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1990, Current topics in membranes and transport, ISBN 9780121533359, Volume 35., xviii, 628
Book
Gut, ISSN 0017-5749, 04/2009, Volume 58, Issue 4, pp. 520 - 529
Background:The antitumoral immune response is one determinant of colorectal cancer (CRC) outcome. Recent work suggests that Foxp3+CD25+CD4+ regulatory T cells... 
PLASMACYTOID DENDRITIC CELLS | REGULATORY-CELLS | SURVIVAL | FOXP3 EXPRESSION | GROWTH-FACTOR-BETA | TGF-BETA | IN-VIVO | DIFFERENTIATION | INTERLEUKIN-6 | GASTROENTEROLOGY & HEPATOLOGY | OVARIAN-CARCINOMA | T-Lymphocyte Subsets - immunology | Adenocarcinoma - pathology | Cell Proliferation | Humans | Middle Aged | Male | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Immune Tolerance - immunology | Aged, 80 and over | Adult | Female | Cytokines - immunology | Neoplasm Invasiveness | Adenocarcinoma - immunology | Immunophenotyping | Colorectal Neoplasms - immunology | Forkhead Transcription Factors - analysis | Lymphocyte Count | Neoplasm Proteins - analysis | Aged | Colorectal Neoplasms - pathology | Neoplasm Staging | Cytokines - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Care and treatment | Immune response | Lymphocytes | Colorectal cancer | Physiological aspects | Development and progression | Research | Proteins | Antigens | Cytokines | Medical prognosis | Software | Experiments | Tumors | Cell adhesion & migration | Adenocarcinoma | Life Sciences | Lymphocytes, Tumor-Infiltrating | Immunology | Neoplasm Proteins | Immunotherapy | T-Lymphocytes, Regulatory | Colorectal Neoplasms | CD4-Positive T-Lymphocytes | T-Lymphocyte Subsets | Lymphocyte Activation | Immune Tolerance | Forkhead Transcription Factors
Journal Article
Science, ISSN 0036-8075, 3/2009, Volume 323, Issue 5920, pp. 1488 - 1492
Most of the immunoglobulin A (IgA) in the gut is generated by B cells in the germinal centers of Peyer's patches through a process that requires the presence... 
T lymphocytes | Spleen | Molecules | Peyers patches | Cytokines | B lymphocytes | Plasma cells | AIDS | Reports | Mice | Small intestine | GERMINAL CENTER FORMATION | CXC CHEMOKINE RECEPTOR-5 | POPULATION | ACTIVATION | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | RETINOIC-ACID | DIFFERENTIATION | INTERLEUKIN-21 | LAMINA PROPRIA | EXPRESSION | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Spleen - immunology | T-Lymphocyte Subsets - cytology | Dendritic Cells - immunology | Germinal Center - immunology | Gene Expression Profiling | Adoptive Transfer | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | CD40 Antigens - metabolism | Forkhead Transcription Factors - metabolism | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | T-Lymphocytes, Regulatory - cytology | Cell Differentiation | Intestine, Small - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Lymphocyte Activation | CD4-Positive T-Lymphocytes - cytology | Down-Regulation | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Spleen - cytology | Lymph Nodes - immunology | Forkhead Transcription Factors - genetics | Lymph Nodes - cytology | Peyer's Patches - cytology | Animals | B-Lymphocytes - immunology | Intestine, Small - cytology | T-Lymphocyte Subsets - metabolism | Dendritic Cells - cytology | Immunoglobulin A, Secretory - biosynthesis | Peyer's Patches - immunology | Lymphatic system | Immunology | Cellular biology | Gene expression | Rodents
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 4/2014, Volume 63, Issue 4, pp. 395 - 406
The programmed death-1 (PD-1) molecule is mainly expressed on functionally “exhausted” CD8+ T cells, dampening the host antitumor immune response. We evaluated... 
Immunology | Medicine & Public Health | Oncology | Cancer Research | Breast cancer | Immune evasion | Regulatory T cells | Cancer immunotherapy | PD-1 | APOPTOSIS | PROGNOSIS | TUMOR | RISK | ANTIBODY | IMMUNOLOGY | CHEMOTHERAPY | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | IMMUNOTHERAPY | CD8(+) T-LYMPHOCYTES | B7-H1 | Carcinoma, Lobular - pathology | Follow-Up Studies | Breast Neoplasms - immunology | Humans | Middle Aged | Programmed Cell Death 1 Receptor - analysis | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Antigens, Differentiation, T-Lymphocyte - analysis | Aged, 80 and over | Carcinoma, Ductal, Breast - pathology | Lymphocytes, Tumor-Infiltrating - chemistry | T-Lymphocytes, Regulatory - chemistry | Carcinoma, Lobular - immunology | CD8-Positive T-Lymphocytes - chemistry | Combined Modality Therapy | Carcinoma, Lobular - radiotherapy | T-Lymphocyte Subsets - pathology | Carcinoma, Ductal, Breast - radiotherapy | Forkhead Transcription Factors - analysis | Survival Analysis | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | T-Lymphocyte Subsets - immunology | Breast Neoplasms - surgery | CD8-Positive T-Lymphocytes - pathology | Prognosis | Carcinoma, Ductal, Breast - immunology | Carcinoma, Ductal, Breast - mortality | Carcinoma, Lobular - mortality | T-Lymphocytes, Cytotoxic - pathology | T-Lymphocyte Subsets - chemistry | Mastectomy | Adult | Female | Radiotherapy, Adjuvant | T-Lymphocytes, Cytotoxic - immunology | Carcinoma, Ductal, Breast - surgery | Carcinoma, Lobular - surgery | Kaplan-Meier Estimate | Disease-Free Survival | Breast Neoplasms - radiotherapy | T-Lymphocytes, Cytotoxic - chemistry | Apoptosis - immunology | Lymphocytes, Tumor-Infiltrating - pathology | Breast Neoplasms - pathology | Lymphocyte Count | Breast Neoplasms - mortality | Aged
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e31318
Background: Ursolic acid (UA), a pentacyclic triterpenoid carboxylic acid, is the major component of many plants including apples, basil, cranberries,... 
SIGNAL-TRANSDUCTION | RESPONSES | ACTIVATION | CYCLOSPORINE-A | CELL-RECEPTOR STIMULATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FACTOR-ALPHA GENE | INHALED CORTICOSTEROIDS | T-CELLS | OLEANOLIC ACID | CD8-Positive T-Lymphocytes - cytology | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Mitogens - pharmacology | Concanavalin A - pharmacology | NF-kappa B - metabolism | CD4-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - immunology | Transcription Factor AP-1 - metabolism | Lymphocyte Activation - genetics | Macrophages - secretion | B-Lymphocytes - secretion | Oxidation-Reduction - drug effects | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Anti-Inflammatory Agents - pharmacology | Antibodies, Monoclonal - pharmacology | CD4-Positive T-Lymphocytes - cytology | NFATC Transcription Factors - metabolism | Cytokines - secretion | CD28 Antigens - immunology | Antioxidants - pharmacology | Macrophages - cytology | CD8-Positive T-Lymphocytes - enzymology | Graft vs Host Disease - pathology | Up-Regulation - drug effects | B-Lymphocytes - drug effects | Animals | CD4-Positive T-Lymphocytes - secretion | CD8-Positive T-Lymphocytes - secretion | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | CD3 Complex - immunology | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | CD4-Positive T-Lymphocytes - drug effects | Mitogen-Activated Protein Kinases - metabolism | Graft-versus-host reaction | Transcription factors | Oregano | Cancer therapies | Cranberries | Anticancer properties | Proteins | Antioxidants | Cell activation | Cell growth | Inhibition | Enzymes | NF-κB protein | Cytokines | Albinism | Immunoregulation | Activator protein 1 | Peppermint | Prunes | JNK protein | T cell receptors | Carboxylic acids | Serum levels | Apples | γ-Interferon | Rosemary | Ursolic acid | Cell proliferation | Health sciences | Phosphorylation | Ordination | Homeostasis | Lymphocytes T | Transplantation | Biology | Activation | NF-AT protein | Kinases | Macrophages | Inflammatory diseases | Interleukin 6 | Lymphocytes | Transcription activation | Cell cycle | Tumor necrosis factor-TNF | Statistical analysis | Antiinflammatory agents | Secretion | Extracellular signal-regulated kinase | Inflammation | Pharmacology | Acids | Lymphocytes B | Interferon | Alzheimers disease | Apoptosis
Journal Article
British Journal of Haematology, ISSN 0007-1048, 01/2013, Volume 160, Issue 2, pp. 123 - 132
Summary Gamma delta (γδ) Τ cells are non‐conventional T lymphocyte effectors that can interact with and eradicate tumour cells. Several data demonstrate that... 
gamma delta T lymphocytes | cancer | immunotherapy | monoclonal antibodies | haematological oncology | Haematological oncology | Monoclonal antibodies | Immunotherapy | Gamma delta T lymphocytes | Cancer | T-Lymphocyte Subsets - immunology | Adjuvants, Immunologic - pharmacology | Dendritic Cells - immunology | Humans | Receptors, Antigen, T-Cell, alpha-beta - analysis | Cells, Cultured - transplantation | Receptors, Antigen, T-Cell, gamma-delta - genetics | Gene Rearrangement, delta-Chain T-Cell Antigen Receptor | Mesenchymal Stromal Cells - immunology | T-Lymphocytes, Regulatory - immunology | Neoplasms - therapy | T-Lymphocytes, Cytotoxic - transplantation | T-Lymphocyte Subsets - chemistry | Diphosphonates - therapeutic use | Killer Cells, Natural - immunology | Cells, Cultured - immunology | Tumor Escape - immunology | Adaptive Immunity | T-Lymphocytes, Cytotoxic - immunology | Cells, Cultured - drug effects | Immunotherapy, Adoptive | Antigens, Neoplasm - immunology | Translational Medical Research | Clinical Trials as Topic | Immunity, Innate | T-Lymphocyte Subsets - transplantation | Immunologic Surveillance - immunology | Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor | T-Lymphocytes, Cytotoxic - chemistry | Receptors, Antigen, T-Cell, gamma-delta - analysis | Neoplasms - immunology | CD8-Positive T-Lymphocytes - immunology | Dendritic Cells - transplantation | Diphosphonates - pharmacology | Immunologic Surveillance | Tumor Escape | Killer Cells, Natural | Dendritic Cells | T-Lymphocytes, Cytotoxic | Neoplasms | CD8-Positive T-Lymphocytes | Life Sciences | Immunology | Mesenchymal Stromal Cells | Receptors, Antigen, T-Cell, alpha-beta | T-Lymphocytes, Regulatory | T-Lymphocyte Subsets | Antigens, Neoplasm | Adjuvants, Immunologic | Cells, Cultured | Diphosphonates | Receptors, Antigen, T-Cell, gamma-delta
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 20254
Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to... 
MESSENGER-RNAS | CANCER-PATIENTS | EXTRACELLULAR VESICLES | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | MICROVESICLES | DIAGNOSTIC BIOMARKERS | INDUCE APOPTOSIS | OVARIAN-CANCER | MODULATION | LYMPHOCYTES | Exosomes - metabolism | Neoplasms - metabolism | CD8-Positive T-Lymphocytes - cytology | T-Lymphocytes, Regulatory - metabolism | T-Lymphocyte Subsets - cytology | Humans | Culture Media, Conditioned - pharmacology | RNA, Messenger - metabolism | Antigens, CD - metabolism | Lectins, C-Type - metabolism | T-Lymphocyte Subsets - drug effects | T-Lymphocytes, Regulatory - cytology | CD8-Positive T-Lymphocytes - metabolism | Real-Time Polymerase Chain Reaction | Microscopy, Electron, Transmission | CD4-Positive T-Lymphocytes - cytology | Apyrase - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Antigens, Differentiation, T-Lymphocyte - metabolism | Down-Regulation - drug effects | Up-Regulation - drug effects | T-Lymphocytes, Regulatory - drug effects | T-Lymphocyte Subsets - metabolism | CD8-Positive T-Lymphocytes - drug effects | Adenosine - metabolism | Neoplasms - pathology | CD4-Positive T-Lymphocytes - drug effects | Microscopy, Fluorescence | Adenosine | Dendritic cells | CD8 antigen | Gene regulation | Data processing | T cell receptors | Lymphocytes T | Gene expression | Exosomes | Cell surface | CD4 antigen | Polymerase chain reaction | CD69 antigen | Cell activation | Lymphocytes | Down-regulation | Peripheral blood
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 07/2008, Volume 118, Issue 7, pp. 2427 - 2437
Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results... 
B-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | ACTIVATION | LYTIC FUNCTION | IMMUNOTHERAPY | ACTIN POLYMERIZATION | GENE-EXPRESSION | LENALIDOMIDE | MALIGNANCIES | CANCER | Protein-Tyrosine Kinases - metabolism | Humans | Actins - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Thalidomide - pharmacology | Lymphocyte Culture Test, Mixed | CD4-Positive T-Lymphocytes - immunology | Thalidomide - analogs & derivatives | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | CD8-Positive T-Lymphocytes - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - blood | Antineoplastic Agents - pharmacology | Microfilament Proteins - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - immunology | Interleukin-2 - metabolism | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism | Superantigens - immunology | Antigen Presentation - immunology | Mice, Inbred Strains | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | CD8-Positive T-Lymphocytes - drug effects | T-Lymphocytes - immunology | Antigen Presentation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Immunologic Factors - pharmacology | Polymerization | Chronic lymphocytic leukemia | T cells | Muscle proteins | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 4, pp. 1263 - 1271
The tumor microenvironment includes a complex network of immune T-cell subpopulations. In this study, we systematically analyzed the balance between cytotoxic... 
BREAST-CANCER | SURVIVAL | LUNG-CANCER | FOXP3 EXPRESSION | RECRUITMENT | ONCOLOGY | GASTRIC-CANCER | EOSINOPHILS | MACROPHAGES | CARCINOMA | LYMPHOCYTES | Th1 Cells - pathology | Th1 Cells - physiology | Prognosis | Th2 Cells - physiology | Tissue Array Analysis | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma - mortality | Gene Expression Profiling | Th2 Cells - immunology | Th1 Cells - immunology | Colorectal Neoplasms - diagnosis | Lymphocytes, Tumor-Infiltrating - physiology | T-Lymphocytes, Cytotoxic - pathology | Th1 Cells - metabolism | Th17 Cells - metabolism | Forkhead Transcription Factors - metabolism | Microarray Analysis | T-Lymphocytes, Helper-Inducer - immunology | Lymphocytes, Tumor-Infiltrating - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-4 - genetics | Th2 Cells - pathology | Th17 Cells - pathology | Colorectal Neoplasms - mortality | T-Lymphocytes, Cytotoxic - immunology | Th17 Cells - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Carcinoma - immunology | Interleukin-4 - metabolism | Carcinoma - diagnosis | Forkhead Transcription Factors - genetics | Th2 Cells - metabolism | T-Lymphocytes, Cytotoxic - physiology | T-Lymphocytes, Helper-Inducer - physiology | Colorectal Neoplasms - immunology | Lymphocytes, Tumor-Infiltrating - pathology | T-Lymphocytes, Cytotoxic - metabolism | Survival Analysis | Th17 Cells - immunology | Carcinoma - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology
Journal Article
2011, Methods in molecular biology, ISBN 1617379786, Volume 707., xi, 282
Book