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Chemical Science, ISSN 2041-6520, 2019, Volume 10, Issue 7, pp. 1976 - 1985
A series of fluorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate... 
CELL | CHEMISTRY, MULTIDISCIPLINARY | LIPOPHILICITY
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 19, pp. 5560 - 5564
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 03/2010, Volume 1, Issue 6, pp. 420 - 434
Journal Article
Tetrahedron, ISSN 0040-4020, 06/2013, Volume 69, Issue 24, pp. 4845 - 4856
A series of 39 boron-dipyrrolylmethenes (BODIPYs) have been synthesized and characterized. Their spectroscopic properties, degree of lipophilicity, chemical... 
Photodegradation | Fluorescence | BODIPY | Singlet oxygen | Lipophilicity | IC50 | Lipophilicity IC | BORON | PHOTODYNAMIC THERAPY | COMPLEXES | CHEMISTRY, ORGANIC | HIGHLY EFFICIENT | NEAR-INFRARED NIR | CHEMISTRY | SPECTRA | Aromatic amines | Hydrogen | Analysis | Corrosion resistance | Spectroscopy | Dyes | Synthesis | Tetrahedrons
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 02/2020, Volume 179, p. 112981
[Display omitted] •log Do/w of partially ionized acids can be estimated through MEEKC measurements.•log Do/w estimation can be achieved up to α = 0.995.•log... 
MEEKC | Octanol-water distribution coefficient | EKC | Ionizable compounds | Lipophilicity | CHEMISTRY, ANALYTICAL | PARTITION-COEFFICIENTS | PHARMACOLOGY & PHARMACY | LIPOPHILICITY DETERMINATION | TOOL
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2016, Volume 55, Issue 2, pp. 674 - 678
Property tuning by fluorination is very effective for a number of purposes, and currently increasingly investigated for aliphatic compounds. An important... 
lipophilicity | fluorinated carbohydrates | NMR spectroscopy | fluoroalcohols | fluorine | PARTITION-COEFFICIENTS | POLARITY | DRUG DISCOVERY | EFFICIENCY | CHEMISTRY, MULTIDISCIPLINARY | Communications | Communication
Journal Article
ChemistryOpen, ISSN 2191-1363, 09/2019, Volume 8, Issue 9, pp. 1153 - 1153
Invited for this month's cover picture is the group of Professor Siegfried Waldvogel. The cover picture displays the robustness achieved by the installation of... 
Fluorination | Lipophilicity | Alcohols
Journal Article
Arabian Journal of Chemistry, ISSN 1878-5352, 04/2015, Volume 12, Issue 5, pp. 664 - 670
Gemifloxacin, a novel, 4th generation fluoroquinolone derivative, was labeled with Tc; its freeze dried kits were prepared and used for infection imaging. Kits... 
Klebsiella pneumoniae | Lipophilicity | Scintigraphy
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 03/2009, Volume 98, Issue 3, pp. 861 - 893
We first review the state‐of‐the‐art in development of log P prediction approaches falling in two major categories: substructure‐based and property‐based... 
methods based on 3D‐structure representation | substructure‐based approaches | empirical approaches | consensus model | molecular dynamics calculations | lattice energy calculations | property‐based approaches | log P calculation | continuum solvation models | atom‐based methods | lipophilicity | fragmental methods | quantum chemical semi‐empirical calculations | topological descriptors | electrotopological‐state (E‐state) descriptors | molecular lipophilicity potential | graph molecular connectivity | Log P calculation | Atom-based methods | Electrotopological-state (E-state) descriptors | Lattice energy calculations | Continuum solvation models | Empirical approaches | Methods based on 3D-structure representation | Topological descriptors | Quantum chemical semi-empirical calculations | Fragmental methods | Molecular lipophilicity potential | Molecular dynamics calculations | Substructure-based approaches | Property-based approaches | Graph molecular connectivity | Consensus model | Lipophilicity | SURFACE-AREA | OCTANOL-WATER PARTITION | HYDROPHOBIC FRAGMENTAL CONSTANT | log P calculation | quantum chemical semi-empirical calculations | property-based approaches | electrotopological-state (E-state) descriptors | ORGANIC-COMPOUNDS | COEFFICIENTS | NEURAL-NETWORK | PHARMACOLOGY & PHARMACY | methods based on 3D-structure representation | substructure-based approaches | CHEMISTRY, MEDICINAL | atom-based methods | SOLVATION ENERGY RELATIONSHIPS | CHEMISTRY, MULTIDISCIPLINARY | PREDICTION | ATOMIC PHYSICOCHEMICAL PARAMETERS | AQUEOUS SOLUBILITY | Models, Molecular | Lipids - chemistry | Molecular Structure | Humans | Mathematical Computing | Drug Design
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2017, Volume 8, Issue 10, pp. 1019 - 1024
Bedaquiline (1) is a new drug for tuberculosis and the first of the diarylquinoline class. It demonstrates excellent efficacy against TB but induces... 
lipophilicity | ATP synthase | diarylquinoline | hERG | Bedaquiline | tuberculosis | DRUG | CHEMISTRY, MEDICINAL | TMC207
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 03/2018, Volume 24, Issue 15, p. n/a
The association of trifluoromethyl group to chalcogens gives new fluorinated substituents with specific properties, mainly in terms of lipophilicity. The... 
trifluoromethylselenyl | selenenium | selenocyanate | Ruppert–Prakash reagent | fluorine | Fluorination | Lipophilicity
Journal Article
YAKUGAKU ZASSHI, ISSN 0031-6903, 2019, Volume 139, Issue 3, pp. 341 - 347
Preventive medicine and anti-aging medicine have received much attention recently due to an increase in the proportion of elderly people in the population, and... 
emulsion | lipophilicity | absorption | transporter | functional food component
Journal Article
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 09/2019, Volume 55, Issue 71, pp. 10539 - 10542
The syntheses of substituted all-cis-1,2,3-trifluorocyclopropanes are described for the first time. The three fluorines located on each of the cyclopropyl... 
HEXAFLUOROCYCLOHEXANE | INHIBITION | DIPOLE-MOMENT | MECHANISM | RING | OZONOLYSIS | GENERATION | 1,2,3,4,5,6-HEXAFLUOROCYCLOHEXANE | CHEMISTRY, MULTIDISCIPLINARY | PHENYLCYCLOPROPYLAMINES | LIPOPHILICITY
Journal Article
The Journal of Physical Chemistry B, ISSN 1520-6106, 02/2008, Volume 112, Issue 6, pp. 1604 - 1610
Ionic liquids (ILs) have recently garnered increased attention because of their potential environmental benefits as “green” replacements over conventional... 
TEMPERATURE | ORGANIC-SOLVENTS | THERMODYNAMIC ANALYSIS | BEHAVIOR | METHYLSULFATE | CHEMISTRY, PHYSICAL | PHASE-EQUILIBRIA | COSMO-RS | IMIDAZOLIUM | PREDICTION | LIPOPHILICITY
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 01/2017, Volume 23, Issue 6, pp. np - n/a
Fluorine Chemistry The introduction of fluorine groups to pharmaceutical compounds can have a dramatic effect on the lipophilicity and metabolic stability of... 
methyl fluorosulfonyldifluoroacetate | trifluoromethylation | fluorine | Organic chemistry | Stability | Fluorine | Lipophilicity | Reagents | Pharmaceuticals
Journal Article