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Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 1, pp. 87 - 92
Journal Article
The Oncologist, ISSN 1083-7159, 06/2016, Volume 21, Issue 6, pp. 762 - 770
摘要 引言 . 敏感且特异性地检测到 ALK 基因组重排为能够从ALK抑制剂治疗获益的非小细胞肺癌 (NSCLC) 患者所必需。 ALK 分离荧光原位杂交 (FISH) 是获得美国食品和药物管理局批准的标准诊断方法, 但使用其他方法在 ALK 重排FISH阴性的NSCLC病例中发现了 ALK 重排,... 
ALK | Crizotinib | Genomic profiling | Fusion | Fluorescence in situ hybridization | HIP1-ALK | NSCLC | ONCOLOGY | ADENOCARCINOMAS | RESISTANCE | FUSION VARIANT | CHEMOTHERAPY | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Pyrazoles - therapeutic use | Carcinoma, Non-Small-Cell Lung - genetics | Genomics | Humans | Male | Gene Expression Profiling | Receptor Protein-Tyrosine Kinases - genetics | Protein Kinase Inhibitors - therapeutic use | Gene Rearrangement | Adult | Female | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | In Situ Hybridization, Fluorescence - methods | Pyridines - therapeutic use | Index Medicus | Lung Cancer
Journal Article
ANNUAL REVIEW OF BIOCHEMISTRY, ISSN 0066-4154, 2008, Volume 77, pp. 383 - 414
Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organisms.... 
NUCLEOTIDE LIPOPHILIC PRODRUGS | proteomics | ACTIVITY-BASED PROTEOMICS | BREAST-CANCER METASTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE INHIBITORS | PENICILLIN-BINDING COMPONENTS | COMPLEX PROTEOMES | ACTIVITY-BASED PROBES | affinity label | ACID AMIDE HYDROLASE | IN-VIVO | mass spectrometry | FUNCTIONAL PROTEOMICS
Journal Article
Blood, ISSN 0006-4971, 10/2013, Volume 122, Issue 14, pp. 2460 - 2466
To explore mechanisms contributing to the clinical heterogeneity of systemic mastocytosis (SM) and to suboptimal responses to diverse therapies, we analyzed 39... 
MYELOFIBROSIS | ACTIVATION | TET2 MUTATIONS | D816V | MAST-CELLS | KIT | KITD816V | KINASE INHIBITOR | JAK2 | HEMATOLOGY | CHRONIC MYELOMONOCYTIC LEUKEMIA | DNA Mutational Analysis | Humans | Middle Aged | Aged, 80 and over | Adult | Female | Male | Proto-Oncogene Proteins c-kit - genetics | Aged | Gene Expression Profiling | Mastocytosis, Systemic - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 09/2017, Volume 125, Issue 9, pp. 097013 - 097013
Journal Article
International Journal of Oncology, ISSN 1019-6439, 04/2014, Volume 44, Issue 4, pp. 1041 - 1055
Journal Article
Cancer Letters, ISSN 0304-3835, 2012, Volume 325, Issue 2, pp. 165 - 174
Abstract We performed next generation sequencing- and microarray-based gene expression profiling of CD44+ /CD24− /CD45− breast CSCs (cancer stem cells)... 
Hematology, Oncology and Palliative Medicine | Breast cancer | PI3K | Cancer stem cells | Next generation sequencing | CD44 | TGFbeta | TRANSCRIPTOME | MARKER | EMT | EPITHELIAL-MESENCHYMAL TRANSITION | THERAPY | ONCOLOGY | ALDH1 | GENE-EXPRESSION | Nucleic Acid Amplification Techniques - methods | Estrogens | Humans | Neoplasm Proteins - physiology | Gene Expression Regulation, Neoplastic | Transcriptome | Neoplastic Stem Cells - chemistry | Breast Neoplasms - enzymology | Immunomagnetic Separation | Sensitivity and Specificity | Estrogen Receptor alpha - analysis | Neoplastic Stem Cells - pathology | Carcinoma, Ductal, Breast - pathology | Female | Neoplasms, Hormone-Dependent - enzymology | Neoplasm Proteins - genetics | Isoenzymes - physiology | RNA, Messenger - genetics | Gene Expression Profiling - methods | Immunophenotyping | Hyaluronan Receptors - analysis | Carcinoma, Ductal, Breast - enzymology | Breast Neoplasms - pathology | CD24 Antigen - analysis | Neoplasms, Hormone-Dependent - pathology | Phosphatidylinositol 3-Kinases - physiology | RNA, Neoplasm - genetics | Neoplastic Stem Cells - enzymology | Flow cytometry | Medical prognosis | Stem cells | Kinases | Gene expression | Apoptosis | Cell adhesion & migration | Index Medicus | DNA microarrays | Platelet-derived growth factor | Epidermal growth factor receptors | 1-Phosphatidylinositol 3-kinase | Tumors
Journal Article
Lancet, The, ISSN 0140-6736, 2016, Volume 387, Issue 10026, pp. 1415 - 1426
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, pp. e115383 - e115383
Background: Cholangiocarcinoma (CCA) is clinically heterogeneous; intra and extrahepatic CCA have diverse clinical presentations. Next generation sequencing... 
MORTALITY | INTRAHEPATIC CHOLANGIOCARCINOMA | MULTIDISCIPLINARY SCIENCES | ERBB2 | GALLBLADDER CANCER | FREQUENT MUTATION | IDENTIFICATION | EXPRESSION | TRENDS | BAP1 | EPIDEMIOLOGY | Multivariate Analysis | Demography | Prognosis | Humans | Middle Aged | Male | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Young Adult | DNA Mutational Analysis | Receptors, Fibroblast Growth Factor - genetics | Aged, 80 and over | Adult | Female | Genes, Neoplasm - genetics | Bile Ducts, Intrahepatic - pathology | Cholangiocarcinoma - therapy | Treatment Outcome | Signal Transduction - genetics | Mutation - genetics | Genome, Human - genetics | Disease-Free Survival | Regression Analysis | Cholangiocarcinoma - pathology | Oncogene Proteins, Fusion - genetics | Cholangiocarcinoma - genetics | Aged | Genetic aspects | Tumor proteins | Health aspects | Cancer | TOR protein | Chromatin | Dehydrogenases | Profiling | Identification methods | Exons | p53 Protein | Genes | Lung cancer | Clinical trials | Medical records | Raf protein | Cancer therapies | DNA repair | Smad4 protein | Subgroups | Cdc4 protein | K-Ras protein | Metastases | Gene sequencing | Liver cancer | Gallbladder | Cholangiocarcinoma | Deoxyribonucleic acid--DNA | Medical research | Epidermal growth factor receptors | Review boards | Introns | MEK inhibitors | MAP kinase | Patients | ErbB-2 protein | Mcl-1 protein | Gene amplification | Chemotherapy | Medical prognosis | Mutation | Aberration | Fibroblast growth factor receptors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article