deficiency | Humans | Antiviral Agents - metabolism | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | Mice, Knockout | Animals | HEK293 Cells | STAT2 Transcription Factor - genetics | Cell Line, Tumor | Mice | STAT2 Transcription Factor - metabolism | Transcriptional Activation - physiology | IRF, interferon regulatory factor | U3C, TNFα, tumour necrosis factor α | WT, wild-type | ISG, interferon-stimulated gene | IRF9-U3C, U3C stably overexpressing human IRF9 | DUOX2, dual oxidase 2 | hST2-U3C, U3C stably overexpressing human STAT2 | qPCR, quantitative real-time PCR | IFI27, interferon alpha-inducible protein | CX3CL1, chemokine (C–X3–C motif) ligand 1 | HERC5, HECT and RLD domain-containing E3 ubiquitin protein ligase 5 | Migr1-U3C, U3C stably overexpressing Migr1 | cytokines | Ifit1, interferon-induced protein with tetratricopeptide repeats 1 | PKR, protein kinase, interferon-inducible double-stranded RNA-dependent activator | IFN, interferon | MS1KO, STAT1-deficient murine embryonic fibroblast cells | VSV, vesicular stomatitis Indiana virus | Migr1-MS1KO, MS1KO stably overexpressing Migr1 | STAT, signal transducer and activator of transcription | qRT-PCR, quantitative reverse transcription–PCR | MEF, murine embryonic fibroblast cells | OAS2, 2′-5′-oligoadenylate synthase 2 | EMCV, encephalomyocarditis virus | NLS, nuclear localization signal | SOCS1, suppressor of cytokine signalling 1 | interferon | mSTAT2-MS1KO, MS1KO stably overexpressing mouse STAT2 | HA, haemagglutinin | MX1, myxovirus (influenza virus) resistance 1, interferon-inducible protein | host–pathogen interactions | HDACi, histone deacetylase inhibitor | RIG-G, retinoic acid-induced gene G | MOI, multiplicity of infection | Ddx60, DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | CCL8, chemokine (C–C motif) ligand 8 | RSAD2, radical S-adenosylmethionine domain-containing 2 | ΔmSTAT2-MS1KO, MS1KO stably overexpressing mouse ΔmSTAT2 | ISRE, IFN-stimulated response element | ISGF3, interferon-stimulated gene factor 3
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1224 - 1231
Breast cancer metastasis is a key determinant of long-term patient survival. By comparing the transcriptomes of primary and metastatic tumor cells in a mouse... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOMIC ANALYSIS | TUMORS | MAMMARY CARCINOMAS | CELL BIOLOGY | ADAPTIVE IMMUNITY | ZOLEDRONIC ACID | MOLECULAR PORTRAITS | I INTERFERONS | PROSTATE-CANCER | GENE-EXPRESSION | SUPPRESSOR-CELLS | Immunologic Surveillance | Mammary Neoplasms, Experimental - immunology | T-Lymphocyte Subsets - immunology | Interferon-alpha - pharmacology | Tumor Escape - genetics | Breast Neoplasms - immunology | Humans | Neoplasm Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Interferon Regulatory Factor-7 - genetics | Mammary Neoplasms, Experimental - genetics | Interferon Regulatory Factor-7 - physiology | Killer Cells, Natural - immunology | Female | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | Receptors, Interferon - deficiency | Gene Silencing | Severe Combined Immunodeficiency - immunology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | Mice, SCID | Tumor Escape - physiology | Severe Combined Immunodeficiency - genetics | Animals | Breast Neoplasms - genetics | Interferon Regulatory Factor-7 - biosynthesis | Interferon Regulatory Factor-7 - antagonists & inhibitors | Interferon-Stimulated Gene Factor 3, gamma Subunit - physiology | Neoplasm Metastasis - physiopathology | Mice, Inbred NOD | Receptors, Interferon - physiology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Interferon-Stimulated Gene Factor 3, gamma Subunit - antagonists & inhibitors | Gene silencing | Care and treatment | Cancer cells | Development and progression | Bones | Breast cancer | Genetic aspects | Metastasis | Research | Human immunogenetics | Signal transduction | Bone cancer | Gene expression | Immune system
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 2011, Volume 35, Issue 12, pp. 1376 - 1387
Interferons (IFNs) are the hallmark of the vertebrate antiviral system. Two of the three IFN families identified in higher vertebrates are now known to be... 
Antiviral defence | Evolution | Interferon | Interferon receptor | Teleost fish | DOUBLE-STRANDED-RNA | RAINBOW-TROUT | ZEBRAFISH DANIO-RERIO | IMMUNOLOGY | TOLL-LIKE RECEPTOR-3 | CARP CYPRINUS-CARPIO | ZOOLOGY | CARASSIUS-AURATUS L | SALMON SALMO-SALAR | TROUT ONCORHYNCHUS-MYKISS | NF-KAPPA-B | REGULATORY FACTOR-I | Receptors, Pattern Recognition - immunology | Virus Diseases - virology | STAT Transcription Factors - immunology | Phylogeny | Interferon Type I - immunology | Fishes - immunology | Fish Proteins - genetics | Signal Transduction - immunology | Fish Diseases - immunology | Janus Kinases - immunology | Interferon-gamma - genetics | Receptors, Interferon - genetics | Fishes - genetics | Virus Diseases - immunology | Fish Proteins - immunology | Janus Kinases - genetics | Gene Expression Regulation - immunology | Suppressor of Cytokine Signaling Proteins - immunology | Interferon Type I - classification | Suppressor of Cytokine Signaling Proteins - genetics | Viruses - immunology | Interferon-gamma - classification | Biological Evolution | STAT Transcription Factors - genetics | Animals | Fish Diseases - virology | Receptors, Interferon - immunology | Interferon-gamma - immunology | Interferon Type I - genetics | Receptors, Pattern Recognition - genetics | Cysteine | Immunoglobulins | Nitric oxide | Genes | Interferon beta | Melanoma | Physiological aspects | Genetics | Biological response modifiers
Journal Article