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Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 12/2017, Volume 96, pp. 535 - 544
Hepatocelluar carcinoma (HCC) is one of the most frequently diagnosed cancers worldwide and among the leading causes of cancer-related death. Although... 
Mechanistic target of rapamycin(mTOR) | Hepatocellular carcinoma(HCC) | Mouse double minute 2 homolog (MDM2) | MiR-758-3p | MEDICINE, RESEARCH & EXPERIMENTAL | PATHWAY | PHARMACOLOGY & PHARMACY | INFECTION | EXPRESSION | P53 | Tumor proteins | Hepatoma
Journal Article
by Xu, YM and Gao, Q and Xue, YQ and Li, XX and Xu, L and Li, CW and Qin, YQ and Fang, J
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 06/2019, Volume 294, Issue 25, pp. 9949 - 9958
Prolyl hydroxylase 3 (PHD3) has initially been reported to hydroxylase hypoxia-inducible factor (HIF) and mediate HIF degradation. More recent studies have... 
APOPTOSIS | STEM-CELLS | PHD3 | PROTEIN | colon cancer | BIOCHEMISTRY & MOLECULAR BIOLOGY | IKK-BETA | mouse double minute 2 homolog (MDM2) | HYPOXIA | protein stability | prolyl hydroxylase 3 | p53 | MDM2 | BINDING-SITE | NANOG | cancer stem cells | DIFFERENTIATION
Journal Article
Clinical and Translational Oncology, ISSN 1699-048X, 2019
Dedifferentiated liposarcoma (DDLPS) is a soft tissue malignancy characterized by amplification of the mouse double minute 2 homolog (MDM2) gene. MDM2 is a... 
Tumor protein 53 (TP53) | Mouse double minute 2 homolog (MDM2) amplification | Dedifferentiated liposarcoma | MDM2-TP53 inhibitor | Patient-derived xenografts
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 23, pp. 9186 - 9197
Autophagy promotes cancer cell survival in response to p53 activation by the anticancer agent Nutlin-3a (Nutlin). We reported previously that Nutlin kills... 
APOPTOSIS | autophagy | Jumonji domain containing protein 2B (JMJD2B) | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | mouse double minute 2 homolog (MDM2) | histone demethylase | epigenetic regulation | p53 | histone methylation | ATG16L1 | ROLES | chromatin regulation | nutlin | ULK1 | cancer | MDM2 proto-oncogene
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 16, pp. 10200 - 10207
Journal Article
Journal Article
Journal Article
The Journal of Biological Chemistry, ISSN 0021-9258, 8/2015, Volume 290, Issue 35, pp. 21536 - 21552
Background: Breast cancer autoantigen nucleolar GTP-binding protein-1 (NGP-1) is overexpressed in cancers. Results: NGP-1 promotes G 1 to S phase transition by... 
E2F transcription factor | mouse double minute 2 homolog (Mdm2) | tumor cell biology | cell cycle | Cell Biology | p53
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 09/2015, Volume 5, Issue 5, pp. 378 - 389
Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong... 
Cancer drug discovery and development | HIF-1α inhibitors | HIF-1α | RCC, renal cell carcinoma | Ras, rat sarcoma | Raf, rapidly accelerated fibrosarcoma | EGF, epidermal growth factor | C-TAD, COOH-terminal TAD | HTS, high throughput screens | ARD-1, arrest-defective-1 | ELISA, enzyme-linked immunosorbent assay | pVHL, von Hippel-Lindau protein | LEP, leptin | ChIP, chromatin immunoprecipitation | IPAS, inhibitory PAS | IGF-BP3, IGF-factor-binding protein 3 | PAS, Per and Sim | mTOR, mammalian target of rapamycin | RT-PCR, reverse transcription polymerase chain reaction | CAC, circulating angiogenic cells | CoCl2, cobalt chloride | AKt, protein kinase B | TPT, topotecan | bHLH, basic-helix-loop-helix | LDHA, lactate dehydrogenase | GLUTs, glucose transporters | P, proline residue | ODDD, oxygen dependent degradation domain | TGF-α, transforming growth factor α | VEGF, vascular endothelial growth factor | CPTs, camptothecins | Mdm2, mouse double minute 2 homolog | PKM, pyruvate kinase M | AhR, aryl hydrocarbon receptor | K, lysine residue | IGF2, insulin-like growth factor 2 | GLUT3, glucose transporter 3 | CBP associated factor | eIF-4E, eukaryotic translation initiation factor 4E | MEK, MAPK | ADM, adrenomedullin | ARNT, aryl hydrocarbon nuclear translocator | HK2, hexokinase 2 | PHDs, prolyl-4-hydroxylases | PCAF, p300 | FIH-1, factor inhibiting HIF-1 | Review | SIRT 1, Sirtuin 1 | ERK kinase | C-MYC, myelocytomatosis virus oncogene cellular homolog | IGF-BP2, IGF-factor-binding protein 2 | N, asparagine residue | TAD, transactivation domains | HDAC, histone deacetylase | EMSA, electrophoretic mobility shift assay | LRP1, LDL-receptor-related protein 1 | Luc, luciferase | GAs, geldanamycins | HIF-1α, hypoxia-inducible factor-1α | HK1, hexokinase 1 | ID2, DNA-binding protein inhibitor | HPH, HIF-1 prolyl hydroxylases | NOS, nitric oxide synthase | N-TAD, NH2-terminal TAD | MNK, MAP kinase interacting kinase | MTs, microtubules | HRE, hypoxia response elements | ERK, extracellular signal-regulated kinase | EPO, erythropoietin | MAPK, mitogen-activated protein kinases | PI3K, phosphatidyl inositol-4,5-bisphosphate-3-kinase | DFO, deferoxamine | Top I, topoisomerase I | GLUT1, glucose transporter 1 | Hsp90, heat shock protein 90 | TGF-β3, transforming growth factor beta3 | 4E-BP1, eukaryotic translation initiation factor 4E (eIF-4E) binding protein p70 S6 kinase (S6K) | GA, geldanamycin
Journal Article