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The New England Journal of Medicine, ISSN 0028-4793, 08/2009, Volume 361, Issue 8, pp. 745 - 755
Men receiving androgen-deprivation therapy for nonmetastatic prostate cancer are at high risk for bone loss and fractures. This placebo-controlled study... 
ZOLEDRONIC ACID | MEDICINE, GENERAL & INTERNAL | PLACEBO | BONE-MINERAL DENSITY | FRACTURES | RISK | COMPLICATIONS | RANDOMIZED CONTROLLED-TRIAL | POSTMENOPAUSAL WOMEN | OSTEOPOROSIS | ALENDRONATE | Lumbar Vertebrae - injuries | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Fractures, Bone - epidemiology | Antibodies, Monoclonal - therapeutic use | Male | Osteoporosis - drug therapy | Prostatic Neoplasms - physiopathology | Bone Remodeling - drug effects | Incidence | Antibodies, Monoclonal, Humanized | Spinal Fractures - prevention & control | RANK Ligand - pharmacology | Injections, Subcutaneous | Aged, 80 and over | RANK Ligand - therapeutic use | Gonadotropin-Releasing Hormone - agonists | Lumbar Vertebrae - physiology | Prostatic Neoplasms - drug therapy | RANK Ligand - adverse effects | Osteoporosis - chemically induced | Bone Density Conservation Agents - adverse effects | Double-Blind Method | Prostatic Neoplasms - surgery | Antibodies, Monoclonal - pharmacology | Spinal Fractures - epidemiology | Bone Density Conservation Agents - therapeutic use | Lumbar Vertebrae - drug effects | Denosumab | Bone Density Conservation Agents - pharmacology | Orchiectomy | Bone Density - drug effects | Androgen Antagonists - therapeutic use | Aged | Androgen Antagonists - adverse effects | Fractures, Bone - prevention & control | Osteoporosis | Bone density | Prostate cancer | Older people | Men | Index Medicus | Abridged Index Medicus
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 02/2011, Volume 103, Issue 3, pp. 232 - 240
Nitrogen-containing bisphosphonates have been associated with the development of osteonecrosis of the jaws (ONJ), but the lack of reliable epidemiological data... 
MULTIPLE-MYELOMA | ZOLEDRONIC ACID | IN-VITRO | RISK-FACTORS | ONCOLOGY | BEAGLE DOGS | NITROGEN-CONTAINING BISPHOSPHONATES | BISPHOSPHONATE-RELATED OSTEONECROSIS | BONE | PREVALENCE | AUTOSOMAL-DOMINANT OSTEOPETROSIS | Jaw Diseases - diagnosis | Osteonecrosis - epidemiology | Humans | Jaw Diseases - prevention & control | Osteomyelitis - chemically induced | Antibodies, Monoclonal - adverse effects | Tomography, X-Ray Computed | Positron-Emission Tomography | Antineoplastic Agents - administration & dosage | Osteonecrosis - metabolism | Jaw Diseases - metabolism | Jaw Diseases - chemically induced | Mouth Mucosa - drug effects | RANK Ligand - immunology | Antibodies, Monoclonal, Humanized | Antineoplastic Agents - adverse effects | Etidronic Acid - adverse effects | Pyrroles - adverse effects | Vitamin D - administration & dosage | Risedronate Sodium | Diphosphonates - adverse effects | Etidronic Acid - analogs & derivatives | RANK Ligand - adverse effects | Osteonecrosis - diagnosis | Radiography, Panoramic | Osteonecrosis - etiology | Bone Density Conservation Agents - adverse effects | Macrophages - pathology | Imidazoles - adverse effects | Jaw Diseases - etiology | Risk Factors | Diphosphonates - administration & dosage | Denosumab | Jaw Diseases - epidemiology | Mevalonic Acid - metabolism | Monocytes - drug effects | Magnetic Resonance Imaging | Alendronate - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Indoles - adverse effects | Signal Transduction - drug effects | Macrophages - drug effects | Osteonecrosis - chemically induced | Osteonecrosis - prevention & control | Diphosphonates - pharmacology | Osteoclasts - drug effects | Complications and side effects | Diphosphonates | Physiological aspects | Bones | Research | Macrophages | Risk factors | Necrosis
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2017, Volume 56, Issue 47, pp. 15088 - 15092
An enantioselective C−H amidation of phosphine oxides by using an iridium(III) catalyst bearing an atropchiral cyclopentadienyl (Cpx) ligand is reported. A... 
iridium | P-chirality | asymmetric catalysis | C−H activation | chiral Cp ligand | Oxides | Catalysis | Enantiomers | Organic acids | Transformation | Catalysts | Phosphine | Phosphorus | Ligands | Carboxylic acids | Iridium | Leucine
Journal Article
Advanced Healthcare Materials, ISSN 2192-2640, 10/2017, Volume 6, Issue 20, p. n/a
The pharmacological manipulation of liver X receptors (LXRs) has been an attractive therapeutic strategy for atherosclerosis treatment as they control reverse... 
atherosclerosis | targeted drug delivery | nanoparticles | liver X receptor (LXR) | GW3965 | PEGYLATED LIPOSOMAL DOXORUBICIN | MATERIALS SCIENCE, BIOMATERIALS | CHOLESTEROL | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | RESOLUTION | CARDIOTOXICITY | NANOSCIENCE & NANOTECHNOLOGY | CELLULAR UPTAKE | INFLAMMATION | GENE-EXPRESSION | POLYMER HYBRID NANOPARTICLES | Liver - pathology | Benzoates - therapeutic use | Nanoparticles - chemistry | Benzoates - chemistry | Cholesterol - blood | Polyethylene Glycols - chemistry | Collagen Type IV - chemistry | Drug Carriers - chemistry | Liver - drug effects | Liver X Receptors - agonists | Nanoparticles - metabolism | Receptors, LDL - deficiency | Nanomedicine | Disease Models, Animal | Collagen Type IV - metabolism | Receptors, LDL - genetics | Atherosclerosis - pathology | Atherosclerosis - drug therapy | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Macrophages - cytology | Atherosclerosis - metabolism | Mice, Knockout | Benzylamines - chemistry | Macrophages - metabolism | Animals | Lipid Metabolism - drug effects | Triglycerides - blood | Benzoates - pharmacology | Macrophages - drug effects | Mice | Benzylamines - pharmacology | Benzylamines - therapeutic use | Drugs | Complications and side effects | Drug delivery systems | Liver | Atherosclerosis | Physiological aspects | Polyols | Vehicles | Encapsulation | Polyethylenes | Lipids | Inflammatory response | Biosynthesis | Macrophages | Nanoparticles | Receptors | Polyethylene glycol | Rodents | liver X receptors | Lipoprotein (low density) receptors | Collagen (type IV) | Lipid metabolism | Lesions | Polyethylene | Hyperlipidemia | Pharmacology | Inflammation | Metabolism | Cholesterol | Arteriosclerosis
Journal Article
Journal of Periodontology, ISSN 0022-3492, 08/2013, Volume 84, Issue 8, pp. 1145 - 1157
Background: Simvastatin is a cholesterol‐lowering drug whose pleiotropic effects may have a therapeutic impact on bone. This study evaluates the effect of... 
hydroxymethylglutaryl‐CoA reductase inhibitors | inflammation | Alveolar bone loss | periodontitis | Inflammation | Hydroxymethylglutaryl-CoA reductase inhibitors | Periodontitis | OVARIECTOMIZED RATS | STATINS | IN-VITRO | METABOLISM | DENTISTRY, ORAL SURGERY & MEDICINE | NITRIC-OXIDE | hydroxymethylglutaryl-CoA reductase inhibitors | MEVALONATE PATHWAY | KAPPA-B LIGAND | PROTEIN PRENYLATION | Interleukin-1beta - drug effects | Simvastatin - therapeutic use | Bone Morphogenetic Protein 2 - drug effects | Rats, Wistar | Matrix Metalloproteinase 8 - drug effects | Alveolar Bone Loss - prevention & control | Receptor Activator of Nuclear Factor-kappa B - drug effects | RANK Ligand - drug effects | Malondialdehyde - analysis | Alanine Transaminase - drug effects | Gingiva - drug effects | Glutathione - drug effects | Anti-Inflammatory Agents - therapeutic use | Female | Osteoprotegerin - drug effects | Interleukin-10 - analysis | Nitrates - analysis | Peroxidase - drug effects | Matrix Metalloproteinase 1 - drug effects | Nitric Oxide Synthase Type II - drug effects | Rats | Aspartate Aminotransferases - drug effects | Alkaline Phosphatase - drug effects | Periodontitis - prevention & control | Antioxidants - therapeutic use | Animals | Tumor Necrosis Factor-alpha - drug effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Nitrites - analysis | Oxidative Stress - drug effects
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 535 - 546
Castration-recurrent prostate cancer (CRPC) is suspected to depend on androgen receptor (AR). The AF-1 region in the amino-terminal domain (NTD) of AR contains... 
CELLCYCLE | CROSS-TALK | SIGNAL-TRANSDUCTION PATHWAYS | STEROID-BINDING | ONCOLOGY | INDEPENDENT TRANSCRIPTIONAL ACTIVATION | NUCLEAR RECEPTORS | CREB-BINDING-PROTEIN | FACTORS INDUCE | BISPHENOL-A | PROLIFERATION | EXPRESSION | CELL BIOLOGY | Protein Binding - genetics | Apoptosis - drug effects | Humans | Protein Conformation - drug effects | Transcriptional Activation - drug effects | Male | Neoplasm Recurrence, Local - pathology | Antineoplastic Agents, Hormonal - adverse effects | CREB-Binding Protein - metabolism | Prostate - pathology | Protein Binding - drug effects | Serine Endopeptidases - genetics | Prostate - drug effects | Prostate-Specific Antigen - metabolism | Benzhydryl Compounds - therapeutic use | Prostatic Neoplasms - drug therapy | Chlorohydrins - therapeutic use | Prostate-Specific Antigen - genetics | Prostate - anatomy & histology | DNA - metabolism | Prostate-Specific Antigen - blood | Androgens - pharmacology | Cell Line, Tumor | Ligands | Mice, Inbred NOD | Mice | Protein Multimerization - drug effects | Androgen Receptor Antagonists | Gene Expression - drug effects | Receptors, Androgen - metabolism | Neoplasm Recurrence, Local - drug therapy | Benzhydryl Compounds - adverse effects | Castration | Antineoplastic Agents, Hormonal - therapeutic use | Molecular Structure | Response Elements - genetics | Chlorohydrins - pharmacology | Chlorohydrins - adverse effects | Prostatic Neoplasms - pathology | Antineoplastic Agents, Hormonal - pharmacology | Prostatic Neoplasms - surgery | Protein Interaction Domains and Motifs - drug effects | Receptors, Steroid - drug effects | Mice, SCID | DNA - genetics | Xenograft Model Antitumor Assays | Animals | Benzhydryl Compounds - pharmacology | Cell Proliferation - drug effects | Chemical oceanography | Prostate cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2016, Volume 537, Issue 7619, pp. 185 - 190
Journal Article
Circulation, ISSN 0009-7322, 04/2010, Volume 121, Issue 16, pp. 1818 - 1827
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 12/2016, Volume 40, Issue 3-4, pp. 716 - 726
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 02/2011, Volume 17, Issue 6, pp. 1872 - 1883
A series of methoxy‐amino‐bis(phenol)s (ONOO R 1,R 2)H2 possessing on the phenol rings R1 ortho substituents with variable steric and electronic properties... 
electronic effects | ring‐opening polymerization | lactide | stereoselectivity | yttrium | ring-opening polymerization | CYCLIC ESTERS | STEREOCONTROL | CRYSTAL-STRUCTURE | RAC-LACTIDE | CHEMISTRY, MULTIDISCIPLINARY | METALLOCENE POLYOLEFIN CATALYSTS | LIGANDS | F-C CONTACTS | YTTRIUM COMPLEXES | INITIATORS | GROUP-3 METAL-COMPLEXES | Chemical Sciences | Catalysis
Journal Article