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Biochemistry and Cell Biology, ISSN 0829-8211, 2019, Volume 97, Issue 1, pp. 58 - 67
The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that senses and integrates environmental information into... 
mTOR | mTORC2 | mTORC1
Journal Article
Oncogene, ISSN 0950-9232, 11/2017, Volume 36, Issue 45, pp. 6225 - 6234
Programmed cell death 4 (Pdcd4), a tumor invasion suppressor, is frequently down-regulated in colorectal cancer and other cancers. In this study, we find that... 
Pdcd4 | Akt | invasion | mTORC2 | Sin1 | eIF4A
Journal Article
Oncotarget, ISSN 1949-2553, 08/2019, Volume 10, Issue 50, p. 5126
Although oncogenic mutations in the three major Ras isoforms, , and , are present in nearly a third of human cancers, therapeutic targeting of Ras remains a... 
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 11/2014, Volume 193, Issue 9, pp. 4297 - 4301
Invariant natural killer T (iNKT) cells have been recently classified into NKT1, NKT2 and NKT17 lineages with distinct transcription factor and cytokine... 
NKT17 | Pten | mTORC2 | iNKT
Journal Article
Biology of Reproduction, ISSN 0006-3363, 09/2016, Volume 95, Issue 3, pp. 71 - 71
In all mammalian species, critical events, including uterine receptivity and development of the conceptus (embryo/fetus and its associated extraembryonic... 
Trophectoderm | SPP1 | Sheep | Cytoskeleton reorganization | MTORC2 | Arginine
Journal Article
Cell Cycle, ISSN 1538-4101, 06/2019, Volume 18, Issue 12, pp. 1295 - 1301
Poly(ADP-ribose) polymerase 3 (PARP3) is the third member of the PARP family that catalyze a post-translational modification of proteins to promote, control or... 
cancer aggressiveness | Poly(ADP-ribose) polymerase 3/EMT/mTORC2 | Poly(ADP-ribose) polymerase 3 | TGF-BETA | PHOSPHORYLATION | DNA | ADP-RIBOSYLATION | PHENOTYPE | mTORC2 | MESENCHYMAL TRANSITION | EMT | CELL BIOLOGY
Journal Article
Journal Article
Cellular Immunology, ISSN 0008-8749, 01/2019, Volume 335, pp. 30 - 40
POTE is known as cancer antigen, expressed in many cancers, along with very few normal tissues like prostate, ovary, testes and embryo. Till date, POTEE... 
POTEE | mTORC2 activation | MΦs | TAMs | Protein-protein interaction
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 01/2020, Volume 499, p. 110604
Until three decades, ago 3,5-diiodothyronine (3,5-T ) and 3,3′-diiodothyronine (3,3′-T ) were considered products of thyroid hormone catabolism without... 
Diiodothyronines | Metabolic homeostasis | Human primary hepatocytes | mTORC2 | mTORC1 | Lipid and glucose metabolism
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 2019, Volume 10, p. 167
Podocytes, dynamic polarized cells wrapped around glomerular capillaries, are an essential component of the glomerular filtration barrier. BK channels consist... 
Podocyte | MTORC2 | Akt | BK channels | PKCα | SGK1
Journal Article
Trends in Endocrinology and Metabolism, ISSN 1043-2760, 11/2018, Volume 29, Issue 11, pp. 737 - 739
Mechanistic target of rapamycin complex (mTORC)1 is the major regulator of metabolism at the cellular and organismal level. mTORC1-mediated regulatory feedback... 
IGF-I | feedback loops | mTORC2 | IRS1 | mTORC1 | METABOLISM | ENDOCRINOLOGY & METABOLISM
Journal Article
Genes and Development, ISSN 0890-9369, 12/2013, Volume 27, Issue 24, pp. 2642 - 2647
Journal Article
Cancers, ISSN 2072-6694, 01/2018, Volume 10, Issue 1, p. 23
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and... 
Targeted therapies | MTORC1 | MTORC2 | Cross-talk | Cancer | MAMMALIAN TARGET | MESSENGER-RNA TRANSLATION | targeted therapies | cross-talk | RENAL-CELL CARCINOMA | PROTEIN-KINASE B | PHASE-III TRIAL | BREAST-CANCER | TUBEROUS SCLEROSIS COMPLEX | TUMOR-SUPPRESSOR COMPLEX | ONCOLOGY | HEMATOPOIETIC STEM-CELLS | cancer | mTORC2 | mTORC1 | NF-KAPPA-B | TOR protein | Cell growth | Rapamycin | Drug resistance | Metabolism | Drug therapy
Journal Article
Cell Reports, ISSN 2211-1247, 10/2019, Volume 29, Issue 1, pp. 236 - 248.e3
Calorie restriction (CR) extends the healthspan and lifespan of diverse species. In mammals, a broadly conserved metabolic effect of CR is improved insulin... 
insulin sensitivity | frailty | calorie restriction | fitness | lifespan | Rictor | adipose | lipogenesis | mTORC2 | healthspan
Journal Article