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The Journal of Cell Biology, ISSN 0021-9525, 9/2001, Volume 154, Issue 5, pp. 925 - 936
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase-promoting complex/cyclosome... 
Gels | Mitosis | Interphase | Kinetochores | Ubiquitins | Cell cycle | HeLa cells | Antibodies | Chromosomes | Anaphase | MAD2 | Kinetochore | Anaphase promoting complex | Mitotic checkpoint | hBUBR1 | mitotic checkpoint | ANAPHASE-PROMOTING COMPLEX | BUDDING YEAST | UBIQUITIN LIGASE | PROTEIN-KINASE | CYCLIN-B | SPINDLE ASSEMBLY CHECKPOINT | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | kinetochore | anaphase promoting complex | CENP-E | UNATTACHED KINETOCHORES | Protein Kinases - metabolism | Anaphase-Promoting Complex-Cyclosome | Cell Fractionation | Ligases - isolation & purification | Humans | Protein-Serine-Threonine Kinases | Immunoblotting | Recombinant Fusion Proteins - metabolism | Ubiquitin-Protein Ligase Complexes | Poly-ADP-Ribose Binding Proteins | Genes, cdc - physiology | Mad2 Proteins | Cdc20 Proteins | Carrier Proteins | Calcium-Binding Proteins - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ligases - metabolism | Genes, Reporter - genetics | Macromolecular Substances | Nuclear Proteins | Ubiquitin-Protein Ligases | Proteins - metabolism | Ligases - antagonists & inhibitors | Mitosis - physiology | Saccharomyces cerevisiae Proteins | Recombinant Fusion Proteins - genetics | HeLa Cells | Fungal Proteins - metabolism | Physiological aspects | Chromosomal proteins | Research | kinetochore; hBUBR1; anaphase promoting complex; MAD2; mitotic checkpoint
Journal Article
Oncogene, ISSN 0950-9232, 05/2008, Volume 27, Issue 24, pp. 3457 - 3464
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2000, Volume 148, Issue 5, pp. 871 - 882
We show that MAD3 encodes a novel 58-kD nuclear protein which is not essential for viability, but is an integral component of the spindle checkpoint in budding... 
Yeasts | Kinetochores | Cell cycle | Antibodies | Amino acids | Anaphase | Genetic mutation | Saccharomycetales | Cells | Mitotic spindle apparatus | CDC20 | MAD3 | MAD2 | Checkpoint | BUB3 | checkpoint | SISTER-CHROMATID COHESION | CYCLIN PROTEOLYSIS | BUDDING YEAST | ESCHERICHIA-COLI | ANAPHASE INITIATION | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | ASSEMBLY CHECKPOINT | CYCLOSOME/ANAPHASE-PROMOTING COMPLEX | MITOTIC CHECKPOINT | UNATTACHED KINETOCHORES | Protein Kinases - genetics | Protein-Serine-Threonine Kinases | Molecular Sequence Data | Cell Cycle Proteins - immunology | Fungal Proteins - immunology | Spindle Apparatus - genetics | Cloning, Molecular | Cell Cycle Proteins - genetics | Mad2 Proteins | Cdc20 Proteins | Saccharomycetales - cytology | Carrier Proteins | Calcium-Binding Proteins - metabolism | Mutagenesis, Site-Directed | Cell Cycle Proteins - metabolism | Protein Structure, Tertiary - genetics | Fungal Proteins - genetics | Saccharomycetales - enzymology | Precipitin Tests | Nuclear Proteins | Sequence Homology, Amino Acid | Saccharomycetales - genetics | Two-Hybrid System Techniques | Proteins - metabolism | Saccharomyces cerevisiae Proteins | Genes, cdc | Fungal Proteins - metabolism | Spindle (Cell division) | Mitosis | Research | MAD3 gene | Bub3 protein | Mad2 protein | Cdc20 protein | Mad3 protein | Original
Journal Article
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 8/2002, Volume 158, Issue 3, pp. 487 - 496
The spindle checkpoint delays anaphase onset until all chromosomes have attached properly to the mitotic spindle. Checkpoint signal is generated at... 
Phosphorylation | Phosphatases | Interphase | Kinetochores | Metaphase | Antibodies | Ova | Chromosomes | Eggs | Mitotic spindle apparatus | Xenopus | Spindle checkpoint | Mad1 | Bub1 | BubR1 | ANAPHASE-PROMOTING COMPLEX | BUDDING YEAST | KINASE | CELL BIOLOGY | CDC20 | ASSEMBLY CHECKPOINT | GENE | COMPONENT | MUTATIONS | MITOTIC CHECKPOINT | spindle checkpoint | UNATTACHED KINETOCHORES | Protein Binding - genetics | Protein Kinases - genetics | Molecular Weight | Xenopus Proteins - genetics | Protein-Serine-Threonine Kinases | Eukaryotic Cells - metabolism | Phosphoproteins - metabolism | Oocytes | Spindle Apparatus - metabolism | Cell Cycle Proteins - genetics | Protein Kinases - isolation & purification | Female | Genes, cdc - physiology | Mad2 Proteins | Cdc20 Proteins | Spindle Apparatus - ultrastructure | Repressor Proteins - metabolism | Carrier Proteins | Xenopus Proteins - isolation & purification | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Xenopus laevis | Cell Cycle Proteins - metabolism | Cells, Cultured | Repressor Proteins - genetics | Fungal Proteins - genetics | Phosphoproteins - genetics | Sequence Homology, Nucleic Acid | Chromosomal Proteins, Non-Histone - genetics | Nuclear Proteins | Sequence Homology, Amino Acid | Kinetochores - ultrastructure | Animals | Saccharomyces cerevisiae Proteins | Eukaryotic Cells - cytology | Calcium-Binding Proteins - genetics | Fungal Proteins - metabolism | Cell research | Carrier proteins | Analysis | Microtubules | Physiological aspects | Genetic aspects | Protein kinases | spindle checkpoint; Xenopus; BubR1; Mad1; Bub1
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 04/2009, Volume 8, Issue 7, pp. 627 - 635
It has been universally believed that spindle assembly checkpoint (SAC) proteins which include the kinetochore proteins are involved in monitoring the faithful... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | hBub1 | hMad2 | shRNA | Spindle assembly checkpoint | Aneuploidy | PUMA | Apoptosis | Genomic instability | p53 | PROTEIN MAD2 | spindle assembly checkpoint | KINASE | apoptosis | KINETOCHORE LOCALIZATION | ASSEMBLY CHECKPOINT | GENE | ONCOLOGY | CHROMOSOME MISSEGREGATION | aneuploidy | CENP-E | cancer | HUMAN CANCERS | genomic instability | CYCLOSOME/ANAPHASE-PROMOTING COMPLEX | BUB1 | Protein-Serine-Threonine Kinases - deficiency | RNA, Small Interfering - genetics | Up-Regulation | Humans | bcl-2-Associated X Protein - biosynthesis | Cell Growth Processes - physiology | Proto-Oncogene Proteins - biosynthesis | Tumor Suppressor Protein p53 - genetics | Spindle Apparatus - metabolism | Spindle Apparatus - genetics | Apoptosis Regulatory Proteins - genetics | Cell Cycle Proteins - genetics | Mad2 Proteins | Protein-Serine-Threonine Kinases - metabolism | bcl-2-Associated X Protein - genetics | Apoptosis Regulatory Proteins - biosynthesis | Calcium-Binding Proteins - biosynthesis | HCT116 Cells | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Cell Cycle Proteins - biosynthesis | Tumor Suppressor Protein p53 - deficiency | Repressor Proteins - biosynthesis | Apoptosis - physiology | Calcium-Binding Proteins - genetics
Journal Article