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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 14, pp. 1727 - 1731
We demonstrate an innovative approach for optimization of kinase inhibitor potency and selectivity utilising kinase mini-panels and kinome-wide panels. We... 
Kinome selectivity | 4-anilinoquinoline | 4-Anilinoquinazoline | Mini-kinome panel | Cyclin G associated kinase (GAK) | MULTIPLE ROLES | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | IDENTIFICATION | Case studies | Drugstores | Quinoline | Medical colleges | Pharmacy
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 08/2013, Volume 41, Issue 4, pp. 969 - 974
Journal Article
BIOLOGICAL PSYCHIATRY, ISSN 0006-3223, 05/2019, Volume 85, Issue 10, pp. S59 - S60
Conference Proceeding
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 11/2017, Volume 118, Issue 11, pp. 3595 - 3606
The kinase enzymes within a cell, known collectively as the kinome, play crucial roles in many signaling pathways, including survival, motility,... 
HOMOGENEOUS ASSAY | QUANTITATIVE PROTEOMICS | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TYROSINE KINASES | KINASE ACTIVITY ASSAYS | HUMAN KINOME | CELL BIOLOGY | BREAST-CANCER | SIGNAL-TRANSDUCTION | KINOME | FLUORESCENCE POLARIZATION ASSAY | CAPILLARY-ELECTROPHORESIS | LIVING CELLS
Journal Article
Bioinformatics, ISSN 1367-4803, 12/2018, Volume 34, Issue 24, pp. 4223 - 4231
Abstract Motivation Kinase-regulated phosphorylation is a ubiquitous type of post-translational modification (PTM) in both eukaryotic and prokaryotic cells.... 
CELL-DIVISION | KINOME | PROMOTERS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DNA-DAMAGE RESPONSE | SEQUENCE | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | CLASS-I | GLYCOSYLATION | PROTEINS | FEATURES
Journal Article
Drug Discovery Today, ISSN 1359-6446, 01/2016, Volume 21, Issue 1, pp. 5 - 10
Journal Article
by Rusk, N
NATURE METHODS, ISSN 1548-7091, 11/2015, Volume 12, Issue 11, pp. 1013 - 1013
Journal Article
Cancers, ISSN 2072-6694, 08/2019, Volume 11, Issue 8, p. 1117
Oral squamous cell carcinoma (OSCC) is one of the major leading causes of cancer-related death worldwide, with limited effective markers for diagnosis and... 
siRNA screening | oral squamous cell carcinoma | biomarker | prognosis | kinome | PLK1
Journal Article
Analytical Chemistry, ISSN 0003-2700, 04/2014, Volume 86, Issue 7, pp. 3594 - 3601
Isobaric mass tag-based quantitative proteomics strategies such as iTRAQ and TMT utilize reporter ions in the low mass range of tandem MS spectra for relative... 
CHEMISTRY, ANALYTICAL | KINOME | QUANTITATION | PROTEIN QUANTIFICATION | MECHANISMS | INHIBITORS | ABSOLUTE QUANTIFICATION | IDENTIFICATION | MASS-SPECTROMETRY | PROTEOMICS | ACCURACY | Neutrons | Ions | Tandem Mass Spectrometry - methods | Proteins | Usage | Analysis | Proteomics | Peptides | Mass spectrometry | Index Medicus | Coalescing | Mass spectrometers | Strategy | Spectra | Coalescence | Tags
Journal Article
Molekuliarnaia biologiia, ISSN 0026-8984, 07/2017, Volume 51, Issue 4, pp. 696 - 703
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 10/2017, Volume 15, Issue 40, pp. 8655 - 8660
A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5-or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction... 
KINOME | ANGIOGENESIS | COMPLEXES | SUNITINIB | CHEMISTRY, ORGANIC | SELECTIVITY | CANCER | RECEPTOR TYROSINE KINASE
Journal Article
Applied Physics Letters, ISSN 0003-6951, 07/2013, Volume 103, Issue 1, pp. 13701 - 13701
A label-free kinase detection system was fabricated by the adsorption of gold nanoparticles functionalized with kinase inhibitor onto AlGaN/GaN high electron... 
PHYSICS, APPLIED | KINOME | INHIBITORS | SRC | Biophysics and Bio-Inspired Systems
Journal Article
Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7296, pp. 305 - 310
Journal Article