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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 24, pp. 8452 - 8457
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to... 
Obesity | Gels | Nonesterified fatty acids | Palmitates | Type 2 diabetes mellitus | Diabetes | Islets of Langerhans | Insulin | Fatty acids | Apoptosis | Type 2 diabetes | 2D difference gel electrophoresis proteomics | Hyperproinsulinemia | Mechanisms of β-cell lipotoxicity | Free fatty acids | LEVELS PREDICT | HUMAN PANCREATIC-ISLETS | ENZYME-ACTIVITY | MULTIDISCIPLINARY SCIENCES | mechanisms of beta-cell lipotoxicity | INSULIN-SECRETION | free fatty acids | ENDOPLASMIC-RETICULUM STRESS | type 2 diabetes | PYRUVATE-DEHYDROGENASE ACTIVITY | PROHORMONE CONVERTASES | FREE FATTY-ACIDS | LINE INS-1 | TRIGLYCERIDE ACCUMULATION | hyperproinsulinemia | Endoplasmic Reticulum - enzymology | Golgi Apparatus - enzymology | Cell Survival | Diabetes Mellitus, Type 2 - genetics | Humans | Cells, Cultured | Diabetes Mellitus, Type 2 - enzymology | Apoptosis - genetics | Proteome | Hyperglycemia - genetics | Insulin-Secreting Cells - ultrastructure | Animals | Insulin-Secreting Cells - drug effects | Mice, Mutant Strains | Palmitates - pharmacology | Carboxypeptidase H - metabolism | Hyperglycemia - enzymology | Hyperinsulinism - enzymology | Hyperinsulinism - genetics | Mice | Palmitates - metabolism | Carboxypeptidase H - genetics | Insulin-Secreting Cells - enzymology | Biological Sciences | mechanisms of β-cell lipotoxicity
Journal Article
Journal Article
Journal Article
BIOLOGICAL RESEARCH, ISSN 0716-9760, 08/2019, Volume 52, Issue 1, pp. 44 - 12
Background: Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic beta-cells that is activated by a variety of... 
Type 2 diabetes | MAMMALIAN TARGET | ACTIVATION | IRS-1 | INSR | MECHANISMS | Akt | Palmitic acid | RECEPTOR SUBSTRATE-1 | STIMULATED INSULIN-SECRETION | FREE FATTY-ACIDS | GLUCOSE | BIOLOGY | mTOR | GENE-EXPRESSION | RESISTANCE | Insulin resistance | beta-cells | FFAR1 | Lipotoxicity | EXPOSURE
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 09/2018, Volume 1861, Issue 9, pp. 803 - 814
Selective β-cell loss is a characteristic of type 2 diabetes mellitus (T2DM). Inhibition of glucose-stimulated β-cell proliferation is one of the results of... 
Egr-1 | Glucolipotoxicity | Wnt5a | β-cell | Lipotoxicity | Saturated fatty acids | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN-SECRETION | ENDOPLASMIC-RETICULUM STRESS | TESTICULAR NEOPLASMS | BIOPHYSICS | GLUCAGON-LIKE PEPTIDE-1 | beta-cell | SIGNALING PATHWAY | PRIMARY MECHANISM | FREE FATTY-ACIDS | GROWTH-FACTOR | TRANSCRIPTION FACTOR
Journal Article
by Li, J and Liu, X and Ran, X and Chen, J and Li, X and Wu, W and Huang, H and Huang, H and Long, Y and Liang, J and Cheng, J and Tian, H
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 01/2010, Volume 12, Issue 1, pp. 35 - 46
Journal Article
Endocrinology, ISSN 0013-7227, 03/2010, Volume 151, Issue 3, pp. 859 - 864
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, p. 44746
Journal Article