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Journal Article
Environmental and Molecular Mutagenesis, ISSN 0893-6692, 07/2013, Volume 54, Issue 6, pp. 397 - 405
Journal Article
Structure, ISSN 0969-2126, 2000, Volume 8, Issue 2, pp. 111 - 122
Background: Epoxide hydrolases have important roles in the defense of cells against potentially harmful epoxides. Conversion of epoxides into less toxic and... 
X-ray crystallography | Drug metabolism | MAD | Epoxide hydrolase | Microsomal epoxide hydrolases | X- ray crystallography | Animals | Humans | Aspergillus niger - enzymology | Models, Molecular | Microsomes - enzymology | Protein Conformation | Binding Sites | Dimerization | Epoxide Hydrolases - chemistry
Journal Article
RNA, ISSN 1355-8382, 06/2013, Volume 19, Issue 6, pp. 752 - 766
Journal Article
MOLECULAR MEDICINE REPORTS, ISSN 1791-2997, 07/2010, Volume 3, Issue 4, pp. 723 - 727
Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic sites have been described in... 
POPULATION | GENETIC POLYMORPHISMS | SUSCEPTIBILITY | polymorphism | ARACHIDONIC-ACID | PATHOLOGY | microsomal epoxide hydrolase | OBSTRUCTIVE PULMONARY-DISEASE | CIGARETTE-SMOKING | METABOLISM | DNA | GLUTATHIONE-S-TRANSFERASE | LUNG-CANCER RISK
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 04/2017, Volume 85, Issue 4, pp. 720 - 730
ABSTRACT A new homology model of human microsomal epoxide hydrolase was derived based on multiple templates. The model obtained was fully evaluated, including... 
epilepsy | clustering | homology models | microsomal epoxide hydrolase | ensemble‐based docking | ensemble-based docking | ASPERGILLUS-NIGER | QUALITY | ENANTIOSELECTIVITY | CATALYZED-HYDROLYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | CARBAMAZEPINE | PARTICLE MESH EWALD | VALPROMIDE | EVOLUTION | BIOPHYSICS | REACTION-MECHANISM | Epoxy Compounds - metabolism | Humans | Substrate Specificity | Valproic Acid - analogs & derivatives | Enzyme Inhibitors - chemistry | Conserved Sequence | Microsomes, Liver - enzymology | Protein Interaction Domains and Motifs | Valproic Acid - chemistry | Epoxide Hydrolases - chemistry | Amino Acid Sequence | Catalytic Domain | Protein Structure, Secondary | Streptomyces - chemistry | Aspergillus niger - enzymology | Microsomes, Liver - chemistry | Aspergillus niger - chemistry | Molecular Dynamics Simulation | Sequence Alignment | Epoxy Compounds - chemistry | Protein Binding | Streptomyces - enzymology | Molecular Docking Simulation | Structural Homology, Protein | Epoxide Hydrolases - metabolism | Kinetics | Epoxide Hydrolases - antagonists & inhibitors | Molecular dynamics | Enzymes | Hydrolases | Models | Analysis | Binding | Residues | Molecular structure | Computer simulation | Stabilization | Homology | Dynamical systems | Epoxide hydrolase | Molecular docking | Intermediates | Proteins | Stereoselectivity | Conserved sequence | Hydrologic data | Computer applications | Catalysis | enantioselectivity | reaction-mechanism | aspergillus-niger | force-field | Biophysics | Chemical Sciences | agrobacterium-radiobacter ad1 | carbamazepine | quality | Biochemistry & Molecular Biology | Kemi | particle mesh ewald | hypersensitivity reactions | catalyzed-hydrolysis
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 06/2014, Volume 1839, Issue 6, pp. 493 - 505
In humans, microsomal epoxide hydrolase (mEH) contributes important biological functions that underlie both detoxification and bioactivation fates arising from... 
Human | Microsomal epoxide hydrolase | Nrf2 | Gene regulation | Alternative gene promoter | OXIDATIVE STRESS | ACTIVATION | SULFORAPHANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NRF2-REGULATED GENES | CHEMOPREVENTION | EXPRESSION PROFILES | IDENTIFICATION | LUNG-CANCER | ANTIOXIDANT RESPONSE ELEMENT | BIOPHYSICS | Altemative gene promoter | MICE | Enzymes | Analysis | Genes | DNA | Genetic research | Hydrolases | B cells | Index Medicus
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 07/2010, Volume 3, Issue 4, pp. 723 - 727
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 2011, Volume 22, Issue 6, pp. 431 - 440
Abstract The pharmacokinetics of carbamazepine (CBZ) and its active 10,11-epoxide metabolite (CBZ-E) were evaluated after intravenous and oral administration... 
Internal Medicine | Psychiatry | Carbamazepine 10,11-epoxide | Pharmacokinetics | Microsomal epoxide hydrolase | Hyperlipidemia | CYP3A1/2 | Carbamazepine | AMIODARONE | PSYCHIATRY | MODEL RATS | Carbamazepine 10, 11-epoxide | PARAMETERS | NEUROSCIENCES | CLINICAL NEUROLOGY | CARBAMAZEPINE-10,11-EPOXIDE | PLASMA | 10,11-EPOXIDE | IN-VIVO | LIVER | NIFEDIPINE | PHARMACOLOGY & PHARMACY | BINDING | Analgesics, Non-Narcotic - pharmacokinetics | Area Under Curve | Microsomes, Liver - metabolism | Male | Thiophenes - metabolism | Chromatography, High Pressure Liquid | Arabidopsis Proteins | Drug Interactions | Intramolecular Transferases | Time Factors | Microsomes, Liver - drug effects | Disease Models, Animal | Analgesics, Non-Narcotic - blood | Surface-Active Agents - toxicity | Rats | Rats, Sprague-Dawley | Epoxide Hydrolases - genetics | Poloxamer - toxicity | Animals | Cytochrome P-450 CYP3A - metabolism | Heterocyclic Compounds, 4 or More Rings - metabolism | Epoxide Hydrolases - metabolism | Carbamazepine - pharmacokinetics | Hyperlipidemias - chemically induced | Carbamazepine - blood | Enzymes | Anticonvulsants | Metabolites | Low density lipoproteins | Cytochrome P-450 | Hydrolases | Drug therapy | Drugs | Intravenous administration | Liver | Oral administration | mRNA | Gene expression | Metabolism | Epoxide hydrolase
Journal Article
Indian Journal of Cancer, ISSN 0019-509X, 04/2016, Volume 53, Issue 2, pp. 213 - 215
Microsomal epoxide hydrolase (mEH) is a crucial biotransformation enzyme that has capability to metabolize a large number of structurally divergent, highly... 
gene-environmental interaction | prostate cancer | gene-gene interaction | Gene polymorphism | microsomal epoxide hydrolase | METABOLISM | ONCOLOGY | RISK | SMOKING
Journal Article