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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 3841 - 3846
The S100A8/S100A9 heterodime/calprotectin (CP) functions in the host response to pathogens through a mechanism termed "nutritional immunity." CP binds Mn²⁺ and... 
Proteins | Pathogens | Antimicrobials | Superoxides | Neutrophils | Bacteria | Infections | Titration | Immunity | Crystal structure | Bacterial pathogenesis | Isothermal titration calorimetry | Protein crystal structure | Staphylococcus aureus | Antibiotic resistance | CRYSTAL-STRUCTURE | PROTEINS 8 | MULTIDISCIPLINARY SCIENCES | protein crystal structure | ESCHERICHIA-COLI | PSORIASIN S100A7 | ZINC | isothermal titration calorimetry | STRUCTURE VALIDATION | antibiotic resistance | CALCIUM | STAPHYLOCOCCUS-AUREUS | bacterial pathogenesis | SUPEROXIDE-DISMUTASE | BINDING | Zinc - metabolism | Humans | Protein Multimerization | Crystallography, X-Ray | Calgranulin A - genetics | Leukocyte L1 Antigen Complex - immunology | Host-Pathogen Interactions - immunology | Calgranulin A - chemistry | Calgranulin B - immunology | Calgranulin B - genetics | Leukocyte L1 Antigen Complex - pharmacology | Calgranulin A - immunology | Binding Sites | Calgranulin B - chemistry | Mutagenesis, Site-Directed | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Immunity, Innate | Manganese - metabolism | Recombinant Proteins - immunology | Leukocyte L1 Antigen Complex - chemistry | Leukocyte L1 Antigen Complex - genetics | Staphylococcus aureus - immunology | Histidine - chemistry | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Amino Acid Substitution | Molecular dynamics | Host-parasite relationships | Immune response | Research | Health aspects | Biological Sciences
Journal Article
PLoS Pathogens, ISSN 1553-7366, 10/2009, Volume 5, Issue 10, pp. e1000639 - e1000639
Neutrophils are the first line of defense at the site of an infection. They encounter and kill microbes intracellularly upon phagocytosis or extracellularly by... 
CALCIUM-BINDING PROTEINS | MICROBIOLOGY | ARACHIDONIC-ACID | RELEASE | MRP14 | S100 PROTEINS | DAMAGE | IN-VITRO | CELL-DEATH PROGRAM | VIROLOGY | CRYPTOCOCCUS-NEOFORMANS | ANTIMICROBIAL ACTIVITY | PARASITOLOGY | Immunohistochemistry | Histones - chemistry | Humans | Leukocyte L1 Antigen Complex - metabolism | Antifungal Agents - chemistry | Leukocyte L1 Antigen Complex - immunology | Lung Diseases, Fungal - microbiology | Cellular Structures - chemistry | Antifungal Agents - metabolism | Abdominal Abscess - immunology | Lung Diseases, Fungal - immunology | Neutrophil Activation | Cells, Cultured | Neutrophils - immunology | Candida albicans - immunology | Immunity, Innate | Mice, Knockout | Abdominal Abscess - microbiology | Host-Pathogen Interactions | Animals | Analysis of Variance | Cellular Structures - ultrastructure | Leukocyte L1 Antigen Complex - chemistry | Cellular Structures - immunology | Mice | Histones - metabolism | Candida albicans | Prevention | Candidiasis | Neutrophils | Physiological aspects | Research | Calcium-binding proteins | Health aspects | Basic Medicine | Clinical Medicine | Medical and Health Sciences | Microbiology in the medical area | Medicin och hälsovetenskap | MEDICIN | Medicinska och farmaceutiska grundvetenskaper | Infektionsmedicin | Infectious Medicine | Mikrobiologi inom det medicinska området | Klinisk medicin | MEDICINE | Fungi | Proteins | Infections | Mortality
Journal Article
Journal Article
Science, ISSN 0036-8075, 2/2008, Volume 319, Issue 5865, pp. 962 - 965
Bacterial infection often results in the formation of tissue abscesses, which represent the primary site of interaction between invading bacteria and the... 
Microbial growth | Kidneys | Antimicrobials | Liver | Abscesses | Neutrophils | Chelation | Reports | Mice | Infections | Staphylococcus | CALPROTECTIN | STAPHYLOCOCCUS-AUREUS | EXPRESSION | MULTIDISCIPLINARY SCIENCES | EF-HAND PROTEINS | ANTIMICROBIAL ACTIVITY | Abscess - microbiology | Abscess - metabolism | Calcium - metabolism | Zinc - metabolism | Leukocyte L1 Antigen Complex - metabolism | Gene Expression Profiling | Liver Abscess - metabolism | Liver Abscess - microbiology | Mass Spectrometry | Leukocyte L1 Antigen Complex - pharmacology | Staphylococcal Infections - microbiology | Dimerization | Neutrophils - metabolism | Kidney Diseases - metabolism | Staphylococcal Infections - metabolism | Staphylococcus aureus - genetics | Kidney Diseases - microbiology | Liver Abscess - pathology | Staphylococcal Infections - immunology | Chelating Agents - pharmacology | Kidney Diseases - immunology | Animals | Manganese - metabolism | Leukocyte L1 Antigen Complex - genetics | Abscess - immunology | Chelating Agents - metabolism | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacterial growth | Control | Care and treatment | Immune response | Bacterial infections | Abscess | Research | Chelation therapy | Methods | Bacteria | Staphylococcus infections | Biomedical research | Immunology | Metals | Rodents
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 143, Issue 5, pp. 1207 - 1217.e2
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 03/2012, Volume 11, Issue 3, pp. 227 - 239
Journal Article
Gut, ISSN 0017-5749, 12/2012, Volume 61, Issue 12, pp. 1693 - 1700
Journal Article