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Journal of Pharmaceutical Sciences, ISSN 0022-3549, 04/2015, Volume 104, Issue 4, pp. 1362 - 1372
Two US FDA-approved antibody-drug conjugates (ADCs; Kadcyla® and Adcetris®) have accelerated clinical interest in the potential of targeted cancer therapeutics... 
protein structure | calorimetry (DSC) | IgG antibody | mass spectrometry | biopharmaceuticals characterization | monoclonal antibody | conjugation | HPLC (high-performance/pressure liquid chromatography) | HPLC (high‐performance/pressure liquid chromatography) | Biopharmaceuticals characterization | Calorimetry (DSC) | Conjugation | Monoclonal antibody | Mass spectrometry | Protein structure | CHEMISTRY, MEDICINAL | STABILITY | ALKYLATION | LIGHT-CHAIN | IGG | MONOCLONAL-ANTIBODY | DISULFIDE BOND | CANCER | CHEMISTRY, MULTIDISCIPLINARY | MOLECULES | LC-MS | REDUCTION | PHARMACOLOGY & PHARMACY | Temperature | Cross-Linking Reagents - chemistry | Maytansine - analogs & derivatives | Drug Stability | Immunoglobulin G - chemistry | Immunoglobulin Heavy Chains - chemistry | Technology, Pharmaceutical - methods | Chromatography, High Pressure Liquid | Cysteine - chemistry | Immunoconjugates - chemistry | Chemistry, Pharmaceutical | Immunoglobulin Light Chains - chemistry | Chromatography, Reverse-Phase | Electrophoresis, Capillary | Peptide Mapping | Mass Spectrometry | Hydrophobic and Hydrophilic Interactions | Maytansine - chemistry | Calorimetry, Differential Scanning | Protein Stability | Oligopeptides - chemistry | Trastuzumab | Antibodies, Monoclonal, Humanized - chemistry | Cysteine | Thiols | Immunoglobulin G | Drug approval | Biopharmaceutics | Cystine | Homeopathy | Materia medica and therapeutics | Therapeutics | Monoclonal antibodies | Chemical properties | Pharmacists | High performance liquid chromatography | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 03/2013, Volume 110, Issue 13, pp. 5145 - 5150
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 2009, Volume 346, Issue 1, pp. 26 - 37
Natural IgA antibodies are abundantly produced to protect serosal surfaces from invading infectious organisms. However, the immunotherapeutic potential of IgA... 
IgA | Purification | Antibody | Production | PROTEIN | EFFECTOR MECHANISMS | FC-RECEPTORS | BIOCHEMICAL RESEARCH METHODS | IMMUNOLOGY | MAMMALIAN-CELLS | GROWTH-FACTOR RECEPTOR | IMMUNOGLOBULIN-A | HUMAN IGG1 | HAMSTER OVARY CELLS | MONOCLONAL-ANTIBODIES | ADSORPTION CHROMATOGRAPHY | Antibody Specificity | Recombinant Fusion Proteins - isolation & purification | Immunoglobulin Heavy Chains - biosynthesis | Cricetulus | Immunoglobulin A - biosynthesis | Humans | Immunoglobulin A - genetics | Immunoglobulin Light Chains - isolation & purification | Immunoglobulin Light Chains - genetics | Transfection | Leukocytes, Mononuclear - immunology | Immunoglobulin Heavy Chains - isolation & purification | CHO Cells | Recombinant Fusion Proteins - biosynthesis | Receptor, Epidermal Growth Factor - immunology | Cricetinae | Immunoglobulin Heavy Chains - pharmacology | Immunoglobulin A - metabolism | Leukocytes, Mononuclear - drug effects | Antibody-Dependent Cell Cytotoxicity | Immunoglobulin A - pharmacology | Immunoglobulin A - isolation & purification | Immunoglobulin Light Chains - metabolism | Immunoglobulin Light Chains - biosynthesis | Animals | Chromatography, Affinity | Immunoglobulin Light Chains - pharmacology | Hybridomas | Cell Line, Tumor | Immunoglobulin Heavy Chains - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Binding Sites, Antibody | Chromatography, Gel | Immunoglobulin Heavy Chains - genetics | Hypertension | Usage | Ligases | Immunotherapy | Immunoglobulin G | Stem cells | Methionine | Fluorescence | Transplantation | Immunoglobulin A | Health aspects | Glutamine
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2017, Volume 292, Issue 24, pp. 9975 - 9987
Immunoglobulin E and its interactions with receptors Fc is an element of RI and CD23 play a central role in allergic disease. Omalizumab, a clinically approved... 
RECEPTOR COMPLEXES | DOMAIN | FC-EPSILON-RI | CONFORMATIONAL-CHANGES | AFFINITY | CRYSTAL-STRUCTURE | BENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCLONAL-ANTIBODY | MAMMALIAN-CELLS | BINDING | Surface Plasmon Resonance | Omalizumab - genetics | Recombinant Fusion Proteins - pharmacology | Immunoglobulin Fc Fragments - metabolism | Humans | Omalizumab - metabolism | Crystallography, X-Ray | Recombinant Fusion Proteins - metabolism | Receptors, IgE - chemistry | Immunoglobulin E - genetics | Immunoglobulin Fab Fragments - metabolism | Fluorescence Resonance Energy Transfer | Protein Interaction Domains and Motifs | Recombinant Proteins - metabolism | Anti-Asthmatic Agents - pharmacology | Omalizumab - chemistry | Pliability | Immunoglobulin Fab Fragments - genetics | Immunoglobulin E - metabolism | Protein Refolding | Solubility | Models, Molecular | Receptors, IgE - antagonists & inhibitors | Recombinant Proteins - chemistry | Immunoglobulin Fc Fragments - chemistry | Recombinant Fusion Proteins - chemistry | Recombinant Proteins - pharmacology | Immunoglobulin Fab Fragments - pharmacology | Immunoglobulin E - chemistry | Point Mutation | Receptors, IgE - metabolism | Immunoglobulin Fab Fragments - chemistry | Omalizumab - pharmacology | Allosteric Site | Immunoglobulin Fc Fragments - pharmacology | Protein Conformation | Immunoglobulin Fc Fragments - genetics | Amino Acid Substitution | X-ray crystallography | Immunology | antibody | immunoglobulin E (IgE) | allergy | omalizumab | allosteric regulation
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e90383
Journal Article
Journal Article
mAbs, ISSN 1942-0862, 01/2015, Volume 7, Issue 1, pp. 167 - 179
Immunoglobulin G (IgG) crystallizable fragment (Fc) glycosylation is crucial for antibody effector functions, such as antibody-dependent cell-mediated... 
IgG glycosylation | method comparison | high-throughput | HILIC-UPLC | APTS labeling | CE-LIF | 2-AB labeling | HPAEC | DNA analyzer | monoclonal antibody (mAb) | glycan analysis | Glycan analysis | High-throughput | Apts labeling | Monoclonal antibody (mab) | Method comparison | Dna analyzer | 2-ab labeling | DNA-sequencer-aided fluorophore-assisted carbohydrate electrophoresis | 2-aminobenzamide | MALDI-MS | InstantAB labeling | MONOCLONAL-ANTIBODY | 2-AB | CHO | LINKED OLIGOSACCHARIDES | 6-trisulfonate | matrix-assisted laser desorption | cartridge-based capillary gel electrophoresis | PROTEIN GLYCOSYLATION | CCGE | ESI-MS | HPAEC-PAD | IAB | CAPILLARY GEL-ELECTROPHORESIS | ANION-EXCHANGE CHROMATOGRAPHY | hydrophilic interaction liquid chromatography-ultra high performance liquid chromatography | Chinese hamster ovary | electrospray ionization-mass spectrometry | 6-trisulfonic acid | CE-LIF-MS | MEDICINE, RESEARCH & EXPERIMENTAL | DSA-FACE | IgG | MASS-SPECTROMETRY | INDUCED FLUORESCENCE | LABELED N-GLYCANS | ionization-mass spectrometry | high-performance anion exchange chromatography with pulsed amperometric detection | antigen-binding | HPLC | high resolution | immunoglobulin G | fragment crystallizable | Fab | 8-aminopyrene-1 | mAb | 8-aminonaphthalene-1 | APTS | fragment | high performance liquid chromatography | ANTS | monoclonal antibody | PULSED AMPEROMETRIC DETECTION | capillary electrophoresis-laser induced fluorescence | Cricetinae | Animals | Cricetulus | Mass Spectrometry | Immunoglobulin Fc Fragments - chemistry | Glycosylation | Chromatography, High Pressure Liquid | Antibodies, Monoclonal - chemistry | CHO Cells
Journal Article
Journal Article