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Publication DateBritish journal of pharmacology, ISSN 0007-1188, 04/2014, Volume 171, Issue 8, pp. 1798 - 1817
clinical trials for mitochondrial disorders | mitochondrial diseases | nutritional and cofactor support in mitochondrial disorders | models for mitochondrial disorders | mitochondrial biogenesis | gene therapy for mitochondrial diseases | treatments for mitochondrial disorders | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Mitochondrial Diseases - drug therapy | Humans | Clinical Trials as Topic | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Oxidative Phosphorylation - drug effects | Antioxidants - therapeutic use | Mitochondrial Turnover - drug effects | Animals | Models, Biological | Mitochondrial Diseases - therapy | Energy Metabolism - drug effects | Molecular Targeted Therapy - methods | Disease Models, Animal | Genetic Therapy - methods | Mitochondrial DNA | Gene expression | Analysis | Exercise therapy | Medical research | Index Medicus | Energy, Injury & Beyond | Mitochondrial Pharmacology | Themed Issue
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Loading RightsNeurotherapeutics, ISSN 1933-7213, 4/2013, Volume 10, Issue 2, pp. 186 - 198
Neurology | Neurosciences | Biomedicine | Neurobiology | Mitochondrial encephalomyopathy | Mitochondrial neurogastrointestinal (MNGIE) disease | Mitochondrial myopathy | Neurosurgery | Hepatocerebral syndrome | Alpers-Huttenlocher syndrome | Pharmacology & Pharmacy | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Mitochondrial Diseases - genetics | Liver Transplantation | DNA, Mitochondrial - metabolism | Humans | Mitochondrial Encephalomyopathies - genetics | DNA, Mitochondrial - physiology | Mutation - genetics | Nervous System Diseases - genetics | Nucleotides - metabolism | Mitochondrial Myopathies - pathology | Mitochondrial Myopathies - therapy | Nervous System Diseases - therapy | Mitochondrial Encephalomyopathies - pathology | Mutation - physiology | Mitochondrial Myopathies - genetics | DNA, Mitochondrial - genetics | Mitochondrial Encephalomyopathies - therapy | DNA Replication - physiology | DNA Replication - genetics | Nervous System Diseases - physiopathology | Mitochondrial Diseases - therapy | Mitochondrial Diseases - physiopathology | Nutritional Support | Thymidine - metabolism | Genetic aspects | Mitochondrial DNA | Health aspects | Genes | Medical genetics | Index Medicus | Review
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Loading RightsMitochondrial DNA, ISSN 1940-1736, 2008
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Annual review of genetics, ISSN 0066-4197, 2005, Volume 39, Issue 1, pp. 359 - 407
Aging | Mitochondria | Reactive oxygen species | Diabetes | Neurodegenerative diseases | Human origins | Neoplasms - metabolism | Metabolic Diseases - pathology | Energy Metabolism | Metabolic Diseases - metabolism | Mitochondria - genetics | Humans | Metabolic Diseases - genetics | Mitochondria - metabolism | Longevity - genetics | Mitochondria - pathology | Neoplasms - pathology | Aging - metabolism | Degeneration (Pathology) | Mitochondrial DNA | Genetic aspects | Research | Diet | Nutrition | Disease | Evolutionary biology | Genetics | Age | Risk factors | Index Medicus | TCA: mitochondrial tricarboxylic acid cycle | SDH: succinate dehydrogenase | LHON: Leber’s hereditary optic neuropathy | ROS: reactive oxygen species, oxygen radicals | CPEO | ANT: adenine nucleotide translocator | OXPHOS: oxidative phosphorylation | Mitochondrial medicine: the new medical discipline that pertains to all clinical problems that involve the mitochondria, Evolutionary medicine: a clinical perspective that posits that many of the common clinical problems of today are rooted in adaptive genetic programs that permitted our human ancestors to survive in the environments which they confronted in the past | neurodegenerative diseases | NARP: neurogenic muscle weaknes, ataxia, and retinitis pigmentosa | MELAS: mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes | MERRF: myoclonic epilepsy and ragged red fiber disease | reactive oxygen species | ETC: mitochondrial electron transport chain, a part of the OXPHOS system | CR: mtDNA control region | human origins | COX: cytochrome c oxidase, complex IV | Oxidative phosphorylation (OXPHOS): the process by which the mitochondrion generates energy through oxidation of organic acids and fats with oxygen to create a capacitor [electron chemical gradient (ΔP = ΔΨ + ΔpH)] across the mitochondrial inner membrane. This ΔP is used as a source of potential energy to generate adenosine triphosphate (ATP), transport substrates or ions, or produce heat. OXPHOS encompasses five multipolypepetide complexes I, II, III, IV and V. Complex I is NADH dehydrogenase or NADH:ubiquinone oxidoreductase, complex II is succinate dehydrogenase (SDH) of succinate:ubiquinone oxidoreductase, complex III is the bc1 complex or ubiquinole: cytochrome c oxidoreductase,complex IV is cytochrome c oxidase (COX) or reduced cytochrome c: oxygen oxidoreductase, and complex V is the ATP synthase or proton-translocating ATP synthase. Complexes I, III, IV, and V encompass both nDNA- and mtDNA-encoded subunits | ZnSOD (Sod1): mitochondrial inner membrane space and cytosolic superoxide dismutase | mtPTP: mitochondrial permeability transition pore | FOXO: mammalian forkhead transcription factor | mitochondria | Mitochondrial DNA (mtDNA): the portion of the mitochondrial genome that currently resides in the matrix of the mitochondrion, as a circular DNA molecule containing the mitochondrial rRNA genes, tRNA genes, and 13 subunits of the mitochondrial oxidative phosphorylation (OXPHOS) enzyme complexes | MnSOD (Sod2): mitochondrial matrix superoxide dismutase | Reactive oxygen species (ROS): primarily superoxide anion (O2• −), hydrogen peroxide (H2O2), and hydroxyl radical (• OH), commonly referred to as oxygen radicals; generated as a toxic by-product of oxidative energy production by OXPHOS damage the mitochondrial and cellular DNA, proteins, lipids, and other molecules causing oxidative stress | PGC-1: PPARγ (peroxisome-proliferating-activated receptor γ) coactivator 1 | Mitochondrion (s), mitochondria (pl): cellular organelle of endosymbiotic origin that resides in the cytosol of most nucleated (eukaryotic) cells and which produces energy by oxidizing organic acids and fats with oxygen by the process oxidative phosphorylation (OXPHOS) and generates oxygen radicals (reactive oxygen species, ROS) as a toxic by-product | KSS: chronic progressive external ophthalmoplegia, Kearn-Sayre syndrome | Apoptosis: a process of programmed cell death resulting in the activation of caspase enzymes and intracellular nucleases that degrade the cellular proteins and nDNA. Apoptosis can be initiated via the mitochondrion through the activation of the mitochondrial permeability transition pore (mtPTP) in response to energy deficiency, increased oxidative stress, excessive Ca2+, and, or other factors | mtDNA: mitochondrial DNA | aging | APP: amyloid precursor protein | diabetes | Unc 1,2,3: uncoupling proteins 1,2,3
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Loading RightsBritish journal of pharmacology, ISSN 0007-1188, 04/2014, Volume 171, Issue 8, pp. 1890 - 1906
OPA1 | mitochondrial morphology | MFN1 | MFN2 | mitochondrial fission | mitochondrial fusion | Drp1 | mitochondrial dynamics | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cardiovascular Diseases - physiopathology | Cell Proliferation | Cardiovascular Diseases - metabolism | Cell Death - physiology | Mitochondrial Proteins - metabolism | Models, Biological | Humans | Myocardium - metabolism | Mitochondrial Proteins - physiology | Molecular Targeted Therapy - methods | Mitochondrial Dynamics - physiology | Proteins | Cardiovascular diseases | Health aspects | Mitochondrial DNA | Index Medicus | Energy, Injury & Beyond | Mitochondrial Pharmacology | Themed Issue
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Loading RightsRedox biology, ISSN 2213-2317, 04/2017, Volume 11, pp. 637 - 645
Type 2 diabetes | Oxidative stress | Redox biology | Mitochondrial dynamics | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Reactive Oxygen Species - metabolism | Mitochondrial Dynamics - genetics | Mitophagy - physiology | Diabetes Mellitus, Type 2 - genetics | Humans | Mitochondria - metabolism | Mitochondrial Proteins - genetics | Diabetes Mellitus, Type 2 - metabolism | Mitochondria - pathology | Mitochondrial Dynamics - physiology | Diabetes Mellitus, Type 2 - physiopathology | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Adenosine Triphosphate - metabolism | Mitophagy - genetics | Index Medicus
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