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Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 3965 - 3976
Psoriasis is a chronic inflammatory disorder of the skin affecting approximately 2% of the world's population. Accumulating evidence has revealed that the... 
GENERALIZED PUSTULAR PSORIASIS | MEDICINE, RESEARCH & EXPERIMENTAL | INFLAMMATORY SKIN-DISEASE | FAMILY-MEMBERS | MOUSE MODEL | DELTA-T-CELLS | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | CUTTING EDGE | TRANSGENIC MICE | Cell Communication - immunology | Interleukin-1 - genetics | Membrane Glycoproteins - metabolism | Dermatitis - immunology | Dendritic Cells - immunology | Receptors, Interleukin-1 - genetics | Interleukin-17 - immunology | Dendritic Cells - pathology | Interleukins - metabolism | Interleukin-23 - genetics | Interleukins - genetics | Psoriasis - genetics | Interleukin-23 - metabolism | Psoriasis - pathology | Interleukins - immunology | Toll-Like Receptor 7 - immunology | Interleukin-1 - immunology | Psoriasis - metabolism | Membrane Glycoproteins - immunology | Dendritic Cells - metabolism | Psoriasis - immunology | Toll-Like Receptor 7 - genetics | Interleukin-1 - metabolism | Toll-Like Receptor 7 - metabolism | Dermatitis - genetics | Receptors, Interleukin-1 - immunology | Interleukin-17 - genetics | Cell Communication - genetics | Interleukin-23 - immunology | Keratinocytes - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Dermatitis - pathology | Interleukin-17 - metabolism | Keratinocytes - pathology | Animals | Keratinocytes - metabolism | Mice | Dermatitis - metabolism | Psoriasis | Interleukins | Keratinocytes | Genetic aspects | Dosage and administration | Diagnosis | Drug therapy
Journal Article
Immunity, ISSN 1074-7613, 10/2015, Volume 43, Issue 4, pp. 739 - 750
Interleukin-23 (IL-23) and IL-17 are cytokines currently being targeted in clinical trials. Although inhibition of both of these cytokines is effective for... 
INFLAMMATORY-BOWEL-DISEASE | CHRONIC PLAQUE PSORIASIS | CROHNS-DISEASE | EPITHELIAL-CELLS | COLITIS | LIPOPOLYSACCHARIDE-BINDING PROTEIN | DOUBLE-BLIND | RECEPTOR COMPLEX | IMMUNOLOGY | T-CELLS | TH17 CELLS | T-Lymphocyte Subsets - immunology | Interleukin-23 Subunit p19 - antagonists & inhibitors | Intestinal Mucosa - physiopathology | ATP Binding Cassette Transporter, Sub-Family B - deficiency | Receptors, Interleukin-17 - immunology | Epithelium - physiopathology | Interleukin-17 - immunology | Interleukin-17 - physiology | Transcriptome | Helicobacter Infections - complications | Interleukin-12 Subunit p40 - antagonists & inhibitors | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-17 - physiology | Female | Colitis - drug therapy | Colitis - immunology | Interleukin-23 - physiology | Disease Models, Animal | Gene Expression Regulation - immunology | Immunoglobulin G - therapeutic use | Helicobacter Infections - immunology | Receptors, Interleukin-17 - antagonists & inhibitors | Permeability | Disease Progression | Interleukin-23 - immunology | Mice, Knockout | Colitis - etiology | Animals | Colitis - microbiology | Forkhead Transcription Factors - analysis | Immunization, Passive | Mice | Interleukin-23 Subunit p19 - immunology | Colitis | Psoriasis | Interleukins | Drug resistance | Analysis | Mortality | Inflammatory bowel disease | Studies | Pathology | Flow cytometry | Immunoglobulins | Histopathology | Cytokines | Infections | Inflammation | Gene expression | Crohns disease
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2009, Volume 119, Issue 10, pp. 3011 - 3023
Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | TGF-BETA | INTERLEUKIN-17 FAMILY | IN-VIVO | GROWTH | IL-17-PRODUCING T-CELLS | FACTOR RECEPTOR P55 | PHASE-II | NECROSIS-FACTOR-ALPHA | NF-KAPPA-B | Humans | Tumor Necrosis Factor-alpha - genetics | Interleukin-17 - immunology | Antibodies, Monoclonal - therapeutic use | Gene Expression Profiling | Chimera - genetics | CD4-Positive T-Lymphocytes - immunology | Interleukin-23 - genetics | Ovarian Neoplasms - genetics | Chimera - immunology | Interleukin-2 Receptor alpha Subunit - genetics | Infliximab | Microarray Analysis | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - therapeutic use | Female | Ovarian Neoplasms - drug therapy | Disease Models, Animal | Interleukin-2 Receptor alpha Subunit - immunology | Receptors, Interleukin - immunology | Mice, Inbred C57BL | Receptors, Tumor Necrosis Factor, Type I | Interleukin-17 - genetics | Clinical Trials as Topic | Receptors, Interleukin - genetics | Interleukin-23 - immunology | Mice, Knockout | Animals | Signal Transduction - physiology | Mice | Ovarian Neoplasms - immunology | Interleukin-2 Receptor alpha Subunit | Signal Transduction | Anti-Inflammatory Agents | Interleukin-23 | Receptors, Interleukin | Antibodies, Monoclonal | Tumor Necrosis Factor-alpha | Life Sciences | Immunology | CD4-Positive T-Lymphocytes | Interleukin-17 | Ovarian Neoplasms | Chimera
Journal Article
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 05/2014, Volume 18, Issue 5, pp. 513 - 525
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2011, Volume 186, Issue 2, pp. 662 - 666
Journal Article
Nature, ISSN 0028-0836, 07/2018, Volume 559, Issue 7714, pp. 363 - 369
Patients with prostate cancer frequently show resistance to androgen-deprivation therapy, a condition known as castration-resistant prostate cancer (CRPC).... 
IMMUNITY | ENZALUTAMIDE MDV3100 | TUMOR PROGRESSION | PLAQUE PSORIASIS | MULTIDISCIPLINARY SCIENCES | ABIRATERONE ACETATE | MECHANISMS | SUPPRESSOR-CELLS | CLINICAL ACTIVITY | DOCETAXEL | EXPRESSION | Androgen Receptor Antagonists - therapeutic use | Cell Proliferation | Phenylthiohydantoin - therapeutic use | Humans | Receptors, Androgen - metabolism | Androgens - deficiency | Interleukin-23 - blood | Male | Androgen Receptor Antagonists - pharmacology | Prostatic Neoplasms, Castration-Resistant - pathology | Receptors, Interleukin - metabolism | Interleukin-23 - metabolism | Interleukin-23 - antagonists & inhibitors | Myeloid-Derived Suppressor Cells - cytology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Prostatic Neoplasms, Castration-Resistant - therapy | Myeloid-Derived Suppressor Cells - metabolism | Phenylthiohydantoin - pharmacology | Myeloid-Derived Suppressor Cells - immunology | Signal Transduction | Cell Survival | Prostatic Neoplasms, Castration-Resistant - blood | Prostatic Neoplasms, Castration-Resistant - metabolism | Interleukin-23 - immunology | Phenylthiohydantoin - analogs & derivatives | Animals | Mice | Castration | Oncology, Experimental | Research | Suppressor cells | Prostate cancer | Methods | Cancer | Cell proliferation | Therapy | Transcription factors | Interleukin 23 | Inactivation | Cancer therapies | Synergism | Metastases | Dependence | Deprivation | Myeloid cells | Cell survival | Deactivation | Psoriasis | Cytokines | Gene expression | Patients | Blood levels | Androgens | Medical prognosis | Infiltration | Prostate | Tumors
Journal Article