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Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2015, Volume 26, Issue 6, pp. 673 - 685
Abstract Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most deaths in westernized societies with numbers increasing at a... 
Advanced Basic Science | Therapeutic avenues | Inflammation | Cytokines | Chemokines | Atherosclerosis | Atherosclerosis - immunology | Cytokines - metabolism | Atherosclerosis - physiopathology | Humans | Endothelium, Vascular - physiopathology | Extracellular Matrix - metabolism | Inflammation - immunology | Lipoproteins - blood | Molecular Targeted Therapy | Extracellular Matrix - chemistry | Macrophages - enzymology | Animals | Atherosclerosis - therapy | Muscle, Smooth, Vascular - chemistry | Myocardial Infarction - physiopathology | Chemokines - metabolism | Mice | Matrix Metalloproteinases - metabolism | Macrophages - immunology | Chemokines - immunology | Cytokines - immunology | Endothelium, Vascular - immunology | Inflammation - physiopathology | Development and progression | Blood lipids | Health aspects | GM-CSF, granulocyte macrophage colony-stimulating factor | ECM, extracellular matrix | RCT, reverse cholesterol transport | ICAM-1, intercellular adhesion molecule-1 | LDLr, low-density lipoprotein receptor | PECAM-1, platelet endothelial cell adhesion molecule-1 | ABC, ATP-binding cassette | IL-1RA, IL-1 receptor antagonist | ADRP, adipocyte differentiation related protein | SREBP, sterol response element binding protein | wt, wild type | G-CSF, granulocyte colony-stimulating factor | PAI, plasminogen activator inhibitor | CSF, colony-stimulating factor | PRR, pattern recognition receptor | TIMP, tissue inhibitor of metalloproteinases | NPC, Niemann-Pick disease, type C | TNF, tumor necrosis factor | TL1A, TNF-like protein 1A | NLR, NOD-like receptor | SMCs, smooth muscle cells | CR, chemokine receptor | Tregs, regulatory T cells | Survey | GDF-15, growth differentiation factor-15 | NK, natural killer | TNFSF12, TNF superfamily member 12 | IL, interleukin | NLRP3, NLR family, pyrin domain containing 3 | mmLDL, minimally modified LDL | LIGHT, homologous to lymphotoxin, exhibits inducible expression, and competes with HSV glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes | TF, tissue factor | Th, T-helper | MMP, matrix metalloproteinase | OxLDL, oxidized LDL | CVD, cardiovascular disease | TLR, Toll-like receptor | DCs, dendritic cells | IL-18BP, IL-18 binding protein | miRNA, micro RNA | CANTOS, Canakinumab Anti-inflammatory Thrombosis Outcomes Study | TRAIL, TNF-related apoptosis-inducing ligand | ACAT-1, acyl-CoA acyl transferase-1 | ECs, endothelial cells | TWEAK, TNF-related weak inducer of apoptosis | TGF, transforming growth factor | LFA1, lymphocyte function-associated antigen 1 | ROS, reactive oxygen species | CIRT, Cardiovascular Inflammation Reduction Trial | LDL, low-density lipoprotein | IFN, interferon | MIF, macrophage migration inhibitory factor | SR, scavenger receptor | eNOS, endothelial nitric oxide synthase | STAT1, signal transducer and activator of transcription-1 | Fn14, fibroblast growth factor-inducible 14 | VCAM-1, vascular cell adhesion molecule-1 | LXR, liver X receptors | MHC, major histocompatibility complex | CCR2, CC-chemokine receptor-2 | NOD, nucleotide-binding oligomerization domain | VLA4, very late antigen 4 | BMT, bone marrow transplantation | SR-PSOX, SR that binds phosphatidyl serine and oxidized lipoprotein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | Apo, apolipoprotein | M-CSF, macrophage-colony stimulating factor | ER, endoplasmic reticulum
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 04/2012, Volume 1821, Issue 4, pp. 706 - 718
The truncated phospholipids 1-palmitoyl-2-(5-oxovaleroyl)- -glycero-3-phosphocholine (POVPC) and 1-palmitoyl-2-glutaroyl- -glycero-3-phosphocholine (PGPC) are... 
Schiff base | Aldehydophospholipid | Functional proteomic analysis | Oxidized LDL | Atherosclerosis | Phospholipid exchange | STOMATIN | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | RECEPTOR | IDENTIFICATION | PLASMA-MEMBRANE | CELL BIOLOGY | BIOPHYSICS | SCHIFF-BASE | SMOOTH-MUSCLE-CELLS | PLATELET-ACTIVATING-FACTOR | CATHEPSIN-D | Macrophages - chemistry | Lipoproteins, LDL - chemistry | Models, Chemical | Humans | Electrophoresis, Gel, Two-Dimensional | Phosphatidylcholines - metabolism | Phosphatidylcholines - pharmacokinetics | Tandem Mass Spectrometry | Cattle | Serum Albumin, Bovine - chemistry | Lipoproteins, LDL - metabolism | Membrane Proteins - metabolism | Molecular Structure | Boron Compounds - chemistry | Cell Line | Fluorescent Dyes - chemistry | Phospholipid Ethers - metabolism | Oxidation-Reduction | Electrophoresis, Polyacrylamide Gel | Macrophages - cytology | Phosphatidylcholines - chemistry | Serum Albumin, Bovine - metabolism | Phospholipid Ethers - chemistry | Macrophages - metabolism | Animals | Proteins - metabolism | Membrane Proteins - chemistry | Protein Binding | Mice | Proteins - chemistry | Microscopy, Fluorescence | Phospholipid Ethers - pharmacokinetics | Schiff bases | Low density lipoproteins | Albumin | Lipids | Development and progression | Phospholipids | Plant lipids | Macrophages | Proteins | Membrane lipids | Physiological aspects | Blood lipids | Protein binding
Journal Article
Autophagy, ISSN 1554-8627, 05/2015, Volume 11, Issue 5, pp. 785 - 795
Adaptive immunity, which plays an important role in the development of atherosclerosis, is mediated by major histocompatibility complex (MHC)-dependent antigen... 
SYK, spleen tyrosine kinase | MAA-LDL, malondialdehyde-acetaldehyde modified low density lipoprotein | DPI, diphenyleneiodonium | MAP1LC3/LC3, microtubule-associated protein 1 light chain 3 | ITAM, immunoreceptor tyrosine-based activation motif | FCGR, Fc fragment of IgG | APCs, antigen-presenting cells | BCR, B cell receptor | low affinity, receptor | PBS, phosphate-buffered saline | HFD, high-fat diet | oxidation-specific antibodies | 3MA, 3-methyladenine | mmLDL, minimally modified low density lipoprotein | ROS, reactive oxygen species | TLR4, toll-like receptor 4 | BMDM, bone marrow-derived macrophage | GFP, green fluorescent protein | IgM, immunoglobulin M | NOX, NAPDH oxidase | autophagy | SYK | MHC-II, major histocompatibility complex class II | TNF, tumor necrosis factor | MDA-LDL, malondialdehyde modified low density lipoprotein | OSE, oxidation specific epitopes | IgG, immunoglobulin G | 1 | OxLDL, oxidized low density lipoprotein | PIC, piceatannol | IL2, interleukin 2 | ROS | Baf, bafilomycin A | LPS, lipopolysaccharide | OxLDL | MAPK, mitogen-activated protein kinase | MHC-II | TCR, T cell receptor | Oxidation-specific antibodies | Autophagy | IMMUNITY | CELLS | HUMAN PLASMA | TYROSINE KINASE | LOW-DENSITY-LIPOPROTEIN | ATHEROSCLEROSIS | JNK1-MEDIATED PHOSPHORYLATION | CELL BIOLOGY | MICE | PLATELET ACTIVATION | PROTEINS | Hypercholesterolemia - immunology | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | NADPH Oxidases - metabolism | Ether-A-Go-Go Potassium Channels - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Protein-Tyrosine Kinases - deficiency | Autophagy - drug effects | CD4-Positive T-Lymphocytes - immunology | Epitopes - immunology | Intracellular Signaling Peptides and Proteins - deficiency | Proto-Oncogene Proteins c-bcl-2 - metabolism | Lymphocyte Activation - immunology | Hypercholesterolemia - pathology | Immunoglobulin G - immunology | Oxidation-Reduction - drug effects | Histocompatibility Antigens Class II - metabolism | Syk Kinase | Mice, Inbred C57BL | Lipoproteins, LDL - pharmacology | Macrophages - cytology | NADPH Oxidase 2 | Up-Regulation - drug effects | Macrophages - metabolism | Animals | Mitogen-Activated Protein Kinase 8 | Macrophages - drug effects | RAW 264.7 Cells | Mice
Journal Article
Redox Biology, ISSN 2213-2317, 04/2015, Volume 4, Issue C, pp. 296 - 307
Journal Article
FEBS Letters, ISSN 0014-5793, 03/2011, Volume 585, Issue 6, pp. 854 - 860
Atherosclerosis is an inflammatory process due to oxidized low-density lipoprotein (oxLDL) accumulation in macrophages. We investigated the involvement of... 
MicroRNA | Lipoprotein | Toll-like receptor 4 | Atherosclerosis | Macrophage | microRNAs | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | oxysterol binding protein-like 9 | toll-like receptors | mmLDL | JNK | v-akt murine thymoma viral oncogene homolog 1 | MyD88 | polyinosinic:polycytidylic acid | interleukin 6 | NF-κB | mitogen-activated protein kinase 14 | oxLDL | CD36 | matrix metallopeptidase 9 | interleukin 8 | Syk | spleen tyrosine kinase | poly I:C | ORP9 | IL-8 | MAPK | IL-6 | TRAF6 | Pyk2 | interleukin-1 receptor-associated kinase 1 | toll-like receptor 3 | lipopolysaccharide | TLR4 | toll-like receptor 4 | MMP-9 | TLR3 | PCR | TLR2 | toll-like receptor 2 | ERK | ELISA | MCP-1 | SRA | miRNAs | Src | chemokine (C–C motif) ligand 2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | LPS | mitogen-activated protein kinase | proline-rich tyrosine kinase 2 | IRAK1 | p38 | minimally modified low-density lipoprotein | polymerase chain reaction | 3′ untranslated region | TNF receptor-associated factor 6 | scavenger receptor A | 3′-UTR | myeloid differentiation primary response gene | AKT | CD36 molecule | mitogen-activated protein kinase 8 | enzyme-linked immunosorbent assay | mitogen-activated protein kinase 1 | oxidized low-density lipoprotein | TLRs | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICRORNAS | MURINE | CELL BIOLOGY | BIOPHYSICS | MICE | EXPRESSION | Oligonucleotide Array Sequence Analysis | Humans | 3' Untranslated Regions - genetics | MicroRNAs - metabolism | Gene Expression Profiling | Matrix Metalloproteinase 9 - metabolism | RNA Interference | Base Sequence | Inflammation Mediators - metabolism | Chemokine CCL2 - metabolism | Lipoproteins, LDL - metabolism | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Cell Line | Cytokines - metabolism | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Macrophages - cytology | Toll-Like Receptor 4 - metabolism | Macrophages - metabolism | Cholesterol, LDL - metabolism | Cytoskeleton - metabolism | Signal Transduction - physiology | MicroRNAs - genetics | HeLa Cells | Mutation
Journal Article
Vascular Pharmacology, ISSN 1537-1891, 09/2017, Volume 96-98, pp. 33 - 39
Minimally modified low density lipoprotein (mmLDL) is a risk factor for cardiovascular disease. This study investigated the effect of mmLDL on mouse mesenteric... 
ETB receptor | ERK1/2 | Mesenteric artery | VCAM-1 | Tail vein injection | mmLDL | ICAM-1 | receptor | ET | CELLS | RAT | ENDOTHELIUM-DEPENDENT RELAXATION | BLOOD-FLOW REDUCTION | INHIBITION | LDL | SUBARACHNOID HEMORRHAGE | PHARMACOLOGY & PHARMACY | TNF-ALPHA | CEREBRAL-ISCHEMIA | 5-HT1B RECEPTORS
Journal Article