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Plant, Cell & Environment, ISSN 0140-7791, 02/2013, Volume 36, Issue 2, pp. 429 - 437
ABSTRACT The methylerythritol phosphate (MEP) pathway in plants produces the prenyl precursors for all plastidic isoprenoids, including carotenoids and... 
MEP pathway | isoprenoids | methylerythritol cyclodiphosphate (MEcDP) | hydroxymethylbutenyl diphosphate synthase (HDS) | dimethylallyl diphosphate (DMADP) | Hydroxymethylbutenyl diphosphate synthase (HDS) | Dimethylallyl diphosphate (DMADP) | Methylerythritol cyclodiphosphate (MEcDP) | Isoprenoids | DIFFERENT ENVIRONMENTAL-CONDITIONS | CHLOROPLASTS | NON-MEVALONATE PATHWAY | 4FE-4S PROTEIN | PLANT SCIENCES | ASPEN LEAVES | BIOSYNTHESIS | DIPHOSPHATE SYNTHASE GCPE | EMISSION | 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE | Darkness | Erythritol - analogs & derivatives | Erythritol - chemistry | Populus - radiation effects | Chromatography, High Pressure Liquid | Acclimatization - radiation effects | Hemiterpenes - metabolism | Reference Standards | Time Factors | Light | Mass Spectrometry | Populus - metabolism | Nitrogen - pharmacology | Erythritol - metabolism | Plant Leaves - drug effects | Fosfomycin - analogs & derivatives | Pentanes - metabolism | Metabolome - radiation effects | Fosfomycin - pharmacology | Plant Extracts | Plant Leaves - radiation effects | Metabolome - drug effects | Plant Leaves - metabolism | Butadienes - metabolism | Metabolic Networks and Pathways - drug effects | Acclimatization - drug effects | Metabolic Networks and Pathways - radiation effects | Phosphates | Hydrogen sulfide | Carotenoids | Metabolites | Phytochemistry | Quinone | Nitriles | Mass spectrometry
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2013, Volume 587, Issue 17, pp. 2806 - 2817
The methylerythritol phosphate (MEP) pathway of ( ) has become an attractive target for anti-malarial drug discovery. This study describes a kinetic model of... 
Drug target | Kinetic model | Malaria | Metabolic control analysis | Methylerythritol phosphate (MEP) | flux control coefficient | 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol | HMBPP | IPP | SBML | 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol kinase | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase | MECPPS | BLAST | Isopentenyl pyrophosphate | FCC | basic local alignment search tool | MECPP | CDPME | GAP | MEP | DMAPP | DXP | DXS | methylerythritol phosphate | DXR | glyceraldehyde 3-phosphate | 2-C-methyl-d-erythritol 2,4-cyclodiphosphate | 1-deoxy-d-xylulose 5-phosphate | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate | PDB | concentration control coefficient | 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol | protein data bank | BLAST-P | dimethylallyl diphosphate | 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol synthase | CCC | PYR | 2-C-methyl-d-erythritol 2,4-cyclodiphosphate synthase | PSI-BLAST | 1-deoxy-d-xylulose 5-phosphate reductoisomerase | HMBPPR | pyruvate | 1-deoxy-d-xylulose 5-phosphate synthase | HMBPPS | system biology markup language | CDPMEP | protein BLAST | CDPMES | position-specific iterated BLAST | CDPMEK | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | NON-MEVALONATE PATHWAY | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE | CELL BIOLOGY | STEADY-STATE TREATMENT | SUBSTRATE-BINDING | BIOPHYSICS | BIOSYNTHESIS | PLANTS | SYSTEMS BIOLOGY | Enzymes - chemistry | Oxidoreductases - antagonists & inhibitors | Plasmodium falciparum - enzymology | Erythritol - analogs & derivatives | Models, Chemical | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Oxidoreductases - chemistry | Terpenes - metabolism | Computer Simulation | Enzyme Inhibitors - chemistry | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Erythritol - metabolism | Phosphorus-Oxygen Lyases - chemistry | Transferases - antagonists & inhibitors | Escherichia coli Proteins - antagonists & inhibitors | Aldose-Ketose Isomerases - chemistry | Escherichia coli - enzymology | Transferases - chemistry | Biosynthetic Pathways | Multienzyme Complexes - antagonists & inhibitors | Multienzyme Complexes - chemistry | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Algorithms | Models, Biological | Kinetics | Aldose-Ketose Isomerases - antagonists & inhibitors | Escherichia coli Proteins - chemistry | Phosphorus-Oxygen Lyases - antagonists & inhibitors | Phosphates | Plasmodium falciparum | Enzymes | Metabolites | Analysis | Phytochemistry | Physiological aspects | Models | Sugars | Monosaccharides
Journal Article
Journal of Integrative Agriculture, ISSN 2095-3119, 03/2019, Volume 18, Issue 3, pp. 644 - 655
The methylerythritol phosphate pathway is responsible for the biosynthesis of terpenoids, the largest class of secondary metabolites. Although the structures... 
methylerythritol phosphate pathway | biological control | transcription | Bacillus subtilis | DISTINCT PATHWAYS | ESCHERICHIA-COLI | 4-PHOSPHATE | HOMOTERPENES | TRANSFER-RNA SYNTHETASE | ISOPRENOID BIOSYNTHESIS | 5-PHOSPHATE | AGRICULTURE, MULTIDISCIPLINARY | BINDING | NONMEVALONATE PATHWAY | RICE
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2003, Volume 541, Issue 1, pp. 115 - 120
The last enzyme (LytB) of the methylerythritol phosphate pathway for isoprenoid biosynthesis catalyzes the reduction of (E)‐4‐hydroxy‐3‐methylbut‐2‐enyl... 
2- C-Methyl- D-erythritol 4-phosphate pathway | Isoprenoid | Isopentenyl diphosphate | ( E)-4-Hydroxy-3-methylbut-2-enyl diphosphate | Dimethylallyl diphosphate | LytB | MEP, 2-C-methyl-D-erythritol 4-phosphate | EPR, electron paramagnetic resonance | ME, 2-C-methyl-D-erythritol | IPP, isopentenyl diphosphate | DAF, 5-deazaflavin (10-methyl-5-deazaisoalloxazine) | HMBPP, (E)-4-hydroxy-3-methylbut-2-enyl diphosphate | (E)-4-Hydroxy-3-methylbut-2-enyl diphosphate | DMAPP, dimethylallyl diphosphate | 2-C-Methyl-D-erythritol 4-phosphate pathway | IRON-SULFUR PROTEINS | 2-C-methyl-D-erythritol 4-phosphate pathway | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | QUANTITATION | LYASE ACTIVATING ENZYME | isopentenyl diphosphate | (E)-4-hydroxy-3-methylbut-2-enyl diphosphate | CELL BIOLOGY | SYNTHASE | BIOPHYSICS | CLUSTERS | HIGHER-PLANTS | 2-C-METHYL-D-ERYTHRITOL | PYROPHOSPHATE | dimethylallyl diphosphate | isoprenoid | NONMEVALONATE PATHWAY | Diphosphates - metabolism | Escherichia coli - enzymology | Electron Spin Resonance Spectroscopy | Erythritol - analogs & derivatives | Models, Chemical | Oxidoreductases - metabolism | Polyisoprenyl Phosphate Sugars - biosynthesis | Escherichia coli Proteins - metabolism | Iron-Sulfur Proteins - chemistry | Organophosphorus Compounds - metabolism | Oxidoreductases - chemistry | Sugar Phosphates - metabolism | Hemiterpenes | Erythritol - metabolism | Iron-Sulfur Proteins - metabolism | Escherichia coli Proteins - chemistry | NADH, NADPH Oxidoreductases - metabolism | isoprenoids | LytB protein | diphosphate reductase | methylerythritol phosphate
Journal Article
Journal Article
by Lang, C and Xi, J
Russian Journal of Plant Physiology, ISSN 1021-4437, 3/2016, Volume 63, Issue 2, pp. 293 - 299
Journal Article
Experimental Parasitology, ISSN 0014-4894, 08/2007, Volume 116, Issue 4, pp. 375 - 384
The apicoplast is a recently discovered, plastid-like organelle present in most apicomplexa. The methylerythritol phosphate (MEP) pathway involved in... 
IPPI | Etmecs | IPP | Coccidia | T. gondii deoxyxylulose 5-phosphate reductoisomerase | Plasmodium falciparum | reverse transcription-polymerase chain reaction | Tghdr | Cryptosporidium parvum | RT-PCR | E. tenella deoxyxylulose 5-phosphate synthase | isopentenyl diphosphate isomerase | 4-diphosphocytidyl methylerythritol synthase | dimethylallyl diphosphate | Fosmidomycin | Apicomplexa | Eimeria tenella | CMS | Isoprenoid biosynthesis | isopentenyl diphosphate | Tgmecs | Cryptosporidium hominis | Etdxs | Toxoplasma gondii | T. gondii hydroxymethylbutenyl 4-diphosphate reductase | MEP | MVA | mevalonic acid | DMAPP | Tgdxr | E. tenella methylerythritol 2,4-cyclodiphosphate synthase | T. gondii methylerythritol 2,4-cyclodiphosphate synthase | methylerythritol phosphate | Cryptosporiditan hominis | Plasmoditunfialcipartun | Euneria tenella | CRYPTOSPORIDIUM-PARVUM | PLASMODIUM-FALCIPARUM MALARIA | GENOME | MOLECULAR ANALYSIS | soprenoid biosynthesis | EIMERIA-TENELLA | Toxoplasina gondii | fosmidomycin | GENE | Cryptosporidium parutan | ISOPENTENYL DIPHOSPHATE | TOXOPLASMA-GONDII | SURFACE-ANTIGEN | MEVALONATE PATHWAY | PARASITOLOGY | Cryptosporidium parvum - growth & development | Genome, Protozoan | Eimeria tenella - genetics | Gene Expression Regulation, Developmental - genetics | Eimeria tenella - growth & development | Cryptosporidium - growth & development | Coccidia - drug effects | Cryptosporidium - metabolism | Coccidia - growth & development | Cryptosporidium parvum - drug effects | Terpenes - metabolism | Toxoplasma - growth & development | Cryptosporidium - genetics | Mice, Inbred CBA | Erythritol - metabolism | Toxoplasma - metabolism | Eimeria tenella - drug effects | Eimeria tenella - metabolism | Fosfomycin - analogs & derivatives | Cell Line | Cell Survival - drug effects | Fosfomycin - pharmacology | Coccidia - metabolism | Erythritol - genetics | Herbicides - pharmacology | Cryptosporidium parvum - genetics | Cryptosporidium parvum - metabolism | Isoxazoles - pharmacology | Animals | Toxoplasma - genetics | Oxazolidinones - pharmacology | Chickens | Coccidia - genetics | Mice | Cryptosporidium - drug effects | Toxoplasma - drug effects | Physiological aspects | Amino acids | Biosynthesis | Synthesis
Journal Article