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triphenylphosphonium (6) 6
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1. Full Text Triphenylphosphonium‐Conjugated Poly(ε‐caprolactone)‐Based Self‐Assembled Nanostructures as Nanosized Drugs and Drug Delivery Carriers for Mitochondria‐Targeting Synergistic Anticancer Drug Delivery
by Cho, Dong Youl and Cho, Hana and Kwon, Kiyoon and Yu, Minjong and Lee, Eunji and Huh, Kang Moo and Lee, Don Haeng and Kang, Han Chang
Advanced Functional Materials, ISSN 1616-301X, 09/2015, Volume 25, Issue 34, pp. 5479 - 5491
For mitochondria‐targeting delivery, a coupling reaction between poly(ε‐caprolactone) diol (PCL diol) and 4‐carboxybutyltriphenylphosphonium (4‐carboxybutyl... 
self‐assembled nanomedicine | mitochondria‐targeting drug delivery | poly(ε‐caprolactone) | triphenylphosphonium | subcellular targeting | mitochondria-targeting drug delivery | self-assembled nanomedicine | poly(ε-caprolactone) | THERAPEUTICS | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | PROTEIN | MATERIALS SCIENCE, MULTIDISCIPLINARY | DOXORUBICIN | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | MICELLES | CHEMISTRY, MULTIDISCIPLINARY | PACLITAXEL | BREAST-CANCER CELLS | NANOPARTICLES | IN-VITRO | poly(epsilon-caprolactone) | CYTOTOXICITY | LIVING CELLS | Nanoparticles | Drugs | Uptakes | Drug delivery systems | Nanostructure | Nanofibers | Polymers | Diols | Anticancer properties
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2. Full Text Self-assembled nanoparticles composed of glycol chitosan-dequalinium for mitochondria-targeted drug delivery
by Mallick, Sudipta and Song, Su Jeong and Bae, Yoonhee and Choi, Joon Sig
International Journal of Biological Macromolecules, ISSN 0141-8130, 07/2019, Volume 132, pp. 451 - 460
Cancer cells divide uncontrollably due to their metabolic imbalance, resistance to mitochondria-mediated apoptosis, and ability to sustain telomere crisis by... 
Mitochondria targeting | Glycol chitosan | Curcumin | Dequalinium | Cancer therapy | Drugs | Nanoparticles | Medical colleges | Telomeres | Drug delivery systems | Cell death | DNA polymerases | Glycols | Polymers | Vehicles
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3. Full Text Mitochondria-targeting self-assembled nanoparticles derived from triphenylphosphonium-conjugated cyanostilbene enable site-specific imaging and anticancer drug delivery
by Kim, Ka Young and Jin, Hanyong and Park, Jaehyeon and Jung, Sung Ho and Lee, Ji Ha and Park, Hyesong and Kim, Sung Kuk and Bae, Jeehyeon and Jung, Jong Hwa
纳米研究：英文版, ISSN 1998-0124, 2018, Volume 11, Issue 2, pp. 1082 - 1098
Subcellular organelle-specific nanoparticles for simultaneous tumor targeting, imaging, and drug delivery are of enormous interest in cancer therapy. Herein,... 
线粒体;装配;指向;交货;成像;地点;癌症治疗;肿瘤生长 | Condensed Matter Physics | Biomedicine, general | Biotechnology | Materials Science | Materials Science, general | fluorescence imaging | mitochondria-targeting | aggregation-induced emission | Atomic/Molecular Structure and Spectra | drug delivery | chemotherapy | Nanotechnology | Chemotherapy | Drug delivery | Fluorescence imaging | Aggregation-induced emission | Mitochondria-targeting | PHYSICS, APPLIED | BLOCK-COPOLYMERS | MATERIALS SCIENCE, MULTIDISCIPLINARY | DOXORUBICIN | CHITOSAN | CHEMISTRY, PHYSICAL | MESOPOROUS SILICA NANOPARTICLES | NANOSCIENCE & NANOTECHNOLOGY | POLYELECTROLYTE | PLATFORM | FLUORESCENT | THERAPY | AGGREGATION-INDUCED-EMISSION | HYPERSENSITIVITY | Drugs | Animal experimentation | Nanoparticles | Anthracyclines | Drug delivery systems | Fluorescence | Vehicles | Cancer | Self assembly | Therapy | Reactive oxygen species | Toxicity | Phosphine | Cytotoxicity | Event-related potentials | Agglomeration | Doxorubicin | Mitochondria | Biological effects | Animal tissues | Xenografts | Biocompatibility | Membrane potential | Nanorods
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4. Full Text Ultrasound triggered drug delivery for mitochondria targeted sonodynamic therapy
by Chen, MengJia and Xu, Airen and He, Wenyue and Ma, Weicheng and Shen, Song
Journal of Drug Delivery Science and Technology, ISSN 1773-2247, 06/2017, Volume 39, pp. 501 - 507
Mitochondria, which play an essential effect in cell apoptosis, are targets for cancer treatment. Here, mitochondria targeted liposomes loaded with... 
Mitochondria targeting | Liposomes | Hematoporphyrin monomethyl ether | TPP | Sonodynamic therapy | CELLS | MECHANISM | VESICLES | PHOTOSENSITIZER | CANCER-THERAPY | NANOPARTICLES | CARCINOGENESIS | IN-VIVO | PHARMACOLOGY & PHARMACY | PROGRESSION
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5. Full Text Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective
by Wang, Zhenjie and Guo, Weiling and Kuang, Xiao and Hou, Shanshan and Liu, Hongzhuo
Asian Journal of Pharmaceutical Sciences, ISSN 1818-0876, 11/2017, Volume 12, Issue 6, pp. 498 - 508
The structure of mitochondria: outer mitochondrial membrane (OMM), inner mitochondrial membrane (IMM), the intermembrane space (IMS) and matrix. In this... 
Nanoparticles | Liposomes | Diabetes | Mitochondria-targeting | DQAsomes | Cancer | GOLD NANOPARTICLES | OXIDATIVE STRESS | LIPOSOME-BASED CARRIER | DF-MITO-PORTER | ALZHEIMERS-DISEASE | HYDROXYAPATITE NANOPARTICLES | IN-VITRO | RESISTANT LUNG-CANCER | PLASMID DNA | PHARMACOLOGY & PHARMACY | MEMBRANE PERMEABILIZATION
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6. Full Text Overcoming drug-resistant lung cancer by paclitaxel loaded dual-functional liposomes with mitochondria targeting and pH-response
by Jiang, Lei and Li, Li and He, Xiaodan and Yi, Qiangying and He, Bin and Cao, Jun and Pan, Weisan and Gu, Zhongwei
Biomaterials, ISSN 0142-9612, 2015, Volume 52, Issue 1, pp. 126 - 139
Abstract Mitochondrion-orientated transportation of smart liposomes has been developed as a promising strategy to deliver anticancer drugs directly to tumor... 
Advanced Basic Science | Dentistry | Mitochondria targeting | pH response | Anticancer efficacy | Dual-functional liposome | Drug-resistant lung cancer | Paclitaxel | PH response | CELLS | MATERIALS SCIENCE, BIOMATERIALS | DELIVERY SYSTEMS | ENGINEERING, BIOMEDICAL | BREAST-CANCER | DNA DELIVERY | NANOPARTICLES | THERAPY | IN-VIVO | CONJUGATE | MULTIDRUG-RESISTANCE | TUMOR MICROENVIRONMENT | Protons | Lung Neoplasms - drug therapy | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Drug Delivery Systems | Peptides - metabolism | Female | Lung - metabolism | Paclitaxel - administration & dosage | Amino Acid Sequence | Lung - pathology | Peptides - chemistry | Cytochromes c - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Paclitaxel - therapeutic use | Liposomes - chemistry | Animals | Mice, Nude | Lung - drug effects | Cell Line, Tumor | Liposomes - metabolism | Mice, Inbred BALB C | Phosphatidylethanolamines - metabolism | Phosphatidylethanolamines - chemistry | Antimitotic agents | Biological products | Lung cancer | Pharmacy | Drugstores | Lipids | Mitochondrial DNA | Drug resistance | Drug therapy | Antineoplastic agents | Hydrogen-ion concentration | Drugs | Mitochondria | Lungs | Peptides | Taxol | Liposomes | Tumors | Cancer
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7. Full Text Development of the MITO-Porter, a Nano Device for Mitochondrial Drug Delivery via Membrane Fusion
by Yamada, Y
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, ISSN 0031-6903, 11/2014, Volume 134, Issue 11, pp. 1143 - 1155
Many human diseases have been reported to be associated with mitochondrial dysfunction. Therefore, mitochondrial therapy would be expected to be useful and... 
SYSTEM | CELLS | LIPOSOME-BASED CARRIER | PROTEIN | mitochondria | BONGKREKIC ACID | MACROMOLECULE | drug delivery system (DDS) | FUSOGENIC ENVELOPES | nano device | mitocondrial gene therapy | PLASMID DNA | DISEASE | PHARMACOLOGY & PHARMACY | TARGETING SIGNAL PEPTIDE | MITO-Porter | mitochondrial medicine | Biological Transport | Membrane Fusion | Nanostructures - administration & dosage | Humans | Mitochondria - metabolism | Liposomes | Drug Delivery Systems - methods
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8. Full Text Mitochondria-targeting photosensitizer-encapsulated amorphous nanocage as a bimodal reagent for drug delivery and biodiagnose in vitro
by Zhou, Lin and Liu, Ji-Hua and Ma, Fei and Wei, Shao-Hua and Feng, Yu-Ying and Zhou, Jia-Hong and Yu, Bo-Yang and Shen, Jian
Biomedical Microdevices, ISSN 1387-2176, 8/2010, Volume 12, Issue 4, pp. 655 - 663
The use of ceramic nano-carriers containing anti-cancer drugs for targeted delivery that span both fundamental and applied research has attracted the interest... 
Biomedical Engineering | Engineering | Amorphous silica-nanocage | Photodynamic | Engineering Fluid Dynamics | Biophysics and Biological Physics | Drug delivery | Time-dependent efficacy | Biodiagnose | Nanotechnology | Mitochondria-targeting | Amorphous silica-nanocage time-dependent efficacy | SYSTEM | CELLS | PHOTODYNAMIC THERAPY | INDUCED APOPTOSIS | ENGINEERING, BIOMEDICAL | MODIFIED SILICA NANOPARTICLES | NANOSCIENCE & NANOTECHNOLOGY | CANCER-THERAPY | CARRIER | HYPOCRELLIN | SINGLET OXYGEN | Photosensitizing Agents - chemistry | Photosensitizing Agents - therapeutic use | Humans | Molecular Conformation | Spectroscopy, Fourier Transform Infrared | Photochemotherapy | Drug Carriers - chemistry | Perylene - therapeutic use | Singlet Oxygen - metabolism | Photosensitizing Agents - pharmacology | Silicon Dioxide - metabolism | Biological Transport | Mitochondria - radiation effects | Indicators and Reagents - chemistry | Quinones - pharmacology | Photobleaching | Perylene - analogs & derivatives | Microscopy, Electron, Transmission | Drug Carriers - metabolism | Perylene - chemistry | Silanes - chemistry | Quinones - chemistry | Silicon Dioxide - chemistry | Quinones - therapeutic use | Models, Molecular | Mitochondria - metabolism | Mitochondria - drug effects | Perylene - pharmacology | Indicators and Reagents - metabolism | Hydrogen Bonding | Intracellular Space - metabolism | HeLa Cells | Nanomaterials | Mitochondria | Drug delivery systems | Photodynamic therapy
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9. Full Text Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy
by Tan, Yanan and Zhu, Yun and Zhao, Yue and Wen, Lijuan and Meng, Tingting and Liu, Xuan and Yang, Xiqin and Dai, Suhuan and Yuan, Hong and Hu, Fuqiang
Biomaterials, ISSN 0142-9612, 02/2018, Volume 154, pp. 169 - 181
Mitochondria, crucial regulators of inducing tumor cells apoptosis, can be treated as the prime target for tumor therapy. The selective and responsive release... 
Intracellular transport and tracking | Mitochondria targeting | Breast cancer | Drug delivery system | Alkaline pH-responsive release | CARCINOMA-CELLS | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | TUMOR-CELLS | TARGETING MITOCHONDRIA | LUNG-CANCER | INTRACELLULAR DELIVERY | POLY(L-LACTIC ACID) MATRIX | LIPOSOMES | TRIPHENYLPHOSPHONIUM | LIVING CELLS | Triterpenes - pharmacology | Apoptosis - drug effects | Triterpenes - therapeutic use | Mitochondria - ultrastructure | Drug Delivery Systems | Time Factors | Micelles | Cell Death | Glycolipids - chemistry | Onium Compounds - chemistry | Tissue Distribution - drug effects | Organophosphorus Compounds - chemistry | Mitochondria - metabolism | Mitochondria - drug effects | Static Electricity | Neoplasms - drug therapy | Particle Size | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Drug Liberation | Neoplasms - pathology | Hydrogen-Ion Concentration | Cytochrome c | Drugs | Drug delivery systems | Therapeutics | Lipids | Hydrogen-ion concentration | Health aspects | Cancer | Homeopathy | Materia medica and therapeutics | Vehicles
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10. Full Text PEGylated polyaminoacid-capped mesoporous silica nanoparticles for mitochondria-targeted delivery of celastrol in solid tumors
by Choi, Han-Gon and Choi, Ju Yeon and Gupta, Biki and Ramasamy, Thiruganesh and Jeong, Jee-Heon and Jin, Sung Giu and Yong, Chul Soon and Kim, Jong Oh
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 05/2018, Volume 165, pp. 56 - 66
The major goal of cancer chemotherapy is to maximize the therapeutic efficacy of anticancer drugs, while minimizing their associated side effects. Celastrol... 
Mesoporous silica nanoparticles | HIF-1α inhibition | Mitochondria targeting | Celastrol | Cancer therapy | THERAPEUTICS | APOPTOSIS | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | HIF-1 alpha inhibition | DOXORUBICIN | CONTROLLED-RELEASE | CHEMISTRY, PHYSICAL | ANTITUMOR-ACTIVITY | CANCER | CARRIERS | THERAPY | BIOPHYSICS | SEQUENTIAL DELIVERY | Medicinal plants | Proteins | Nanoparticles | Drugs | Drug delivery systems | Chemotherapy | Analysis | Medicine, Botanic | Medicine, Herbal | Silica | Cancer | Vehicles | Index Medicus
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11. Full Text Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer
by Yang, Guangbao and Xu, Ligeng and Xu, Jun and Zhang, Rui and Song, Guosheng and Chao, Yu and Feng, Liangzhu and Han, Fengxuan and Dong, Ziliang and Li, Bin and Liu, Zhuang
Nano Letters, ISSN 1530-6984, 04/2018, Volume 18, Issue 4, pp. 2475 - 2484
Photodynamic therapy (PDT) is an oxygen-dependent light-triggered noninvasive therapeutic method showing many promising aspects in cancer treatment. For... 
NEAR-INFRARED LIGHT | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | Photodynamic therapy | DRUG-DELIVERY | COMBINATION THERAPY | PHOTOSENSITIZER | MATERIALS SCIENCE, MULTIDISCIPLINARY | nanoreactors | tumor hypoxia | CHEMISTRY, PHYSICAL | MESOPOROUS SILICA NANOPARTICLES | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | HIGHLY EFFICIENT | CHECKPOINT BLOCKADE | mitochondria targeting | IN-VIVO | UP-CONVERSION NANOPARTICLES | check-point-blockade therapy | SINGLET-OXYGEN | Tumor Microenvironment - drug effects | Immunotherapy - methods | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Photosensitizing Agents - therapeutic use | Photochemotherapy - methods | Silicon Dioxide - chemistry | Tumor Hypoxia - drug effects | Delayed-Action Preparations - chemistry | Mitochondria - metabolism | Breast Neoplasms - drug therapy | Breast Neoplasms - metabolism | Drug Delivery Systems | Hydrogen Peroxide - metabolism | Breast Neoplasms - therapy | Photosensitizing Agents - administration & dosage | Animals | Cell Line, Tumor | Female | Mice | Hydrogen-Ion Concentration
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12. Full Text Mechanism‐Guided Design and Synthesis of a Mitochondria‐Targeting Artemisinin Analogue with Enhanced Anticancer Activity
by Zhang, Chong‐Jing and Wang, Jigang and Zhang, Jianbin and Lee, Yew Mun and Feng, Guangxue and Lim, Teck Kwang and Shen, Han‐Ming and Lin, Qingsong and Liu, Bin
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2016, Volume 55, Issue 44, pp. 13770 - 13774
Understanding the mechanism of action (MOA) of bioactive natural products will guide endeavor to improve their cellular activities. Artemisinin and its... 
fluorescent probe | anticancer activity | drug delivery | triphenylphosphonium | mitochondria targeting | CELLS | OXIDATIVE STRESS | IRON CHELATORS | DESFERRIOXAMINE | CHEMISTRY, MULTIDISCIPLINARY | STRATEGIES | ANTIMALARIAL-DRUGS | HEME | PLASMODIUM-FALCIPARUM | TRADITIONAL CHINESE MEDICINE | MALARIA | Cell Survival - drug effects | Artemisinins - chemical synthesis | Antineoplastic Agents - chemical synthesis | HCT116 Cells | Humans | Structure-Activity Relationship | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Drug Design | Antineoplastic Agents - pharmacology | Molecular Structure | Artemisinins - chemistry | Drug Screening Assays, Antitumor | Drugs | Proteins | Care and treatment | Drug delivery systems | Malaria | Heme | Cancer | Vehicles | Cell proliferation | Surgical implants | Transcription factors | Artemisinin | Attachment | Parasites | Drug development | Anticancer properties | Design optimization | Design | Mitochondria | Biomedical materials | Design improvements | Biocompatibility | Inhibition | Killing | Vector-borne diseases | Effectiveness | Analogue | Derivatives | Natural products | Proteomics | Antitumor activity
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13. Full Text Core–Shell Nanoparticle-Based Peptide Therapeutics and Combined Hyperthermia for Enhanced Cancer Cell Apoptosis
by Shah, Birju P and Pasquale, Nicholas and De, Gejing and Tan, Tao and Ma, Jianjie and Lee, Ki-Bum
ACS Nano, ISSN 1936-0851, 09/2014, Volume 8, Issue 9, pp. 9379 - 9387
Mitochondria-targeting peptides have garnered immense interest as potential chemotherapeutics in recent years. However, there is a clear need to develop... 
combined therapy | magnetic core-shell nanoparticle | magnetically facilitated delivery | mitochondria-targeting peptide | amphipathic tail-anchoring peptide | magnetic hyperthermia | GOLD NANOPARTICLES | PROTEIN | GENE DELIVERY | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | MAGNETOFECTION | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | TARGETING MITOCHONDRIA | MAGNETIC NANOPARTICLES | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | THERAPY | EXPRESSION | Amino Acid Sequence | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Molecular Sequence Data | Membrane Potential, Mitochondrial - drug effects | Integrins - metabolism | Drug Carriers - chemistry | Hyperthermia, Induced | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Oligopeptides - pharmacology | Oligopeptides - chemistry | magnetic core−shell nanoparticle
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14. Full Text ROS-responsive mitochondria-targeting blended nanoparticles: Chemo- and photodynamic synergistic therapy for lung cancer with on-demand drug release upon irradiation with a single light source
by Yue, Caixia and Yang, Yuming and Zhang, Chunlei and Alfranca, Gabriel and Cheng, Shangli and Ma, Lijun and Liu, Yanlei and Zhi, Xiao and Ni, Jian and Jiang, Weihua and Song, Jie and de la Fuente, Jesús M and Cui, Daxiang
Theranostics, ISSN 1838-7640, 2016, Volume 6, Issue 13, pp. 2352 - 2366
Mitochondria in cancer cells maintain a more negative membrane potential than normal cells. Mitochondria are the primary source of cellular reactive oxygen... 
Camptothecin | Photodynamic therapy | ROS-responsive | Mitochondria-targeting nanoparticles | Zinc phthalocyanine | CARCINOMA-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | mitochondria-targeting nanoparticles | photodynamic therapy | COMBINATION THERAPY | NANOCARRIERS | MECHANISMS | DELIVERY | camptothecin | IN-VIVO | RESISTANCE | THERANOSTICS | EFFICIENT | LIPOSOMES | Cell Survival - drug effects | Reactive Oxygen Species - metabolism | Photochemotherapy - methods | Humans | Drug Liberation - radiation effects | Treatment Outcome | Lung Neoplasms - therapy | Mitochondria - metabolism | Mitochondria - drug effects | Cell Survival - radiation effects | Drug Delivery Systems | Animals | Heterografts | Drug Therapy - methods | Light | Cell Line, Tumor | Combined Modality Therapy - methods | Mice, Inbred BALB C | Nanoparticles - administration & dosage
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