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Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 560 - 572
The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a... 
RNA interference screen | GFP, green fluorescent protein | MTOR, mechanistic target of rapamycin | autophagy | autophagy response | RNAi, RNA interference | Cyto-ID | FBS, fetal bovine serum | LAMP1, lysosomal-associated membrane protein 1 | MAP3K6, mitogen-activated protein kinase kinase kinase 6 | shRNA, short-hairpin RNA | RAB5A, member RAS oncogene family | spectrophotometric assay | 3-MA, 3-methyladenine | SQSTM1, sequestosome 1 | MDC, monodansylcadaverine | NS, nonsilencing | WNK2, WNK lysine deficient protein kinase 2 | mRFP, monomeric red fluorescent protein | small molecule screen | autophagy flux | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta | Utophagy | Spectrophotometric assay | Autophagy flux | Small molecule screen | Autophagy response | member RAS oncogene family | RNA interference | LC3B | sequestosome 1 | mechanistic target of rapamycin | MDC | monodansylcadaverine | CELL BIOLOGY | GFP | MAP1LC3B | LAMP1 | shRNA | FBS | lysosomal-associated membrane protein 1 | MAP3K6 | LC3 | SIRNA SCREEN | CELLS | RNAi | WNK lysine deficient protein kinase 2 | MARKER | microtubule-associated protein 1 light chain 3 beta | mitogen-activated protein kinase kinase kinase 6 | nonsilencing | CHLOROQUINE | green fluorescent protein | MTOR | short-hairpin RNA | fetal bovine serum | WNK2 | DISEASE | 3-MA | monomeric red fluorescent protein | mRFP | RAB5A | SQSTM1 | 3-methyladenine | Fluorescent Dyes - chemistry | Neoplasm Transplantation | Spectrometry, Fluorescence - methods | Dactinomycin - chemistry | Lysosomes - chemistry | Cell Survival | Humans | Mice, Inbred C57BL | Leukemia - metabolism | MAP Kinase Kinase Kinases - metabolism | Gene Expression Regulation, Leukemic | Mice, SCID | Autophagy | Imatinib Mesylate - chemistry | Animals | RNA Interference | Chloroquine - chemistry | HEK293 Cells | K562 Cells | Endosomes - chemistry | Mice | HeLa Cells | Microscopy, Fluorescence | Protein-Serine-Threonine Kinases - metabolism | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 07/2015, Volume 11, Issue 7, pp. 1037 - 1051
Cadmium is one of the most toxic metal compounds found in the environment. It is well established that Cd induces hepatotoxicity in humans and multiple animal... 
autophagy | mitochondrial ROS | hepatotoxicity | cadmium | melatonin | SOD2 | SIRT3 | Cadmium | Melatonin | Mitochondrial ROS | Autophagy | Hepatotoxicity | PROTEIN | O-2(center dot-) | bafilomycin A | sequestosome 1 | ALT | GPT | H2O2 | ACTB | CELL BIOLOGY | 3-triazol-4-yl)pyridine | mROS | mitochondrial | LC3 | superoxide anion | CALORIE RESTRICTION | OXIDATIVE STRESS | hydrogen peroxide | TOXICITY | SIRT1 | p62 | DAMAGE | CELL-DEATH | actin | 3-TYP | SQSTM1 | superoxide dismutase 2 | 3-methyladenine | IMPROVES MITOCHONDRIAL-FUNCTION | Baf A1 | microtubule-associated protein 1 light chain 3 | mel | MANGANESE-SUPEROXIDE-DISMUTASE | glutamic-pyruvate transaminase (alanine aminotransferase) | 3-(1H-1 | sirtuin 1 | cadmium chloride | tf-LC3 | sirtuin 3 | ROS PRODUCTION | CdCl2 | 3-MA | mitochondrial reactive oxygen species | tandem fluorescent mRFP-GFP-LC3B | Reactive Oxygen Species - metabolism | Sirtuin 3 - metabolism | Cadmium - toxicity | Apoptosis - drug effects | Humans | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - ultrastructure | Autophagy - drug effects | Hep G2 Cells | Acetylation - drug effects | Animals | Models, Biological | Cytoprotection - drug effects | Superoxides - metabolism | Pyridines - pharmacology | Melatonin - pharmacology | Superoxide Dismutase - metabolism | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1208 - 1218.e2
Journal Article
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 769 - 784
CAV1 (caveolin 1, caveolae protein, 22kDa) is well known as a principal scaffolding protein of caveolae, a specialized plasma membrane structure. Relatively,... 
lipid rafts | CTxB, cholera toxin subunit B | transporting lysosomal 38kDa, V0 subunit d1 | EGF, epidermal growth factor | TSC, tuberous sclerosis complex | LAMP1, lysosomal-associated membrane protein 1 | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | PTRF, polymerase I and transcript release factor | PBS, phosphate-buffered saline | CAV1, caveolin 1 | TFRC, transferrin receptor | CHO, water-soluble cholesterol | MEF, mouse embryonic fibroblasts | CQ, choloroquine | caveolin 1 | MTOR, mechanistic target of rapamycin | autophagy | PI, propidium iodide | WT, wild type | breast cancer | tfLC3B, mRFP-GFP tandem fluorescent-tagged LC3B | CTSL, cathepsin L | + | ATP6V0D1, ATPase H | 1 | PLA, proximity ligation assay | KO, knockout | Baf, bafilomycin A | DRF, detergent-resistant fraction | MBCD, methyl-β-cyclodextrin | lysosome | DSF, detergent-soluble fraction | Breast cancer | Lipid rafts | Caveolin 1 | Autophagy | Lysosome | ACTIVATION | PROTEIN | CHOLESTEROL | STROMAL CAVEOLIN-1 | DOWN-REGULATION | RECEPTOR | DEATH | PLASMA-MEMBRANE | CAVEOLIN-1-NULL MICE | CELL BIOLOGY | Membrane Fusion | Cell Survival | Membrane Microdomains - metabolism | Down-Regulation | Humans | Phagosomes - metabolism | Stress, Physiological | Caveolin 1 - deficiency | Vacuolar Proton-Translocating ATPases - metabolism | Breast Neoplasms - metabolism | Caveolin 1 - metabolism | Animals | Lysosomes - metabolism | MCF-7 Cells | Breast Neoplasms - pathology | Models, Biological | Female | Mice | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2008, Volume 412, Issue 2, pp. 287 - 298
DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2... 
Fibroblast growth factor (FGF) | Transcription | Phosphatase | Mitogen-activated protein kinase phosphatase-3 (MKP-3) | Mitogen-activated protein kinase (MAPK) | Dual-specificity phosphatase 6 (DUSP6) | ACTIVATED PROTEIN-KINASE | transcription | MKP3 | MAP-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | mitogen-activated protein kinase phosphatase-3 (MKP-3) | FAMILY | EMBRYO | IN-VIVO | fibroblast growth factor (FGF) | phosphatase | dual-specificity phosphatase 6 (DUSP6) | EXPRESSION | DUAL-SPECIFICITY PHOSPHATASES | CATALYTIC ACTIVATION | VERTEBRATE LIMB | Dual Specificity Phosphatase 6 - genetics | Proto-Oncogene Proteins c-ets - genetics | Humans | Molecular Sequence Data | Phosphatidylinositol 3-Kinases - metabolism | Fibroblast Growth Factors - metabolism | Base Sequence | Mitogen-Activated Protein Kinase 1 - genetics | Proto-Oncogene Proteins c-ets - metabolism | Transgenes | Binding Sites | Cell Line | Promoter Regions, Genetic | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - genetics | Dual Specificity Phosphatase 6 - metabolism | Sequence Alignment | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - physiology | Mice | Enzyme Activation | Feedback, Physiological - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | MEK, MAPK | SRF, serum-response factor | SRY, sex-determining region Y | PI3K, phosphoinositide 3-kinase | FGFR, FGF receptor | MKP, MAPK phosphatase | βGal, β-galactosidase | Ets, E twenty-six | JNK, c-Jun N-terminal kinase | ERK kinase | DUSP, dual-specificity phosphatase | ChIP, chromatin immunoprecipitation | HH10, Hamburger and Hamilton stage 10 | ERK, extracellular-signal-regulated kinase | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | mRFP, monomeric red fluorescent protein | TNFα, tumour necrosis factor α | IκBα, inhibitor of nuclear factor κB α | EGFP, enhanced green fluorescent protein | NF-κB, nuclear factor κB | PBX1, pre-B-cell leukaemia transcription factor 1 | Elk1, Ets-like kinase 1 | FBS, fetal bovine serum | FKHD, Forkhead mutant | FGF, fibroblast growth factor | RSV, rous sarcoma virus | MKK, MAPK kinase | HA, haemagglutinin | EMSA, electrophoretic mobility-shift assay | ER, oestrogen receptor | AER, apical ectodermal ridge | ConA, concanavalin A | MKKK, MAPK kinase kinase | MAPK, mitogen-activated protein kinase
Journal Article
Molecules and cells, ISSN 1016-8478, 11/2017, Volume 40, Issue 11, pp. 828 - 836
Eukaryotic cells consist of a complex network of thousands of proteins present in different organelles where organelle-specific cellular processes occur.... 
GFP | fluorescent proteins | subcellular localization | ECFP | biolistic bombardment | cell organelle markers | co-localization | rice | mRFP | EYFP | YEAST 2-HYBRID SYSTEM | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBCELLULAR-LOCALIZATION | LINES | CELL BIOLOGY | INTERACTOME ANALYSIS | GENE-EXPRESSION | FLUORESCENT-PROTEIN | PLANTS | ARABIDOPSIS
Journal Article
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2012, Volume 53, Issue 4, pp. 475 - 486
Journal Article