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Cold Spring Harbor perspectives in biology, ISSN 1943-0264, 2010, Volume 2, Issue 2, pp. a001107 - a001107
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7568, pp. 206 - 211
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2007, Volume 9, Issue 5, pp. 573 - 580
Tp53 is the most commonly mutated tumour- suppressor gene in human cancers(1). In addition to the loss of tumour-suppression function, some missense mutants... 
RESPONSES | TARGETED DISRUPTION | THYMIC LYMPHOMA | ACTIVATION | LI-FRAUMENI-SYNDROME | EMBRYONIC STEM-CELLS | DNA-DAMAGE | MOUSE | HISTONE H2AX | MUTATIONS | CELL BIOLOGY | Neoplasms - metabolism | Cell Cycle - genetics | Genomic Instability | Translocation, Genetic | Phosphorylation | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - genetics | DNA Breaks, Double-Stranded - radiation effects | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Ultraviolet Rays | Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | DNA Repair Enzymes - metabolism | ATP-Binding Cassette Transporters - metabolism | Transcription, Genetic | Thymus Gland - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Thymus Gland - cytology | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Nuclear Proteins - metabolism | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | Cell Transformation, Neoplastic - metabolism | Animals | Fibroblasts - radiation effects | Mice | Histones - metabolism | Mutation | Tumor suppressor genes | Research | Translocation (Genetics) | Gene mutations
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
EMBO reports, ISSN 1469-221X, 11/2017, Volume 18, Issue 11, pp. 2030 - 2050
Cancer‐associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of... 
replication | gain‐of‐function | mutant p53 | Cdc7‐Dbf4 | origin firing | Cdc7-Dbf4 | gain-of-function | CANCER-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | DNA-REPLICATION | CELL BIOLOGY | CYCLIN-DEPENDENT KINASES | RESISTANCE | S-PHASE | CDC7 KINASE | STRESS | FORK PROGRESSION | Neoplasm Transplantation | RNA, Small Interfering - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | DNA, Neoplasm - metabolism | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-myb - genetics | Lung Neoplasms - pathology | Male | Gene Expression Profiling | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Adenocarcinoma - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Adenocarcinoma - genetics | Protein-Serine-Threonine Kinases - metabolism | Lung Neoplasms - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | DNA Replication | Minichromosome Maintenance Complex Component 2 - genetics | Minichromosome Maintenance Complex Component 2 - metabolism | Mice, SCID | Proto-Oncogene Proteins c-myb - metabolism | Animals | Survival Analysis | Cell Line, Tumor | Mice, Inbred NOD | Mice | DNA, Neoplasm - genetics | Mutation | Neoplasm Staging | Adenocarcinoma - mortality | RNA, Small Interfering - metabolism | Adenocarcinoma | Chromatin | p53 Protein | Replication initiation | Patients | Mutants | Initiation factors | DNA biosynthesis | Signaling | Eukaryotes | Replication origins | Lungs | Replication | Tumorigenesis | Deoxyribonucleic acid--DNA | Cancer | Signal Transduction | DNA Replication, Repair & Recombination
Journal Article
by Xu, J and Wang, J and Hu, Y and Qian, J and Xu, B and Chen, H and Zou, W and Fang, J.-Y
Cell Death and Disease, 2014, Volume 5, Issue 3
Journal Article