The New England Journal of Medicine, ISSN 0028-4793, 01/2015, Volume 372, Issue 3, pp. 249 - 263
Multiple-system atrophy is a neurodegenerative disease characterized by progressive autonomic failure, parkinsonism, and cerebellar and pyramidal tract...
MEDICINE, GENERAL & INTERNAL | NEUROGENIC ORTHOSTATIC HYPOTENSION | OLIVOPONTOCEREBELLAR ATROPHY | NOCTURNAL HYPERTENSION | DOUBLE-BLIND | CYTOPLASMIC INCLUSIONS | CLINICAL-FEATURES | NATURAL-HISTORY | IDIOPATHIC PARKINSONS-DISEASE | AUTONOMIC FAILURE | PROGRESSIVE SUPRANUCLEAR PALSY | Multiple System Atrophy - therapy | Neuroprotective Agents - therapeutic use | Diagnosis, Differential | Humans | Hypotension - etiology | Multiple System Atrophy - diagnosis | Disease Progression | Multiple System Atrophy - etiology | Atrophy | Symptomatology | Care and treatment | Analysis | Adults | Diagnosis | Health aspects | Risk factors | Cerebellum | Basal ganglia | Neuropathology | Central nervous system diseases | Synuclein | Neurodegeneration | Autonomic nervous system | Inclusion bodies | Ataxia | Mutation | Movement disorders | Neurological disorders
MEDICINE, GENERAL & INTERNAL | NEUROGENIC ORTHOSTATIC HYPOTENSION | OLIVOPONTOCEREBELLAR ATROPHY | NOCTURNAL HYPERTENSION | DOUBLE-BLIND | CYTOPLASMIC INCLUSIONS | CLINICAL-FEATURES | NATURAL-HISTORY | IDIOPATHIC PARKINSONS-DISEASE | AUTONOMIC FAILURE | PROGRESSIVE SUPRANUCLEAR PALSY | Multiple System Atrophy - therapy | Neuroprotective Agents - therapeutic use | Diagnosis, Differential | Humans | Hypotension - etiology | Multiple System Atrophy - diagnosis | Disease Progression | Multiple System Atrophy - etiology | Atrophy | Symptomatology | Care and treatment | Analysis | Adults | Diagnosis | Health aspects | Risk factors | Cerebellum | Basal ganglia | Neuropathology | Central nervous system diseases | Synuclein | Neurodegeneration | Autonomic nervous system | Inclusion bodies | Ataxia | Mutation | Movement disorders | Neurological disorders
Journal Article
The New England journal of medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 14, pp. 1375 - 1375
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 14, pp. 1374 - 1376
To the Editor: Fanciulli and Wenning's review (Jan. 15 issue) 1 on multiple-system atrophy is comprehensive and up to date. In it, the authors state that the...
MEDICINE, GENERAL & INTERNAL | OLIVOPONTOCEREBELLAR ATROPHY | Neuroprotective Agents - therapeutic use | Humans | Multiple System Atrophy | Atrophy | Cerebellum | Diagnosis | Gait | Gabapentin | Patients
MEDICINE, GENERAL & INTERNAL | OLIVOPONTOCEREBELLAR ATROPHY | Neuroprotective Agents - therapeutic use | Humans | Multiple System Atrophy | Atrophy | Cerebellum | Diagnosis | Gait | Gabapentin | Patients
Journal Article
Lancet Neurology, The, ISSN 1474-4422, 2009, Volume 8, Issue 12, pp. 1172 - 1178
Summary Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative disorder that presents with autonomic failure in combination with...
Neurology | OLIVOPONTOCEREBELLAR ATROPHY | DELAYED-START TRIAL | AUTONOMIC DYSFUNCTION | GROUP EMSA-SG | GLIAL CYTOPLASMIC INCLUSIONS | DOUBLE-BLIND | ALPHA-SYNUCLEIN | TRANSGENIC MOUSE MODEL | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY | PARKINSONS-DISEASE | Multiple System Atrophy - therapy | Excitatory Amino Acid Antagonists - therapeutic use | Prognosis | Multiple System Atrophy - pathology | Humans | Riluzole - therapeutic use | alpha-Synuclein - genetics | Multiple System Atrophy - genetics | Multiple System Atrophy - epidemiology | Multiple System Atrophy - etiology | Atrophy | Neuroimaging | Basal ganglia | Neurodegenerative diseases | Autonomic nervous system | Cerebellar ataxia | Central nervous system diseases | Clinical trials | Minocycline | Growth hormone | Epidemiology | Movement disorders
Neurology | OLIVOPONTOCEREBELLAR ATROPHY | DELAYED-START TRIAL | AUTONOMIC DYSFUNCTION | GROUP EMSA-SG | GLIAL CYTOPLASMIC INCLUSIONS | DOUBLE-BLIND | ALPHA-SYNUCLEIN | TRANSGENIC MOUSE MODEL | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY | PARKINSONS-DISEASE | Multiple System Atrophy - therapy | Excitatory Amino Acid Antagonists - therapeutic use | Prognosis | Multiple System Atrophy - pathology | Humans | Riluzole - therapeutic use | alpha-Synuclein - genetics | Multiple System Atrophy - genetics | Multiple System Atrophy - epidemiology | Multiple System Atrophy - etiology | Atrophy | Neuroimaging | Basal ganglia | Neurodegenerative diseases | Autonomic nervous system | Cerebellar ataxia | Central nervous system diseases | Clinical trials | Minocycline | Growth hormone | Epidemiology | Movement disorders
Journal Article
Lancet Neurology, ISSN 1474-4422, 2004, Volume 3, Issue 2, pp. 93 - 103
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder characterised clinically by any combination of parkinsonian, autonomic, cerebellar, or...
SHY-DRAGER SYNDROME | NEUROGENIC ORTHOSTATIC HYPOTENSION | DE-NOVO PARKINSONISM | RICHARDSON-OLSZEWSKI SYNDROME | I-123 IODOBENZAMIDE-SPECT | GLIAL CYTOPLASMIC INCLUSIONS | PURE AUTONOMIC FAILURE | STRIATONIGRAL DEGENERATION | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY | SLEEP BEHAVIOR DISORDER | Multiple System Atrophy - therapy | Diagnostic Imaging | Diagnosis, Differential | Animals | Humans | Middle Aged | Brain - pathology | Multiple System Atrophy - diagnosis | Multiple System Atrophy - physiopathology | Atrophy
SHY-DRAGER SYNDROME | NEUROGENIC ORTHOSTATIC HYPOTENSION | DE-NOVO PARKINSONISM | RICHARDSON-OLSZEWSKI SYNDROME | I-123 IODOBENZAMIDE-SPECT | GLIAL CYTOPLASMIC INCLUSIONS | PURE AUTONOMIC FAILURE | STRIATONIGRAL DEGENERATION | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY | SLEEP BEHAVIOR DISORDER | Multiple System Atrophy - therapy | Diagnostic Imaging | Diagnosis, Differential | Animals | Humans | Middle Aged | Brain - pathology | Multiple System Atrophy - diagnosis | Multiple System Atrophy - physiopathology | Atrophy
Journal Article
Annals of Neurology, ISSN 0364-5134, 09/2008, Volume 64, Issue 3, pp. 239 - 246
To this day, the cause of multiple system atrophy (MSA) remains stubbornly enigmatic. A growing body of observations regarding the clinical, morphological, and...
OLIVOPONTOCEREBELLAR ATROPHY | MICROGLIAL ACTIVATION | GLIAL CYTOPLASMIC INCLUSIONS | CENTRAL-NERVOUS-SYSTEM | ALPHA-SYNUCLEIN | STRIATONIGRAL DEGENERATION | NEUROSCIENCES | LEWY BODIES | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY | PARKINSONS-DISEASE | CLINICOPATHOLOGICAL CORRELATIONS | Biomarkers - metabolism | Oligodendroglia - metabolism | Myelin Basic Protein - metabolism | Multiple System Atrophy - pathology | Brain - physiopathology | Humans | Biomarkers - analysis | Nerve Tissue Proteins - genetics | Myelin Basic Protein - genetics | Nerve Tissue Proteins - metabolism | Oligodendroglia - pathology | Animals | Nerve Fibers, Myelinated - physiology | Brain - pathology | Inclusion Bodies - pathology | alpha-Synuclein - genetics | Multiple System Atrophy - physiopathology | Inclusion Bodies - metabolism | alpha-Synuclein - metabolism
OLIVOPONTOCEREBELLAR ATROPHY | MICROGLIAL ACTIVATION | GLIAL CYTOPLASMIC INCLUSIONS | CENTRAL-NERVOUS-SYSTEM | ALPHA-SYNUCLEIN | STRIATONIGRAL DEGENERATION | NEUROSCIENCES | LEWY BODIES | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY | PARKINSONS-DISEASE | CLINICOPATHOLOGICAL CORRELATIONS | Biomarkers - metabolism | Oligodendroglia - metabolism | Myelin Basic Protein - metabolism | Multiple System Atrophy - pathology | Brain - physiopathology | Humans | Biomarkers - analysis | Nerve Tissue Proteins - genetics | Myelin Basic Protein - genetics | Nerve Tissue Proteins - metabolism | Oligodendroglia - pathology | Animals | Nerve Fibers, Myelinated - physiology | Brain - pathology | Inclusion Bodies - pathology | alpha-Synuclein - genetics | Multiple System Atrophy - physiopathology | Inclusion Bodies - metabolism | alpha-Synuclein - metabolism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 48, pp. 19555 - 19560
Prions are proteins that adopt alternative conformations, which become self-propagating. Increasing evidence argues that prions feature in the...
Brain | Nervous system diseases | Neurodegenerative diseases | Neurons | Prions | Multiple system atrophy | Parkinson disease | Prion diseases | Mice | Alzheimers disease | Bioluminescence imaging | Neurodegeneration | Proteinopathies | Seeding | PROTEIN | MULTIDISCIPLINARY SCIENCES | neurodegeneration | bioluminescence imaging | SPONGIFORM ENCEPHALOPATHY | proteinopathies | NEURODEGENERATIVE DISEASES | seeding | PATHOLOGICAL ALPHA-SYNUCLEIN | GLIAL CYTOPLASMIC INCLUSIONS | ORTHOSTATIC HYPOTENSION | CREUTZFELDT-JAKOB-DISEASE | LEWY BODIES | PARKINSONS-DISEASE | TAU INCLUSIONS | Prions - metabolism | Multiple System Atrophy - pathology | Humans | Male | Mice, Transgenic | Animals | Multiple System Atrophy - metabolism | Aged, 80 and over | Aged | alpha-Synuclein - genetics | Disease Transmission, Infectious | alpha-Synuclein - metabolism | Atrophy | Genetic aspects | Research | Identification and classification | Brain mapping | Biological Sciences
Brain | Nervous system diseases | Neurodegenerative diseases | Neurons | Prions | Multiple system atrophy | Parkinson disease | Prion diseases | Mice | Alzheimers disease | Bioluminescence imaging | Neurodegeneration | Proteinopathies | Seeding | PROTEIN | MULTIDISCIPLINARY SCIENCES | neurodegeneration | bioluminescence imaging | SPONGIFORM ENCEPHALOPATHY | proteinopathies | NEURODEGENERATIVE DISEASES | seeding | PATHOLOGICAL ALPHA-SYNUCLEIN | GLIAL CYTOPLASMIC INCLUSIONS | ORTHOSTATIC HYPOTENSION | CREUTZFELDT-JAKOB-DISEASE | LEWY BODIES | PARKINSONS-DISEASE | TAU INCLUSIONS | Prions - metabolism | Multiple System Atrophy - pathology | Humans | Male | Mice, Transgenic | Animals | Multiple System Atrophy - metabolism | Aged, 80 and over | Aged | alpha-Synuclein - genetics | Disease Transmission, Infectious | alpha-Synuclein - metabolism | Atrophy | Genetic aspects | Research | Identification and classification | Brain mapping | Biological Sciences
Journal Article
Neurology, ISSN 0028-3878, 08/2008, Volume 71, Issue 9, pp. 670 - 676
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2013, Volume 369, Issue 3, pp. 233 - 244
Multiple-system atrophy is a rare neurodegenerative disease characterized by autonomic failure. Mutations affecting an enzyme essential for the synthesis of...
SKELETAL-MUSCLE | MEDICINE, GENERAL & INTERNAL | OLIVOPONTOCEREBELLAR ATROPHY | OXIDATIVE STRESS | IMMUNOREACTIVITY | VARIANTS | GLIAL CYTOPLASMIC INCLUSIONS | ALPHA-SYNUCLEIN | TRANSGENIC MOUSE MODEL | PARKINSONS-DISEASE | DEGENERATION | Cell Line | Ubiquinone - analysis | Humans | Ubiquinone - analogs & derivatives | Male | Multiple System Atrophy - genetics | Alkyl and Aryl Transferases - genetics | DNA Mutational Analysis | Pedigree | Female | Brain Chemistry | Mutation | Genetic Linkage | Atrophy | Ubiquinones | Genetic aspects | Research | Gene mutations | Risk factors | Cerebellum | Basal ganglia | Disease | Cerebellar ataxia | Central nervous system diseases | Genomes | High-performance liquid chromatography | Enzymatic activity | Neurodegeneration | Autonomic nervous system | Autopsy | Coenzyme Q10 | Genetics | Ataxia | Complementation | Movement disorders | Linkage analysis
SKELETAL-MUSCLE | MEDICINE, GENERAL & INTERNAL | OLIVOPONTOCEREBELLAR ATROPHY | OXIDATIVE STRESS | IMMUNOREACTIVITY | VARIANTS | GLIAL CYTOPLASMIC INCLUSIONS | ALPHA-SYNUCLEIN | TRANSGENIC MOUSE MODEL | PARKINSONS-DISEASE | DEGENERATION | Cell Line | Ubiquinone - analysis | Humans | Ubiquinone - analogs & derivatives | Male | Multiple System Atrophy - genetics | Alkyl and Aryl Transferases - genetics | DNA Mutational Analysis | Pedigree | Female | Brain Chemistry | Mutation | Genetic Linkage | Atrophy | Ubiquinones | Genetic aspects | Research | Gene mutations | Risk factors | Cerebellum | Basal ganglia | Disease | Cerebellar ataxia | Central nervous system diseases | Genomes | High-performance liquid chromatography | Enzymatic activity | Neurodegeneration | Autonomic nervous system | Autopsy | Coenzyme Q10 | Genetics | Ataxia | Complementation | Movement disorders | Linkage analysis
Journal Article
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 07/2014, Volume 371, Issue 1, pp. 81 - 81
Journal Article
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 07/2014, Volume 371, Issue 1, pp. 81 - 82
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