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Biotechnology and Bioengineering, ISSN 0006-3592, 11/2019, Volume 116, Issue 11, pp. 2906 - 2918
Concentration gradients that occur in large industrial‐scale bioreactors due to mass transfer limitations have significant effects on process efficiency.... 
scale‐down | scale‐up effects | modeling | mini‐bioreactors | Escherichia coli | Cultivation | Oscillations | Risk reduction | Amino acids | Glucose | Insulin | Mass transfer | Feeding | E coli | Bioreactors | Phenotyping | Dissolved oxygen | Recombinant | Concentration gradient
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 01/2018, Volume 115, Issue 1, pp. 92 - 102
Journal Article
Bioengineering (Basel, Switzerland), ISSN 2306-5354, 11/2018, Volume 5, Issue 4, p. 101
Mini-bioreactor systems enabling automatized operation of numerous parallel cultivations are a promising alternative to accelerate and optimize bioprocess... 
biomanufacturing | mini-bioreactors | dynamical bioprocesses | high throughput bioprocess development | digitalization | laboratory automation | multivariate analysis
Journal Article
Engineering in Life Sciences, ISSN 1618-0240, 11/2017, Volume 17, Issue 11, pp. 1195 - 1201
Bioprocess development, optimization, and control in mini‐bioreactor systems require information about essential process parameters, high data densities, and... 
Automated data processing | Mini‐bioreactors | Bioprocess optimization | Scheduling | Laboratory automation | Mini-bioreactors | DESIGN | ESCHERICHIA-COLI | REPRODUCIBILITY | CULTIVATIONS | BIOREACTORS | OXYGEN | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL-CULTURE | Fermentation | Analysis
Journal Article
Biotechnology Progress, ISSN 8756-7938, 07/2010, Volume 26, Issue 4, pp. 1095 - 1103
Journal Article
Frontiers in Bioengineering and Biotechnology, ISSN 2296-4185, 2015, Volume 3, p. 147
The use of genetically encoded fluorescent reporters allows speeding up the initial optimization steps of microbial bioprocesses. These reporters can be used... 
High-throughput | Single cell | Flow cytometry | Mini-bioreactors | Microbiological synthesis | Fluorescent antibody technique | Usage | Immunofluorescence | Analysis | Methods | GFP | single cell | Flow Cytometry | high-throughput
Journal Article
Biotechnology, Agronomy and Society and Environment, ISSN 1370-6233, 2010, Volume 14, Issue 2, pp. 531 - 536
Journal Article
BIOTECHNOLOGIE AGRONOMIE SOCIETE ET ENVIRONNEMENT, ISSN 1370-6233, 2010, Volume 14, Issue s2, pp. 531 - 536
Trehalose is a reserve carbohydrate produced by Saccharomyces cerevisiae under stress conditions and used as a cryoprotectant during freeze drying. So the... 
mini-bioreactors | COMPLEX | AGRONOMY | PERFORMANCE | BAKERS-YEAST | trehalose | CULTURE | RESPONSES | ENVIRONMENTAL SCIENCES | scale-down reactors | ACCUMULATION | Saccharomyces cerevisiae | SACCHAROMYCES-CEREVISIAE CELLS
Journal Article
Journal of Chemical Technology & Biotechnology, ISSN 0268-2575, 01/1998, Volume 71, Issue 1, pp. 51 - 56
This paper describes the use of a novel porous matrix, Porocell, for high density, tissue‐like culture of two insulinoma cell lines, CRI‐D2 and CRI‐D11. Both... 
glucose | porous | insulin | mini‐bioreactors | insulinoma | Glucose | Insulin | Insulinoma | Mini-bioreactors | Porous | ANIMAL-CELLS | ENGINEERING, CHEMICAL | mini-bioreactors | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Mass Spectrometry Reviews, ISSN 0277-7037, 03/2009, Volume 28, Issue 2, pp. 362 - 375
Metabolic flux analysis via 13C labeling (13C MFA) quantitatively tracks metabolic pathway activity and determines overall enzymatic function in cells. Three... 
steady state | mass spectrometry | functional genomics | mini‐bioreactor | isotopomer modeling | Mini-bioreactor | Isotopomer modeling | Mass spectrometry | Steady state | Functional genomics
Journal Article
MASS SPECTROMETRY REVIEWS, ISSN 0277-7037, 03/2009, Volume 28, Issue 2, pp. 362 - 375
Metabolic flux analysis via C-13 labeling (C-13 MFA) quantitatively tracks metabolic pathway activity and determines overall enzymatic function in cells. Three... 
steady state | GC-MS ANALYSIS | C-13-LABELING EXPERIMENTS | mini-bioreactor | ESCHERICHIA-COLI | functional genomics | BIDIRECTIONAL REACTION STEPS | SPECTROSCOPY | BACILLUS-SUBTILIS | AMINO-ACIDS | mass spectrometry | SHEWANELLA-ONEIDENSIS MR-1 | CHROMATOGRAPHY-MASS SPECTROMETRY | CENTRAL CARBON METABOLISM | isotopomer modeling | CORYNEBACTERIUM-GLUTAMICUM
Journal Article