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Journal of receptor and signal transduction research, ISSN 1079-9893, 1995
Journal
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2007, Volume 104, Issue 16, pp. 6519 - 6526
Two classes of sterols, cholesterol and oxysterols, block export of sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum (ER) to... 
Transfection | Sterols | Plasmids | Cell lines | Antibodies | Amino acids | Cell membranes | CHO cells | Cholesterols | P branes | COPII vesicles | Cholesterol homeostasis | Oxysterols | SREBP pathway | COAT | cholesterol homeostasis | COENZYME-A REDUCTASE | CHOLESTEROL | oxysterols | MULTIDISCIPLINARY SCIENCES | CLEAVAGE-ACTIVATING PROTEIN | INHIBITION | ER MEMBRANES | HAMSTER OVARY CELLS | SENSING DOMAIN | BINDING | VESICLE | Protein Sorting Signals - physiology | Cricetulus | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - immunology | Protein Transport - physiology | Antibodies, Blocking - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Vesicular Transport Proteins - antagonists & inhibitors | Clone Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | CHO Cells | Amino Acid Sequence | Cricetinae | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | COP-Coated Vesicles - metabolism | Membrane Proteins - immunology | Sterol Regulatory Element Binding Proteins - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Golgi Apparatus - metabolism | Intracellular Signaling Peptides and Proteins - physiology | Homeostasis | Research | Endoplasmic reticulum | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e36616
Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular... 
PROMOTES CELL-GROWTH | METABOLISM | MULTIDISCIPLINARY SCIENCES | TUMOR-SUPPRESSOR | INHIBITORS | AUTOPHAGY | IDENTIFICATION | SLC36 FAMILY | CANCER | MTOR | DROSOPHILA | Humans | Multiprotein Complexes | Ras Homolog Enriched in Brain Protein | Phosphatidylinositol 3-Kinases - metabolism | Amino Acids - pharmacology | Endosomes - metabolism | Mechanistic Target of Rapamycin Complex 1 | Drosophila melanogaster - metabolism | Lysosomes - metabolism | Protein Binding - drug effects | Endosomes - drug effects | HEK293 Cells | Female | Proto-Oncogene Proteins c-akt - metabolism | Lysosomes - drug effects | Endocytosis - drug effects | Drosophila melanogaster - cytology | Neuropeptides - metabolism | Amino Acid Transport Systems - metabolism | Symporters - metabolism | Animals | GTP Phosphohydrolases - metabolism | Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Signal Transduction - drug effects | Drosophila melanogaster - growth & development | Intracellular Membranes - drug effects | TOR Serine-Threonine Kinases | Intracellular Membranes - metabolism | Type 2 diabetes | Amino acids | G proteins | Cells | Adenosine triphosphatase | TOR protein | Cell culture | Membranes | Disease | Genes | Acidification | Lysosomes | Intracellular signalling | AKT protein | Activation | Kinases | Autophagy | Cell surface | Proteins | Endocytosis | Compartments | Cell cycle | Genetics | Physiology | Localization | Growth factors | H+-transporting ATPase | Translocation | Intracellular levels | Drosophila | Rapamycin | Anatomy & physiology | Mammals | 1-Phosphatidylinositol 3-kinase | Insects | In vivo methods and tests | Intracellular | Transporter | Cancer | Endosomes | Kidney transplantation
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7456, pp. 50 - 54
53BP1 (also called TP53BP1) is a chromatin-associated factor that promotes immunoglobulin class switching and DNA double-strand-break (DSB) repair by... 
CRB2 | RECRUITMENT | FISSION YEAST | METHYLATION | CHROMATIN | DEPENDENT RESPONSE | RESECTION | MULTIDISCIPLINARY SCIENCES | SITES | DOUBLE-STRAND BREAKS | CLASS-SWITCH RECOMBINATION | Schizosaccharomyces pombe Proteins - chemistry | Histones - chemistry | Nucleosomes - chemistry | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Male | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - deficiency | Cell Cycle Proteins - chemistry | Intracellular Signaling Peptides and Proteins - deficiency | Ubiquitination | Schizosaccharomyces pombe Proteins - metabolism | Female | Lysine - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Schizosaccharomyces | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Signal Transduction | Cell Cycle Proteins - metabolism | Nucleosomes - metabolism | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Chromosomal Proteins, Non-Histone - deficiency | Amino Acid Motifs | Chromosomal Proteins, Non-Histone - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Mutant Proteins - chemistry | Protein Binding | Mice | DNA Damage | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Chromosomal Proteins, Non-Histone - chemistry | Ubiquitin | Research | Properties | DNA repair | DNA damage | Proteins | DNA methylation | Mutation | Experiments | Recruitment
Journal Article
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 225 - 244
Autophagy is the process of cellular self-eating by a double-membrane organelle, the autophagosome. A range of signaling processes converge on two protein... 
COPII | Atg1 | membrane remodeling | vesicle | tethering complex | nanoscale biology | ULK1 | Vps34 | membrane fusion | phosphatidylinositol 3-kinase | Vesicle | Membrane fusion | Membrane remodeling | Phosphatidylinositol 3-kinase | Nanoscale biology | Tethering complex | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHAGOPHORE ASSEMBLY SITE | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | REGULATES AUTOPHAGY | MAMMALIAN AUTOPHAGY | BECLIN 1 PHOSPHORYLATION | SACCHAROMYCES-CEREVISIAE | SELECTIVE AUTOPHAGY | ATG1 KINASE COMPLEX | ENDOPLASMIC-RETICULUM | ULK1 COMPLEX | Humans | Protein Multimerization | Eukaryotic Cells - metabolism | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Eukaryotic Cells - ultrastructure | Class III Phosphatidylinositol 3-Kinases - chemistry | Phagosomes - ultrastructure | Cell Membrane - metabolism | Autophagy - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phosphatidylinositol 3-Kinase - metabolism | COP-Coated Vesicles - ultrastructure | Gene Expression | Signal Transduction | Phagosomes - metabolism | Gene Expression Regulation | COP-Coated Vesicles - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Cell Membrane - ultrastructure | Autophagy-Related Protein-1 Homolog - chemistry | Phosphatidylinositol 3-Kinase - chemistry | Phosphatidylinositol 3-Kinase - genetics | Class III Phosphatidylinositol 3-Kinases - genetics | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | Autophagy-Related Protein-1 Homolog - genetics | Physiological aspects | Autophagy (Cytology) | Genetic aspects | Research | Gene expression
Journal Article