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Nature, ISSN 0028-0836, 04/2006, Volume 440, Issue 7086, pp. 940 - 943
Journal Article
Journal of Dental Research, ISSN 0022-0345, 4/2015, Volume 94, Issue 4, pp. 594 - 601
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2010, Volume 14, Issue 12, pp. 2803 - 2815
It is unknown whether zoledronic acid (ZA) at clinically relevant doses is active against tumours not located in bone. Mice transgenic for the activated ErbB-2... 
Zoledronic acid | Angiogenesis | Tumour-associated macrophages | Tumour microenvironment | Mevalonate pathway | MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | angiogenesis | tumour-associated macrophages | DELTA T-CELLS | mevalonate pathway | ANTITUMOR-ACTIVITY | CELL BIOLOGY | BREAST-CANCER | NITRIC-OXIDE PRODUCTION | zoledronic acid | PROSTATE-CANCER | IN-VIVO | HER-2/NEU TRANSGENIC MICE | BONE METASTASIS | tumour microenvironment | AMERICAN-SOCIETY | Neovascularization, Pathologic | Imidazoles - administration & dosage | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Antineoplastic Agents - administration & dosage | Interferon-gamma - metabolism | Nitric Oxide Synthase - genetics | Protein Prenylation | Interleukin-10 - metabolism | Female | Antineoplastic Agents - pharmacology | Macrophages - immunology | Nitric Oxide - biosynthesis | Mammary Neoplasms, Animal - immunology | Mammary Glands, Animal - pathology | Mice, Transgenic | Diphosphonates - administration & dosage | Imidazoles - pharmacology | Mevalonic Acid - metabolism | Macrophages - metabolism | Mammary Neoplasms, Animal - pathology | Animals | Metabolic Networks and Pathways | Genes, erbB-2 | Mammary Neoplasms, Animal - metabolism | Macrophages - drug effects | Mammary Neoplasms, Animal - drug therapy | Mice | Mice, Inbred BALB C | Cell Transformation, Neoplastic - drug effects | Nitric Oxide - metabolism | Diphosphonates - pharmacology | Genotype & phenotype | Cytokines | Rodents | Nitric oxide | Interferon | Tumors | Cancer | Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 9/1999, Volume 121, Issue 1, pp. 153 - 162
Plants are able to respond to herbivore damage with de novo biosynthesis of an herbivore-characteristic blend of volatiles. The signal transduction initiating... 
Gallates | Leaves | Solvents | Quantification | Terpenoids | Diterpenes | Amino acids | Biosynthesis | Diphosphates | Herbivores | Plant-Microbe and Plant-Insect Interactions | INDUCED GENE-EXPRESSION | NICOTIANA-SYLVESTRIS | PROTEINASE-INHIBITORS | ISOPRENOID BIOSYNTHESIS | ISOPENTENYL DIPHOSPHATE | PHASEOLUS-LUNATUS | ACYCLIC HOMOTERPENES | JASMONIC ACID | BETA-GLUCOSIDASE | PARASITIC WASPS | PLANT SCIENCES | Amino Acids - pharmacology | Oxylipins | Stearic Acids - metabolism | alpha-Linolenic Acid - pharmacology | Amino Acids - metabolism | Terpenes - metabolism | Time Factors | Volatilization | Oils, Volatile - metabolism | Plant Leaves - drug effects | Physical Stimulation | Indenes - pharmacology | Fatty Acids, Unsaturated - antagonists & inhibitors | Cucurbitaceae | Fatty Acids, Unsaturated - pharmacology | Stearic Acids - antagonists & inhibitors | Cyclopentanes - antagonists & inhibitors | Cyclopentanes - pharmacology | Fatty Acids, Unsaturated - metabolism | Mevalonic Acid - metabolism | Cellulase - pharmacology | alpha-Linolenic Acid - antagonists & inhibitors | Plant Leaves - metabolism | Signal Transduction - drug effects | Fabaceae - metabolism | alpha-Linolenic Acid - metabolism | Fabaceae - drug effects | Cyclopentanes - metabolism | Plant Growth Regulators - antagonists & inhibitors | Plant Growth Regulators - metabolism | Plant Growth Regulators - pharmacology | Stearic Acids - pharmacology | Plants, Medicinal | Physiological aspects | Research | Lima bean | Index Medicus | Space life sciences
Journal Article
Planta, ISSN 0032-0935, 11/2011, Volume 234, Issue 5, pp. 903 - 914
In plants, the mevalonic acid (MVA) pathway provides precursors for the formation of triterpenes, sesquiterpenes, phytosterols and primary metabolites... 
Proteins | Enzymes | Yeasts | Haploidy | Peroxisomes | Complementary DNA | Plasmids | Terpenoids | Alleles | Cytosol | Life Sciences | Arabidopsis | Mevalonic acid pathway | Forestry | Peroxisome | Ecology | Agriculture | Isoprenoid | Plant Sciences | Catharanthus | PHOSPHOMEVALONATE KINASE | SUBCELLULAR-LOCALIZATION | PLANT SCIENCES | HMG-COA SYNTHASE | ISOPRENOID BIOSYNTHESIS | PROTEOME ANALYSIS | THALIANA | GENES | REDUCTASE | TARGETING SIGNALS | ARABIDOPSIS LEAF PEROXISOMES | Transformation, Genetic | Amino Acid Sequence | Catharanthus - enzymology | Saccharomyces cerevisiae - genetics | Phosphotransferases (Phosphate Group Acceptor) - genetics | DNA, Complementary - genetics | Molecular Sequence Data | Phosphotransferases (Alcohol Group Acceptor) - genetics | RNA, Plant - genetics | Mevalonic Acid - metabolism | Genetic Complementation Test | Peroxisomes - metabolism | Arabidopsis - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Arabidopsis - genetics | Mevalonic Acid - analogs & derivatives | Saccharomyces cerevisiae - metabolism | Cloning, Molecular | Gene Expression Regulation, Plant | Cytosol - metabolism | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Catharanthus - genetics | DNA, Complementary - metabolism | Luminescent Proteins - metabolism | Arabidopsis thaliana | Saponins | Sesquiterpenes | Phytosterols | Fluorescence | Plant metabolites | Index Medicus
Journal Article
The Plant Journal, ISSN 0960-7412, 07/2018, Volume 95, Issue 2, pp. 358 - 370
The proteinogenic branched‐chain amino acids ( BCAA s) leucine, isoleucine and valine are essential nutrients for mammals. In plants, BCAA s double as... 
senescence | ubiquinone | Arabidopsis thaliana | catabolism | comparative genomics | branched‐chain amino acid | mitochondrion | branched-chain amino acid | PATHWAYS | ARABIDOPSIS-THALIANA | NETWORK | PROTEIN | CROTONASE SUPERFAMILY | VALINE | SEED DEVELOPMENT | DEHYDROGENASE | PLANT SCIENCES | ELECTRON-TRANSFER FLAVOPROTEIN | DEGRADATION | Leucine - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - enzymology | Oryza - metabolism | Amino Acids, Branched-Chain - metabolism | Mitochondria - metabolism | Metabolism | Oryza - enzymology | Arabidopsis - metabolism | Gene Knockdown Techniques | Isoleucine - metabolism | Arabidopsis Proteins - metabolism | Plant Proteins - genetics | Sequence Alignment | Valine - metabolism | Hydro-Lyases - metabolism | Plant Proteins - metabolism | Hydro-Lyases - genetics | Fluorescence | Enzymes | Plants | Branched chain amino acids | Analysis | Tricarboxylic acid cycle | Senescence | Seeds | Alternative energy | Chain branching | Amino acids | Chains | Energy sources | Homology | Leucine | Essential nutrients | Dehydration | Accumulation | Degradation | Proteins | Leaves | Mitochondria | Mevalonic acid | Alternative energy sources | Nutrients | Fusion protein | Recombinant | Isoleucine | Biodegradation | Carbohydrates | Starvation | Phenotypes | Intermediates | Valine | Green fluorescent protein | Catabolism | Rosette | Electron transport | Index Medicus
Journal Article
ChemBioChem, ISSN 1439-4227, 10/2018, Volume 19, Issue 20, pp. 2146 - 2151
The enzymatic synthesis of terpenes was investigated by using a cascade based on the mevalonic acid pathway. Suitable enzymes from all kingdoms of life were... 
natural products | enzyme catalysis | terpenoids | biocatalysis | biosynthesis | SYSTEM | ISOPRENE | CHEMISTRY, MEDICINAL | MEVALONATE KINASE | BIOCHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATP | Phosphates | Enzymes | Biological products | Sesquiterpenes | Physiological aspects | Biosynthesis | Catalysis | Acetic acid | Organic acids | Enzymatic synthesis | Regeneration | Mevalonic acid | Acids | Patchoulol | Geosmin | Terpenes | Conversion
Journal Article
Journal Article