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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14622 - 14627
Dominantly inherited mutations in leucine-rich repeat kinase 2 (LRRK2) are a common genetic cause of Parkinson's disease (PD). The importance of the R1441... 
Chromaffin cells | Locomotion | Receptors | Neurons | Parkinson disease | Antibodies | Catecholamines | Agonists | Mice | Genetic mutation | Quinpirole | Knockin | Amphetamine | Dopamine D2 receptor | Parkinson's disease | DISEASE-ASSOCIATED MUTATIONS | KINASE-ACTIVITY | knockin | MULTIDISCIPLINARY SCIENCES | ADRENAL CHROMAFFIN CELLS | amphetamine | DEFICIENT MICE | GTP-BINDING | AGONISTS | quinpirole | NEURONAL DEGENERATION | dopamine D2 receptor | GENE | RECEPTORS | PARKINSONS-DISEASE | Immunohistochemistry | Chromaffin Cells - cytology | Motor Activity - physiology | Synaptic Transmission - physiology | Catecholamines - metabolism | Synaptic Transmission - genetics | Neurons - cytology | Glial Fibrillary Acidic Protein - metabolism | Brain - metabolism | Mice, Mutant Strains | Neurons - physiology | Neurons - metabolism | Action Potentials - drug effects | Dopamine - metabolism | Protein-Serine-Threonine Kinases - metabolism | Brain - cytology | Mice, Inbred C57BL | Receptors, Dopamine D2 - agonists | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mice, Inbred Strains | Blotting, Western | Receptors, Dopamine D2 - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Blotting, Northern | Chromaffin Cells - metabolism | Animals | Receptors, Dopamine D2 - physiology | Quinpirole - pharmacology | Mutation | alpha-Synuclein - metabolism | Amino Acid Substitution | Physiological aspects | Neural transmission | Genetic aspects | Gene mutations | Phosphotransferases | Proteins | Neurotransmitters | Rodents | Parkinsons disease | Kinases | Gene expression | Cells | Index Medicus | Biological Sciences
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1874, pp. 71 - 86
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 10/2018, Volume 215, Issue 10, pp. 2686 - 2695
We developed a method for rapid generation of B cell receptor (BCR) monoclonal mice expressing prerearranged Igh and Igk chains monoallelically from the Igh... 
MEDICINE, RESEARCH & EXPERIMENTAL | NEUTRALIZING ANTIBODIES | GENE | IG KNOCKIN MICE | IMMUNOGLOBULIN-MU | LIGHT-CHAIN | MOUSE | ANTIBODY REPERTOIRE | GERMINAL-CENTERS | IMMUNOLOGY | TRANSGENIC MICE | LYMPHOCYTES | Index Medicus
Journal Article
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 02/2017, Volume 525, Issue 2, pp. 302 - 318
Type 1 cannabinoid (CB 1 ) receptors are widely distributed in the brain. Their physiological roles depend on their distribution pattern, which differs... 
knockin rodents | electron microscopy | endocannabinoid system | synapses | hippocampus | RRID:AB_2571530 | LOCALIZATION | FOOD-INTAKE | NEUROSCIENCES | TRANSMISSION | MOSSY CELLS | ZOOLOGY | ULTRASTRUCTURE | NEURONS | RAT-BRAIN | EXPRESSION | MODULATION | GABA | Physiological aspects | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2006, Volume 103, Issue 24, pp. 9333 - 9338
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 3782 - 3787
Journal Article
PLOS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1
GABA(A) receptors consisting of rho 1, rho 2, or rho 3 subunits in homo-or hetero-pentamers have been studied mainly in retina but are detected in many brain... 
PERIODIC WITHDRAWAL | CONDITIONED TASTE-AVERSION | MUTANT MICE | BEHAVIORAL-RESPONSES | MULTIDISCIPLINARY SCIENCES | NULL MUTANT | KNOCKIN MICE | MOUSE RETINA | ION CHANNELS | ALCOHOL-INTOXICATION | ALPHA-1 SUBUNIT
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2016, Volume 477, Issue 3, pp. 473 - 476
Mammalian zygote-mediated genome-engineering by CRISPR/Cas is currently used for the generation of genome-modified animals. Here we report that a derived... 
Genome engineering | Knockout mice | Knockin mice | CRISPR/Cas | ENDONUCLEASE | BIOPHYSICS | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFICIENT GENERATION | CAS9 | ONE-STEP GENERATION | NUCLEASES | Animals | Mice, Inbred C57BL | Clustered Regularly Interspaced Short Palindromic Repeats | Zygote - metabolism | Female | Mice | Genome | Streptococcus - metabolism | Usage | Genomics | Index Medicus
Journal Article
Cell Reports, ISSN 2211-1247, 06/2019, Volume 27, Issue 13, pp. 3780 - 3789.e4
Genetically engineered mouse models harboring large sequence insertions or modifications are critical for a wide range of applications including endogenous... 
mouse models | CRISPR | genome editing | knockin | HDR editing | AAV | CRISPR-EZ | electroporation | RECOMBINANT ADENOASSOCIATED VIRUS | VIVO | TRANSDUCTION | GENE-THERAPY | RATE-LIMITING STEP | VECTORS | GENOME | ONE-STEP GENERATION | MOUSE ZYGOTES | DELIVERY | CELL BIOLOGY
Journal Article