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eLife, ISSN 2050-084X, 08/2014, Volume 3, Issue 2014, pp. 1 - 17
The Cdc45/Mcm2-7/GINS ( CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains... 
replication fork | DNA replication | helicase | motor proteins | AAA+ ATPase | Mcm2-7 | MCM2-7 HELICASE | HEXAMERIC HELICASE | MINICHROMOSOME MAINTENANCE PROTEIN | ARCHAEAL MCM | BUDDING YEAST | STRUCTURAL BASIS | BIOLOGY | REPLICATIVE HELICASE | ELECTRON-MICROSCOPY | 26S PROTEASOME | CRYO-EM STRUCTURE | Minichromosome Maintenance Proteins - metabolism | Protein Multimerization | Eukaryotic Cells - metabolism | Drosophila Proteins - metabolism | Minichromosome Maintenance Proteins - chemistry | Protein Subunits - metabolism | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Multiprotein Complexes - metabolism | Adenosine Triphosphate - metabolism | Protein Structure, Quaternary | Repressor Proteins - metabolism | Protein Structure, Tertiary | Repressor Proteins - chemistry | Chromosomal Proteins, Non-Histone - metabolism | DNA, Single-Stranded - metabolism | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | RNA Splicing Factors | Adenosine Triphosphatases - metabolism | Models, Molecular | DNA Replication | DNA - metabolism | Drosophila Proteins - chemistry | Microscopy, Electron | DNA-Binding Proteins - chemistry | Adenosine Triphosphate - analogs & derivatives | DNA, Single-Stranded - chemistry | Multiprotein Complexes - ultrastructure | DNA - chemistry | Multiprotein Complexes - chemistry | Animals | Protein Binding | Adenosine Triphosphatases - chemistry | Protein Subunits - chemistry | Adenosine Triphosphate - chemistry | Chromosomal Proteins, Non-Histone - chemistry | RNA-Binding Proteins - metabolism | Medical research | Single-stranded DNA | Hexamers | Electron microscopy | DNA biosynthesis | DNA helicase | Handedness | Microscopy | Insects | Cdc45 protein | Cell cycle | Polarity | Dimerization | Deoxyribonucleic acid--DNA | Adenosine triphosphatase
Journal Article
Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
... and that encode proteins that are essential... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects
Journal Article
Neuron, ISSN 0896-6273, 2005, Volume 47, Issue 6, pp. 817 - 831
The molecular mechanisms controlling the differentiation of neural progenitors into distinct subtypes of neurons during neocortical development are unknown.... 
AREA IDENTITY | MIGRATION | CELL FATE SPECIFICATION | IN-VIVO | MOUSE | CENTRAL-NERVOUS-SYSTEM | ZINC-FINGER GENE | SUBVENTRICULAR ZONE | EXPRESSION | NEUROSCIENCES | CEREBRAL-CORTEX | Membrane Glycoproteins - metabolism | Embryo, Mammalian | Homeodomain Proteins - metabolism | Nerve Tissue Proteins - deficiency | S100 Proteins - genetics | POU Domain Factors - genetics | Forkhead Transcription Factors - metabolism | In Situ Hybridization - methods | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | POU Domain Factors - metabolism | Animals, Newborn | DNA-Binding Proteins - physiology | Motor Neurons - physiology | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | S100 Proteins - metabolism | In Situ Nick-End Labeling - methods | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Immunohistochemistry - methods | Annexin A2 - genetics | Cell Death - physiology | Green Fluorescent Proteins - biosynthesis | Mice | Annexin A2 - metabolism | Age Factors | Phosphopyruvate Hydratase - metabolism | Cell Movement - physiology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Motor Neurons - cytology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Bromodeoxyuridine - metabolism | Cell Differentiation - physiology | Pyramidal Tracts - physiology | Nerve Tissue Proteins - physiology | Neocortex - growth & development | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Count - methods | Neocortex - cytology | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Neurosciences | Neurons | Developmental biology | Stem cells | Studies | Brain | Ultrasonic imaging | Transcription factors | Hybridization | Neurogenesis
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2013, Volume 32, Issue 6, pp. 886 - 898
...‐proteins during import. Our analyses revealed that the presequence receptor Tim50 interacts with Tim21 in a signal... 
import | mitochondria | presequence | TIM23 complex | CONTACT SITES | MATRIX | INNER MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | PREPROTEIN TRANSLOCASES | MITOCHONDRIAL TIM23 COMPLEX | CELL BIOLOGY | TIM50 | STRUCTURAL BASIS | MOLECULAR MACHINES | MOTOR | Protein Sorting Signals - physiology | Protein Interaction Domains and Motifs - physiology | Saccharomyces cerevisiae - genetics | Substrate Specificity | Membrane Transport Proteins - physiology | Mitochondrial Membrane Transport Proteins - genetics | Saccharomyces cerevisiae - metabolism | Mitochondrial Membrane Transport Proteins - physiology | Membrane Transport Proteins - genetics | Protein Interaction Domains and Motifs - genetics | Membrane Transport Proteins - metabolism | Membrane Proteins - metabolism | Binding Sites | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Protein Structure, Secondary | Membrane Proteins - genetics | Models, Molecular | Saccharomyces cerevisiae Proteins - genetics | Protein Transport - genetics | Membrane Transport Proteins - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Membrane Proteins - chemistry | Protein Sorting Signals - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae Proteins - physiology | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Signal transduction | Membranes
Journal Article
Nature, ISSN 0028-0836, 11/2002, Volume 420, Issue 6912, pp. 178 - 182
Journal Article
Journal of Cell Science, ISSN 0021-9533, 05/2008, Volume 121, Issue 9, pp. 1506 - 1513
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 41, pp. 28689 - 28696
Translocation of proteins from the cytosol across the mitochondrial inner membrane is driven by action of the matrix-localized multi-subunit import motor, which is associated with the TIM23 translocon... 
J-DOMAIN | COMPLEX | HSP70 | PRESEQUENCE TRANSLOCASE | PROTEIN SECONDARY STRUCTURE | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | CROSS-LINKING | SACCHAROMYCES-CEREVISIAE | PREPROTEIN TRANSLOCASE | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Molecular Motor Proteins - genetics | Mitochondrial Membrane Transport Proteins - genetics | Photochemical Processes | Saccharomyces cerevisiae - metabolism | Membrane Transport Proteins - genetics | Light | Mitochondrial Membranes - chemistry | Membrane Transport Proteins - metabolism | Molecular Motor Proteins - metabolism | Membrane Proteins - metabolism | Gene Expression Regulation, Fungal | Protein Structure, Tertiary | Amino Acid Sequence | Mitochondrial Membrane Transport Proteins - chemistry | Mitochondrial Membrane Transport Proteins - metabolism | Protein Structure, Secondary | Membrane Proteins - genetics | Mitochondria - metabolism | Saccharomyces cerevisiae Proteins - genetics | Molecular Motor Proteins - chemistry | Membrane Transport Proteins - chemistry | Mitochondrial Membranes - metabolism | Protein Transport | Membrane Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Cytosol - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Protein Translocation | Mitochondria | Yeast | Protein-Protein Interaction | TIM23 Complex | Cell Biology | Protein Cross-linking
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2010, Volume 38, Issue 1, pp. 89 - 100
Heat shock proteins 70 (Hsp70) represent a ubiquitous and conserved family of molecular chaperones involved in a plethora of cellular processes... 
PROTEINS | ALLOSTERIC REGULATION | INTERDOMAIN COMMUNICATION | PRECURSOR PROTEINS | SUBSTRATE-BINDING | STRUCTURAL BASIS | MOLECULAR CHAPERONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROBABILITY-DISTRIBUTION ANALYSIS | RESONANCE ENERGY-TRANSFER | PROTEIN IMPORT MOTOR | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Calcium-Transporting ATPases - chemistry | Molecular Chaperones - metabolism | Humans | Bacterial Proteins - chemistry | Adenosine Diphosphate - chemistry | Molecular Chaperones - chemistry | Adenosine Triphosphate - metabolism | Fluorescence Resonance Energy Transfer | Calcium-Transporting ATPases - metabolism | HSP70 Heat-Shock Proteins - chemistry | Membrane Proteins - metabolism | HSP40 Heat-Shock Proteins - chemistry | HSP40 Heat-Shock Proteins - metabolism | Bacterial Proteins - genetics | Models, Molecular | Escherichia coli Proteins - metabolism | HSP70 Heat-Shock Proteins - genetics | Mitochondria - metabolism | Protein Folding | HSP70 Heat-Shock Proteins - metabolism | Membrane Proteins - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Escherichia coli Proteins - genetics | Bacterial Proteins - metabolism | Protein Conformation | Adenosine Diphosphate - metabolism | Adenosine Triphosphate - chemistry | Escherichia coli Proteins - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Hydrolysis | Analysis | Physiological aspects | Fluorescence | Heat shock proteins | Nucleotides
Journal Article
Autophagy, ISSN 1554-8627, 04/2019, Volume 15, Issue 4, pp. 631 - 651
Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons counteracts aggregate-prone misfolded protein toxicity... 
autophagy | neurodegeneration | spinal and bulbar muscular atrophy | TFEB | Amyotrophic lateral sclerosis | motoneuron diseases | trehalose | lactulose | calcineurin | protein quality control | lysosomes | melibiose | galectin-3 | MITOCHONDRIAL BIOGENESIS | MUTANT ANDROGEN RECEPTOR | REGULATES AUTOPHAGY | AMYOTROPHIC-LATERAL-SCLEROSIS | SELECTIVE AUTOPHAGY | CELL BIOLOGY | MOUSE MODEL | PROTEIN B8 HSPB8 | MISFOLDED PROTEINS | POLYGLUTAMINE AGGREGATION | MEMBRANE PERMEABILIZATION | RNA, Small Interfering - genetics | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Autophagosomes - enzymology | Lysosomes - enzymology | Amyotrophic Lateral Sclerosis - drug therapy | Autophagy - drug effects | Motor Neurons - pathology | Motor Neurons - ultrastructure | Neuroprotection - drug effects | Autophagosomes - drug effects | Calcineurin - genetics | Cell Nucleus - metabolism | Lysosomes - metabolism | Trehalose - analogs & derivatives | Cell Differentiation | Membrane Proteins - metabolism | Autophagy - genetics | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Induced Pluripotent Stem Cells - metabolism | Induced Pluripotent Stem Cells - pathology | Lysosomes - drug effects | Induced Pluripotent Stem Cells - enzymology | Unfolded Protein Response - genetics | Membrane Proteins - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry | Induced Pluripotent Stem Cells - ultrastructure | Signal Transduction - genetics | Autophagosomes - metabolism | Bulbo-Spinal Atrophy, X-Linked - metabolism | Motor Neurons - enzymology | Neuroprotection - genetics | Bulbo-Spinal Atrophy, X-Linked - drug therapy | Down-Regulation - genetics | Lysosomes - ultrastructure | Motor Neurons - metabolism | Animals | Signal Transduction - drug effects | Amyotrophic Lateral Sclerosis - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Autophagy-Related Proteins - metabolism | Calcineurin - metabolism | RNA, Small Interfering - metabolism | Trehalose - pharmacology
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 01/2014, Volume 39, Issue 1, pp. 131 - 155
There is serious interest in understanding the dynamics of the receptor-receptor and receptor-protein interactions in space and time and their integration in GPCR heteroreceptor complexes of the CNS... 
receptorreceptor interactions | moonlighting | neuropsychiatric disorders | G protein-coupled receptors | neurotherapeutic targets | heterodimerization | PSYCHIATRY | RESONANCE ENERGY-TRANSFER | FIBROBLAST-GROWTH-FACTOR | NEUROSCIENCES | INDUCED MOTOR COMPLICATIONS | receptor-receptor interactions | ADENOSINE A(2A) RECEPTORS | DOPAMINE D2 RECEPTORS | HIGHER-ORDER OLIGOMERS | ANTIPSYCHOTIC-DRUGS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | PARKINSONS-DISEASE | MOLECULAR-MECHANISMS | Schizophrenia - metabolism | Antiparkinson Agents - pharmacology | Receptors, G-Protein-Coupled - metabolism | Humans | Drug Discovery - methods | Parkinson Disease - drug therapy | Antidepressive Agents - therapeutic use | Antiparkinson Agents - therapeutic use | Cocaine - pharmacology | Depression - drug therapy | Protein Interaction Mapping - methods | Depression - metabolism | Animals | Cocaine-Related Disorders - metabolism | Antipsychotic Agents - therapeutic use | Antidepressive Agents - pharmacology | Cocaine-Related Disorders - drug therapy | Parkinson Disease - metabolism | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Cocaine - adverse effects | Molecular Targeted Therapy - methods | Allosteric properties | receptor–receptor interactions | Receptor Pharmacology | Dopamine | Development | Neuropharmacology | Drug Discovery | Neuropsychopharmacology Reviews
Journal Article