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Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2003, Volume 171, Issue 6, pp. 3202 - 3209
Studies in IL-6-deficient (IL-6(-/-)) mice highlight that IL-6 contributes to arthritis progression. However, the molecular mechanism controlling its activity... 
RHEUMATOID-ARTHRITIS | INTERLEUKIN-6 RECEPTOR | TUMOR-NECROSIS-FACTOR | COLLAGENASE | SERUM INTERLEUKIN-6 | ENDOTHELIAL-CELLS | GP130 | CYTOKINE | T-CELL | IMMUNOLOGY | HUMANIZED ANTIBODY | Arthritis, Experimental - genetics | Humans | Recombinant Fusion Proteins - therapeutic use | Synovial Fluid - metabolism | Male | Receptors, Interleukin-6 - antagonists & inhibitors | Synovial Fluid - chemistry | Cell Movement - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Arthritis, Experimental - pathology | Cell Movement - immunology | Arthritis, Rheumatoid - metabolism | Signal Transduction - immunology | Receptors, Interleukin-6 - administration & dosage | Arthritis, Experimental - prevention & control | Leukocytes, Mononuclear - immunology | Interleukin-6 - administration & dosage | Interleukin-6 - metabolism | Recombinant Fusion Proteins - administration & dosage | Fibroblasts - metabolism | Severity of Illness Index | Cytokine Receptor gp130 | Interleukin-6 - genetics | Receptors, Interleukin-6 - genetics | Membrane Glycoproteins - pharmacology | Mice, Inbred C57BL | Solubility | Protein Isoforms - analysis | Arthritis, Experimental - immunology | Signal Transduction - genetics | Interleukin-6 - deficiency | Protein Isoforms - physiology | Mice, Knockout | Protein Isoforms - pharmacology | Synovial Fluid - immunology | Leukocytes, Mononuclear - pathology | Receptors, Interleukin-6 - physiology | Animals | Chemokine CCL2 - biosynthesis | Antigens, CD - pharmacology | Fibroblasts - immunology | Mice | Arthritis, Rheumatoid - immunology | Protein Isoforms - antagonists & inhibitors
Journal Article
Journal Article
Blood, ISSN 1528-0020, 2009, Volume 114, Issue 4, pp. 891 - 900
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 11/2014, Volume 111, Issue 45, pp. 16136 - 16141
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1744-7631, 2007, Volume 11, Issue 5, pp. 613 - 624
IL-6 plays a pivotal role in immune responses and certain oncologic conditions. The intense investigation of its biological activity and function led to the... 
cytokine | inflammation | colon cancer | soluble receptor | trans-signalling | rheumatoid arthritis | IL-6 | Soluble | Colon cancer | Receptor | Rheumatoid arthritis | Cytokine | Inflammation | Trans-signalling | RHEUMATOID-ARTHRITIS | CROHNS-DISEASE | SIGNAL-TRANSDUCING RECEPTOR | NECROSIS-FACTOR-ALPHA | T-CELL | INFLAMMATORY-BOWEL-DISEASE | SOLUBLE INTERLEUKIN-6 RECEPTOR | IN-VIVO | ANTI-INTERLEUKIN-6 MONOCLONAL-ANTIBODY | PHARMACOLOGY & PHARMACY | IL-6 RECEPTOR | Neoplasms - metabolism | Receptors, Interleukin-6 - chemistry | Interleukin-6 - antagonists & inhibitors | Alternative Splicing | Colonic Neoplasms - drug therapy | Humans | Recombinant Fusion Proteins - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Receptors, Interleukin-6 - antagonists & inhibitors | Drug Delivery Systems | Cell Line - drug effects | Cytokine Receptor gp130 - physiology | Inflammation - metabolism | Arthritis, Rheumatoid - drug therapy | Inflammation - drug therapy | Interleukin-6 - physiology | Anti-Inflammatory Agents - therapeutic use | Antineoplastic Agents - pharmacology | Colitis - drug therapy | Colitis - immunology | Drug Evaluation, Preclinical | Autoimmune Diseases - metabolism | Autoimmune Diseases - drug therapy | Disease Models, Animal | Anti-Inflammatory Agents - pharmacology | Receptors, Interleukin-6 - genetics | Solubility | Transforming Growth Factor beta - physiology | Clinical Trials as Topic | Asthma - drug therapy | Neoplasms - drug therapy | Receptors, Interleukin-6 - physiology | Animals | Signal Transduction - drug effects | Arthritis - drug therapy | Mice | Leukocytes - metabolism
Journal Article
Journal Article
Journal Article