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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2015, Volume 35, Issue 5, pp. 1166 - 1178
Objectives-Pulmonary hypertension (PH) is a process of lung vascular remodeling, which can lead to right heart dysfunction and significant morbidity. The... 
hypertension, pulmonary | endothelium | mitochondrial uncoupling protein 2 | autophagy | PTEN-induced putative kinase | mitochondrial degradation | APOPTOSIS | LUNG | MITOCHONDRIAL BIOGENESIS | CELL PROLIFERATION | MECHANISMS | MOUSE MODELS | DEFICIENCY | ARTERIAL | PERIPHERAL VASCULAR DISEASE | STRESS | HEMATOLOGY
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 665 - 680
Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | GLUCOSE-METABOLISM | ATP-CITRATE LYASE | UCP2 | SEPTIC SHOCK | CELL-GROWTH | CRITICALLY-ILL PATIENTS | INTENSIVE INSULIN THERAPY | CANCER | MITOCHONDRIAL UNCOUPLING PROTEINS | Fatty Acid Synthase, Type I - genetics | Fatty Acid Synthase, Type I - biosynthesis | Lipids - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Interleukin-1beta - genetics | Lipids - biosynthesis | Sepsis - pathology | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Sepsis - metabolism | Macrophages - pathology | Down-Regulation - genetics | Inflammasomes - genetics | Sepsis - genetics | Mice, Knockout | Carrier Proteins - genetics | Enzyme Induction - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Sepsis - chemically induced | Ion Channels - metabolism | Caspase 1 - genetics | Sepsis - therapy | Mice | Uncoupling Protein 2 | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cellular proteins | Immune response | Synthesis | Sepsis | Development and progression | Lipids | Genetic aspects | Properties | Enzymes | Cytokines | Pathogenesis | Mortality | Glucose | Metabolism | Gene expression | Fatty acids | Proteins | Studies | Metabolites | Consent | Rodents
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2003, Volume 112, Issue 12, pp. 1831 - 1842
Failure to secrete adequate amounts of insulin in response to increasing concentrations of glucose is an important feature of type 2 diabetes. The mechanism... 
MEDICINE, RESEARCH & EXPERIMENTAL | CONCANAVALIN-A | OXYGEN SPECIES PRODUCTION | OXIDATIVE STRESS | CHRONIC EXPOSURE | FREE FATTY-ACIDS | OB-OB MICE | INSULIN-SECRETION | GLUTATHIONE-PEROXIDASE | ENERGY-METABOLISM | GLUCOSE TOXICITY
Journal Article