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1. Full Text Proteins as binding targets of isothiocyanates in cancer prevention
by Mi, Lixin and Di Pasqua, Anthony J and Chung, Fung-Lung
Carcinogenesis, ISSN 0143-3334, 10/2011, Volume 32, Issue 10, pp. 1405 - 1413
Isothiocyanates are versatile cancer-preventive compounds. Evidence from animal studies indicates that the anticarcinogenic activities of ITCs involve all the... 
PHENETHYL ISOTHIOCYANATE | ALLYL ISOTHIOCYANATE | ORGANIC ISOTHIOCYANATES | ONCOLOGY | MIGRATION INHIBITORY FACTOR | FLUORESCEIN ISOTHIOCYANATE | PHENYLETHYL ISOTHIOCYANATE | CELL-CYCLE ARREST | N-ACETYLCYSTEINE | DIETARY ISOTHIOCYANATES | BENZYL ISOTHIOCYANATE | Isothiocyanates - metabolism | Neoplasms - metabolism | Animals | Isothiocyanates - therapeutic use | Proteins - metabolism | Humans | Protein Binding | Neoplasms - prevention & control | Anticarcinogenic Agents - metabolism | Anticarcinogenic Agents - therapeutic use | Index Medicus | Reviews
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2. Full Text Are isothiocyanates potential anti-cancer drugs?
by Wu, Xiang and Zhou, Qing-Hua and Xu, Ke
Acta Pharmacologica Sinica, ISSN 1671-4083, 05/2009, Volume 30, Issue 5, pp. 501 - 512
Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both... 
Anticarcinogenic | Isothiocyanate | Chemoprevention | Antitumor | Cell cycle | Apoptosis | PHENETHYL ISOTHIOCYANATE | isothiocyanate | antitumor | cell cycle | CHEMOPREVENTIVE ISOTHIOCYANATES | apoptosis | CELL-CYCLE ARREST | anticarcinogenic | BENZYL ISOTHIOCYANATE | DNA ADDUCT FORMATION | CHEMISTRY, MULTIDISCIPLINARY | 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE METABOLISM | CRUCIFEROUS VEGETABLES | ESOPHAGEAL TUMORIGENESIS | chemoprevention | ARYLALKYL ISOTHIOCYANATES | PHARMACOLOGY & PHARMACY | DIETARY ISOTHIOCYANATES | Isothiocyanates - metabolism | Animals | Isothiocyanates - therapeutic use | Models, Biological | Humans | Anticarcinogenic Agents | Antineoplastic Agents, Phytogenic - therapeutic use | Isothiocyanates - pharmacology | Index Medicus | Review
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3. Full Text Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro
by Waterman, Carrie and Cheng, Diana M and Rojas-Silva, Patricio and Poulev, Alexander and Dreifus, Julia and Lila, Mary Ann and Raskin, Ilya
Phytochemistry, ISSN 0031-9422, 07/2014, Volume 103, pp. 114 - 122
Fresh leaf concentrate of (MC) utilized for bioconversion of glucosinolates ( – ) to chemically stable isothiocyanates ( – ). MC significantly reduced... 
Moringaceae | 4-[(4′-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate | Moringa oleifera | Chronic inflammation | 4-[(α-L-rhamnosyloxy)benzyl]isothiocyanate | Isothiocyanates | 4-[(4′-O-acetyl-α- L-rhamnosyloxy)benzyl]isothiocyanate | 4-[(4'-O-acetyl-alpha-L-rhamnosyloxy) benzyl]isothiocyanate | Moringaceae Chronic inflammation | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 4-[(alpha-L-rhamnosyloxy) benzyl]isothiocyanate | ALPHA | INDUCTION | CANCER | ANTIOXIDANT PROPERTIES | PLANT SCIENCES | PHYTOCHEMICALS | INHIBITION | TREE | NF-KAPPA-B | EXPRESSION | Plant Leaves - chemistry | Cell Line | Plant Extracts - chemistry | Anti-Inflammatory Agents - pharmacology | Plant Extracts - pharmacology | Macrophages - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Interleukin-1beta - metabolism | Isothiocyanates - chemistry | Water - chemistry | Macrophages - drug effects | Mice | Nitric Oxide - metabolism | Isothiocyanates - pharmacology | Nitric Oxide Synthase Type II - metabolism | Interleukins | Nitric oxide | Polyphenols | Chronic diseases | Inflammation | B cells | Macrophages | Gene expression | isothiocyanates | chronic inflammation | 4-[(4'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate
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4. Full Text Isothiocyanates: An overview of their antimicrobial activity against human infections
by Romeo, Letizia and Iori, Renato and Rollin, Patrick and Bramanti, Placido and Mazzon, Emanuela
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 624
The use of plant-derived products as antimicrobial agents has been investigated in depth. Isothiocyanates (ITCs) are bioactive products resulting from... 
Benzyl isothiocyanate (BITC) | Phenyl isothiocyanate (PITC) | Sulforaphane (SFN) | Allyl isothiocyanate (AITC) | Phenyl ethyl isothiocyanate (PEITC) | Antibiotics | Microbial infection | Moringin (MGN) | Isothiocyanates (ITCs) | PHENETHYL ISOTHIOCYANATE | RISK-FACTORS | sulforaphane (SFN) | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANT STAPHYLOCOCCUS-AUREUS | CHEMISTRY, MULTIDISCIPLINARY | moringin (MGN) | isothiocyanates (ITCs) | benzyl isothiocyanate (BITC) | microbial infection | HYDROLYSIS PRODUCTS | allyl isothiocyanate (AITC) | phenyl isothiocyanate (PITC) | IN-VITRO | ANTIBACTERIAL ACTIVITY | PSEUDOMONAS-AERUGINOSA | phenyl ethyl isothiocyanate (PEITC) | CLOSTRIDIUM-PERFRINGENS | antibiotics | HELICOBACTER-PYLORI | MORINGA-OLEIFERA | Infection - drug therapy | Anti-Infective Agents - pharmacology | Humans | Anti-Infective Agents - therapeutic use | Biological Products - pharmacology | Infection - etiology | Biological Products - chemistry | Infection - metabolism | Isothiocyanates - therapeutic use | Metabolic Networks and Pathways | Isothiocyanates - chemistry | Anti-Infective Agents - chemistry | Isothiocyanates - pharmacology | Pathogens | Food plants | Secondary metabolites | Phenotypes | Antimicrobial activity | Metabolites | Glucosinolates | Antimicrobial agents | Plants | Antiinfectives and antibacterials | Public health
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5. Full Text Direct and Indirect Antioxidant Activity of Polyphenol- and Isothiocyanate-Enriched Fractions from Moringa oleifera
by Tumer, Tugba Boyunegmez and Rojas-Silva, Patricio and Poulev, Alexander and Raskin, Ilya and Waterman, Carrie
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 02/2015, Volume 63, Issue 5, pp. 1505 - 1513
Moringa oleifera Lam. is a fast-growing, tropical tree with various edible parts used as nutritious food and traditional medicine. This study describes an... 
4-[(4′-O-acetyl-α- l -rhamnosyloxy)benzyl]isothiocyanate | FCPC | NQO1 | polyphenols | Moringa oleifera | antioxidants | 4-[(α- l -rhamnosyloxy)benzyl]isothiocyanate | isothiocyanates | QUINONE REDUCTASE | ASSAY | SULFORAPHANE | FOOD SCIENCE & TECHNOLOGY | HEPATOMA-CELLS | INDUCERS | INDUCTION | ANTICARCINOGENIC MARKER ENZYME | RADICAL ABSORBENCY CAPACITY | PHYTOCHEMICALS | 4-[(4 '-O-acetyl-alpha-L-rhamnosyloxy)]osptjopcuamate | IN-VITRO | 4-[(alpha-L-rhamnosyloxy)benzyl]isothiocyanate | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | Cell Line | Plant Extracts - chemistry | Polyphenols - isolation & purification | Antioxidants - chemistry | Plant Extracts - isolation & purification | Moringa oleifera - chemistry | Animals | Antioxidants - isolation & purification | Isothiocyanates - chemistry | Polyphenols - chemistry | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | NAD(P)H Dehydrogenase (Quinone) - analysis | Isothiocyanates - isolation & purification | 4-[(4′-O-acetyl-α-l-rhamnosyloxy)benzyl]isothiocyanate | 4-[(α-l-rhamnosyloxy)benzyl]isothiocyanate
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6. Full Text Taste detection of the non-volatile isothiocyanate moringin results in deterrence to glucosinolate-adapted insect larvae
by Müller, Caroline and van Loon, Joop and Ruschioni, Sara and De Nicola, Gina Rosalinda and Olsen, Carl Erik and Iori, Renato and Agerbirk, Niels
Phytochemistry, ISSN 0031-9422, 10/2015, Volume 118, pp. 139 - 148
The non-volatile isothiocyanate moringin deterred larvae of the sawfly and two species, and elicited response from a deterrent taste neuron in . Recovery of... 
Stimulant | NMR | Glucosinolate | HPLC–MS/MS | Neuron | Deterrent | Isothiocyanate | Taste | Sensory physiology | Specialist herbivores | Brassicales | HPLCMS/MS | ALLYL ISOTHIOCYANATE | lsothiocyanate | CHEMICAL DEFENSE | BRASSICA-JUNCEA | PLANT VOLATILES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SAWFLY ATHALIA-ROSAE | HOST | CHROMOSOME-NUMBERS | PLANT SCIENCES | PIERIS-RAPAE | HPLC-MS/MS | FEEDING STIMULANTS | MYROSINASE SYSTEM | Rhamnose - chemistry | Isothiocyanates - analysis | Herbivory - physiology | Brassicaceae - chemistry | Lepidoptera - physiology | Plant Leaves | Rhamnose - pharmacology | Rhamnose - analogs & derivatives | Choline - chemistry | Glucosinolates - chemistry | Taste - physiology | Feeding Behavior - physiology | Animals | Isothiocyanates - chemistry | Larva - drug effects | Choline - analogs & derivatives | Hymenoptera - physiology | Nuclear Magnetic Resonance, Biomolecular | Isothiocyanates - isolation & purification | Isothiocyanates - pharmacology
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7. Full Text Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells
by Li Tang and Yuesheng Zhang
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2005, Volume 4, Issue 8, pp. 1250 - 1259
Many isothiocysanates (ITC) are promising cancer-preventive agents, and induction of apoptosis is one of their underlying mechanisms of action. We recently... 
apoptosis | isothiocyanate | chemoprevention | bladder cancer | mitochondria | ALLYL ISOTHIOCYANATE | PHENETHYL ISOTHIOCYANATE | ONCOLOGY | CHEMOPREVENTIVE ISOTHIOCYANATES | CYCLE ARREST | ANTICARCINOGENIC ISOTHIOCYANATES | DIETARY ISOTHIOCYANATES | CYTOCHROME-C RELEASE | BENZYL ISOTHIOCYANATE | ADENINE-NUCLEOTIDE TRANSLOCASE | PERMEABILITY TRANSITION | Membrane Potentials - drug effects | Caspase 9 | Phosphorylation | Cytochromes c - metabolism | Humans | Urinary Bladder Neoplasms - enzymology | Mitochondria - metabolism | Mitochondria - drug effects | Isothiocyanates - toxicity | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Anticarcinogenic Agents - toxicity | Urinary Bladder Neoplasms - pathology | Intracellular Membranes - drug effects | Enzyme Activation | Tumor Cells, Cultured | Anticarcinogenic Agents - pharmacology | Urinary Bladder Neoplasms - metabolism | Isothiocyanates - pharmacology | Apoptosis
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8. Full Text Allyl isothiocyanate as a cancer chemopreventive phytochemical
by Zhang, Yuesheng
Molecular Nutrition & Food Research, ISSN 1613-4125, 01/2010, Volume 54, Issue 1, pp. 127 - 135
Allyl isothiocyanate (AITC), which occurs in many common cruciferous vegetables, is widely and often frequently consumed by humans. Besides antimicrobial... 
Allyl isothiocyanate | Sinigrin | Cruciferous vegetable | Chemoprevention | TRANSPORTER-MEDIATED EXPORT | N-ACETYLCYSTEINE CONJUGATE | URINARY-BLADDER | FOOD SCIENCE & TECHNOLOGY | ANTICARCINOGENIC ISOTHIOCYANATES | CRUCIFEROUS VEGETABLES | IN-VITRO | ORGANOSULFUR COMPOUNDS | HUMAN HEPATOMA-CELLS | DIETARY ISOTHIOCYANATES | CELLULAR ACCUMULATION | Anti-Infective Agents - metabolism | Gram-Positive Bacteria - drug effects | Protective Agents - pharmacokinetics | Anti-Infective Agents - pharmacology | Humans | Protective Agents - metabolism | Biological Availability | Male | Anticarcinogenic Agents - metabolism | Anticarcinogenic Agents - pharmacokinetics | Isothiocyanates - metabolism | Gram-Negative Bacteria - drug effects | Animals | Protective Agents - pharmacology | Anti-Infective Agents - pharmacokinetics | Female | Penicillium chrysogenum - drug effects | Phytotherapy | Anticarcinogenic Agents - pharmacology | Isothiocyanates - pharmacokinetics | Isothiocyanates - pharmacology | chemoprevention | sinigrin | allyl isothiocyanate | cruciferous vegetable
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9. Full Text Glucosinolates and isothiocyanates in health and disease
by Dinkova-Kostova, Albena T and Kostov, Rumen V
Trends in Molecular Medicine, ISSN 1471-4914, 2012, Volume 18, Issue 6, pp. 337 - 347
Glucosinolates and isothiocyanates have both been objects of research for more than half a century. Interest in these unique phytochemicals escalated following... 
Pathology | PHENETHYL ISOTHIOCYANATE | MEDICINE, RESEARCH & EXPERIMENTAL | MIGRATION INHIBITORY FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | BENZYL ISOTHIOCYANATE | CRUCIFEROUS VEGETABLES | SULFORAPHANE RESTORES | CELL BIOLOGY | TRANSCRIPTION FACTOR NRF2 | TRAUMATIC BRAIN-INJURY | INTRACEREBRAL HEMORRHAGE | SPINAL-CORD-INJURY | BROCCOLI SPROUT BEVERAGES | Cardiovascular Diseases - drug therapy | Humans | Isothiocyanates - administration & dosage | Diabetic Nephropathies - drug therapy | Glucosinolates - chemistry | Neuroprotective Agents - pharmacology | Anticarcinogenic Agents - administration & dosage | Isothiocyanates - chemistry | Anti-Bacterial Agents - chemistry | Helicobacter Infections - drug therapy | Models, Animal | Neuroprotective Agents - administration & dosage | Anticarcinogenic Agents - pharmacology | Isothiocyanates - pharmacology | Neuroprotective Agents - chemistry | Cardiotonic Agents - chemistry | Cardiotonic Agents - pharmacology | Animals | Anticarcinogenic Agents - chemistry | Cardiotonic Agents - administration & dosage | Glucosinolates - pharmacology | Central Nervous System - drug effects | Anti-Bacterial Agents - pharmacology | Cell Transformation, Neoplastic - drug effects | Anti-Bacterial Agents - administration & dosage | Glucosinolates - administration & dosage | Skin - drug effects | Proteins | Analysis
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10. Full Text The antibacterial properties of isothiocyanates
by Dufour, Virginie and Dufour, Virginie and Stahl, Martin and Stahl, Martin and Baysse, Christine and Baysse, Christine
Microbiology (United Kingdom), ISSN 1350-0872, 2015, Volume 161, Issue 2, pp. 229 - 243
Isothiocyanates (ITCs) are natural plant products generated by the enzymic hydrolysis of glucosinolates found in Brassicaceae vegetables. These natural sulfur... 
ALLYL ISOTHIOCYANATE | 2-COMPONENT REGULATORY SYSTEM | HEAT-SHOCK PROTEINS | ENZYMATIC-HYDROLYSIS PRODUCTS | N-ACETYLCYSTEINE CONJUGATE | GLUCOSINOLATE-DERIVED ISOTHIOCYANATES | QUORUM SENSING INHIBITORS | ESCHERICHIA-COLI O157H7 | MURINE HEPATOMA-CELLS | MICROBIOLOGY | SYNTHETIC HYDROXY ISOTHIOCYANATES | Plant Extracts - chemistry | Bacteria - metabolism | Plant Extracts - pharmacology | Brassicaceae - chemistry | Bacteria - drug effects | Cell Membrane - genetics | Bacteria - genetics | Isothiocyanates - chemistry | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - pharmacology | Cell Membrane - metabolism | Cell Membrane - drug effects | Isothiocyanates - pharmacology | Life Sciences
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11. Full Text The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates
by Zhang, Yuesheng
Carcinogenesis, ISSN 0143-3334, 2012, Volume 33, Issue 1, pp. 2 - 9
Organic isothiocyanates (ITCs), which are characterized by the presence of an -N=C=S group, are among the most extensively studied cancer chemopreventive... 
ALLYL ISOTHIOCYANATE | TRANSPORTER-MEDIATED EXPORT | HUMAN HEPATOMA-CELLS | ONCOLOGY | N-ACETYLCYSTEINE CONJUGATE | PROSTATE-CANCER CELLS | ANTICARCINOGEN PHENETHYL ISOTHIOCYANATE | APOPTOTIC SIGNALING PATHWAYS | HISTONE DEACETYLASE INHIBITORS | BENZYL ISOTHIOCYANATE | CRUCIFEROUS VEGETABLES | Humans | Isothiocyanates - administration & dosage | Intracellular Signaling Peptides and Proteins - metabolism | Anticarcinogenic Agents - metabolism | Transcription Factor AP-1 - metabolism | Isothiocyanates - metabolism | Toll-Like Receptor 4 - physiology | Tubulin - metabolism | Animals | Diet | NF-E2-Related Factor 2 - metabolism | Kelch-Like ECH-Associated Protein 1 | Isothiocyanates - pharmacology | Index Medicus | Review
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