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Biochemical Journal, ISSN 0264-6021, 08/2007, Volume 405, Issue 3, pp. 513 - 522
The mTOR (mammalian target of rapamycin) protein kinase is an important regulator of cell growth. Two complexes of mTOR have been identified: complex 1,... 
Mammalian target of rapamycin (mTOR) | Protein kinase | Protein observed with Rictor-1 (Protor) | mTOR complex-2 (mTORC2) | Proline-rich repeat protein-5 (PRR-5) | Rapamycin-insensitive companion of mTOR (Rictor) | Cancer | proline-rich repeat protein-5 (PRR-5) | protein observed with Rictor-1 (Protor) | ACTIVATION | AKT/PKB | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | mammalian target of rapamycin (mTOR) | rapamycin-insensitive companion of mTOR (Rictor) | protein kinase | RAPTOR | REGULATOR | PATHWAY | TOR | GROWTH | cancer | PDK1 | Protein Kinases - metabolism | Cell Line | Carrier Proteins - metabolism | Humans | Protein Isoforms | Gene Silencing | Protein Binding | TOR Serine-Threonine Kinases | Rapamycin-Insensitive Companion of mTOR Protein | Index Medicus | HEK-293 cells, human embryonic kidney cells | SPAK, Ste20 | PI3K, phosphoinositide 3-kinase | mTORC, mTOR complex | EST, expressed sequence tag | Protor, protein observed with Rictor | DTT, dithiothreitol | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | NCBI, National Center for Biotechnology Information | IGF-1, insulin-like growth factor-1 | S6K, S6 kinase | mTOR, mammalian target of rapamycin | TAP, tandem affinity purification | Rictor, rapamycin-insensitive companion of mTOR | Raptor, regulatory associated protein of mTOR | siRNA, small interfering RNA | I.M.A.G.E., Integrated Molecular Analysis of Genomes and their Expression | SPS1-related proline | alanine-rich kinase
Journal Article
Japanese Journal of Clinical Urology, ISSN 0385-2393, 04/2015, Volume 69, Issue 5, pp. 394 - 399
Journal Article
AMERICAN JOURNAL OF PSYCHIATRY, ISSN 0002-953X, 05/2019, Volume 176, Issue 5, pp. 410 - 411
Journal Article
Nature communications, ISSN 2041-1723, 11/2018, Volume 9, Issue 1, pp. 4874 - 17
The metabolic checkpoint kinase mechanistic/mammalian target of rapamycin (mTOR) regulates natural killer (NK) cell development and function, but the exact... 
IMMUNITY | NATURAL-KILLER-CELLS | ACTIVATION | IFN-GAMMA PRODUCTION | METABOLISM | KINASE MTOR | MULTIDISCIPLINARY SCIENCES | DISEASE | IL-15 | LYMPHOID-CELLS | T-BET | Humans | Rapamycin-Insensitive Companion of mTOR Protein - deficiency | STAT5 Transcription Factor - immunology | T-Box Domain Proteins - immunology | Interleukin-15 - immunology | STAT5 Transcription Factor - genetics | Large Neutral Amino Acid-Transporter 1 - immunology | Rapamycin-Insensitive Companion of mTOR Protein - genetics | Rapamycin-Insensitive Companion of mTOR Protein - immunology | Killer Cells, Natural - immunology | Cell Differentiation | Interleukin-2 Receptor beta Subunit - genetics | Signal Transduction | Lymphocyte Activation | Regulatory-Associated Protein of mTOR - immunology | Mice, Inbred C57BL | Gene Expression Regulation | Large Neutral Amino Acid-Transporter 1 - genetics | Mice, Transgenic | T-Box Domain Proteins - genetics | Killer Cells, Natural - cytology | Animals | Interleukin-15 - genetics | Regulatory-Associated Protein of mTOR - deficiency | Mice | Interleukin-2 Receptor beta Subunit - immunology | Regulatory-Associated Protein of mTOR - genetics | TOR protein | Maturation | Stat5 protein | Rapamycin | Metabolism | Kinases | Interleukin 15 | Anticancer properties | Signaling | Cell activation | Clonal deletion | Deletion | Kinetics | Natural killer cells | CD122 antigen | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2012, Volume 130, Issue 7, pp. 1695 - 1705
Lung cancer is one of the most commonly occurring malignancies. It has been reported that mammalian target of rapamycin (mTOR) is phosphorylated in lung cancer... 
lung cancer | signaling | PI3K | fisetin | mTOR | Akt | flavonoid | dual inhibition | ACTIVATED PROTEIN-KINASE | CYCLE ARREST | KAPPA-B | TUBEROUS-SCLEROSIS | ONCOLOGY | PROSTATE-CANCER | GROWTH | TUMOR-SUPPRESSOR | MTOR INHIBITORS | PI3K/AKT/MTOR PATHWAY | EXPRESSION | Protein Kinases - metabolism | Lung Neoplasms - drug therapy | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Lung Neoplasms - metabolism | Eukaryotic Initiation Factor-4E - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Regulatory-Associated Protein of mTOR | Flavonoids - pharmacology | Phosphorylation - drug effects | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Tumor Suppressor Proteins - metabolism | Lung Neoplasms - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | MTOR Associated Protein, LST8 Homolog | Carcinoma, Non-Small-Cell Lung - metabolism | Carrier Proteins - antagonists & inhibitors | PTEN Phosphohydrolase - metabolism | Eukaryotic Initiation Factor-4E - antagonists & inhibitors | Carrier Proteins - metabolism | Cell Line, Tumor | Stem Cells - drug effects | Cell Proliferation - drug effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Kinases | Phosphorylation | Lung cancer | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2015, Volume 35, Issue 41, pp. 14042 - 14056
Journal Article
Pharmacological Research, ISSN 1043-6618, 01/2015, Volume 91, pp. 57 - 68
Rapamycin, an inhibitor of mTOR activity, is a potent inducer of erythroid differentiation and fetal hemoglobin production in β-thalassemic patients.... 
mTOR | Sp1 | Erythroid induction | Raptor | Mithramycin | Fetal hemoglobin | KINASE | FETAL-HEMOGLOBIN | PHARMACOLOGY & PHARMACY | GLOBIN MESSENGER-RNA | DIFFERENTIATION | ACCUMULATION | J-J LOCUS | BETA-THALASSEMIA | PROMOTER SEQUENCES | PRECURSOR CELLS | DNA-BINDING DRUGS | TOR Serine-Threonine Kinases - metabolism | Humans | Multiprotein Complexes - genetics | Pyrrolidonecarboxylic Acid - analogs & derivatives | RNA, Messenger - metabolism | Pyrrolidonecarboxylic Acid - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Regulatory-Associated Protein of mTOR | Cell Differentiation | Rapamycin-Insensitive Companion of mTOR Protein | Promoter Regions, Genetic | Gene Expression | Oligopeptides - genetics | Oligopeptides - metabolism | Plicamycin - pharmacology | Carrier Proteins - genetics | Carrier Proteins - metabolism | Cell Cycle | Adaptor Proteins, Signal Transducing - genetics | K562 Cells | Adaptor Proteins, Signal Transducing - metabolism | Genetic aspects | Genetic transcription | Index Medicus | TBS, tris-buffered saline | Rictor, rapamycin-insensitive companion of mTOR | FBS, fetal bovine serum | ODN, oligonucleotide | Raptor, regulatory associated protein of mTOR | Sp1, specific protein 1 | RAPA, rapamycin | ChIP, chromatin immunoprecipitation | HbF, fetal hemoglobin | mTORC1, mTOR complex 1 | MTH, mithramycin | PBS, phosphate-buffered saline | m-TORC2, mTOR complex 2 | mTOR, mammalian target of rapamycin | EMSA, electrophoretic mobility shift assay
Journal Article
Journal of Arrhythmia, ISSN 1880-4276, 2011, Volume 27, Issue Supplement, p. OP04_2
Background: Hypertension is known to develop atrial hypertrophy and fibrosis leading to atrial fibrillation. In the ventricle, signaling through the mammalian... 
mTOR
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 02/2019, Volume 33, Issue 2, pp. 2514 - 2525
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2011, Volume 438, Issue 1, pp. 53 - 62
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted... 
Phosphoinositide 4-kinase (PI4K) | Pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PIK3CA | p110α E545k mutation | PIK3CA H1047R mutation | 3T3-L1 ADIPOCYTES | CATALYTIC SUBUNIT | BIOCHEMISTRY & MOLECULAR BIOLOGY | p110 alpha E545K mutation | phosphoinositide 4-kinase (PI4K) | pan-phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 | BREAST-CANCER | INSULIN | P110-BETA | phosphoinositide 3-kinase alpha (PI3K alpha) | PIK3CA GENE | IN-VIVO | MUTATIONS | INHIBITORS | IA PI3K ISOFORMS | Class Ia Phosphatidylinositol 3-Kinase - metabolism | Humans | Neoplasms, Experimental - prevention & control | Enzyme Inhibitors - therapeutic use | Class Ia Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Mice, Knockout | Neoplasms, Experimental - pathology | Tissue Distribution | Animals | Enzyme Inhibitors - pharmacokinetics | Signal Transduction - drug effects | Protein Isoforms | Mice | Neoplasms, Experimental - metabolism | Tumor Cells, Cultured | Homeodomain Proteins - physiology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | PI3K, phosphoinositide 3-kinase | BID, twice daily dosing | p110α E545K mutation | mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235; phosphoinositide 3-kinase α (PI3Kα) | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | pan-phosphoinositide 3kinase (PI3K) | PI4K, phosphoinositide 4-kinase | QD, once daily dosing | mTOR, mammalian target of rapamycin | TGI, tumour growth inhibition
Journal Article
Clinical Science, ISSN 0143-5221, 04/2012, Volume 122, Issue 7, pp. 349 - 359
DEPTOR [DEP-domain-containing and mTOR (mammalian target of rapamycin)-interacting protein] is a modulator of mTOR signalling that binds to mTORC (mTOR... 
Cortisol | DEP-domain-containing and mammalian target of rapamycin-interacting protein (DEPTOR) | Mammalian | RAPAMYCIN | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX | FETAL-GROWTH | mammalian target of rapamycin (mTOR) | PRETERM BIRTH | CANCER | BIRTH OUTCOMES | MTOR | cortisol | maternal stress | TOR | placenta | CORTISOL-LEVELS | Cell Line | Demography | TOR Serine-Threonine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins | Pregnancy - psychology | Protein Transport - drug effects | Down-Regulation - drug effects | Placenta - drug effects | Placenta - metabolism | Carrier Proteins - genetics | Stress, Psychological - genetics | Carrier Proteins - metabolism | TOR Serine-Threonine Kinases - genetics | Pregnancy - metabolism | Stress, Psychological - metabolism | Adaptor Proteins, Signal Transducing - genetics | Fluorescent Antibody Technique | Polymerase Chain Reaction | Female | Regulatory-Associated Protein of mTOR | Hydrocortisone - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Index Medicus | DEPTOR, DEP-domain-containing and mammalian target of rapamycin-interacting protein; FBS, fetal bovine serum | rictor, rapamycin-insensitive companion of mTOR | CS, Caesarean section | RQ, relative quantity S6K1, S6 kinase 1 | DAPI, 4′,6-diamidino-2-phenylindole | mTORC, mTOR complex | BMI, body mass index | raptor, regulatory associated protein of mTOR | IUGR, intrauterine growth restriction | GβL, G-protein β-like | mTOR, mammalian target of rapamycin | Q-PCR, quantitative PCR | MEM, minimal essential medium
Journal Article
FASEB Journal, ISSN 0892-6638, 10/2018, Volume 32, Issue 10, pp. 5602 - 5611
ERa | MTOR | FGF21
Journal Article
FRONTIERS IN MOLECULAR NEUROSCIENCE, ISSN 1662-5099, 2011, Volume 4, pp. 51 - 51
The phosphatidylinositol 3-kinase (P13K)/AKT/mammalian target of rapamycin (mTOR) pathway is activated in the majority of human cancers. This pathway is known... 
nitric oxide | PI3K/AKT/mTOR | NEUROSCIENCES | angiogenesis | VEGF | angiopoietins | Angiogenesis | Nitric Oxide | Angiopoietins
Journal Article
International Immunology, ISSN 0953-8178, 2018, Volume 30, Issue 8, pp. 357 - 373
T helper type 1 (Th1) cells form one of the most stable CD4 T-cell subsets, and direct conversion of fully differentiated Th1 to regulatory T (Treg) cells has... 
TGF-ß | MTOR
Journal Article
Journal of Virology, ISSN 0022-538X, 2019, Volume 93, Issue 12
Low-risk human papillomaviruses (LR-HPVs) are the causative agents of genital warts, which are a widespread sexually transmitted disease. How LR-HPVs affect... 
AKT/mTOR | E6 | Erk/mTOR | Autophagy | LR-HPV
Journal Article