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Journal Article
Biogerontology, ISSN 1389-5729, 2013, Volume 14, Issue 3, pp. 303 - 323
During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle... 
Life Sciences | Sarcopenia | FoxO | Geriatrics/Gerontology | Ageing | mTOR | IGF1 | Akt | Developmental Biology | Cell Biology | LIFE-SPAN | IGF-I | ALPHA-V-BETA-3 INTEGRIN | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | GERIATRICS & GERONTOLOGY | GROWTH-HORMONE | MESSENGER-RNA | GENETIC-DETERMINANTS | FAST-TWITCH | CELL-CYCLE | S6 KINASE | Microtubule-Associated Proteins - genetics | SKP Cullin F-Box Protein Ligases - genetics | Humans | SKP Cullin F-Box Protein Ligases - physiology | Male | Forkhead Transcription Factors - physiology | Ubiquitin-Protein Ligases - physiology | Tripartite Motif Proteins | Young Adult | Aged, 80 and over | Adult | Female | Mice, Inbred DBA | Models, Animal | TOR Serine-Threonine Kinases - physiology | Muscle Proteins - physiology | Serpin E2 - physiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins c-akt - physiology | Muscle, Skeletal - physiology | Mice, Knockout | Microtubule-Associated Proteins - physiology | Muscle Proteins - genetics | Autophagy-Related Protein 7 | Sarcopenia - physiopathology | Serpin E2 - genetics | Animals | Aging - physiology | Insulin-Like Growth Factor I - physiology | Adolescent | Signal Transduction - physiology | Aged | Forkhead Box Protein O1 | Mice | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Muscles | Ligases | Proteolysis | Analysis | Index Medicus | SKP Cullin F-Box Protein Ligases | Muscle Proteins | Aging | Serpin E2 | Signal Transduction | Biochemistry, Molecular Biology | Microtubule-Associated Proteins | Insulin-Like Growth Factor I | Proto-Oncogene Proteins c-akt | Ubiquitin-Protein Ligases | TOR Serine-Threonine Kinases | Muscle, Skeletal | Forkhead Transcription Factors | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Clinical Neurophysiology | Klinisk neurofysiologi | Klinisk medicin
Journal Article
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 03/2015, Volume 9, pp. 1555 - 1584
Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to... 
ALS | Osteosarcoma | Autophagy | EMT | PI3K/Akt/mTOR pathway | Apoptosis | MASTER | CHEMISTRY, MEDICINAL | autophagy | METASTASIS | CANCER CELLS | apoptosis | SIRTUINS | FAMILY | EMT TRANSCRIPTION FACTORS | METABOLISM | PHARMACOLOGY & PHARMACY | osteosarcoma | PROGRAM | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Structure-Activity Relationship | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Pyrimidines - chemistry | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Azepines - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Azepines - pharmacology | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Mitogen-Activated Protein Kinases - metabolism | Development and progression | Genetic aspects | Cellular signal transduction | Gene expression | Health aspects | Crosstalk | Nuclear engineering | AKT protein | Aurora kinase | Metastasis | Cancer therapies | Anticancer properties | Proteins | Signal transduction | Mitochondria | N-Cadherin | Surgery | Biocompatibility | Inhibition | Stress response | AMP | Mortality | MAP kinase | Rapamycin | Metabolism | 1-Phosphatidylinositol 3-kinase | Nuclear safety | Chemotherapy | Hospitals | Inhibitors | Phagocytosis | TOR protein | Adolescence | Biotechnology | Oxidative stress | Mesenchyme | Laboratories | Bone tumors | Activation | Kinases | E-cadherin | Cyclin B1 | Cell adhesion & migration | Pathways | Cell cycle | Children | Trends | Inducers | Phenotypes | Signaling | Bone cancer | Cell death | Cell lines | Index Medicus
Journal Article
FRONTIERS IN MOLECULAR NEUROSCIENCE, ISSN 1662-5099, 2011, Volume 4, pp. 51 - 51
The phosphatidylinositol 3-kinase (P13K)/AKT/mammalian target of rapamycin (mTOR) pathway is activated in the majority of human cancers. This pathway is known... 
nitric oxide | PI3K/AKT/mTOR | NEUROSCIENCES | angiogenesis | VEGF | angiopoietins | Angiogenesis | Nitric Oxide | Angiopoietins
Journal Article
Journal Article
Journal Article
by Zhao, T and Du, H and Ding, X and Walls, K and Yan, C
Oncogene, ISSN 0950-9232, 05/2014, Volume 34, Issue 15, pp. 1938 - 1948
Journal Article
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 06/2017, Volume 329, pp. 166 - 171
Few studies suggest that antidepressants exert their effects by activating some signaling pathways, including the phosphatidylinositol 3-kinase (PI3K).... 
mTOR | Depression | Akt | PI3K | Valproic acid | BEHAVIORAL DESPAIR | BDNF LEVELS | ARACHIDONIC-ACID | NEUROSCIENCES | PREFRONTAL CORTEX | MOOD STABILIZERS LITHIUM | MTOR SIGNALING PATHWAY | SODIUM VALPROATE | BIPOLAR DEPRESSION | GENE-EXPRESSION | BEHAVIORAL SCIENCES | RAT HIPPOCAMPUS | Divalproex | Rapamycin | Antidepressants | Analysis | Depression, Mental
Journal Article
Journal Article