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science & technology (58) 58
kinases (52) 52
life sciences & biomedicine (48) 48
animals (32) 32
phosphotransferases - metabolism (32) 32
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1. Full Text IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family
by Wang, Huanchen and Derose, Eugene F and London, Robert E and Shears, Stephen B
Nature communications, ISSN 2041-1723, 06/2014, Volume 5, Issue 1, pp. 4178 - 4178
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Multigene Family | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Crystallography, X-Ray | Protozoan Proteins - genetics | Phosphotransferases (Phosphate Group Acceptor) - chemistry | Inositol Phosphates - chemistry | Entamoeba histolytica - chemistry | Protozoan Proteins - metabolism | Entamoeba histolytica - genetics | Adenosine Triphosphate - metabolism | Entamoeba histolytica - enzymology | Sensitivity and Specificity | Protozoan Proteins - chemistry | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Catalysis | Adenosine Triphosphate - chemistry | Inositol Phosphates - metabolism | Binding Sites | Evolution, Molecular | Index Medicus | specificity | kinases | evolution | structure | inositol pyrophosphates
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2. Full Text Protein kinase- and lipase inhibitors of inositide metabolism deplete IP7 indirectly in pancreatic β-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity
by Rajasekaran, Subu Surendran and Illies, Christopher and Shears, Stephen B and Wang, Huanchen and Ayala, Thais S and Martins, Joilson O and Daré, Elisabetta and Berggren, Per-Olof and Barker, Christopher J
Cellular signalling, ISSN 0898-6568, 01/2018, Volume 42, pp. 127 - 133
Inositol pyrophosphate | ATP/ADP | Pancreatic β-cell | Di-phosphoinositol pentakisphosphate | Pharmacological inhibitors | Inositol hexakisphosphate kinase | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus | PLC, phospholipase C | PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase | ADP | IP6K, inositol hexakisphosphate kinase | PI4K, phosphatidylinositol 4-kinase | IP7, 5-di-phosphoinositol pentakisphosphate | ATP | IR, insulin receptor | Medicin och hälsovetenskap
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3. Full Text The Key Role of IP6K: A Novel Target for Anticancer Treatments?
by Minini, Mirko and Senni, Alice and Unfer, Vittorio and Bizzarri, Mariano
Molecules (Basel, Switzerland), 10/2020, Volume 25, Issue 19, p. 4401
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Index Medicus | inositol pyrophosphates (PP-IPs) | diphosphoinositol pentakisphosphate (5-IP7 or IP7) | Review | inositol hexakisphosphate kinase (IP6K) | anticancer activity | myo-inositol
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4. Full Text Protein kinase- and lipase inhibitors of inositide metabolism deplete IP.sub.7 indirectly in pancreatic [beta]-cells: Off-target effects on cellular bioenergetics and direct effects on IP6K activity
by Rajasekaran, Subu Surendran and Illies, Christopher and Shears, Stephen B and Wang, Huanchen and Ayala, Thais S and Martins, Joilson O and DarAaAaAeA@, Elisabet and Berggren, Per-Olof and Barker, Christopher J
Cellular signalling, ISSN 0898-6568, 01/2018, Volume 42, p. 127
Phosphates | Telomeres | Inositol | Pancreatic beta cells | Analysis | Physiological aspects | Cellular signal transduction | Lipase | Protein kinases
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5. Full Text The emerging roles of inositol pyrophosphates in eukaryotic cell physiology
by Thota, Swarna Gowri and Bhandari, Rashna
Journal of biosciences, ISSN 0250-5991, 9/2015, Volume 40, Issue 3, pp. 593 - 605
Microbiology | Zoology | inositol hexakisphosphate (IP 6 ) kinase (IP6K) | diphosphoinositol pentakisphosphate (IP 7 ) | Biomedicine general | Cell Biology | Life Sciences | Bisdiphosphoinositol tetrakisphosphate (IP 8 ) | Life Sciences, general | cell signalling | PP-IP 5 kinase (PPIP5K) | pyrophosphorylation | Plant Sciences | kinase (IP6K) | Bisdiphosphoinositol tetrakisphosphate (IP | PP-IP | inositol hexakisphosphate (IP | kinase (PPIP5K) | diphosphoinositol pentakisphosphate (IP | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Inositol Phosphates - chemistry | Animals | DNA Repair - physiology | Eukaryotic Cells - metabolism | Signal Transduction - physiology | Biological Transport - physiology | Apoptosis - physiology | Energy Metabolism - physiology | Inositol Phosphates - metabolism | Inositol | Cellular signal transduction | Genetic engineering | Research | Pyrophosphates | Recombinant proteins | Signal transduction | Eukaryotes | Cellular biology | Molecular biology | Index Medicus
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6. Full Text Inositol pyrophosphates: Between signalling and metabolism
by Wilson, Miranda S. C and Livermore, Thomas M and Saiardi, Adolfo
Biochemical journal, ISSN 0264-6021, 06/2013, Volume 452, Issue 3, pp. 369 - 379
kinase (IP6K) | Bisdiphosphoinositol tetrakisphosphate (IP | Inositol hexakisphosphate (IP | PP-IP | 5-diphosphoinositol pentakisphosphate (IP | Inositol phosphate | Metabolism | kinase (PPIP5K) | Polymer inorganic polyphosphate (polyP) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Diphosphates - metabolism | Humans | Inositol Phosphates - physiology | Signal Transduction - genetics | Phosphotransferases (Phosphate Group Acceptor) - chemistry | Phosphotransferases (Phosphate Group Acceptor) - deficiency | Diphosphates - chemistry | Inositol Phosphates - chemistry | Animals | Phosphotransferases (Phosphate Group Acceptor) - physiology | Signal Transduction - physiology | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Energy Metabolism - genetics | Energy Metabolism - physiology | Inositol Phosphates - metabolism | Index Medicus
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7. Full Text The inositol hexakisphosphate kinases IP6K1 and-2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export
by Wilson, Miranda S and Jessen, Henning J and Saiardi, Adolfo
The Journal of biological chemistry, ISSN 0021-9258, 07/2019, Volume 294, Issue 30, pp. 11597 - 11608
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phosphates - metabolism | Biological Transport | Receptors, G-Protein-Coupled - metabolism | Receptors, Virus - metabolism | Adenosine Triphosphate - metabolism | HCT116 Cells | Humans | Phosphotransferases (Phosphate Group Acceptor) - genetics | Homeostasis | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Gene Knockdown Techniques | Index Medicus | phosphate homeostasis | IP7 | mammal | cell signaling | inositol pyrophosphate | inositol hexakisphosphate kinase (IP6K) | SPX domain | ATP | Cell Biology | inositol phosphate | metabolic regulation
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8. Full Text TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
by Ghoshal, Sarbani and Zhu, Qingzhang and Asteian, Alice and Lin, Hua and Xu, Haifei and Ernst, Glen and Barrow, James C and Xu, Baoji and Cameron, Michael D and Kamenecka, Theodore M and Chakraborty, Anutosh
Molecular metabolism (Germany), ISSN 2212-8778, 2016, Volume 5, Issue 10, pp. 903 - 917
Endocrinology & Metabolism | Inositol pyrophosphate | Energy expenditure | Obesity | Akt | Diabetes | IP6K | Life Sciences & Biomedicine | Science & Technology
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