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Blood, ISSN 0006-4971, 07/2014, Volume 124, Issue 2, pp. 277 - 286
Megakaryocyte (MK) development in the bone marrow progresses spatially from the endosteal niche, which promotes MK progenitor proliferation, to the sinusoidal... 
PROGENITOR CELLS | PLATELET-RELEASE | CHEMOKINE RECEPTOR CXCR4 | DIPROTIN-A | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | C-MPL LIGAND | HEMATOLOGY | PROPLATELET FORMATION | DIPEPTIDYL PEPTIDASE-IV | MARROW VASCULAR NICHE | Chemokine CXCL12 - physiology | Stem Cell Niche - radiation effects | Bone Marrow Cells - physiology | Cell Movement - genetics | Thrombopoiesis - genetics | Cell Differentiation - genetics | Megakaryocyte Progenitor Cells - radiation effects | Bone Marrow Cells - drug effects | Female | Megakaryocytes - cytology | Megakaryocytes - radiation effects | Thrombopoiesis - drug effects | Stem Cell Niche - genetics | Chemokine CXCL12 - administration & dosage | Megakaryocyte Progenitor Cells - cytology | Radiation Injuries, Experimental - genetics | Cell Differentiation - radiation effects | Megakaryocyte Progenitor Cells - drug effects | Bone Marrow Cells - cytology | Megakaryocyte Progenitor Cells - physiology | Mice, Inbred C57BL | Cells, Cultured | Megakaryocytes - physiology | Receptors, CXCR4 - administration & dosage | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Cell Movement - radiation effects | Receptors, CXCR4 - metabolism | Cell Movement - drug effects | Thrombopoiesis - radiation effects | Animals | Cell Differentiation - drug effects | Mice | Stem Cell Niche - drug effects | Megakaryocytes - drug effects | Platelets and Thrombopoiesis
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 584 - 596
We report a knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we... 
CELLCYCLE | POLYCYTHEMIA-VERA | ACTIVATING MUTATION | ONCOLOGY | IN-VIVO | TYROSINE KINASE JAK2 | CONDITIONAL EXPRESSION | MYELODYSPLASTIC-SYNDROMES | ESSENTIAL THROMBOCYTHEMIA | VERA-LIKE DISEASE | CHRONIC MYELOMONOCYTIC LEUKEMIA | CHRONIC MYELOID-LEUKEMIA | Erythropoietin - pharmacology | Gene Expression - genetics | Cell Count | Humans | Hematocrit | Hematopoietic Stem Cells - pathology | Polycythemia Vera - genetics | Gene Expression Profiling | Myeloproliferative Disorders - pathology | Spleen - drug effects | Antigens, CD - metabolism | Bone Marrow Transplantation | Megakaryocyte-Erythroid Progenitor Cells - transplantation | Polycythemia Vera - pathology | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Megakaryocyte-Erythroid Progenitor Cells - metabolism | Hematopoietic Stem Cell Transplantation | Mice, Transgenic | Myeloid Progenitor Cells - pathology | Megakaryocyte-Erythroid Progenitor Cells - drug effects | Sulfonamides - pharmacology | Megakaryocyte Progenitor Cells - metabolism | Erythroid Precursor Cells - pathology | Survival Analysis | Erythroid Precursor Cells - metabolism | Mice | Megakaryocyte Progenitor Cells - pathology | Myeloproliferative Disorders - genetics | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Cell Differentiation - genetics | Janus Kinase 2 - metabolism | Bone Marrow Cells - drug effects | Spleen - pathology | Hematopoietic Stem Cells - drug effects | Myeloid Progenitor Cells - metabolism | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Hematopoietic Stem Cells - metabolism | Myeloproliferative Disorders - drug therapy | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Bone Marrow - pathology | Heterozygote | Protein Kinase Inhibitors - pharmacology | Amino Acid Substitution | Megakaryocyte-Erythroid Progenitor Cells - pathology | Physiological aspects | Medical colleges | Analysis | Hematopoietic stem cells | Tumors
Journal Article
Genome Biology, ISSN 1474-7596, 2016, Volume 17, Issue 1, p. 83
Journal Article
Journal Article
Blood, ISSN 0006-4971, 10/2013, Volume 122, Issue 18, pp. 3178 - 3187
Journal Article
DNA Repair, ISSN 1568-7864, 07/2016, Volume 43, pp. 78 - 88
The family of Ten-Eleven Translocation (TET) proteins is implicated in the process of active DNA demethylation and thus in epigenetic regulation. TET 1, 2 and... 
TET2 | Genetic instability | 5-hmC | TDG | Cell cycle | 5-METHYLCYTOSINE | CONVERSION | ACUTE MYELOID-LEUKEMIA | TET PROTEINS | MLL | THYMINE DNA GLYCOSYLASE | DEMETHYLATION | GENETICS & HEREDITY | TOXICOLOGY | 5-FORMYLCYTOSINE | 5-CARBOXYLCYTOSINE | Cytosine - analogs & derivatives | Genomic Instability | 5-Methylcytosine - analogs & derivatives | Epigenesis, Genetic | Humans | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Cytosine - metabolism | Base Sequence | S Phase | Thymine DNA Glycosylase - genetics | B-Lymphocytes - metabolism | Megakaryocyte Progenitor Cells - cytology | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | B-Lymphocytes - cytology | Hydroxylation | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Megakaryocyte Progenitor Cells - metabolism | Animals | 5-Methylcytosine - metabolism | Mutagenesis | DNA Repair | Thymine DNA Glycosylase - deficiency | Fibroblasts - cytology | Mice | Index Medicus | Megakaryocyte Progenitor Cells/metabolism | Thymine DNA Glycosylase/genetics | Proto-Oncogene Proteins/genetics | Cytosine/metabolism | B-Lymphocytes/metabolism | Genomics | Cytosine/analogs & derivatives | Tumor Suppressor Protein p53/metabolism | DNA-Binding Proteins/metabolism | B-Lymphocytes/cytology | Life Sciences | Thymine DNA Glycosylase/deficiency | Fibroblasts/metabolism | Fibroblasts/cytology | Biochemistry, Molecular Biology | 5-Methylcytosine/metabolism | Proto-Oncogene Proteins/metabolism | Tumor Suppressor Protein p53/genetics | Megakaryocyte Progenitor Cells/cytology | 5-Methylcytosine/analogs & derivatives | DNA-Binding Proteins/genetics
Journal Article
Journal Article