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index medicus (145) 145
biochemistry & molecular biology (109) 109
mtor complex (97) 97
humans (90) 90
animals (88) 88
tor serine-threonine kinases - metabolism (71) 71
signal transduction (70) 70
mice (62) 62
mechanistic target of rapamycin complex 1 (60) 60
mtorc (59) 59
phosphorylation (56) 56
multiprotein complexes - metabolism (44) 44
activation (42) 42
mtor (42) 42
cell biology (40) 40
mtorc1 (35) 35
mammalian target (34) 34
proto-oncogene proteins c-akt - metabolism (34) 34
tor serine-threonine kinases - genetics (34) 34
biological phenomena, cell phenomena, and immunity (31) 31
pathway (31) 31
proteins (31) 31
rapamycin (31) 31
autophagy (30) 30
cell line (27) 27
cell line, tumor (26) 26
cancer (25) 25
metabolism (23) 23
raptor (23) 23
hek293 cells (22) 22
multiprotein complexes - genetics (22) 22
tor serine-threonine kinases (22) 22
multiprotein complexes (21) 21
akt (20) 20
growth (20) 20
mice, knockout (20) 20
carrier proteins - metabolism (19) 19
cell-growth (19) 19
insulin (18) 18
male (18) 18
phosphatidylinositol 3-kinases - metabolism (18) 18
signal transduction - drug effects (18) 18
kinases (17) 17
rictor (17) 17
akt pkb (16) 16
amino acid (16) 16
female (16) 16
mice, inbred c57bl (16) 16
proto-oncogene proteins c-akt - genetics (15) 15
signaling (15) 15
transcription factors - metabolism (15) 15
apoptosis (14) 14
cell proliferation (14) 14
complex (14) 14
hela cells (14) 14
protein binding (14) 14
proteins - metabolism (14) 14
s6 kinase (14) 14
signal transduction - physiology (14) 14
adaptor proteins, signal transducing - metabolism (13) 13
cells, cultured (13) 13
immunology (13) 13
lysosomes - metabolism (13) 13
mutation (13) 13
oncology (13) 13
phosphoproteins - metabolism (13) 13
rag gtpases (13) 13
rheb (13) 13
carrier proteins - genetics (12) 12
mechanistic target of rapamycin complex 2 (12) 12
mtor, mammalian target of rapamycin (12) 12
protein-kinase (12) 12
rapamycin-insensitive companion of mtor protein (12) 12
tor protein (12) 12
transcription factors - genetics (12) 12
phosphorylation - drug effects (11) 11
protein (11) 11
rats (11) 11
rna interference (11) 11
sirolimus - pharmacology (11) 11
1 (10) 10
expression (10) 10
gene-expression (10) 10
in-vivo (10) 10
inhibition (10) 10
mtorc, mtor complex (10) 10
original research (10) 10
protein biosynthesis (10) 10
protein synthesis (10) 10
protein-serine-threonine kinases - metabolism (10) 10
tor serine-threonine kinases - antagonists & inhibitors (10) 10
translation (10) 10
tuberous sclerosis (10) 10
tuberous sclerosis complex (10) 10
tumor suppressor proteins - metabolism (10) 10
amino acids - metabolism (9) 9
gene expression (9) 9
inhibitor (9) 9
lysosome (9) 9
mammalian target of rapamycin (9) 9
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The EMBO Journal, ISSN 0261-4189, 02/2019, Volume 38, Issue 3, pp. e99548 - n/a
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 35, pp. 29579 - 29588
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases that act downstream of insulin and growth factor signaling. Here we... 
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | LIPID-METABOLISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | MOTIF PHOSPHORYLATION | RICTOR | MICE | KINASE-B | INDUCED INSULIN-RESISTANCE | Phosphorylation - physiology | Humans | Glycogen Synthase Kinase 3 beta | GTPase-Activating Proteins - metabolism | Phosphoproteins - metabolism | Cholesterol - genetics | Proto-Oncogene Proteins c-akt - genetics | Fatty Acids - genetics | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Insulin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Tumor Suppressor Proteins - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Glucose - genetics | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | GTPase-Activating Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cholesterol - biosynthesis | Index Medicus | mTOR Complex (mTORC) | Liver Metabolism | mTOR Complex 2 (mTORC2) | Akt | Metabolism | Lipogenesis | Insulin | Gluconeogenesis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 42, pp. 16390 - 16401
Glutamine is a key nutrient required for sustaining cell proliferation, contributing to nucleotide, protein, and lipid synthesis. The mTOR complex 1 (mTORC1)... 
RHEB (Ras homolog expressed in brain) | phospholipase D | RalA | Arf1 | Rag GTPase | phosphatidic acid | glutamine | α-ketoglutarate | mTOR complex (mTORC) | CANCER-CELLS | SURVIVAL | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RAPTOR | ARF | RHEB | GROWTH | ketoglutarate | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2014, Volume 289, Issue 46, pp. 31950 - 31959
Journal Article
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2007, Volume 405, Issue 3, pp. 513 - 522
The mTOR (mammalian target of rapamycin) protein kinase is an important regulator of cell growth. Two complexes of mTOR have been identified: complex 1,... 
Mammalian target of rapamycin (mTOR) | Protein kinase | Protein observed with Rictor-1 (Protor) | mTOR complex-2 (mTORC2) | Proline-rich repeat protein-5 (PRR-5) | Rapamycin-insensitive companion of mTOR (Rictor) | Cancer | proline-rich repeat protein-5 (PRR-5) | protein observed with Rictor-1 (Protor) | ACTIVATION | AKT/PKB | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | mammalian target of rapamycin (mTOR) | rapamycin-insensitive companion of mTOR (Rictor) | protein kinase | RAPTOR | REGULATOR | PATHWAY | TOR | GROWTH | cancer | PDK1 | Protein Kinases - metabolism | Cell Line | Carrier Proteins - metabolism | Humans | Protein Isoforms | Gene Silencing | Protein Binding | TOR Serine-Threonine Kinases | Rapamycin-Insensitive Companion of mTOR Protein | Index Medicus | HEK-293 cells, human embryonic kidney cells | SPAK, Ste20 | PI3K, phosphoinositide 3-kinase | mTORC, mTOR complex | EST, expressed sequence tag | Protor, protein observed with Rictor | DTT, dithiothreitol | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | NCBI, National Center for Biotechnology Information | IGF-1, insulin-like growth factor-1 | S6K, S6 kinase | mTOR, mammalian target of rapamycin | TAP, tandem affinity purification | Rictor, rapamycin-insensitive companion of mTOR | Raptor, regulatory associated protein of mTOR | siRNA, small interfering RNA | I.M.A.G.E., Integrated Molecular Analysis of Genomes and their Expression | SPS1-related proline | alanine-rich kinase
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 24, pp. 9388 - 9398
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating disease that is characterized by the accumulation of numerous fluid-filled cysts in the... 
MAMMALIAN TARGET | long noncoding RNA (long ncRNA | CRISPR | ACTIVATION | lncRNA | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | epithelial cell | CANCER | INACTIVATION | kidney | Cas | GENE | CYST FORMATION | PATHWAY | MALAT-1 | mTOR complex (mTORC) | Index Medicus | RNA | long noncoding RNA (long ncRNA, lncRNA)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 36, pp. 30240 - 30256
Dendrites are the main site of information input into neurons. Their development is a multistep process controlled by mammalian target of rapamycin (mTOR)... 
PROTEIN | PHOSPHORYLATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | KINASE | GROWTH | INHIBITS MTORC2 | GENE-EXPRESSION | AKT | RICTOR | Humans | Multiprotein Complexes | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | HEK293 Cells | Regulatory-Associated Protein of mTOR | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Rapamycin-Insensitive Companion of mTOR Protein | Dendrites - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Rats | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Hippocampus - cytology | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Hippocampus - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | TOR Serine-Threonine Kinases | Adaptor Proteins, Signal Transducing - metabolism | Dendrites - genetics | Index Medicus | mTOR Complex (mTORC) | shRNA | Neurobiology | Neurodevelopment | Rictor | Dendritic Arbor | mTOR | Akt PKB | Raptor | Dendrite
Journal Article