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Free Radical Biology and Medicine, ISSN 0891-5849, 11/2015, Volume 88, Issue Pt B, pp. 417 - 426
In light of the emerging interplay between redox and metabolic signaling pathways we investigated the potential cross talk between nuclear factor E2-related... 
Xanthohumol | Nrf2 | ER stress | AMPK | HO-1 | PERK | LKB1 | MEF | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MECHANISMS | ENERGY SENSOR | CELL DEFENSE PATHWAY | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | NRF2-MEDIATED INDUCTION | HEME OXYGENASE-1 | STRESS | AMP-Activated Protein Kinases - metabolism | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress - physiology | Propiophenones - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Cross-Talk - physiology | Blotting, Western | Animals | Flow Cytometry | Fibroblasts - drug effects | NF-E2-Related Factor 2 - metabolism | Signal Transduction - physiology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Mice | Real-Time Polymerase Chain Reaction | Unfolded Protein Response - physiology | Fibroblasts - metabolism | RNA | Glycogen | Synthesis | ACC, acetyl-CoA carboxylase | CHO, Chinese hamster ovary | GSH, glutathione (reduced) | OCR, oxygen consumption rate | HO-1, heme oxygenase 1 | CaMKK, calcium calmodulin-dependent kinase kinase | Maf, small musculoaponeurotic fibrosarcoma | PERK, protein kinase RNA-like endoplasmic reticulum kinase | Xn, xanthohumol | Hrd1, synoviolin | TAK, transforming growth factor β-activated kinase | UPR, unfolded protein response | Hrd1 (HMG-CoA reductase degradation)-ubiquitin ligase | MEF, mouse embryonic fibroblasts | βTrcP1, β-transducin-repeat containing protein 1 | mTOR, mammalian target of rapamycin | ROS, reactive oxygen species | LKB1, liver kinase B1 | Keap1, Kelch-like ECH-associated protein | GSSG, oxidized glutathione | ARE, antioxidant response element | WT, wild type | GSK3β, glycogen synthase kinase 3β | Nrf2, nuclear factor E2-related factor 2 | AMPK, AMP-activated kinase | DCF, dichlorofluorescein | NADPH, nicotinamide adenine dinucleotide phosphate | DMSO, dimethyl sulfoxide | ER, endoplasmic reticulum | FCS, fetal calf serum
Journal Article