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Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 305 - 331
The identification of heterozygous mutations in the metabolic enzyme isocitrate dehydrogenase (IDH) in subsets of cancers, including secondary glioblastoma,... 
cancer therapeutics | allosteric inhibition | metabolism | oncometabolite | Allosteric inhibition | Cancer therapeutics | Metabolism | Oncometabolite | GLIOMA-CELLS | SELECTIVE-INHIBITION | RAT-LIVER | MUTANT IDH1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | REDUCTIVE CARBOXYLATION | POTENT INHIBITOR | ISOTOPOMER ANALYSIS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | CARBON-DIOXIDE | Glutarates - analysis | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - therapeutic use | Enzyme Inhibitors - chemical synthesis | Isocitrate Dehydrogenase - antagonists & inhibitors | Benzeneacetamides - chemical synthesis | Acetamides - chemical synthesis | Leukemia, Myeloid, Acute - enzymology | Benzeneacetamides - therapeutic use | Acetamides - therapeutic use | Isoenzymes - metabolism | Biomarkers, Tumor - metabolism | Leukemia, Myeloid, Acute - drug therapy | Imidazoles - chemical synthesis | Imidazoles - therapeutic use | Benzimidazoles - therapeutic use | Gene Expression | Biomarkers, Tumor - analysis | Isoenzymes - genetics | Leukemia, Myeloid, Acute - pathology | Benzimidazoles - chemical synthesis | Translational Medical Research | Small Molecule Libraries - therapeutic use | Models, Molecular | Small Molecule Libraries - chemical synthesis | Isocitrate Dehydrogenase - genetics | Drug Discovery | Enzyme Inhibitors - therapeutic use | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mutation | Isoenzymes - antagonists & inhibitors | Leukemia, Myeloid, Acute - genetics | Antimitotic agents | Gene mutations | Physiological aspects | Genetic aspects | Oxidoreductases | Research | Antineoplastic agents
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