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PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e63404 - e63404
Although multidrug-resistance-associated protein-1 (MRP1) is a major contributor to multi-drug resistance (MDR), the regulatory mechanism of Mrp1 still remains... 
OXIDATIVE STRESS | GAMMA-GLUTAMYLCYSTEINE SYNTHETASE | TRANSCRIPTION FACTOR NRF2 | MRP/GS-X PUMP | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR P-GLYCOPROTEIN | ANTICANCER DRUGS | DRUG-RESISTANCE | ADAPTIVE RESPONSE | RESPONSIVE ELEMENT | INDUCIBLE EXPRESSION | Immunohistochemistry | Antioxidants - metabolism | Drug Resistance, Multiple - drug effects | Humans | Lung Neoplasms - metabolism | Molecular Sequence Data | 5' Flanking Region - genetics | Gene Knockdown Techniques | Small Cell Lung Carcinoma - metabolism | Base Sequence | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents - pharmacology | Response Elements - genetics | Gene Expression Regulation, Neoplastic - drug effects | Lung Neoplasms - genetics | Drug Resistance, Multiple - genetics | Signal Transduction - genetics | Small Cell Lung Carcinoma - genetics | Mutation - genetics | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Software | Multidrug Resistance-Associated Proteins - metabolism | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Comparative analysis | Drug resistance | Lung cancer | Cancer | Drugs | Oxidative stress | Enzymes | Genes | Multidrug resistance | Regulatory sequences | Drug development | Gene expression | Tissues | Cancer therapies | Proteins | Antioxidants | Pathology | Toxicology | Reporter gene | Correlation analysis | Rodents | Regulatory mechanisms (biology) | Localization | MRP1 protein | Index Medicus
Journal Article
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 01/2017, Volume 1859, Issue 1, pp. 69 - 79
Multidrug resistance (MDR) is the main cause of diminished success in cancer chemotherapy. ABC transport proteins are considered to be one important factor of... 
MRP1 | ABCC1 | Transport activation | Flux ratio | Activator | ABC transporter | GLUTATHIONE TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | GSH EFFLUX | P-GLYCOPROTEIN | SUBSTRATE-SPECIFICITY | BIOPHYSICS | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | CYSTEINE SUBSTITUTIONS | TRANSPORT ACTIVITY | BIOLOGICAL EVALUATION | SELECTIVE INHIBITORS | HUMAN TUMOR-CELLS | Pyrimidines - chemical synthesis | Drug Resistance, Multiple - drug effects | Fluoresceins - metabolism | Humans | Daunorubicin - pharmacology | Fluorescent Dyes - metabolism | Structure-Activity Relationship | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | ATP Binding Cassette Transporter, Sub-Family B - agonists | Madin Darby Canine Kidney Cells | Multidrug Resistance-Associated Proteins - genetics | Antineoplastic Agents - pharmacology | Neoplasm Proteins - genetics | Purines - chemical synthesis | Gene Expression | Drug Resistance, Multiple - genetics | Purines - pharmacology | Pyrimidines - pharmacology | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - agonists | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics | Drug Resistance, Neoplasm - genetics | Pyrroles - pharmacology | Animals | Pyrroles - chemical synthesis | Neoplasm Proteins - agonists | Dogs | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Line, Tumor | Multidrug Resistance-Associated Proteins - agonists | Kinetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | Drug Resistance, Neoplasm - drug effects | Alkaloids | Drug resistance in microorganisms | Chemotherapy | Anthracyclines | Carrier proteins | Lung cancer | Cancer | Index Medicus
Journal Article
Journal Article
Toxicological Sciences, ISSN 1096-6080, 01/2016, Volume 149, Issue 1, pp. 202 - 212
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2009, Volume 52, Issue 4, pp. 1214 - 1218
Journal Article
Pharmacogenetics and Genomics, ISSN 1744-6872, 03/2009, Volume 19, Issue 3, pp. 206 - 216
Journal Article
Cancer Letters, ISSN 0304-3835, 2006, Volume 246, Issue 1, pp. 300 - 307
Abstract We recently reported that schisandrin B (Sch B) was a novel P-glycoprotein (P-gp) inhibitor. In this study, we revealed that Sch B was also an... 
Hematology, Oncology and Palliative Medicine | Cancer multidrug resistance | Schisandrin B | Multidrug resistance - associated protein 1 | Probenecid | probenecid | CELLS | TRANSPORTERS | HUMAN LUNG-CANCER | DRUG-RESISTANCE | MRP GENE | cancer multidrug resistance | CHEMOTHERAPY | BREAST-CANCER | multidrug resistance - associated protein 1 | schisandrin B | ONCOLOGY | REVERSAL AGENTS | LEUKEMIA | EXPRESSION | Antibiotics, Antineoplastic - pharmacology | Drug Resistance, Multiple - drug effects | Fluoresceins - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Gene Expression Regulation, Neoplastic | Daunorubicin - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | RNA, Messenger - metabolism | Lignans - pharmacology | Dose-Response Relationship, Drug | Flow Cytometry | Fluoresceins - administration & dosage | Multidrug Resistance-Associated Proteins - genetics | Cyclooctanes - pharmacology | Molecular Structure | Daunorubicin - metabolism | Polycyclic Compounds - chemistry | Lignans - chemistry | RNA, Messenger - genetics | Probenecid - pharmacology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Polycyclic Compounds - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Cyclooctanes - chemistry | HL-60 Cells | Antibiotics, Antineoplastic - metabolism | Multidrug Resistance-Associated Proteins - metabolism | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Proteins | Polymerization | Drug resistance | Drug dosages | Cancer | Index Medicus
Journal Article