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PLoS pathogens, ISSN 1553-7374, 11/2013, Volume 9, Issue 11, pp. e1003773 - e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Index Medicus | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Cytokine & growth factor reviews, ISSN 1359-6101, 04/2015, Volume 26, Issue 2, pp. 103 - 111
Abstract Interferons (IFN) are key cytokines with multifaceted antiviral and cell-modulatory properties. Three distinct types of IFN are recognized (I–III)... 
Advanced Basic Science | Interferon types I–III | Interferon–interferon interactions | Interferon genes and receptors | Anti-interferon strategies | Interferon types I-III | Interferon-interferon interactions | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Proliferation | Virus Diseases - immunology | Signal Transduction | Antiviral Agents - immunology | Humans | Transcriptional Activation | Interferon-gamma - physiology | Receptor, Interferon alpha-beta - physiology | Virus Diseases - virology | Interferon Type I - immunology | Interferons - immunology | Genetic Variation | Interferon Type I - genetics | Cell Differentiation | Interferon Type I - physiology | Interferons - physiology | Interferons - genetics | Virus diseases | Interferon | Biological response modifiers | Health aspects | Genetic polymorphisms | IRF, interferon regulatory factor | WNV, West Nile virus | ADAR1, adenosine deaminase acting on RNA 1 | CREB-binding protein | IPS-1, interferon promoter-stimulating factor 1 | EM, environmental mycobacteria | HSE, herpes simplex encephalitis | NEMO, nuclear factor (NF)-kB essential modulator | hCMV, human Cytomegalovirus | APCs, antigen presenting cells | NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells | IRAK-4, interleukin-1 receptor-associated kinase 4 | ds, double strand | SARS, severe acute respiratory syndrome | GAS, gamma interferon activation site | ss, single strand | IFI16, gamma-interferon-inducible protein 16 | TREX1, three prime repair exonuclease 1 | Th, lymphocytes T helper | p300 | PKR, dsRNA-dependent protein kinase | TYK2, tyrosine kinase 2 | IL, interleukin | CRF2, class II cytokine receptor family | IFNGR, interferon gamma receptor | ISGF3, interferon-stimulated gene factor 3 | CHIKV, Chickungunya virus | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | HCV, hepatitis C virus | ATF6, activating transcription factor 6 | EAE, experimental allergic encephalomyelitis | MSMD, Mendelian susceptibility to mycobacterial disease | MxA, Myxovirus Resistance Gene A | RIG-1, retinoic-acid-inducible gene 1 | CBP, chromatin remodeling associated p300 | AP-1, activator protein 1 | OAS, 2′,5′-oligo adenylate synthetase A | HSV-1, herpes simplex virus-1 | SAMHD1, SAM domain and HD domain-containing protein 1 | SARS-CoV, severe acute respiratory syndrome-associated coronavirus | STAT, Signal Transducer and Activator of Transcription | VZV, Varicella-Zoster virus | IFN, interferon | VSV, vesicular stomatitis virus | LASV, Lassa virus | cGAS, cyclic GMP-AMP synthase | ISRE, interferon stimulated response element | EMCV, encephalomyocarditis virus | IFNAR, interferon alpha receptor | BCG, bacille Calmette–Guérin | MHC, major histocompatibility complex | MS, multiple sclerosis | SNPs, single nucleotide polymorphisms | PD-L1, programmed death ligand 1 | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | MAPK, mitogen-activated protein kinases | NK, natural killer cells | PRRs, pattern-recognition receptors
Journal Article
Journal of virology, ISSN 1098-5514, 01/2017, Volume 91, Issue 1
Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection in >95% of adults worldwide and are associated with a variety of malignancies.... 
Acute infection | Interferon | IRF-1 | Viral replication | Gammaherpesvirus | Spleen - virology | Interferon-Induced Helicase, IFIH1 - genetics | Interferon-beta - immunology | Spleen - immunology | Herpesviridae Infections - mortality | Humans | Gammaherpesvirinae - pathogenicity | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Lung - virology | Macrophages - virology | Interferon-alpha - genetics | Interferon-beta - genetics | Receptor, Interferon alpha-beta - genetics | Herpesviridae Infections - genetics | Interferon-gamma - genetics | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Interferon Regulatory Factor-3 - immunology | Gammaherpesvirinae - growth & development | Signal Transduction | Interferon Regulatory Factor-1 - immunology | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Regulatory Factor-7 - immunology | Herpesviridae Infections - virology | Interferon-Induced Helicase, IFIH1 - immunology | Antigens, Differentiation, Myelomonocytic - genetics | Proteins - immunology | Interferon Regulatory Factor-1 - genetics | Interferon-alpha - immunology | Mice, Knockout | Host-Pathogen Interactions | Proteins - genetics | Animals | Antigens, Nuclear - genetics | Receptor, Interferon alpha-beta - immunology | Interferon-gamma - immunology | Survival Analysis | Mice | Primary Cell Culture | Antigens, Nuclear - immunology | Lung - immunology | Herpesviridae Infections - immunology | Index Medicus
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 02/2011, Volume 71, Issue 7, pp. 2488 - 2496
Journal Article
Journal of virology, ISSN 1098-5514, 09/2012, Volume 86, Issue 18, pp. 9888 - 9898
Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we show that CHIKV infection of adult mice deficient in interferon response... 
Life Sciences & Biomedicine | Science & Technology | Virology | Interferon-alpha - pharmacology | Shock, Hemorrhagic - prevention & control | Humans | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Receptor, Interferon alpha-beta - physiology | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Host-Pathogen Interactions - immunology | Alphavirus Infections - prevention & control | Interferon Regulatory Factor-7 - physiology | Chikungunya virus - physiology | Receptor, Interferon alpha-beta - genetics | Chikungunya virus - pathogenicity | Chikungunya Fever | Virus Replication - drug effects | Adaptor Proteins, Vesicular Transport - physiology | Interferon-alpha - biosynthesis | Receptor, Interferon alpha-beta - deficiency | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Interferon-beta - biosynthesis | Alphavirus Infections - immunology | Chikungunya virus - immunology | Alphavirus Infections - pathology | Interferon Regulatory Factor-3 - physiology | Mice, Knockout | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Host-Pathogen Interactions - genetics | Interferon Regulatory Factor-7 - deficiency | Myeloid Differentiation Factor 88 - physiology | Mice | Shock, Hemorrhagic - immunology | Index Medicus | Life Sciences | Santé publique et épidémiologie | Pathogenesis and Immunity
Journal Article