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Journal of Animal Science, ISSN 0021-8812, 12/2018, Volume 96, Issue suppl_3, pp. 261 - 262
Abstract The objective of this study was to assess the role of the mechanistic target of rapamycin complex 1 (mTORC1) in sensing glucose levels and controlling... 
bovine | Glucose | mTORC1 | Abstracts
Journal Article
Biochemistry and Cell Biology, ISSN 0829-8211, 2019, Volume 97, Issue 1, pp. 58 - 67
The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that senses and integrates environmental information into... 
mTOR | mTORC2 | mTORC1
Journal Article
Journal Article
European journal of immunology, ISSN 0014-2980, 2016, Volume 46, Issue 2, pp. 291 - 299
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 07/2018, Volume 24, Issue 2, pp. 489 - 502
The genetic basis of naive pluripotency maintenance and loss is a central question in embryonic stem cell biology. Here, we deploy CRISPR-knockout-based... 
CRISPR | screening | exit from pluripotency | GATOR1 | Nprl2 | Tsc2 | Akt | naive pluripotency | mTORC2 | mTORC1 | GAP ACTIVITY | TRANSITION | TARGET | COMPLEX | GROUND-STATE PLURIPOTENCY | EMBRYONIC STEM-CELLS | GENETIC SCREENS | SELF-RENEWAL | DIFFERENTIATION | MTORC1 PATHWAY | CELL BIOLOGY
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2015, Volume 92, Issue 2
ABSTRACT The greatest limitation to reproductive performance in most mammals, including humans, is embryonic mortality, which, in general, claims 20%–40% of... 
SPP1 | trophectoderm | MTORC1 | arginine | sheep
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 67, Issue 3, pp. 512 - 527.e4
Aberrant signaling by the mammalian target of rapamycin (mTOR) contributes to the devastating features of cancer cells. Thus, mTOR is a critical therapeutic... 
dual mTORC1/2 inhibition | tumor resistance | Akt | mTORC2 | mTORC1 | MAMMALIAN TARGET | MESSENGER-RNA TRANSLATION | RAPAMYCIN MTOR | ACTIVATION | COMPLEX | METASTASIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | KINASE INHIBITORS | CANCER | CELL BIOLOGY | Focal Adhesion Kinase 1 - genetics | Phosphorylation | Skin Neoplasms - drug therapy | TOR Serine-Threonine Kinases - metabolism | Humans | Melanoma - enzymology | Drug Resistance, Neoplasm | Integrin alpha2 - metabolism | Mechanistic Target of Rapamycin Complex 2 | Proto-Oncogene Proteins c-akt - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Breast Neoplasms - enzymology | Skin Neoplasms - enzymology | Transfection | RNA Interference | Time Factors | Female | Proto-Oncogene Proteins c-akt - metabolism | Focal Adhesion Kinase 1 - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Skin Neoplasms - pathology | Cell Survival - drug effects | Neoplasm Invasiveness | Melanoma - pathology | Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Tumor Burden - drug effects | Breast Neoplasms - pathology | Mice, Nude | Receptors, Somatomedin - metabolism | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Receptors, Somatomedin - genetics | Protein Kinase Inhibitors - pharmacology | Receptors, Somatomedin - antagonists & inhibitors | Prevention | Medical colleges | Digital integrated circuits | Melanoma | Cancer | Integrins | dual mTORC1 | 2 inhibition
Journal Article
Circulation research, ISSN 0009-7330, 5/2014, Volume 114, Issue 10, pp. 1576 - 1584
Journal Article
Journal Article
The Journal of cell biology, ISSN 0021-9525, 2017, Volume 216, Issue 12, pp. 3895 - 3898
The lysosomal Ragulator complex regulates cell metabolism and growth by coordinating the activities of metabolic signaling pathways with nutrient availability.... 
COMPLEX | MTORC1 | CANCER | CELL BIOLOGY
Journal Article
Journal Article