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1. Full Text Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease
by Sciarretta, Sebastiano and Volpe, Massimo and Sadoshima, Junichi
Circulation Research, ISSN 0009-7330, 01/2014, Volume 114, Issue 3, pp. 549 - 564
The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions by... 
autophagy | mechanistic target of rapamycin complex 1 | hypertrophy | sirolimus | metabolism | heart | ischemia | LIFE-SPAN | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | ACTIVATED PROTEIN-KINASE | PATHOLOGICAL HYPERTROPHY | MYOCARDIAL-INFARCTION | HEART-FAILURE | DIET-INDUCED OBESITY | ISCHEMIA-REPERFUSION INJURY | RICTOR-MTOR COMPLEX | INSULIN-RESISTANCE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Animals | Heart Diseases - metabolism | Heart Diseases - physiopathology | Humans | Myocardium - metabolism | Myocardium - pathology | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Heart Diseases - pathology | Myocardium - cytology
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2. Full Text Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice : Potential role of attenuated oxidative stress and altered contractile protein expression
by Das, Anindita and Durrant, David and Koka, Saisudha and Salloum, Fadi N and Xi, Lei and Kukreja, Rakesh C
Journal of Biological Chemistry, ISSN 0021-9258, 02/2014, Volume 289, Issue 7, pp. 4145 - 4160
Background: Elevated mammalian target of rapamycin (mTOR) signaling contributes to diabetic complications. Results: mTOR inhibitor, rapamycin, improves... 
Cardiovascular Disease | CARDIOMYOCYTE HYPERTROPHY | NEBULETTE MUTATIONS | Oxidative Stress | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOCARDIAL-ISCHEMIA | COENZYME-A SYNTHESIS | DILATED CARDIOMYOPATHY | SIROLIMUS-ELUTING STENTS | INDUCED INSULIN-RESISTANCE | Antioxidants | ISCHEMIA-REPERFUSION INJURY | CARBONIC-ANHYDRASE-II | Proteomics | mTOR | Diabetes | RENAL TUBULAR-ACIDOSIS | Contractile Proteins - biosynthesis | Contractile Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Diabetes Mellitus, Type 2 - genetics | Myocardial Contraction - drug effects | Glucose - genetics | Male | Myocardium - pathology | Sirolimus - pharmacokinetics | Diabetes Mellitus, Type 2 - metabolism | Gene Expression Regulation - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | Diabetes Mellitus, Type 2 - physiopathology | TOR Serine-Threonine Kinases - genetics | Mice, Mutant Strains | Myocardium - metabolism | Glucose - metabolism | Anti-Bacterial Agents - pharmacology | Mice | Oxidative Stress - drug effects | Molecular Bases of Disease
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3. Full Text SIRT1 negatively regulates the mammalian target of rapamycin
by Ghosh, Hiyaa Singhee and McBurney, Michael and Robbins, Paul D
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9199
The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+... 
NAD | MULTIDISCIPLINARY SCIENCES | DISEASE | DOWN-REGULATION | EXTENDS LIFE-SPAN | TOXICITY | MICE | CELL-GROWTH | SACCHAROMYCES-CEREVISIAE | MTOR | CALORIE RESTRICTION | Sirtuin 1 - metabolism | Immunoprecipitation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Stilbenes - pharmacology | Sirtuin 1 - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Jurkat Cells | Cells, Cultured | Antioxidants - pharmacology | Blotting, Western | Mice, Knockout | Animals | Signal Transduction - drug effects | Models, Biological | Fibroblasts - drug effects | Sirtuin 1 - physiology | Protein Binding | Signal Transduction - physiology | Fibroblasts - cytology | Mice | TOR Serine-Threonine Kinases | HeLa Cells | Niacinamide - pharmacology | Type 2 diabetes | Niacinamide | Rapamycin | Analysis | Resveratrol | NADPH | TOR protein | Phosphorylation | Yeast | Neuropathology | Cytotoxicity | Insulin-like growth factors | Kinases | TSC1 protein | Autophagy | Proteins | Dietary restrictions | Genotype & phenotype | Signal transduction | Cell growth | Rodents | Fibroblasts | Aging | Nutrients | Telomerase | Growth factors | Stresses | Insulin | SIRT1 protein | Stress | Energy balance | TSC2 protein | Signaling | Insects | Protein synthesis | Nicotinamide | Mutation | Alzheimers disease | Cellular stress response
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4. Full Text Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
by García-Martínez, Juan M and Moran, Jennifer and Clarke, Rosemary G and Gray, Alex and Cosulich, Sabina C and Chresta, Christine M and Alessi, Dario R
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | HYDROPHOBIC MOTIF | cancer | serum and glucocorticoid protein kinase (SGK) | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
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5. Full Text Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
by Dowling, Ryan J.O and Zakikhani, Mahvash and Fantus, I. George and Pollak, Michael and Sonenberg, Nahum
Cancer Research, ISSN 0008-5472, 11/2007, Volume 67, Issue 22, pp. 10804 - 10812
Metformin is used for the treatment of type 2 diabetes because of its ability to lower blood glucose. The effects of metformin are explained by the activation... 
ACTIVATED PROTEIN-KINASE | MECHANISM | METABOLISM | ONCOLOGY | PHOSPHORYLATION | UPSTREAM | DOWNSTREAM | GROWTH | SENSITIVITY | LKB1 | MTOR | Cell Proliferation | Humans | Metformin - pharmacology | Multienzyme Complexes - metabolism | Ribosomes - metabolism | Mice, Transgenic | AMP-Activated Protein Kinases | Breast Neoplasms - metabolism | Animals | Breast Neoplasms - pathology | Models, Biological | Protein Kinases - physiology | Cell Line, Tumor | Polyribosomes - metabolism | Protein Biosynthesis - drug effects | Mice | TOR Serine-Threonine Kinases | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism
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6. Full Text Curcumin disrupts the mammalian target of rapamycin-raptor complex
by Beevers, Christopher S and Chen, Long and Liu, Lei and Luo, Yan and Webster, Nicholas J. G and Huang, Shile
Cancer Research, ISSN 0008-5472, 02/2009, Volume 69, Issue 3, pp. 1000 - 1008
Curcumin (diferuloylmethane), a polyphenol natural product of the plant Curcuma longa, is undergoing early clinical trials as a novel anticancer agent.... 
BINDING PARTNER | RICTOR-MTOR COMPLEX | SIGNALING PATHWAYS | FKBP12-RAPAMYCIN-ASSOCIATED PROTEIN | TUBEROUS SCLEROSIS COMPLEX | ONCOLOGY | TUMOR-SUPPRESSOR PROTEINS | GENE-PRODUCTS | KINASE | TSC2 GAP ACTIVITY | CELL-GROWTH | Calcium-Binding Proteins - metabolism | Receptor, IGF Type 1 - metabolism | AMP-Activated Protein Kinases - metabolism | Ribosomal Protein S6 Kinases - metabolism | Humans | Multiprotein Complexes | Rhabdomyosarcoma - metabolism | Curcumin - pharmacology | Transcription Factors - antagonists & inhibitors | Phosphoproteins - metabolism | Mechanistic Target of Rapamycin Complex 1 | HT29 Cells | Transcription Factors - metabolism | Proteins - metabolism | Signal Transduction - drug effects | Regulatory-Associated Protein of mTOR | Rhabdomyosarcoma - drug therapy | Antineoplastic Agents - pharmacology | TOR Serine-Threonine Kinases | Phosphorylation - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism
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7. Full Text Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
by Sun, Shi-Yong and Rosenberg, Laura M and Wang, Xuerong and Zhou, Zhongmei and Yue, Ping and Fu, Haian and Khuri, Fadlo R
Cancer Research, ISSN 0008-5472, 08/2005, Volume 65, Issue 16, pp. 7052 - 7058
The mammalian target of rapamycin (mTOR) has emerged as an important cancer therapeutic target. Rapamycin and its derivatives that specifically inhibit mTOR... 
LUNG-CARCINOMA CELLS | ENHANCED SENSITIVITY | ONCOLOGY | PHOSPHORYLATION | CAP-DEPENDENT TRANSLATION | GROWTH | DYSREGULATION | RESISTANCE | MTOR INHIBITORS | EXPRESSION | CANCER-THERAPY | Protein Kinases - metabolism | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Eukaryotic Initiation Factor-4E - metabolism | Chromones - administration & dosage | Phosphatidylinositol 3-Kinases - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Lung Neoplasms - enzymology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Cell Growth Processes - drug effects | Morpholines - administration & dosage | Carcinoma, Non-Small-Cell Lung - metabolism | Sirolimus - pharmacology | Proto-Oncogene Proteins c-akt | Sirolimus - administration & dosage | Signal Transduction - drug effects | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Enzyme Activation
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8. Full Text Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy
by Petherick, Katy J and Conway, Owen J.L and Mpamhanga, Chido and Osborne, Simon A and Kamal, Ahmad and Saxty, Barbara and Ganley, Ian G
Journal of Biological Chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 18, pp. 11376 - 11383
Autophagy is a cell-protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of... 
CROSS-TALK | HYDROXYCHLOROQUINE | COMPLEX | ADVANCED SOLID TUMORS | PHASE-I TRIAL | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMPK | VPS34 | MTOR
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9. Full Text Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: Implication for Alzheimer disease
by Tang, Zhi and Bereczki, Erika and Zhang, Haiyan and Wang, Shan and Li, Chunxia and Ji, Xinying and Branca, Rui M and Lehtiö, Janne and Guan, Zhizhong and Filipcik, Peter and Xu, Shaohua and Winblad, Bengt and Pei, Jin-Jing
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 22, pp. 15556 - 15570
Previous evidence from post-mortem Alzheimer disease (AD) brains and drug (especially rapamycin)-oriented in vitro and in vivo models implicated an aberrant... 
GLYCOGEN-SYNTHASE KINASE-3-BETA | HYPERPHOSPHORYLATED-TAU | MICROTUBULE-BINDING | AMYLOID-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROFIBRILLARY DEGENERATION | ABNORMALLY PHOSPHORYLATED-TAU | NEUROBLASTOMA | UP-REGULATION | P70 S6 KINASE | TEMPORAL CORTEX | Neurons - pathology | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Homeostasis | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Male | Brain - physiology | Brain - metabolism | Cyclin-Dependent Kinase 5 - genetics | Phosphorylation - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | TOR Serine-Threonine Kinases - genetics | tau Proteins - genetics | Oncogene Protein v-akt - genetics | Aged, 80 and over | Female | Neurons - metabolism | Oncogene Protein v-akt - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Protein Phosphatase 2 - genetics | Glycogen Synthase Kinase 3 - metabolism | Cyclin-Dependent Kinase 5 - metabolism | Glycogen Synthase Kinase 3 - genetics | Alzheimer Disease - metabolism | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Aged | Alzheimer Disease - genetics | Aggregation | Molecular Bases of Disease | Phosphorylation | Translation | Tau Synthesis | Tau Phosphorylation | mTOR | Tau | Tau Aggregation | Alzheimer Disease
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10. Full Text Antianglogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
by Del Bufalo, D and Ciuffreda, L and Triscinoglio, D and Desideri, M and Cognetti, F and Zupi, G and Milella, M
CANCER RESEARCH, ISSN 0008-5472, 06/2006, Volume 66, Issue 11, pp. 5549 - 5554
Mammalian target of rapamycin (mTOR) is increasingly recognized as a master regulator of fundamental cellular functions, whose deregulation may underlie... 
BREAST-CANCER | CELLS | ANGIOGENESIS | ONCOLOGY | CCI-779 | PATHWAY | LINE | INDUCTION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | MTOR INHIBITOR
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11. Full Text Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
by Qian Sun and Xinxin Chen and Jianhui Ma and Haiyong Peng and Fang Wang and Xiaojun Zha and Yanan Wang and Yanling Jing and Hongwang Yang and Rongrong Chen and Long Chang and Yu Zhang and June Goto and Hiroaki Onda and Tong Chen and Ming-Rong Wang and Youyong Lu and Han You and David Kwiatkowski and Hongbing Zhang and Tak Wah Mak
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 10, pp. 4129 - 4134
Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions, including when, how, and why cancer cells become highly glycolytic,... 
Tumor cell line | Enzymes | Up regulation | Cell growth | Cellular metabolism | Cell lines | Glycolysis | Gene expression regulation | Tumors | Cancer | PTEN | Glyceraldehyde 3-phosphate dehydrogenase | Hexokinase II | Lactate dehydrogenase-B | Tuberous sclerosis 1 | hexokinase II | CANCER-CELLS | tuberous sclerosis 1 | SIGNALING PATHWAYS | MULTIDISCIPLINARY SCIENCES | VEGF EXPRESSION | TSC2 | CELL-GROWTH | NULL-CELLS | MTOR | TUBEROUS SCLEROSIS COMPLEX | METABOLISM | RENAL-CARCINOMA | lactate dehydrogenase-B | glyceraldehyde 3-phosphate dehydrogenase | Neoplasms - metabolism | Up-Regulation | Aerobiosis | Cell Proliferation | Pyruvate Kinase - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Neoplasms - enzymology | Genes, myc | Animals | TOR Serine-Threonine Kinases - physiology | Mice | Neoplasms - pathology | Glucose metabolism | Development and progression | Genetic aspects | Research | Health aspects | Biological Sciences
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12. The complexes of mammalian target of rapamycin
by Zhou, Hongyu and Huang, Shile
Current Protein and Peptide Science, ISSN 1389-2037, 2010, Volume 11, Issue 6, pp. 409 - 424
The mammalian target of rapamycin (mTOR) has attracted substantial attention because of its involvement in a variety of diseases, such as cancer, cardiac... 
mTOR | Rictor | 4E-BP1 | Rapamycin | Diabetes | Raptor | Cancer | S6K1 | RICH AKT SUBSTRATE | raptor | 40 KDA PRAS40 | ACTIVATED PROTEIN-KINASE | PEUTZ-JEGHERS-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | P70 S6 KINASE | TUBEROUS-SCLEROSIS | GROWTH-FACTOR RECEPTOR | RICTOR-MTOR COMPLEX | rictor | TUMOR-SUPPRESSOR PROTEINS | SQUAMOUS-CELL CARCINOMA | cancer | diabetes
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13. Full Text Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer ROLE OF SPECIFICITY PROTEIN (Sp) TRANSCRIPTION FACTORS
by Nair, V and Sreevalsan, S and Basha, R and Abdelrahim, M and Abudayyeh, A and Hoffman, AR and Safe, S
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2014, Volume 289, Issue 40, pp. 27692 - 27701
Background: Metformin inhibits pancreatic cancer cell and tumor growth and down-regulated Sp transcription factors. Results: Inhibition of mTOR and Ras... 
Specificity Protein 1 (Sp1) | Gene Expression | mTOR Down-regulation | Epidermal Growth Factor Receptor (EGFR) | DUCTAL ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | Pancreatic Cancer | Sp Transcription Factors | CELL-GROWTH | IGFR Down-regulation | DIABETIC-PATIENTS | BREAST-CANCER | GROWTH-FACTOR RECEPTOR | Ras Inhibition | ANTIDIABETIC DRUG | COLORECTAL-CANCER | Metformin | NF-KAPPA-B | TUMOR-GROWTH | Insulin-like Growth Factor (IGF) | EGF RECEPTOR | ras Proteins - genetics | Pancreatic Neoplasms - metabolism | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Humans | Metformin - pharmacology | ras Proteins - antagonists & inhibitors | ras Proteins - metabolism | Male | Pancreatic Neoplasms - genetics | Sp Transcription Factors - metabolism | Down-Regulation - drug effects | Pancreatic Neoplasms - drug therapy | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | TOR Serine-Threonine Kinases - genetics | Mice, Nude | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | Sp Transcription Factors - genetics | Gene Expression Regulation, Neoplastic - drug effects
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14. Full Text Mammalian target of rapamycin as a therapeutic target in osteoporosis
by Shen, Gengyang and Ren, Hui and Qiu, Ting and Zhang, Zhida and Zhao, Wenhua and Yu, Xiang and Huang, Jinjing and Tang, Jingjing and Liang, De and Yao, Zhensong and Yang, Zhidong and Jiang, Xiaobing
Journal of Cellular Physiology, ISSN 0021-9541, 05/2018, Volume 233, Issue 5, pp. 3929 - 3944
The mechanistic target of rapamycin (mTOR) plays a key role in sensing and integrating large amounts of environmental cues to regulate organismal growth,... 
homeostasis | therapeutic target | mTOR signaling | osteoporosis bone | RHEUMATOID-ARTHRITIS | PHYSIOLOGY | OSTEOGENIC DIFFERENTIATION | MESENCHYMAL STEM-CELLS | CELL BIOLOGY | BREAST-CANCER CELLS | COMPLEX 1 MTORC1 | BONE-FORMATION | TOLL-LIKE RECEPTORS | INHIBITS OSTEOCLAST DIFFERENTIATION | STROMAL CELLS | NF-KAPPA-B | Sirolimus - therapeutic use | Animals | Osteoporosis - pathology | TOR Serine-Threonine Kinases - metabolism | Bone and Bones - metabolism | Humans | Osteoblasts - drug effects | Osteoporosis - drug therapy | Osteoblasts - metabolism | Osteoclasts - metabolism | Osteoclasts - drug effects | Osteoporosis | Health aspects | Stem cells | TOR protein | Cues | Mesenchyme | Pathogenesis | Homeostasis | Osteocytes | Rapamycin | Bone turnover | Osteoblasts | Machinery | Machinery and equipment | Bone resorption | Osteoclastogenesis | Signaling | Bone growth | Osteoblastogenesis | Bone marrow | Biocompatibility | Osteoclasts | Bone | Osteogenesis
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