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Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling
Cancer Cell, ISSN 1535-6108, 01/2017, Volume 31, Issue 1, pp. 21 - 34
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying...
gastric cancer | stem cell | tuft cell | YAP | Lgr5 | acetylcholine | NGF | wnt | Dclk1 | muscarinic acetylcholine receptor type 3 | PROGENITOR CELLS | STEM-CELLS | ENTERIC NEURONS | ONCOLOGY | HAIR FOLLICLE | BONE-MARROW | BRUSH CELLS | INTRAEPITHELIAL NEOPLASIA | GLIAL-CELLS | MUSCARINIC ACETYLCHOLINE-RECEPTORS | TRANSGENIC MICE | CELL BIOLOGY | Protein-Serine-Threonine Kinases - analysis | Adaptor Proteins, Signal Transducing - physiology | Animals | Nerve Growth Factor - physiology | Mice, Inbred C57BL | Gastric Mucosa - innervation | Receptor, Muscarinic M3 - physiology | Signal Transduction - physiology | Mice | Phosphoproteins - physiology | Acetylcholine - physiology | Stomach Neoplasms - etiology | Medical colleges | Nerve growth factor | Acetylcholine | Liver | Stem cells | Tumors | Development and progression | Ablation (Surgery) | muscarinic acetylcholine recepter type 3 | Wnt
gastric cancer | stem cell | tuft cell | YAP | Lgr5 | acetylcholine | NGF | wnt | Dclk1 | muscarinic acetylcholine receptor type 3 | PROGENITOR CELLS | STEM-CELLS | ENTERIC NEURONS | ONCOLOGY | HAIR FOLLICLE | BONE-MARROW | BRUSH CELLS | INTRAEPITHELIAL NEOPLASIA | GLIAL-CELLS | MUSCARINIC ACETYLCHOLINE-RECEPTORS | TRANSGENIC MICE | CELL BIOLOGY | Protein-Serine-Threonine Kinases - analysis | Adaptor Proteins, Signal Transducing - physiology | Animals | Nerve Growth Factor - physiology | Mice, Inbred C57BL | Gastric Mucosa - innervation | Receptor, Muscarinic M3 - physiology | Signal Transduction - physiology | Mice | Phosphoproteins - physiology | Acetylcholine - physiology | Stomach Neoplasms - etiology | Medical colleges | Nerve growth factor | Acetylcholine | Liver | Stem cells | Tumors | Development and progression | Ablation (Surgery) | muscarinic acetylcholine recepter type 3 | Wnt
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e95433
Orexin-A (a neuropeptide in the hypothalamus) plays an important role in many physiological functions, including the regulation of glucose metabolism. We have...
DIABETIC MICE | NUCLEUS-TRACTUS-SOLITARIUS | MESSENGER-RNA | INSULIN-RESISTANCE | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | DORSAL-ROOT GANGLION | ISCHEMIC-STROKE | MUSCARINIC ACETYLCHOLINE-RECEPTORS | NEURONAL DAMAGE | HYPOCRETIN OREXIN | Glucose Intolerance - metabolism | Intracellular Signaling Peptides and Proteins - pharmacology | Benzoxazoles - pharmacology | Orexin Receptors - metabolism | Orexins | Proto-Oncogene Proteins c-fos - metabolism | Vagus Nerve - drug effects | Male | Infarction, Middle Cerebral Artery - metabolism | Choline O-Acetyltransferase - metabolism | Liver - innervation | Vagus Nerve - physiology | Animals | Hypothalamus - metabolism | Neuroprotective Agents - pharmacology | Neuropeptides - pharmacology | Urea - analogs & derivatives | Mice | Hypothalamus - drug effects | Urea - pharmacology | Glucose metabolism | Brain research | Glucose intolerance | Health aspects | Analysis | Occlusion | Brain | Neuroprotection | Energy metabolism | Liver | Homeostasis | Nervous system | Glucose | Hypothalamus | Recovery | Carotid arteries | Receptors | Hyperglycemia | Ischemia | Fos protein | Insulin receptors | Autonomic nervous system | Cerebral blood flow | Rodents | Animal tissues | Medulla oblongata | Acetyltransferase | Vagus nerve | Localization | Damage | c-Fos protein | Pharmaceutical sciences | Stroke | vagotomy | Metabolism | Insulin | Glucose tolerance | Intolerance | Communications systems | Pharmacy | Insulin resistance | Hypoxia | Diabetes | Laboratory animals | Parasympathetic nervous system | Veins & arteries
DIABETIC MICE | NUCLEUS-TRACTUS-SOLITARIUS | MESSENGER-RNA | INSULIN-RESISTANCE | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | DORSAL-ROOT GANGLION | ISCHEMIC-STROKE | MUSCARINIC ACETYLCHOLINE-RECEPTORS | NEURONAL DAMAGE | HYPOCRETIN OREXIN | Glucose Intolerance - metabolism | Intracellular Signaling Peptides and Proteins - pharmacology | Benzoxazoles - pharmacology | Orexin Receptors - metabolism | Orexins | Proto-Oncogene Proteins c-fos - metabolism | Vagus Nerve - drug effects | Male | Infarction, Middle Cerebral Artery - metabolism | Choline O-Acetyltransferase - metabolism | Liver - innervation | Vagus Nerve - physiology | Animals | Hypothalamus - metabolism | Neuroprotective Agents - pharmacology | Neuropeptides - pharmacology | Urea - analogs & derivatives | Mice | Hypothalamus - drug effects | Urea - pharmacology | Glucose metabolism | Brain research | Glucose intolerance | Health aspects | Analysis | Occlusion | Brain | Neuroprotection | Energy metabolism | Liver | Homeostasis | Nervous system | Glucose | Hypothalamus | Recovery | Carotid arteries | Receptors | Hyperglycemia | Ischemia | Fos protein | Insulin receptors | Autonomic nervous system | Cerebral blood flow | Rodents | Animal tissues | Medulla oblongata | Acetyltransferase | Vagus nerve | Localization | Damage | c-Fos protein | Pharmaceutical sciences | Stroke | vagotomy | Metabolism | Insulin | Glucose tolerance | Intolerance | Communications systems | Pharmacy | Insulin resistance | Hypoxia | Diabetes | Laboratory animals | Parasympathetic nervous system | Veins & arteries
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 1991, Volume 200, Issue 1, pp. 45 - 52
Multiple cortical neuronal responses were elicited by the iontophoretic application of muscarinic receptor agonists and antagonists in the rat cerebral...
Muscarinic receptor agonists | Cerebral cortex | Muscarinic receptor antagonists | Neuronal activity | Rat | Modulation | MUSCARINIC RECEPTOR AGONISTS | RAT | ACETYLCHOLINE | SUBTYPES | RELEASE | CEREBRAL CORTEX | HIPPOCAMPUS | RESPONSES | NEURONAL ACTIVITY | CORTICAL-NEURONS | CAT VISUAL-CORTEX | MUSCARINIC RECEPTOR ANTAGONISTS | PHARMACOLOGY & PHARMACY | CHOLINERGIC MODULATION | MODULATION | BRAIN | Oxotremorine - pharmacology | Rats | Male | Muscarinic Antagonists | Rats, Inbred Strains | Evoked Potentials - drug effects | Iontophoresis | Animals | (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride - pharmacology | Oxotremorine - analogs & derivatives | Cerebral Cortex - physiology | Neurons - drug effects | Parasympathomimetics - pharmacology | Receptors, Muscarinic - physiology
Muscarinic receptor agonists | Cerebral cortex | Muscarinic receptor antagonists | Neuronal activity | Rat | Modulation | MUSCARINIC RECEPTOR AGONISTS | RAT | ACETYLCHOLINE | SUBTYPES | RELEASE | CEREBRAL CORTEX | HIPPOCAMPUS | RESPONSES | NEURONAL ACTIVITY | CORTICAL-NEURONS | CAT VISUAL-CORTEX | MUSCARINIC RECEPTOR ANTAGONISTS | PHARMACOLOGY & PHARMACY | CHOLINERGIC MODULATION | MODULATION | BRAIN | Oxotremorine - pharmacology | Rats | Male | Muscarinic Antagonists | Rats, Inbred Strains | Evoked Potentials - drug effects | Iontophoresis | Animals | (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride - pharmacology | Oxotremorine - analogs & derivatives | Cerebral Cortex - physiology | Neurons - drug effects | Parasympathomimetics - pharmacology | Receptors, Muscarinic - physiology
Journal Article
European Journal of Pharmacology: Molecular Pharmacology, ISSN 0922-4106, 1991, Volume 208, Issue 4, pp. 287 - 295
The present study examines the mechanism(s) of action of anethole trithione compared to the sialogogue pilocarpine. This was done by comparing the acute...
α1-Adrenoceptor | β1-Adrenoceptor | Sialogogues | cGMP | Oxygen consumption | cAMP | Parotid gland (rat) | Muscarinic acetylcholine receptor | parotid gland (rat) | adrenoceptor | oxygen consumption | muscarinic acetylcholine receptor | sialogogues | CELLS | MUSCARINIC RECEPTORS | ALPHA-1-ADRENOCEPTOR | BETA-1-ADRENOCEPTOR | STIMULATION-INDUCED CHANGES | SIALOGOGUES | ACINI | MUSCARINIC ACETYLCHOLINE RECEPTOR | PAROTID GLAND (RAT) | CALCIUM | CGMP | PHARMACOLOGY & PHARMACY | OXYGEN CONSUMPTION | BINDING | CAMP
α1-Adrenoceptor | β1-Adrenoceptor | Sialogogues | cGMP | Oxygen consumption | cAMP | Parotid gland (rat) | Muscarinic acetylcholine receptor | parotid gland (rat) | adrenoceptor | oxygen consumption | muscarinic acetylcholine receptor | sialogogues | CELLS | MUSCARINIC RECEPTORS | ALPHA-1-ADRENOCEPTOR | BETA-1-ADRENOCEPTOR | STIMULATION-INDUCED CHANGES | SIALOGOGUES | ACINI | MUSCARINIC ACETYLCHOLINE RECEPTOR | PAROTID GLAND (RAT) | CALCIUM | CGMP | PHARMACOLOGY & PHARMACY | OXYGEN CONSUMPTION | BINDING | CAMP
Journal Article
European Journal of Pharmacology: Molecular Pharmacology, ISSN 0922-4106, 1991, Volume 208, Issue 1, pp. 9 - 15
Muscarinic receptor-linked Ca2+ mobilization and changes in cyclic AMP were studied in SH-SY5Y and IMR 32 human neuroblastoma cell lines. Muscarinic agonists...
Cyclic AMP | SH-SY5Y | Muscarinic M 1, M 2, M 3 receptors | IMR 32 human neuroblastoma cells | Ca 2+ mobilization | CYCLIC AMP | PHARMACOLOGY & PHARMACY | MUSCARINIC M1,M2,M3 RECEPTORS | CA-2+ MOBILIZATION | IMR-32 HUMAN NEUROBLASTOMA CELLS
Cyclic AMP | SH-SY5Y | Muscarinic M 1, M 2, M 3 receptors | IMR 32 human neuroblastoma cells | Ca 2+ mobilization | CYCLIC AMP | PHARMACOLOGY & PHARMACY | MUSCARINIC M1,M2,M3 RECEPTORS | CA-2+ MOBILIZATION | IMR-32 HUMAN NEUROBLASTOMA CELLS
Journal Article
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