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Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9199
The IGF/mTOR pathway, which is modulated by nutrients, growth factors, energy status and cellular stress regulates aging in various organisms. SIRT1 is a NAD+... 
NAD | MULTIDISCIPLINARY SCIENCES | DISEASE | DOWN-REGULATION | EXTENDS LIFE-SPAN | TOXICITY | MICE | CELL-GROWTH | SACCHAROMYCES-CEREVISIAE | MTOR | CALORIE RESTRICTION | Sirtuin 1 - metabolism | Immunoprecipitation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Stilbenes - pharmacology | Sirtuin 1 - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Jurkat Cells | Cells, Cultured | Antioxidants - pharmacology | Blotting, Western | Mice, Knockout | Animals | Signal Transduction - drug effects | Models, Biological | Fibroblasts - drug effects | Sirtuin 1 - physiology | Protein Binding | Signal Transduction - physiology | Fibroblasts - cytology | Mice | TOR Serine-Threonine Kinases | HeLa Cells | Niacinamide - pharmacology | Type 2 diabetes | Niacinamide | Rapamycin | Analysis | Resveratrol | NADPH | TOR protein | Phosphorylation | Yeast | Neuropathology | Cytotoxicity | Insulin-like growth factors | Kinases | TSC1 protein | Autophagy | Proteins | Dietary restrictions | Genotype & phenotype | Signal transduction | Cell growth | Rodents | Fibroblasts | Aging | Nutrients | Telomerase | Growth factors | Stresses | Insulin | SIRT1 protein | Stress | Energy balance | TSC2 protein | Signaling | Insects | Protein synthesis | Nicotinamide | Mutation | Alzheimers disease | Cellular stress response
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | HYDROPHOBIC MOTIF | cancer | serum and glucocorticoid protein kinase (SGK) | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 08/2005, Volume 65, Issue 16, pp. 7052 - 7058
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2013, Volume 288, Issue 22, pp. 15556 - 15570
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2015, Volume 290, Issue 18, pp. 11376 - 11383
Autophagy is a cell-protective and degradative process that recycles damaged and long-lived cellular components. Cancer cells are thought to take advantage of... 
CROSS-TALK | HYDROXYCHLOROQUINE | COMPLEX | ADVANCED SOLID TUMORS | PHASE-I TRIAL | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMPK | VPS34 | MTOR
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 06/2006, Volume 66, Issue 11, pp. 5549 - 5554
Mammalian target of rapamycin (mTOR) is increasingly recognized as a master regulator of fundamental cellular functions, whose deregulation may underlie... 
BREAST-CANCER | CELLS | ANGIOGENESIS | ONCOLOGY | CCI-779 | PATHWAY | LINE | INDUCTION | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | MTOR INHIBITOR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 10, pp. 4129 - 4134
Journal Article
Current Protein and Peptide Science, ISSN 1389-2037, 2010, Volume 11, Issue 6, pp. 409 - 424
The mammalian target of rapamycin (mTOR) has attracted substantial attention because of its involvement in a variety of diseases, such as cancer, cardiac... 
mTOR | Rictor | 4E-BP1 | Rapamycin | Diabetes | Raptor | Cancer | S6K1 | RICH AKT SUBSTRATE | raptor | 40 KDA PRAS40 | ACTIVATED PROTEIN-KINASE | PEUTZ-JEGHERS-SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | P70 S6 KINASE | TUBEROUS-SCLEROSIS | GROWTH-FACTOR RECEPTOR | RICTOR-MTOR COMPLEX | rictor | TUMOR-SUPPRESSOR PROTEINS | SQUAMOUS-CELL CARCINOMA | cancer | diabetes
Journal Article
Journal Article
Future oncology (London, England), ISSN 1479-6694, 2013, Volume 9, Issue 12, pp. 1883 - 1892
With the recent introduction of inhibitors of mammalian target of rapamycin (mTOR) in oncology, distinct cutaneous and oral adverse events have been... 
oral mucositis | targeted therapy | stomatitis | MANAGEMENT | RIDAFOROLIMUS | TOXICITY | RENAL-CELL CARCINOMA | CANCER-PATIENTS | THERAPY | ONCOLOGY | TEMSIROLIMUS | mTOR | SUNITINIB | MTOR INHIBITORS | mTOR inhibitor-associated stomatitis
Journal Article