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Obesity Facts, ISSN 1662-4025, 04/2009, Volume 2, Issue 2, pp. 80 - 86
Background: Melanocortin 3 and 4 receptors (MC3R and MC4R) are known to play an essential role in hypothalamic weight regulation. In addition to these two... 
Original Article | GPCR | Weight regulation | Hypothalamus | Paraventricular nucleus | Dimerization | Arcuate nucleus | GABA(B) RECEPTORS | ONSET OBESITY | CROSS-TALK | MC4R | TARGETED DISRUPTION | NUTRITION & DIETETICS | ENDOCRINOLOGY & METABOLISM | NEURONS | FRAMESHIFT MUTATION | OLIGOMERIZATION | MELANOCORTIN-4 RECEPTOR | Receptors, G-Protein-Coupled - metabolism | Receptor, Melanocortin, Type 3 - genetics | Humans | Cercopithecus aethiops | Receptor, Melanocortin, Type 3 - metabolism | Receptors, Neuropeptide Y - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Receptors, Neuropeptide - metabolism | Receptors, Peptide - chemistry | Obesity - genetics | Receptors, Peptide - genetics | Transfection | Gene Expression - physiology | Receptor, Serotonin, 5-HT1B - genetics | Fluorescence Resonance Energy Transfer | Receptor, Cannabinoid, CB1 - chemistry | Receptor, Serotonin, 5-HT1B - metabolism | Receptors, Cell Surface - chemistry | Receptor, Melanocortin, Type 3 - chemistry | Receptors, Opioid, mu - chemistry | Enzyme-Linked Immunosorbent Assay | Receptor, Melanocortin, Type 4 - chemistry | Receptors, Opioid, mu - metabolism | Arcuate Nucleus of Hypothalamus - metabolism | Receptors, Cell Surface - metabolism | Receptors, Neuropeptide - genetics | Obesity - physiopathology | Kidney - cytology | Receptor, Melanocortin, Type 4 - genetics | Obesity - metabolism | Receptors, Neuropeptide Y - chemistry | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Receptors, Neuropeptide Y - genetics | Paraventricular Hypothalamic Nucleus - metabolism | Receptor, Serotonin, 5-HT1B - chemistry | Receptors, G-Protein-Coupled - genetics | Receptors, Opioid, mu - genetics | Body Weight - physiology | COS Cells | Receptors, G-Protein-Coupled - chemistry | Receptors, Neuropeptide - chemistry | Receptors, Cell Surface - genetics | Receptors, Peptide - metabolism | Original
Journal Article
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 08/2014, Volume 394, Issue 1-2, pp. 99 - 104
•5 Were peptides tested for antagonistic activity at the 5 human melanocortin receptors.•2 Peptides dose-dependently antagonized ACTH-stimulated MC2R... 
Antagonist | Adrenocorticotropic hormone (ACTH) | Melanocortin 2 receptor (MC2R) | Cushing’s disease | ACTIVATION | ANALOGS | MEDICAL-TREATMENT | PEPTIDE | CELL BIOLOGY | CUSHINGS-SYNDROME | Cushing's disease | ADRENOCORTICOTROPIN RECEPTOR | DISEASE | ENDOCRINOLOGY & METABOLISM | CONSENSUS STATEMENT | BINDING | RESIDUES | Receptor, Melanocortin, Type 3 - genetics | Humans | Adrenocorticotropic Hormone - pharmacology | Molecular Sequence Data | Receptor, Melanocortin, Type 3 - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Structure-Activity Relationship | Receptor, Melanocortin, Type 1 - metabolism | Adrenocorticotropic Hormone - genetics | Pituitary ACTH Hypersecretion - drug therapy | Receptor, Melanocortin, Type 2 - metabolism | Dose-Response Relationship, Drug | Receptor, Melanocortin, Type 2 - genetics | Peptides - chemical synthesis | Transfection | Receptor, Melanocortin, Type 1 - chemistry | Receptors, Melanocortin - metabolism | Drug Design | HEK293 Cells | Receptor, Melanocortin, Type 2 - chemistry | Receptor, Melanocortin, Type 2 - antagonists & inhibitors | Receptor, Melanocortin, Type 3 - chemistry | Adrenocorticotropic Hormone - metabolism | Amino Acid Sequence | Gene Expression | Receptor, Melanocortin, Type 4 - chemistry | Receptor, Melanocortin, Type 1 - genetics | Receptor, Melanocortin, Type 4 - genetics | Receptors, Melanocortin - genetics | Peptides - pharmacology | Receptors, Melanocortin - chemistry | Protein Binding | Peptides
Journal Article
Endocrinology, ISSN 0013-7227, 06/2009, Volume 150, Issue 6, pp. 2646 - 2653
Journal Article
Neuroendocrinology, ISSN 0028-3835, 06/2012, Volume 95, Issue 4, pp. 277 - 288
The worldwide obesity epidemic is increasing, yet at this time, no long-acting and specific pharmaceutical therapies are available. Peripheral hormonal signals... 
G protein-coupled receptor | Growth hormone secretagogue receptor | Melanocortin 3 receptor | Weight regulation | Melanocortin 4 receptor | Dimerization | HUMAN MELANOCORTIN-4 RECEPTOR | GHRELIN RECEPTOR | FOOD-INTAKE | PROTEIN-COUPLED RECEPTORS | PHARMACOLOGICAL IN-VITRO | CONSTITUTIVE ACTIVITY | NEUROSCIENCES | ENERGY-BALANCE | ENDOCRINOLOGY & METABOLISM | AIRWAY SMOOTH-MUSCLE | HORMONE SECRETAGOGUE RECEPTOR | PRADER-WILLI-SYNDROME | Paraventricular Hypothalamic Nucleus - physiology | Arcuate Nucleus of Hypothalamus - metabolism | Humans | Receptor, Melanocortin, Type 3 - metabolism | Receptor, Melanocortin, Type 4 - metabolism | Receptors, Ghrelin - physiology | Arcuate Nucleus of Hypothalamus - physiology | Animals | Arcuate Nucleus of Hypothalamus - anatomy & histology | Models, Biological | Protein Multimerization - physiology | Paraventricular Hypothalamic Nucleus - metabolism | Receptors, Ghrelin - metabolism | Paraventricular Hypothalamic Nucleus - anatomy & histology | Receptor, Melanocortin, Type 3 - physiology | Appetite Regulation - physiology | Body Weight - physiology | Receptor, Melanocortin, Type 4 - physiology | Drugs | Brain | Epidemics | Obesity | Energy metabolism | G protein-coupled receptors | Arcuate nucleus | Body weight | Melanocortin MC4 receptors | Hypothalamus | Paraventricular nucleus | Reviews | Melanocortin receptors | Receptor mechanisms | Growth hormone | Pharmaceuticals
Journal Article
JOURNAL OF MOLECULAR ENDOCRINOLOGY, ISSN 0952-5041, 06/2014, Volume 52, Issue 3, pp. T29 - T42
The melanocortin receptors (MCRs) are a family of G protein-coupled receptors that are activated by melanocortin ligands derived from the proprotein,... 
HYPOTHALAMIC CONTROL | ACTH-DERIVED PEPTIDES | ACTH | CARTILAGINOUS FISH | SPINY DOGFISH | MC4R | melanocortin peptides | MC2R | HUMAN MELANOCORTIN-2 RECEPTOR | FUNCTIONAL EXPRESSION | ADRENOCORTICOTROPIN RECEPTOR | ENDOCRINOLOGY & METABOLISM | alpha-MSH | ACCESSORY PROTEIN MRAP | PHYSIOLOGICAL FUNCTIONS | MRAP2 | melanocortin receptors | MRAP1 | SQUALUS-ACANTHIAS
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 03/2015, Volume 7, Issue 3, pp. 288 - 298
Journal Article
Journal Article
Journal Article