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Journal of Biological Chemistry, ISSN 0021-9258, 08/2009, Volume 284, Issue 34, pp. 23001 - 23011
Fibroblasts degrade type I collagen, the major extracellular protein found in mammals, during events ranging from bulk tissue resorption to invasion through... 
1-MATRIX METALLOPROTEINASE | TYPE-1 MATRIX-METALLOPROTEINASE | SUBSTRATE DEGRADATION | GELATINASE-A | CELL-MIGRATION | CYSTEINE PROTEINASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TARGETED MUTATION | EXTRACELLULAR-MATRIX | DEFICIENT MICE | MEDIATED INHIBITION | Matrix Metalloproteinase 9 - physiology | Matrix Metalloproteinase 8 - physiology | Matrix Metalloproteinase 2 - physiology | Tissue Inhibitor of Metalloproteinase-2 - genetics | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - genetics | Plasminogen - pharmacology | Matrix Metalloproteinase 16 - genetics | Membrane Proteins - metabolism | Fibroblasts - metabolism | Matrix Metalloproteinase 8 - genetics | Collagen Type I - metabolism | Proto-Oncogene Proteins c-sis | Matrix Metalloproteinase 13 - genetics | Mice, Inbred C57BL | Cells, Cultured | Platelet-Derived Growth Factor - pharmacology | Microscopy, Electron | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Tissue Inhibitor of Metalloproteinase-2 - physiology | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase 14 - physiology | Animals | Matrix Metalloproteinase 16 - physiology | Matrix Metalloproteinase 13 - physiology | Fibroblasts - drug effects | Fluorescent Antibody Technique | Matrix Metalloproteinase 14 - genetics | Cell Proliferation - drug effects | Mice | Collagenases - metabolism | Molecular Basis of Cell and Developmental Biology
Journal Article
Developmental Dynamics, ISSN 1058-8388, 05/2011, Volume 240, Issue 5, pp. 1127 - 1141
We used an antibody array to compare the protein expression of matrix metalloproteinases (MMPs)-1, -2, -3, -8, -9, -10, and -13, as well as the tissue... 
Matrix metalloproteinases | Histolysis | Limb regeneration | Amphibian | Blastema | BREAST EPITHELIAL-CELLS | TIMP-2 | blastema | MECHANISM | ANATOMY & MORPHOLOGY | DEVELOPMENTAL BIOLOGY | amphibian | GROWTH-PROMOTING ACTIVITY | AXOLOTL | histolysis | SIGNALING PATHWAY | FORELIMB REGENERATION | limb regeneration | TISSUE INHIBITOR | EXTRACELLULAR-MATRIX | matrix metalloproteinases | NEWT TRITURUS-VIRIDESCENS | Xenopus - physiology | Matrix Metalloproteinases - genetics | Xenopus Proteins - genetics | Xenopus - embryology | Extremities - embryology | Tissue Inhibitor of Metalloproteinases - genetics | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 8 - metabolism | Matrix Metalloproteinase 9 - genetics | Regeneration - genetics | Matrix Metalloproteinase 10 - metabolism | Extremities - physiology | Matrix Metalloproteinase 1 - genetics | Matrix Metalloproteinase 8 - genetics | Matrix Metalloproteinase 10 - genetics | Matrix Metalloproteinase 13 - genetics | Matrix Metalloproteinase 3 - metabolism | Regeneration - physiology | Blotting, Western | Tissue Inhibitor of Metalloproteinases - metabolism | Matrix Metalloproteinase 13 - metabolism | Animals | Xenopus - metabolism | Xenopus Proteins - metabolism | Matrix Metalloproteinases - metabolism | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics
Journal Article
World Journal of Surgery, ISSN 0364-2313, 05/2017, Volume 41, Issue 5, pp. 1259 - 1266
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2013, Volume 21, Issue 21, pp. 6456 - 6465
Journal Article
Matrix Biology, ISSN 0945-053X, 2011, Volume 30, Issue 2, pp. 145 - 153
Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix... 
MMP | ADAMTS | Interglobular domain | Chondroitin-sulfate-2 region | Aggrecan catabolism | RHEUMATOID-ARTHRITIS | PROTEOLYTIC CLEAVAGE | CLEAVAGE SITE | ACTIVATION MECHANISMS | LARGE AGGREGATING PROTEOGLYCAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | HUMAN ARTICULAR-CARTILAGE | MATRIX METALLOPROTEINASES | OSTEOARTHRITIC CARTILAGE | ONCOSTATIN-M | Matrix Metalloproteinases, Secreted - metabolism | Interleukin-1beta - pharmacology | Phenylmercuric Acetate - pharmacology | Matrix Metalloproteinase 12 - genetics | Cartilage - drug effects | Oncostatin M - pharmacology | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 7 - metabolism | Cattle | Isoenzymes - metabolism | Matrix Metalloproteinase 8 - metabolism | Gelatinases - metabolism | Matrix Metalloproteinase 1 - genetics | Recombinant Proteins - metabolism | Endopeptidases - metabolism | Matrix Metalloproteinase 8 - genetics | Peptide Fragments - metabolism | Isoenzymes - genetics | Matrix Metalloproteinase 2 - metabolism | Matrix Metalloproteinase 3 - metabolism | Aggrecans - metabolism | Matrix Metalloproteinase 12 - metabolism | Cartilage - metabolism | Aggrecans - genetics | ADAM Proteins - metabolism | Enzyme Precursors - metabolism | Matrix Metalloproteinase 7 - genetics | Animals | Endopeptidases - genetics | Matrix Metalloproteinases, Secreted - genetics | Phenylmercuric Acetate - analogs & derivatives | ADAM Proteins - genetics | Cartilage - enzymology | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 08/2006, Volume 8, Issue 5, pp. R142 - R142
Excess proteolysis of the extracellular matrix (ECM) of articular cartilage is a key characteristic of arthritis. The main enzymes involved belong to the... 
IN-VITRO | ONCOSTATIN-M | MATRIX-METALLOPROTEINASE | PROTECTS CARTILAGE | GENE-EXPRESSION | PROTEOGLYCAN CATABOLISM | ARTICULAR CHONDROCYTES | NECROSIS-FACTOR-ALPHA | EXTRACELLULAR-MATRIX | RHEUMATOLOGY | BOVINE NASAL CARTILAGE | Matrix Metalloproteinase 12 - genetics | Gene Expression Profiling | Gene Expression Regulation, Enzymologic - physiology | Metalloproteases - metabolism | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Nasal Septum - cytology | Cattle | Matrix Metalloproteinase 9 - genetics | Matrix Metalloproteinase 16 - genetics | Tissue Inhibitor of Metalloproteinase-3 - metabolism | Up-Regulation - physiology | Cartilage - cytology | Cartilage - physiology | Matrix Metalloproteinase 1 - genetics | Organ Culture Techniques | Tissue Inhibitor of Metalloproteinase-3 - genetics | Matrix Metalloproteinase 2 - metabolism | Matrix Metalloproteinase 13 - genetics | Matrix Metalloproteinase 16 - metabolism | Metalloproteases - genetics | Matrix Metalloproteinase 3 - metabolism | Matrix Metalloproteinase 12 - metabolism | Matrix Metalloproteinase 14 - metabolism | Matrix Metalloproteinase 13 - metabolism | Down-Regulation - physiology | Collagen - metabolism | Matrix Metalloproteinase 2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | ADAM Proteins - metabolism | Animals | Homeostasis - physiology | Matrix Metalloproteinase 14 - genetics | ADAM Proteins - genetics | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics
Journal Article
Bioscience, Biotechnology, and Biochemistry, ISSN 0916-8451, 10/2015, Volume 79, Issue 10, pp. 1597 - 1602
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade many extracellular matrix components and that have been implicated in the... 
inhibitor | matrix metalloproteinase | chemical arrays | Inhibitor | Chemical arrays | Matrix metalloproteinase | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | MICROBIAL METABOLITES | THIOESTERASES | CANCER | DISEASES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MATRIX-METALLOPROTEINASE-9 | HEMOPEXIN DOMAIN | PROTEIN-LIGAND INTERACTIONS | CHEMISTRY, APPLIED | SMALL-MOLECULE MICROARRAYS | TOOLS | Fluoresceins - pharmacology | Small Molecule Libraries - pharmacology | Fibroblasts - enzymology | Humans | Matrix Metalloproteinase 12 - genetics | Histidine - metabolism | Recombinant Fusion Proteins - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Microarray Analysis | Matrix Metalloproteinase 2 - chemistry | Fluoresceins - chemistry | Gene Expression | Matrix Metalloproteinase 13 - chemistry | Matrix Metalloproteinase 2 - metabolism | Extracellular Matrix - drug effects | Matrix Metalloproteinase 13 - genetics | Oligopeptides - genetics | Histidine - genetics | Matrix Metalloproteinase Inhibitors - chemistry | Isoxazoles - chemistry | Matrix Metalloproteinase 12 - metabolism | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Fibroblasts - pathology | Drug Discovery | Matrix Metalloproteinase 12 - chemistry | Matrix Metalloproteinase 13 - metabolism | Isoxazoles - pharmacology | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase Inhibitors - pharmacology | Small Molecule Libraries - chemistry | High-Throughput Screening Assays | Fibroblasts - drug effects | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Matrix Metalloproteinase 9 - chemistry
Journal Article
Experimental Cell Research, ISSN 0014-4827, 08/2012, Volume 318, Issue 13, pp. 1517 - 1527
Co-culture of periodontal ligament (PDL) fibroblasts and SCC-25 oral squamous carcinoma cells (OSCC), results in conversion of PDLs into carcinoma-associated... 
Metastasis | Co-culture insert | HNSCC | Matrix remodeling | HEAD | ACTIVATION | TRANSCRIPTION | OVARIAN-CANCER | MESENCHYMAL TRANSITION | CELL BIOLOGY | LUNG-CANCER | SYNOVIAL FIBROBLASTS | ONCOLOGY | GENE-EXPRESSION | STROMAL FIBROBLASTS | CLINICAL-SIGNIFICANCE | Matrix Metalloproteinases - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Coculture Techniques | Humans | Gene Expression Regulation, Neoplastic | Mouth Neoplasms - metabolism | Periodontal Ligament - metabolism | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Tissue Inhibitor of Metalloproteinases - genetics | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Mouth Neoplasms - genetics | Fibroblasts - metabolism | Paracrine Communication | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | RNA, Messenger - genetics | Cells, Cultured | Fibroblasts - pathology | Matrix Metalloproteinase 14 - metabolism | Tissue Inhibitor of Metalloproteinases - metabolism | Periodontal Ligament - pathology | Gene Expression Regulation, Enzymologic | Matrix Metalloproteinase 2 - genetics | Models, Biological | Matrix Metalloproteinase 14 - genetics | Cell Line, Tumor | Mouth Neoplasms - pathology | RNA, Neoplasm - genetics | Matrix Metalloproteinases - metabolism | Fibronectins | Squamous cell carcinoma | Care and treatment | Dexamethasone | Carcinoma | Corticosteroids | RNA | Transforming growth factors | Gene expression | Analysis | Tumors | Integrins | Cancer | Proteins | Enzymes | Oral cancer | Ligaments | 1MMP, matrix metalloproteinase | MT1-MMP, membrane-type 1 matrix metalloproteinase | EMT, epithelial-to-mesenchymal transition | HNSCC, head and neck squamous cell carcinoma | ECM, extracellular matrix | FN, fibronectin | DEX, dexamethasone | COX-2, prostaglandin-endoperoxide synthase 2 | CAFs, carcinoma-associated fibroblasts | IMVD, intratumoral microvessel density | TGF-β1, transforming growth factor-β1 | IL, interleukin | PDL, periodontal ligament (PDL) fibroblasts | FBS, foetal bovine serum | OSCC, oral squamous cell carcinoma | TIMP, tissue inhibitor of metalloproteinases | LTBP-1, latent-transforming growth factor beta-binding protein
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2017, Volume 359, Issue 2, pp. 431 - 440
Extracellular matrix (ECM) remodeling is necessary for a health adipose tissue (AT) expansion and also has a role during weight loss. We investigate the ECM... 
Adipose tissue | Matrix metalloproteinase | Extracellular matrix remodeling | Ilomastat | GM6001 | PATHWAYS | CELLS | TISSUE | REGAIN | DIET-INDUCED OBESITY | CELL BIOLOGY | THERMOGENESIS | METABOLISM | ONCOLOGY | INSULIN-RESISTANCE | FLUCTUATIONS | Caloric Restriction | Diet, High-Fat - adverse effects | Extracellular Matrix - metabolism | Male | Matrix Metalloproteinase 12 - genetics | Weight Loss - drug effects | Obesity - genetics | Matrix Metalloproteinase 9 - metabolism | Protein Isoforms - metabolism | Matrix Metalloproteinase 8 - metabolism | Matrix Metalloproteinase 9 - genetics | Obesity - etiology | Weight Gain - drug effects | Collagen - genetics | Intra-Abdominal Fat - drug effects | Matrix Metalloproteinase 8 - genetics | Gene Expression | Matrix Metalloproteinase 2 - metabolism | Dipeptides - pharmacology | Extracellular Matrix - drug effects | Matrix Metalloproteinase 3 - metabolism | Matrix Metalloproteinase 12 - metabolism | Intra-Abdominal Fat - metabolism | Obesity - pathology | Collagen - metabolism | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase Inhibitors - pharmacology | Animals | Energy Metabolism | Lipid Metabolism - drug effects | Inflammation - prevention & control | Mice | Obesity - enzymology | Matrix Metalloproteinase 3 - genetics | Protein Isoforms - genetics | Obesity | Medical colleges | Collagen
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 05/2016, Volume 68, Issue 5, pp. 1111 - 1123
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0127063 - e0127063
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal... 
CELL LUNG-CANCER | RHEUMATOID-ARTHRITIS | INFLAMMATORY-BOWEL-DISEASE | TUMOR PROGRESSION | MATRIX-METALLOPROTEINASE INHIBITORS | MATRIX-METALLOPROTEINASE-9 MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | GELATINASE-B | IN-VIVO | GENE-EXPRESSION | DOWN-REGULATION | Dextran Sulfate | Epitope Mapping | Colitis, Ulcerative - enzymology | Allosteric Regulation | Colorectal Neoplasms - genetics | Humans | Colitis, Ulcerative - genetics | Gene Expression Regulation, Neoplastic | Rats, Inbred Lew | Male | Antineoplastic Agents - metabolism | Matrix Metalloproteinase 9 - metabolism | Antineoplastic Agents - isolation & purification | Matrix Metalloproteinase 9 - genetics | Antibodies, Monoclonal, Humanized - biosynthesis | Antibodies, Monoclonal, Humanized - isolation & purification | Antibodies, Monoclonal, Humanized - pharmacology | Colorectal Neoplasms - drug therapy | Female | Antineoplastic Agents - pharmacology | Colitis, Ulcerative - drug therapy | Drug Evaluation, Preclinical | Disease Models, Animal | Recombinant Proteins - metabolism | Colorectal Neoplasms - enzymology | Signal Transduction | Rats | Recombinant Proteins - genetics | Matrix Metalloproteinase Inhibitors - metabolism | Recombinant Proteins - administration & dosage | Xenograft Model Antitumor Assays | Matrix Metalloproteinase Inhibitors - pharmacology | Animals | Colitis, Ulcerative - chemically induced | Mice, Nude | Hybridomas - immunology | Mice | Colorectal Neoplasms - pathology | Matrix Metalloproteinase Inhibitors - isolation & purification | Matrix Metalloproteinase 9 - administration & dosage | Monoclonal antibodies | Inflammation | Metastasis | Health aspects | Colorectal cancer | Ulcerative colitis | Drugs | Animal models | Inflammatory bowel diseases | Matrix metalloproteinases | Disease | Toxicity | Colorectal carcinoma | Biology | Biochemistry | Matrix metalloproteinase | Drug development | Kinases | Metastases | Allosteric properties | Rodents | Surgery | Sodium sulfate | Xenografts | Tumorigenesis | Metalloproteinase | Inhibition | Drug therapy | Growth factors | Medical research | Cytokines | Neutrophils | Stroma | Metabolism | Patients | Gelatinase B | Inflammatory bowel disease | Dextran | Inhibitors | Sodium | Sulfate | Tumors | Cancer | Apoptosis | Index Medicus
Journal Article