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Neurobiology of Disease, ISSN 0969-9961, 11/2018, Volume 119, pp. 190 - 198
Metabotropic glutamate receptor 5 (mGluR ) is a drug target for central nervous system disorders such as fragile X syndrome that involve excessive... 
Amyloid-beta precursor protein | AFQ-056 | MPEP | mGluR5 | Fmr1 | MRZ-8456 | mGluR
Journal Article
Neuropharmacology, ISSN 0028-3908, 09/2019, Volume 155, pp. 121 - 130
The ability to either erase or update the memories of a previously learned spatial task is an essential process that is required to modify behaviour in a... 
mGluR-mediated priming of LTP | mGluR-LTD | Barnes maze | Reversal learning | MAP kinase signalling | Hippocampus | METAPLASTICITY | ACTIVATION | KINASE | LTP | PROTEIN-SYNTHESIS | NEUROSCIENCES | POTENTIATION | MEMORY | LONG-TERM DEPRESSION | PHARMACOLOGY & PHARMACY | SWITCH | Protein kinases
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2014, Volume 34, Issue 41, pp. 13614 - 13628
Journal Article
Neurochemistry International, ISSN 0197-0186, 10/2019, Volume 129, pp. 104515 - 104515
Lysophosphatidic acid (LPA) is a glycerophospholipid that can be detected in serum, saliva and cerebrospinal fluid. However, the effect of LPA on neuronal... 
ER stress | Homer1 | LPA | mGluRs | Index Medicus
Journal Article
NEURON, ISSN 0896-6273, 02/2010, Volume 65, Issue 4, pp. 445 - 459
Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGIuRs) at the periphery. of their postsynaptic density.... 
FREELY MOVING RATS | GROUP-I MGLUR | METABOTROPIC GLUTAMATE-RECEPTOR | IMMEDIATE-EARLY GENE | CEREBELLAR PURKINJE-CELLS | CYTOSKELETON-ASSOCIATED PROTEIN | FRAGILE-X-SYNDROME | MICROTUBULE-ASSOCIATED PROTEIN | MENTAL-RETARDATION PROTEIN | DHPG-INDUCED LTD | NEUROSCIENCES
Journal Article
Neurobiology of disease, 08/2019, pp. 104602 - 104602
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2009, Volume 34, Issue 9, pp. 2057 - 2071
Highly selective positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGluR5) have emerged as a potential approach to treat... 
Group I mGluR | LTP | Allosteric potentiator | LTD | MGluR5 | Synaptic plasticity | GROUP-I MGLUR | METABOTROPIC GLUTAMATE-RECEPTOR | PSYCHIATRY | PROTEIN-KINASE ACTIVATION | NEUROSCIENCES | X MENTAL-RETARDATION | group I mGluR | CA1 REGION | allosteric potentiator | LONG-TERM DEPRESSION | PREPULSE INHIBITION DEFICIT | PHARMACOLOGY & PHARMACY | synaptic plasticity | mGluR5 | SIGNAL-REGULATED KINASE | METHYL-D-ASPARTATE | Learning - drug effects | Allosteric Regulation | Receptors, N-Methyl-D-Aspartate - metabolism | Neuronal Plasticity - drug effects | Male | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Long-Term Synaptic Depression - drug effects | Space Perception - physiology | Neuronal Plasticity - physiology | Long-Term Potentiation - drug effects | Space Perception - drug effects | Excitatory Amino Acid Agents - pharmacology | src-Family Kinases - metabolism | Long-Term Potentiation - physiology | Receptor, Metabotropic Glutamate 5 | Phosphatidylinositols - metabolism | Long-Term Synaptic Depression - physiology | Maze Learning - physiology | Rats | Rats, Sprague-Dawley | Learning - physiology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Glutamic Acid - metabolism | Hippocampus - physiology | In Vitro Techniques | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2019, Volume 25, Issue 4, pp. 381 - 387
Depressive disorders represent protean psychiatric illnesses with heterogeneous clinical manifestations and a multitude of comorbidities leading to severe... 
Antipsychotics | Mglur | Ketamine | Antidepressants | Nmda | Postsynaptic density | Glutamate | Depressive disorders
Journal Article
Brain Structure and Function, ISSN 1863-2653, 1/2016, Volume 221, Issue 1, pp. 21 - 37
This study investigates the mechanism of action of spadin, a putative fast-acting peptidic antidepressant (AD) and a functional blocker of the K+ TREK-1... 
mGluR 2/3 receptors | Neurology | Medial prefrontal cortex | Neurosciences | 5-HT 4 receptors | Biomedicine | 5-HT neurons | 5-HT depolarization block | Cell Biology | Spadin | receptors | 5-HT | mGluR
Journal Article
Journal Article
Small Ruminant Research, ISSN 0921-4488, 03/2014, Volume 117, Issue 1, pp. 84 - 93
We have previously demonstrated a differential role for metabotropic glutamate receptors (mGluRs) using behavioral evidence, the role of mGluRs in spinal... 
Catecholamines | Cortisol | Colonic distension | mGluR antagonist | MGluR antagonist
Journal Article
Journal Article